{"disease":{"id":"syphilis","name":"Syphilis","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":12,"pipeline_drug_count":0,"trial_count":3},"drugs":{"marketed":[{"drug_id":"penicillin-g-sodium","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"PENICILLIN G SODIUM","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":25,"revenue":null,"mechanism":null},{"drug_id":"doxycycline","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vibramycin","generic_name":"doxycycline","company_name":"Generic (originally Pfizer)","drug_phase":"marketed","molecular_target":"72 kDa type IV collagenase, Stromelysin-1, Collagenase 3","drug_class":"Tetracycline antibiotic","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"fusidic-acid","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ramycin","generic_name":"FUSIDIC ACID","company_name":"","drug_phase":"phase_3","molecular_target":"Bile salt export pump","drug_class":"fusidic acid","quality_score":47,"revenue":null,"mechanism":"Fusidic acid works by inhibiting the function of the bacterial ribosome, preventing the production of essential proteins."},{"drug_id":"doxycyclin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Doxycyclin","company_name":"Bulovka Hospital","drug_phase":"marketed","molecular_target":"72 kDa type IV collagenase, Stromelysin-1, Collagenase 3","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"benzylpenicillin","indication_name":"Asymptomatic Congenital Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Congenital syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Late latent syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Late syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Latent early syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Latent syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Neurosyphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Primary genital syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Secondary syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"benzylpenicillin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Penicillin G Potassium In Plastic Container","generic_name":"Benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Penicillin-class Antibacterial","quality_score":32,"revenue":null,"mechanism":""},{"drug_id":"amphotericin-b","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abelcet","generic_name":"AMPHOTERICIN B","company_name":"Astellas Pharma","drug_phase":"marketed","molecular_target":"","drug_class":"Lipid-based Polyene Antifungal [EPC]","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"demeclocycline","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Demethylchlortetracycline","generic_name":"DEMECLOCYCLINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Estrogen receptor beta","drug_class":"Tetracycline-class Antimicrobial","quality_score":51,"revenue":null,"mechanism":""},{"drug_id":"erythromycin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"E-Mycin","generic_name":"erythromycin","company_name":"Generic (originally Abbott/Lilly)","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Bile salt export pump, Cytochrome P450 1B1","drug_class":"Macrolide [EPC]","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"meclocycline","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Meclan","generic_name":"MECLOCYCLINE","company_name":"Johnson And Johnson","drug_phase":"marketed","molecular_target":"","drug_class":"meclocycline","quality_score":19,"revenue":null,"mechanism":""},{"drug_id":"erythrocin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Benzamycin","generic_name":"Erythromycin Lactobionate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Potassium voltage-gated channel subfamily H member 2","drug_class":"Macrolide","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"benzathine-benzylpenicillin","indication_name":"Syphilis excluding neurosyphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bicillin C-R","generic_name":"benzathine benzylpenicillin","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"benzathine benzylpenicillin","quality_score":60,"revenue":null,"mechanism":"Bicillin C-R works by binding to penicillin-binding proteins on bacterial cell walls, preventing them from forming a strong cell wall and ultimately leading to bacterial cell death."},{"drug_id":"minocycline","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Minocycline Hydrochloride","generic_name":"MINOCYCLINE","company_name":"Rempex","drug_phase":"marketed","molecular_target":"","drug_class":"Tetracycline-class Drug","quality_score":75,"revenue":null,"mechanism":"MINOCYCLINE works by inhibiting protein synthesis in bacteria, ultimately leading to their death."},{"drug_id":"doxycycline","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vibramycin","generic_name":"doxycycline","company_name":"Generic (originally Pfizer)","drug_phase":"marketed","molecular_target":"72 kDa type IV collagenase, Stromelysin-1, Collagenase 3","drug_class":"Tetracycline antibiotic","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"penicillin","indication_name":"Asymptomatic Congenital Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Congenital syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Late latent syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Late syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Latent early syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Latent syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Neurosyphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Primary genital syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Secondary syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"penicillin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"penicillin","company_name":"Karlstad University","drug_phase":"marketed","molecular_target":"Bacterial penicillin-binding protein, Beta-lactamase, Beta-lactamase TEM","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"minocyclin","indication_name":"Syphilis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Minocyclin","company_name":"University of Southern California","drug_phase":"marketed","molecular_target":"30S ribosomal protein S4, 30S ribosomal protein S9, Tetracycline resistance protein, class B","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":33,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT02353117","title":"Preventing Congenital Syphilis","phase":"NA","overall_status":"COMPLETED","enrollment_count":60386,"lead_sponsor_name":"Tulane University School of Public Health and Tropical Medicine","has_results":false},{"nct_id":"NCT07388979","title":"MAGIA H3S Point of Care Test Performance for HIV, HBV, HCV, and Syphilis Screening in Pregnant Women in DR Congo","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":7500,"lead_sponsor_name":"Gardiens de Vies","has_results":false},{"nct_id":"NCT06743204","title":"The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":5560,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT02019043","title":"Evaluation of Enhanced Syphilis Screening Among HIV-positive Men","phase":"NA","overall_status":"COMPLETED","enrollment_count":3895,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT06468462","title":"Periodic Presumptive Treatment vs. doxyPEP for STI Control in Kenyan MSM","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":2900,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT04325555","title":"Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard","phase":"","overall_status":"COMPLETED","enrollment_count":2647,"lead_sponsor_name":"New York University","has_results":false},{"nct_id":"NCT06428643","title":"A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":2322,"lead_sponsor_name":"Tulane University","has_results":false},{"nct_id":"NCT06058286","title":"MENJAGA: Continuous Quality Improvement for Antenatal HIV, Syphilis and Hepatitis B Testing in Indonesia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Yanri Wijayanti Subronto, MD, PhD,","has_results":false},{"nct_id":"NCT02752152","title":"Counseling and Reminders for Regular HIV and STIs Screening","phase":"NA","overall_status":"COMPLETED","enrollment_count":1961,"lead_sponsor_name":"Institut de Recherche pour le Developpement","has_results":false},{"nct_id":"NCT03418441","title":"Central Nervous System Infections in Denmark","phase":"","overall_status":"RECRUITING","enrollment_count":1900,"lead_sponsor_name":"Aalborg University Hospital","has_results":false},{"nct_id":"NCT07516912","title":"Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1800,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT05063344","title":"NOWDx Test for the Diagnosis of Syphilis","phase":"","overall_status":"COMPLETED","enrollment_count":1535,"lead_sponsor_name":"NOWDiagnostics, Inc.","has_results":false},{"nct_id":"NCT04514848","title":"Point of Care Tests for Syphilis and HIV","phase":"NA","overall_status":"COMPLETED","enrollment_count":1526,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT06645106","title":"Offering Routine and Rapid Point of Care (POC) Syphilis Testing in Pregnant Patients Presenting to the Emergency Department","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT06367621","title":"Retrospective Study of iStatis Syphilis Ab Test (POC)","phase":"","overall_status":"COMPLETED","enrollment_count":1500,"lead_sponsor_name":"bioLytical Laboratories","has_results":false},{"nct_id":"NCT06365606","title":"Study to Evaluate Diagnostic Sensitivity and Specificity of iStatis Syphilis Ab Test at the Point- Of-Care Sites","phase":"NA","overall_status":"COMPLETED","enrollment_count":1500,"lead_sponsor_name":"bioLytical Laboratories","has_results":false},{"nct_id":"NCT07525076","title":"Implementation of an Opt-Out Testing and Rapid Diagnostic Strategy for Syphilis and HIV in Pregnant Patients Presenting to the Emergency Department","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1400,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT06586905","title":"A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.","phase":"NA","overall_status":"RECRUITING","enrollment_count":1300,"lead_sponsor_name":"MedMira Laboratories Inc.","has_results":false},{"nct_id":"NCT03156751","title":"Feasibility of Introducing an Onsite Test for Syphilis in the Package of Antenatal Care in Burkina Faso","phase":"","overall_status":"COMPLETED","enrollment_count":1205,"lead_sponsor_name":"Institut de Recherche en Sciences de la Sante, Burkina Faso","has_results":false},{"nct_id":"NCT05541081","title":"Investigating Point-of-care Diagnostics for Sexually Transmitted Infections and Antimicrobial Resistance in Primary Care in Zimbabwe","phase":"NA","overall_status":"COMPLETED","enrollment_count":1005,"lead_sponsor_name":"London School of Hygiene and Tropical Medicine","has_results":false},{"nct_id":"NCT06082453","title":"Modernizing Perinatal Syphilis Testing","phase":"NA","overall_status":"RECRUITING","enrollment_count":924,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT06716450","title":"Multiplo Tp/HIV Self-Test","phase":"NA","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT04947475","title":"Project MATLINK: Development and Evaluation of a Screening, Brief