{"disease":{"id":"renal-insufficiency","name":"renal insufficiency"},"drugs":{"marketed":[{"drug_id":"hydrocortisone-succinate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Solu-Cortef","generic_name":"hydrocortisone succinate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"hydrocortisone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortifoam","generic_name":"HYDROCORTISONE ACETATE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"cortisone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortone","generic_name":"CORTISONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":29,"revenue":null,"mechanism":""},{"drug_id":"betamethasone-acetate","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Celestone Soluspan","generic_name":"BETAMETHASONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"dexamethasone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Decadron","generic_name":"dexamethasone","company_name":"Generic (originally Merck)","drug_phase":"marketed","molecular_target":"Annexin A1, Interleukin-4, Androgen receptor","drug_class":"Corticosteroid [EPC]","quality_score":44,"revenue":null,"mechanism":""},{"drug_id":"methylprednisolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Medrol","generic_name":"methylprednisolone","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"Glucocorticoid (corticosteroid)","quality_score":62,"revenue":null,"mechanism":"Potent synthetic glucocorticoid with 5x hydrocortisone potency and minimal mineralocorticoid activity, used for severe inflammatory conditions."},{"drug_id":"hydrocortisone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortef","generic_name":"hydrocortisone","company_name":"Generic (originally Merck/Upjohn)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"Corticosteroid [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"triamcinolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rodinolone","generic_name":"TRIAMCINOLONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"betamethasone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Betametasone","generic_name":"BETAMETHASONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":65,"revenue":null,"mechanism":"Betamethasone works by binding to the glucocorticoid receptor, which then triggers a series of downstream effects that reduce inflammation and suppress the immune system."},{"drug_id":"cortisol","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cortisol","company_name":"University of Zurich","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"prednisolone","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prelone","generic_name":"prednisolone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"Glucocorticoid (corticosteroid)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"prednisolon","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"prednisolon","company_name":"Hannover Medical School","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"methylprednisolon","indication_name":"Severe adrenal insufficiency","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Methylprednisolon","company_name":"Leiden University Medical Center","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":13,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05455528","title":"Preoperative Renal Insufficiency Predicts Postoperative Adverse Outcomes","phase":"","overall_status":"COMPLETED","enrollment_count":2421286,"lead_sponsor_name":"Taipei Medical University Hospital","has_results":false},{"nct_id":"NCT03575247","title":"The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":111804,"lead_sponsor_name":"University of Leeds","has_results":false},{"nct_id":"NCT01767883","title":"Improving Evidence-Based Primary Care for Chronic Kidney Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":27000,"lead_sponsor_name":"American Academy of Family Physicians","has_results":false},{"nct_id":"NCT00960128","title":"Observational Prospective Study on Patients Treated With Norditropin®","phase":"","overall_status":"COMPLETED","enrollment_count":21249,"lead_sponsor_name":"Novo Nordisk A/S","has_results":false},{"nct_id":"NCT02769975","title":"Evaluation of Children With Endocrine and Metabolic-Related Conditions","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT07103629","title":"Bringing Knowledge About Chronic Kidney Disease in Brazil: Filling the Gap","phase":"","overall_status":"COMPLETED","enrollment_count":8428,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT05630326","title":"Association Between COVID-19 and UTIs Caused by ESBL Organism in Infants","phase":"","overall_status":"COMPLETED","enrollment_count":5600,"lead_sponsor_name":"Hamad Medical Corporation","has_results":false},{"nct_id":"NCT03899298","title":"Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":5000,"lead_sponsor_name":"R3 Stem Cell","has_results":false},{"nct_id":"NCT03041987","title":"Chinese Cohort Study of Chronic Kidney Disease","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Peking University First Hospital","has_results":false},{"nct_id":"NCT03921242","title":"Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease","phase":"","overall_status":"COMPLETED","enrollment_count":4888,"lead_sponsor_name":"Weill Medical College of Cornell University","has_results":false},{"nct_id":"NCT01661387","title":"A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)","phase":"","overall_status":"TERMINATED","enrollment_count":3258,"lead_sponsor_name":"Shire","has_results":false},{"nct_id":"NCT03013166","title":"THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone","phase":"","overall_status":"COMPLETED","enrollment_count":3000,"lead_sponsor_name":"Shire","has_results":false},{"nct_id":"NCT02668250","title":"Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality","phase":"NA","overall_status":"COMPLETED","enrollment_count":2495,"lead_sponsor_name":"Centre Hospitalier Universitaire de Saint Etienne","has_results":false},{"nct_id":"NCT01351675","title":"Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":2185,"lead_sponsor_name":"Biogen","has_results":false},{"nct_id":"NCT01742702","title":"HaemoDYNAMICs in Primary and Secondary Hypertension","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Tampere