{"disease":{"id":"sj-gren-s-syndrome","name":"Sjögren's syndrome","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":0,"trial_count":2},"drugs":{"marketed":[{"drug_id":"pilocarpine","indication_name":"Dry mouth in Sjogren's syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Salagen","generic_name":"PILOCARPINE","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"Cholinergic Receptor Agonist","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"eledoisin","indication_name":"Sjögren's syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Eledone Peptide","generic_name":"ELEDOISIN","company_name":"","drug_phase":"phase_2","molecular_target":"Neuromedin-K receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Eledoisin works by binding to the Neuromedin-K receptor, which is involved in various physiological processes."},{"drug_id":"pilocarpine","indication_name":"Xerostomia Secondary to Sjogren's Syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Salagen","generic_name":"PILOCARPINE","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"Cholinergic Receptor Agonist","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"cevimeline","indication_name":"Xerostomia Secondary to Sjogren's Syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Evoxac","generic_name":"CEVIMELINE","company_name":"Cosette","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Cholinergic Receptor Agonist","quality_score":35,"revenue":null,"mechanism":""},{"drug_id":"prednisolone","indication_name":"Sjögren's syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prelone","generic_name":"prednisolone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"Glucocorticoid (corticosteroid)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"prednisolon","indication_name":"Sjögren's syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"prednisolon","company_name":"Hannover Medical School","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"salagen","indication_name":"Xerostomia Secondary to Sjogren's Syndrome","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Salagen","company_name":"Alberta Health services","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03938207","title":"Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT04239521","title":"The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata","phase":"","overall_status":"COMPLETED","enrollment_count":51955,"lead_sponsor_name":"Momentum Data","has_results":false},{"nct_id":"NCT06982482","title":"Artificial Intelligence Based Models for Primary Sjögren's Syndrome Diagnosis","phase":"","overall_status":"COMPLETED","enrollment_count":27432,"lead_sponsor_name":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","has_results":false},{"nct_id":"NCT03047369","title":"The Myelin Disorders Biorepository Project","phase":"","overall_status":"RECRUITING","enrollment_count":12000,"lead_sponsor_name":"Children's Hospital of Philadelphia","has_results":false},{"nct_id":"NCT04806620","title":"Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Brain Inflammation Collaborative","has_results":false},{"nct_id":"NCT04402086","title":"Rheumatology Patient Registry and Biorepository","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Yale University","has_results":false},{"nct_id":"NCT03501420","title":"Adelphi Primary Sjogren's Syndrome (pSS) Disease Specific Programme (DSP)","phase":"","overall_status":"COMPLETED","enrollment_count":2223,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT05879419","title":"Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2005,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT04747288","title":"Objective Measurement With TCM Pattern for AIDDES","phase":"","overall_status":"UNKNOWN","enrollment_count":1800,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT00001196","title":"Evaluation of Salivary Gland Dysfunction","phase":"","overall_status":"TERMINATED","enrollment_count":1740,"lead_sponsor_name":"National Institute of Dental and Craniofacial Research (NIDCR)","has_results":false},{"nct_id":"NCT04749875","title":"Study of Leukocyte Populations in Patients With Chronic Inflammatory","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT02327884","title":"Characterization of Diseases With Salivary Gland Involvement","phase":"","overall_status":"RECRUITING","enrollment_count":1150,"lead_sponsor_name":"National Institute of Dental and Craniofacial Research (NIDCR)","has_results":false},{"nct_id":"NCT04931160","title":"B-dependant Rare AutoImmune diseaSES - Cohort of Patients With Suspected Diagnosis of Primitive Sjögren Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT06437652","title":"An AI Algorithm for Lymphocyte Focus Score of Minor Salivary Gland Biopsy Samples for Diagnosing Sjogren's Syndrome","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","has_results":false},{"nct_id":"NCT03276923","title":"Maternal Autoimmune Disease Research Alliance (MADRA) Registry","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT06747949","title":"A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":844,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT05904301","title":"Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"Santé Arménie French-Armenian Research Center","has_results":false},{"nct_id":"NCT05946941","title":"A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":774,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT06741969","title":"Nipocalimab in Moderate to Severe Sjogren's Disease","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":655,"lead_sponsor_name":"Janssen Research & Development, LLC","has_results":false},{"nct_id":"NCT06104124","title":"A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":651,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT05985915","title":"A Randomized, Double-blind 2-arm, Followed by an Open-label 1-arm, NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":612,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT03430388","title":"Yellow Fever Vaccine in Patients With Rheumatic Diseases","phase":"NA","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT04345159","title":"Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease","phase":"","overall_status":"COMPLETED","enrollment_count":572,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT00001852","title":"Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome","phase":"","overall_status":"COMPLETED","enrollment_count":560,"lead_sponsor_name":"National Institute of Dental and Craniofacial Research (NIDCR)","has_results":false},{"nct_id":"NCT06680310","title":"Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":501,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04843345","title":"Sjogren's Lung Study","phase":"","overall_status":"SUSPENDED","enrollment_count":500,"lead_sponsor_name":"Stanford University","has_results":false},{"nct_id":"NCT07188285","title":"Mass Spectrometry-based Immune Profiling in Autoimmune Diseases","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Peking University People's Hospital","has_results":false},{"nct_id":"NCT06339957","title":"Rheumatology Diet Study","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"University of Central Florida","has_results":false},{"nct_id":"NCT06245408","title":"A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":434,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT01807689","title":"Salivary Biomarkers for Sjögren's Syndrome Detection","phase":"","overall_status":"COMPLETED","enrollment_count":420,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT05673993","title":"A Study to Evaluate the Efficacy and Safety of Telitacicept in Subjects With Active Primary Sjogren's Syndrome","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":381,"lead_sponsor_name":"RemeGen Co., Ltd.","has_results":false},{"nct_id":"NCT03248518","title":"Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases","phase":"NA","overall_status":"COMPLETED","enrollment_count":368,"lead_sponsor_name":"University of Aberdeen","has_results":false},{"nct_id":"NCT05961267","title":"Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism","phase":"","overall_status":"COMPLETED","enrollment_count":318,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT05113004","title":"New Clinical End-points in Patients With Primary Sjögren's Syndrome","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04762108","title":"Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"University College, London","has_results":false},{"nct_id":"NCT01425892","title":"The Pathogenesis and Natural History of Sjogren's Disease","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"National Institute of Dental and Craniofacial Research (NIDCR)","has_results":false},{"nct_id":"NCT03540823","title":"Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT03578900","title":"Quality of Life and Sjögren Syndrome","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":289,"lead_sponsor_name":"Grupo de Investigação em Bioquímica e Biologia Oral","has_results":false},{"nct_id":"NCT00100204","title":"Salivary Proteins in Disease and Health","phase":"","overall_status":"COMPLETED","enrollment_count":264,"lead_sponsor_name":"National Institute of Dental and Craniofacial Research (NIDCR)","has_results":false},{"nct_id":"NCT04798911","title":"SS-INQ Information Needs Questionnaire in Sjögren's Syndrome","phase":"","overall_status":"COMPLETED","enrollment_count":243,"lead_sponsor_name":"University College, London","has_results":false},{"nct_id":"NCT04212572","title":"Ultrasound Abnormalities of the Salivary Glands in Primary Sjögren's Syndrome According to the Duration of the Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":242,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT02699190","title":"LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies","phase":"","overall_status":"COMPLETED","enrollment_count":236,"lead_sponsor_name":"Children's Hospital of Philadelphia","has_results":true},{"nct_id":"NCT06771427","title":"Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome","phase":"","overall_status":"RECRUITING","enrollment_count":220,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT06475027","title":"Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":220,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT05782049","title":"Ultrasound Characteristics of the Salivary Glands in Patients With Rheumatoid Arthritis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":210,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT06312020","title":"A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":209,"lead_sponsor_name":"Amgen","has_results":false},{"nct_id":"NCT04541589","title":"Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":206,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT07180537","title":"Creating Health Course Study for People With Rheumatological Conditions","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Terry L. Wahls","has_results":false},{"nct_id":"NCT06406933","title":"Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT05958446","title":"Fetal-Hope Study: Home Monitoring of Fetal Heart Rate in SSA+ Pregnant Women","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"ASST Fatebenefratelli Sacco","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}