{"disease":{"id":"retinal-vascular","name":"retinal vascular"},"drugs":{"marketed":[{"drug_id":"verteporfin","indication_name":"Choroidal retinal neovascularization","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Visudyne","generic_name":"VERTEPORFIN","company_name":"Bausch Lomb Ireland","drug_phase":"marketed","molecular_target":"","drug_class":"Photoenhancer [EPC]","quality_score":10,"revenue":null,"mechanism":"Visudyne selectively binds to neovascular tissue, which is then activated by light to induce a phototoxic reaction."},{"drug_id":"visudyne","indication_name":"Choroidal retinal neovascularization","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Visudyne","company_name":"Bayer","drug_phase":"discontinued","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":""},{"drug_id":"lucentis","indication_name":"Choroidal retinal neovascularization","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Lucentis","company_name":"Santen Inc.","drug_phase":"marketed","molecular_target":"Vascular endothelial growth factor A","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"ranibizumab-nuna","indication_name":"Choroidal retinal neovascularization","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"BYOOVIZ","generic_name":"RANIBIZUMAB-NUNA","company_name":"SAMSUNG BIOEPIS CO LTD","drug_phase":"marketed","molecular_target":"Vascular endothelial growth factor A","drug_class":"","quality_score":null,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":4,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04620876","title":"Bimodal and Coaxial High Resolution Ophtalmic Imaging","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1200,"lead_sponsor_name":"Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts","has_results":false},{"nct_id":"NCT04505618","title":"Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":1050,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT03422965","title":"Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus","phase":"NA","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Hospital Clinic of Barcelona","has_results":false},{"nct_id":"NCT05130385","title":"High Resolution Optical Coherence Tomography","phase":"","overall_status":"UNKNOWN","enrollment_count":550,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT03211741","title":"Longterm Efficiency and Safety of Intravitreal Injections With Bevacizumab in Patients With Neovascularisation or Macular Edema","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"University Hospital, Ghent","has_results":false},{"nct_id":"NCT06717139","title":"Recurrence and Predictive OCT Biomarkers in Quiescent Neovascular AMD","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":220,"lead_sponsor_name":"St. Erik Eye Hospital","has_results":false},{"nct_id":"NCT04455399","title":"Time Efficiency Comparison of Two IntraVitreal Injection Techniques","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Peregrine Eye and Laser Institute","has_results":false},{"nct_id":"NCT05657158","title":"Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion","phase":"","overall_status":"COMPLETED","enrollment_count":198,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT04773561","title":"Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":166,"lead_sponsor_name":"Khon Kaen University","has_results":false},{"nct_id":"NCT07034612","title":"Choroidal Changes During Cardiopulmonary Bypass","phase":"","overall_status":"COMPLETED","enrollment_count":102,"lead_sponsor_name":"Samsun University","has_results":false},{"nct_id":"NCT05624255","title":"Correlating the Measure of Retinal Vascular Density Through Angio-OCT with Calcium Score","phase":"NA","overall_status":"COMPLETED","enrollment_count":101,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT03250000","title":"Changes in Microcirculation and Functional Status During Exacerbation of COPD","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Hasselt University","has_results":false},{"nct_id":"NCT07434362","title":"Serum Endocan, Alarin, and Galanin-Like Peptide Levels in Diabetic Retinopathy","phase":"NA","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Elazıg Fethi Sekin Sehir Hastanesi","has_results":false},{"nct_id":"NCT03279939","title":"Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module","phase":"","overall_status":"COMPLETED","enrollment_count":88,"lead_sponsor_name":"Heidelberg Engineering