{"disease":{"id":"thiamin-deficiency","name":"Thiamin deficiency","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":2,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"thiamine","indication_name":"Thiamin deficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Thiamine Hydrochloride","generic_name":"THIAMINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Heat shock protein HSP 90-alpha","drug_class":"thiamine (vit B1)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"thiamin","indication_name":"Thiamin deficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Thiamin","company_name":"Hospital Sao Domingos","drug_phase":"marketed","molecular_target":"Thiamin pyrophosphokinase 1, Thiamine transporter 1, Thiamine-triphosphatase","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT03626337","title":"Thiamine Responsive Disorders (TRD) Among Infants in Lao PDR","phase":"","overall_status":"COMPLETED","enrollment_count":1394,"lead_sponsor_name":"University of California, Davis","has_results":false},{"nct_id":"NCT03616288","title":"Trial of Thiamine Supplementation in Cambodia","phase":"NA","overall_status":"COMPLETED","enrollment_count":335,"lead_sponsor_name":"Mount Saint Vincent University","has_results":false},{"nct_id":"NCT05480943","title":"Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans","phase":"","overall_status":"COMPLETED","enrollment_count":206,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT04641104","title":"The Thiamine Administration After Cardiac Surgery Trial","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Sarah Saxena","has_results":false},{"nct_id":"NCT03550794","title":"Thiamine as a Renal Protective Agent in Septic Shock","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":95,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":true},{"nct_id":"NCT06298344","title":"The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease","phase":"EARLY_PHASE1","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"Universitas Sumatera Utara","has_results":false},{"nct_id":"NCT03263442","title":"High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"UNC Lineberger Comprehensive Cancer Center","has_results":true},{"nct_id":"NCT04453761","title":"Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"National Cardiovascular Center Harapan Kita Hospital Indonesia","has_results":false},{"nct_id":"NCT03554668","title":"Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)","phase":"","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Glasgow Royal Infirmary","has_results":false},{"nct_id":"NCT05390086","title":"Further Development and Assessment of Tools to Measure Risk Factors for and Treatment of Thiamine Deficiency Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"University of California, Davis","has_results":false},{"nct_id":"NCT02974257","title":"Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":41,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":true},{"nct_id":"NCT05663164","title":"Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Universitas Sumatera Utara","has_results":false},{"nct_id":"NCT03444155","title":"Natural Versus Synthetic Vitamin B Complexes in Human","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Medical University of Graz","has_results":true},{"nct_id":"NCT01524315","title":"Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT03228030","title":"Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Hamilton Health Sciences Corporation","has_results":false},{"nct_id":"NCT03746106","title":"The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":7,"lead_sponsor_name":"University of California, San Francisco","has_results":true},{"nct_id":"NCT03122678","title":"Thiamine Supplementation in Patients With Septic Shock","phase":"PHASE1","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"The Cleveland Clinic","has_results":false}],"total":18},"guidelines":[],"source":"Drug Landscape verified database"}