Intervention, & Referral to Treatment (SBIRT) Program for Opioid Dependent Prisoners and Probationers Transitioning to the Community","phase":"NA","overall_status":"COMPLETED","enrollment_count":835,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT06738407","title":"Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":760,"lead_sponsor_name":"Westat","has_results":false},{"nct_id":"NCT03709862","title":"Global Syphilis Sequencing","phase":"","overall_status":"COMPLETED","enrollment_count":726,"lead_sponsor_name":"London School of Hygiene and Tropical Medicine","has_results":false},{"nct_id":"NCT06069141","title":"Comparisons of Treatment Responses of Early Syphilis to Benzathine Penicillin G With or Without Doxycycline","phase":"NA","overall_status":"RECRUITING","enrollment_count":688,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT03980223","title":"Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":641,"lead_sponsor_name":"University of California, San Francisco","has_results":true},{"nct_id":"NCT06927843","title":"Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":600,"lead_sponsor_name":"University of Manitoba","has_results":false},{"nct_id":"NCT05831098","title":"Evaluation of the Sensitivity, Specificity, and Utility of the Reveal® TP (Syphilis) Antibody POCT","phase":"NA","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"MedMira Laboratories Inc.","has_results":false},{"nct_id":"NCT04084379","title":"Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases","phase":"","overall_status":"UNKNOWN","enrollment_count":560,"lead_sponsor_name":"Hospital de Niños R. Gutierrez de Buenos Aires","has_results":false},{"nct_id":"NCT07189208","title":"Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT07300254","title":"Treponemal Shedding, Load, and Viability, in Women and Men-who-have-sex-with-women-only With Early Infectious Syphilis: Implications for Transmission","phase":"","overall_status":"RECRUITING","enrollment_count":480,"lead_sponsor_name":"Monash University","has_results":false},{"nct_id":"NCT04050540","title":"Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":449,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT04793750","title":"Ending the HIV Epidemic Through Point-of-Care Technologies (EHPOC)","phase":"NA","overall_status":"COMPLETED","enrollment_count":419,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT05534633","title":"APPROACH 2.0: HIV, HCV and Syphilis Testing Through Pharmacies","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":407,"lead_sponsor_name":"Memorial University of Newfoundland","has_results":false},{"nct_id":"NCT07397403","title":"The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Bangrak STIs Center","has_results":false},{"nct_id":"NCT04958122","title":"Cefixime Clinical Trial","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"University of Southern California","has_results":false},{"nct_id":"NCT07457385","title":"Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":374,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT05975502","title":"Congenital Syphilis in Switzerland","phase":"","overall_status":"COMPLETED","enrollment_count":265,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT05307991","title":"Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe","phase":"","overall_status":"COMPLETED","enrollment_count":249,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":false},{"nct_id":"NCT03637660","title":"Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":249,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":true},{"nct_id":"NCT07150871","title":"Impact of Covid-19 on Syphilis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":240,"lead_sponsor_name":"Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria","has_results":false},{"nct_id":"NCT04838717","title":"Clinical Trial of Doxycycline VS BPG for Early Syphilis (SY-DOXY)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06791928","title":"Peer Delivered HIV/Syphilis Self-Testing With Assisted Partner Notification Services","phase":"PHASE2","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":200,"lead_sponsor_name":"Makerere University","has_results":false},{"nct_id":"NCT05692505","title":"Multicenter Performance Study of QuadQuik Invitro Diagnostic Device","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Genlantis Diagnostics","has_results":false},{"nct_id":"NCT06152393","title":"Value of an Intrathecal Synthesis Index of Specific Antitreponema IgG for Neurosyphilis Diagnosis","phase":"","overall_status":"COMPLETED","enrollment_count":181,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT03752112","title":"Trial Evaluating the Clinical Efficacy of Cefixime for Treatment of Early Syphilis in Non-pregnant Women","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":180,"lead_sponsor_name":"World Health Organization","has_results":false},{"nct_id":"NCT07498153","title":"Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting","phase":"NA","overall_status":"COMPLETED","enrollment_count":149,"lead_sponsor_name":"The University of Texas Health Science Center, Houston","has_results":false},{"nct_id":"NCT06877351","title":"Oral Amoxicillin Compared to Penicillin G Benzathine for the Treatment of Acquired Syphilis.","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":120,"lead_sponsor_name":"Hospital de Niños R. Gutierrez de Buenos Aires","has_results":false},{"nct_id":"NCT05980871","title":"Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":109,"lead_sponsor_name":"National Taiwan University Hospital","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}