GmbH","has_results":false},{"nct_id":"NCT04604002","title":"Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types","phase":"","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"Heidelberg Engineering GmbH","has_results":false},{"nct_id":"NCT04116814","title":"High Resolution Imaging of Retinal Vessels as a Biomarker of Cardiovascular Disease in Patients With Renal Insufficiency - RI","phase":"","overall_status":"UNKNOWN","enrollment_count":83,"lead_sponsor_name":"Ramsay Générale de Santé","has_results":false},{"nct_id":"NCT05353790","title":"Dietary Exchanges With Avocado and Mango in Pre-diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":82,"lead_sponsor_name":"Clinical Nutrition Research Center, Illinois Institute of Technology","has_results":false},{"nct_id":"NCT02876198","title":"Study of the Modification of the Retinal Nerve Fiber Layer in Patients Treated With Intravitreous Injection of Anti-VEGF","phase":"","overall_status":"COMPLETED","enrollment_count":74,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT04731415","title":"Physiologic Change of Posterior Ocular Segment During Pregnancy","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":69,"lead_sponsor_name":"Khon Kaen University","has_results":false},{"nct_id":"NCT03767738","title":"Study to Evaluate an Aflibercept (EYLEA®) Prefilled Syringe","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":65,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT06879301","title":"Effectiveness of Intravitreal Injection of Aflibercept 8 mg in Resistant Diabetic Macular Edema, Retinal Vein Occlusion and Myopic Choroidal Neovascularisation Patients","phase":"EARLY_PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT06520410","title":"Safety and Efficacy of 18 mm Short Vitrectomy Probe for Pediatric Vitreoretinal Surgeries","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT06595355","title":"Efficacy and Safety of Intravitreal Injection of Bevacizumab with and Without Oral Curcumin","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":52,"lead_sponsor_name":"Isfahan University of Medical Sciences","has_results":false},{"nct_id":"NCT06416241","title":"Intravitreal Aflibercept for Macular Edema Due to Central Retinal Vein Occlusion","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"University of Athens","has_results":false},{"nct_id":"NCT05704725","title":"A Study to Evaluate ABP 938 and Aflibercept (Eylea®) in Participants With Chorioretinal Vascular Disease (CVD)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":49,"lead_sponsor_name":"Amgen","has_results":true},{"nct_id":"NCT04731207","title":"Physiologic Changes of Posterior Ocular Segment During the Menstrual Cycle","phase":"NA","overall_status":"UNKNOWN","enrollment_count":39,"lead_sponsor_name":"Khon Kaen University","has_results":false},{"nct_id":"NCT03530449","title":"Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module","phase":"","overall_status":"TERMINATED","enrollment_count":39,"lead_sponsor_name":"Heidelberg Engineering GmbH","has_results":false},{"nct_id":"NCT05986786","title":"Clinical Study to Evaluate the Handling and Safety of AVT06 PFS in Subjects With Chorioretinal Vascular Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"Alvotech Swiss AG","has_results":false},{"nct_id":"NCT04408677","title":"Normative Data Collection Study of the Zilia Ocular for the Measurement of Oxygen Saturation in the Retina","phase":"NA","overall_status":"TERMINATED","enrollment_count":33,"lead_sponsor_name":"Zilia Inc.","has_results":false},{"nct_id":"NCT04928196","title":"Retinal Microvasculature Before and After Silicone Oil by OCTA","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Kasr El Aini Hospital","has_results":false},{"nct_id":"NCT03864380","title":"Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort","phase":"","overall_status":"COMPLETED","enrollment_count":29,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT05227248","title":"Chocolate Dynamic Vessel Analysis","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Querques Giuseppe","has_results":false},{"nct_id":"NCT05650047","title":"Home OCT Guided Management Study of Subjects Diagnosed With Neovascular-AMD","phase":"","overall_status":"UNKNOWN","enrollment_count":15,"lead_sponsor_name":"Notal Vision Inc.","has_results":false},{"nct_id":"NCT04650672","title":"Daily Testing at Home by NV-AMD Subjects With Notal Home OCT.","phase":"","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Notal Vision Inc.","has_results":false}],"total":34},"guidelines":[],"source":"Drug Landscape verified database"}