{"disease":{"id":"rett-s-disorder","name":"rett s disorder"},"drugs":{"marketed":[{"drug_id":"haloperidol","indication_name":"Control of Tics and Vocal Utterances in Tourette's Disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Haldol","generic_name":"haloperidol","company_name":"Johnson & Johnson (Janssen)","drug_phase":"marketed","molecular_target":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A","drug_class":"Typical Antipsychotic [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"pimozide","indication_name":"Tourette's Disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Orap","generic_name":"PIMOZIDE","company_name":"Teva","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 7","drug_class":"Typical Antipsychotic [EPC]","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03944447","title":"Outcomes Mandate National Integration With Cannabis as Medicine","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":200000,"lead_sponsor_name":"OMNI Medical Services, LLC","has_results":false},{"nct_id":"NCT04806620","title":"Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Brain Inflammation Collaborative","has_results":false},{"nct_id":"NCT06848959","title":"Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Yun Liu,PhD","has_results":false},{"nct_id":"NCT03194958","title":"Helping Poor Smokers Quit","phase":"NA","overall_status":"COMPLETED","enrollment_count":1944,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT01019343","title":"Physiological Investigations of Movement Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":1273,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT02845440","title":"Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness","phase":"NA","overall_status":"COMPLETED","enrollment_count":1165,"lead_sponsor_name":"Massachusetts General Hospital","has_results":true},{"nct_id":"NCT00001308","title":"Central Mechanisms in Speech Motor Control Studied With H215O PET","phase":"","overall_status":"TERMINATED","enrollment_count":1163,"lead_sponsor_name":"National Institute on Deafness and Other Communication Disorders (NIDCD)","has_results":false},{"nct_id":"NCT02705677","title":"Biobanking of Rett Syndrome and Related Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":752,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT02271919","title":"Varenicline and Combined NRT for Smoking Cessation","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":631,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT04463316","title":"GROWing Up With Rare GENEtic Syndromes","phase":"","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"dr. Laura C. G. de Graaff-Herder","has_results":false},{"nct_id":"NCT03259971","title":"The Role of Probiotics PS128 in Movement Disorders","phase":"NA","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT00496210","title":"Predictors of Caregiver Adaptation to Pervasive Developmental Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":324,"lead_sponsor_name":"National Human Genome Research Institute (NHGRI)","has_results":false},{"nct_id":"NCT04335175","title":"Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT03916055","title":"Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":221,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT07366294","title":"Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smokers","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Titin Andri Wihastuti","has_results":false},{"nct_id":"NCT03077308","title":"Rare Diseases Clinical Research Network: Neurophysiological Correlates","phase":"","overall_status":"COMPLETED","enrollment_count":185,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT06613126","title":"Effectiveness of Symptom Management Application on Parental Care Ability of Children With Tourette Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"National Taipei University of Nursing and Health Sciences","has_results":false},{"nct_id":"NCT01416441","title":"Safety and Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":170,"lead_sponsor_name":"Otsuka Pharmaceutical Development & Commercialization, Inc.","has_results":true},{"nct_id":"NCT01418339","title":"Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":135,"lead_sponsor_name":"Otsuka Pharmaceutical Development & Commercialization, Inc.","has_results":true},{"nct_id":"NCT05269953","title":"Median Nerve Stimulation for Tourette Syndrome and Chronic Tic Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":132,"lead_sponsor_name":"Nottingham University Hospitals NHS Trust","has_results":false},{"nct_id":"NCT06585618","title":"A Multicenter Pediatric Deep Brain Stimulation Registry","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT06194305","title":"Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Minnesota","has_results":false},{"nct_id":"NCT03087201","title":"CANNAbinoids in the Treatment of TICS (CANNA-TICS)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":98,"lead_sponsor_name":"Hannover Medical School","has_results":false},{"nct_id":"NCT02697227","title":"Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":85,"lead_sponsor_name":"M.D. Anderson Cancer Center","has_results":false},{"nct_id":"NCT01418352","title":"Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder (TD)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":83,"lead_sponsor_name":"Otsuka Pharmaceutical Development & Commercialization, Inc.","has_results":true},{"nct_id":"NCT06335368","title":"Assessment of Nutritional and Growth Status in Rett Syndrome Patients","phase":"","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT00056420","title":"Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement","phase":"","overall_status":"COMPLETED","enrollment_count":54,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT03625453","title":"Study of ABX-1431 in Adult Patients With Tourette Syndrome or Chronic Motor Tic Disorder","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Abide Therapeutics","has_results":false},{"nct_id":"NCT03914664","title":"Neural Correlates of Sensory Phenomena in Tourette Syndrome","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":50,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT00033995","title":"Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT05696769","title":"Tourette Discrimination (TD) Stigma Scale","phase":"","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":false},{"nct_id":"NCT00081419","title":"Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT04087616","title":"Internet-based CBIT for Children With Chronic Tics","phase":"NA","overall_status":"UNKNOWN","enrollment_count":40,"lead_sponsor_name":"Tel Aviv Medical Center","has_results":false},{"nct_id":"NCT03564132","title":"Evaluating the Efficacy and Safety of Yi-Gan San in Children and Adolescents With Tourette's Disorder","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"China Medical University Hospital","has_results":false},{"nct_id":"NCT03822416","title":"Treating Smokers With Mental Illness","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"University of Minnesota","has_results":true},{"nct_id":"NCT03771235","title":"Online Mindfulness-based Tic Reduction (Phase Two)","phase":"NA","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Bowdoin College","has_results":false},{"nct_id":"NCT04568395","title":"Acute Effects of TCIG vs ECIG in PLWH","phase":"NA","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT03661983","title":"Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Participants With Tourette's Disorder","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":36,"lead_sponsor_name":"Otsuka Pharmaceutical Development & Commercialization, Inc.","has_results":true},{"nct_id":"NCT03508245","title":"Investigating Circadian Rhythms in Youth With Persistent Tic Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT04731714","title":"Median Nerve Stimulation Pilot","phase":"NA","overall_status":"COMPLETED","enrollment_count":34,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT05016765","title":"Open-label MNS for Tourette Syndrome","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT06679790","title":"Trajectories of Change in Tourette Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"University of Minnesota","has_results":false},{"nct_id":"NCT02205918","title":"Brain-Behavior Interactions in Tic Suppression","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"University of Minnesota","has_results":false},{"nct_id":"NCT04284813","title":"Families With Substance Use and Psychosis: A Pilot Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":29,"lead_sponsor_name":"Mclean Hospital","has_results":true},{"nct_id":"NCT03058562","title":"A Study to Evaluate the Effects of ABX-1431 on Patients With Tourette Syndrome","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":23,"lead_sponsor_name":"Abide Therapeutics","has_results":false},{"nct_id":"NCT07129590","title":"Trauma-Informed Care for Smoking Cessation for Pregnancy","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT04246112","title":"A Handwriting Intervention Program for Children With Tic Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":12,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT03213418","title":"Electroretinogram: a New Human Biomarker for Smoking Cessation Treatment","phase":"NA","overall_status":"TERMINATED","enrollment_count":11,"lead_sponsor_name":"New York State Psychiatric Institute","has_results":false},{"nct_id":"NCT04498364","title":"Extinction Learning in Adults With Tourette Syndrome","phase":"NA","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT05047705","title":"Investigating Distress Tolerance in Adults With Tourette Syndrome","phase":"NA","overall_status":"COMPLETED","enrollment_count":9,"lead_sponsor_name":"Johns Hopkins University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}