{"disease":{"id":"sinus-headache","name":"Sinus headache","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":13,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"mepyramine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pyrilamine","generic_name":"mepyramine","company_name":"Impax Labs","drug_phase":"marketed","molecular_target":"Histamine H1 receptor","drug_class":"Central Nervous System Stimulant [EPC]","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"phenylpropanolamine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Propadrine","generic_name":"PHENYLPROPANOLAMINE","company_name":"Alpharma Us Pharms","drug_phase":"marketed","molecular_target":"Sodium-dependent noradrenaline transporter","drug_class":"Indirectly Acting Sympathomimetic Amines","quality_score":36,"revenue":null,"mechanism":""},{"drug_id":"caffeine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norgesic","generic_name":"caffeine","company_name":"Hikma","drug_phase":"marketed","molecular_target":"Adenosine receptor A2a","drug_class":"Central Nervous System Stimulant [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"phenylephrine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sudafed PE","generic_name":"phenylephrine","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptor, Alpha-1D adrenergic receptor","drug_class":"Alpha-1 adrenergic agonist (decongestant/vasopressor)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"guaifenesin","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mucinex","generic_name":"guaifenesin","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Vagal gastric reflex → increased respiratory secretions","drug_class":"Expectorant [EPC]","quality_score":27,"revenue":null,"mechanism":""},{"drug_id":"phenylephrine-bitartrate","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Phenergan Vc W/ Codeine","generic_name":"PHENYLEPHRINE BITARTRATE","company_name":"ANI Pharmaceuticals","drug_phase":"marketed","molecular_target":"Alpha-1B adrenergic receptor","drug_class":"Nonsteroidal Anti-inflammatory Drug [EPC]","quality_score":45,"revenue":null,"mechanism":""},{"drug_id":"ephedrine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Akovaz","generic_name":"EPHEDRINE","company_name":"","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"Norepinephrine Releasing Agent","quality_score":52,"revenue":null,"mechanism":"Akovaz works by releasing norepinephrine, a natural chemical in the body that helps to relieve symptoms of respiratory and allergic conditions."},{"drug_id":"ibuprofen","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Advil","generic_name":"ibuprofen","company_name":"Generic (originally Boots Group)","drug_phase":"marketed","molecular_target":"Sodium-coupled monocarboxylate transporter 1, Acid-sensing ion channel 1, Aldo-keto reductase family 1 member C2","drug_class":"Nonsteroidal Anti-inflammatory Drug [EPC]","quality_score":40,"revenue":null,"mechanism":"Ibuprofen inhibits prostaglandin synthetase, reducing pain, fever, and inflammation."},{"drug_id":"acetylsalicylic-acid","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norgesic","generic_name":"acetylsalicylic acid","company_name":"Endo","drug_phase":"marketed","molecular_target":"reticular formation (brain stem)","drug_class":"centrally acting muscle relaxant with anticholinergic properties","quality_score":82,"revenue":null,"mechanism":"Orphenadrine citrate centrally acts on brain stem to selectively block facilitatory reticular functions."},{"drug_id":"pseudoephedrine","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sudafed","generic_name":"pseudoephedrine","company_name":"Generic (multiple manufacturers)","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor, Alpha-2A adrenergic receptor, Beta-2 adrenergic receptor","drug_class":"Nasal decongestant (sympathomimetic)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"paracetamol","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Acetaminophen","generic_name":"Paracetamol","company_name":"Polymedica","drug_phase":"marketed","molecular_target":"Transient receptor potential cation channel subfamily V member 4","drug_class":"acetaminophen","quality_score":60,"revenue":null,"mechanism":"Acetaminophen works by blocking pain signals in the brain."},{"drug_id":"phenylpropanol","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"phenylpropanol","company_name":"","drug_phase":"unknown","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"naproxen","indication_name":"Sinus headache","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aleve","generic_name":"naproxen","company_name":"Generic (originally Syntex)","drug_phase":"marketed","molecular_target":"Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Prostaglandin G/H synthase 1","drug_class":"NSAID","quality_score":null,"revenue":null,"mechanism":"Reversibly inhibits COX-1 and COX-2 with a long half-life, providing sustained anti-inflammatory, analgesic, and antipyretic effects."}],"pipeline":[],"offLabel":[],"totalMarketed":13,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05865613","title":"Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.","phase":"NA","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT05861817","title":"Effect of Low Level Laser Therapy in Patients With Chronic Rhinosinusitis.","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Cairo University","has_results":false}],"total":2},"guidelines":[],"source":"Drug Landscape verified database"}