University","has_results":false},{"nct_id":"NCT07524101","title":"Moderate-Intensity Statin Plus Ezetimibe in CKD and ASCVD","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1952,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT05607797","title":"Genetic of Chronic Kidney Disease and Gout in New Caledonia","phase":"NA","overall_status":"COMPLETED","enrollment_count":1858,"lead_sponsor_name":"Lille Catholic University","has_results":false},{"nct_id":"NCT07245186","title":"Strategies for Proactive Health in People With Kidney Function Decline","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1800,"lead_sponsor_name":"Huashan Hospital","has_results":false},{"nct_id":"NCT03815175","title":"XIENCE 28 USA Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":1605,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT00005664","title":"Evaluation of Patients With Endocrine-Related Conditions","phase":"","overall_status":"TERMINATED","enrollment_count":1588,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT03923972","title":"Exercise Training and Physical Rehabilitation in Patients With Chronic Kidney Disease in Europe - What is the Problem?","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Skane University Hospital","has_results":false},{"nct_id":"NCT04096547","title":"Rivaroxaban in Elderly NVAF Patients With or Without Renal Impairment","phase":"","overall_status":"UNKNOWN","enrollment_count":1200,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT05056727","title":"A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1112,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT04364139","title":"African American Study of Kidney Disease and Hypertension","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1094,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT04334707","title":"Kidney Precision Medicine Project","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Icahn School of Medicine at Mount Sinai","has_results":false},{"nct_id":"NCT03355742","title":"XIENCE 28 Global Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":963,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT04145609","title":"Intensified Acute Kidney Disease Care to Reduce Chronic Kidney Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":690,"lead_sponsor_name":"Taipei Medical University Shuang Ho Hospital","has_results":false},{"nct_id":"NCT03146793","title":"The Early Administration of Sodium Thiosulfate Should Help to Reduce the Mortality of Dialysis Patients With Calciphylaxis, From a National Cohort","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Centre Hospitalier St Esprit","has_results":false},{"nct_id":"NCT05225077","title":"Short-term Use of Dapagliflozin to Protect Kidney Function in CKD Patients","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Dong-A University","has_results":false},{"nct_id":"NCT06407154","title":"Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave","phase":"","overall_status":"COMPLETED","enrollment_count":578,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT02925962","title":"Evaluation of an Electronic CKD Clinical Decision Support System (CDSS) in Clinical Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":542,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT03253172","title":"Potassium Supplementation in CKD","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":532,"lead_sponsor_name":"Erasmus Medical Center","has_results":false},{"nct_id":"NCT06156319","title":"Clonal Hematopoiesis on Prognosis in Patients With Myocardial Infarction","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Yang Jing","has_results":false},{"nct_id":"NCT06600750","title":"Artificial Intelligence-based Prediction of Radio-cephalic Arteriovenous Fistula Maturation Using Preoperative Duplex Examination","phase":"","overall_status":"COMPLETED","enrollment_count":494,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT04263922","title":"Huaiqihuang Granule in the Treatment of Primary Glomerulonephritis of Stage CKD3","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":466,"lead_sponsor_name":"The First Affiliated Hospital of Dalian Medical University","has_results":false},{"nct_id":"NCT02533128","title":"Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":458,"lead_sponsor_name":"Miodrag Filipovic, Prof. Dr. med.","has_results":false},{"nct_id":"NCT04170309","title":"Collection of Data of Ceftobiprole Treated Patients: Comparison of Patients With and Without Certain Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":428,"lead_sponsor_name":"Advanz Pharma","has_results":false},{"nct_id":"NCT00509262","title":"Sitagliptin Versus Glipizide in Participants With Type 2 Diabetes Mellitus and Chronic Renal Insufficiency (MK-0431-063 AM1)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":426,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT00709865","title":"Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":420,"lead_sponsor_name":"Biogen","has_results":false},{"nct_id":"NCT01962116","title":"Citrate Versus Heparin for the Lock of Non-tunneled Hemodialysis Catheters in Patients Hospitalised in ICU","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":405,"lead_sponsor_name":"Centre Hospitalier Universitaire Dijon","has_results":false},{"nct_id":"NCT04788394","title":"Renal Involvement in Hospitalized Children With COVID-19","phase":"","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Hamad Medical Corporation","has_results":false},{"nct_id":"NCT05326399","title":"Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment","phase":"","overall_status":"RECRUITING","enrollment_count":369,"lead_sponsor_name":"RenJi Hospital","has_results":false},{"nct_id":"NCT03767803","title":"Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women","phase":"","overall_status":"UNKNOWN","enrollment_count":344,"lead_sponsor_name":"Progenity, Inc.","has_results":false},{"nct_id":"NCT05117450","title":"Comparison of HYDROLINK™ and HeprAN™ mEmbranes in a Per Dialytic Heparin Weaning Strategy in Chronic Hemodialysis Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":302,"lead_sponsor_name":"CHU de Reims","has_results":false},{"nct_id":"NCT02203084","title":"Social Determinants in Chronic Disease in British Columbia","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04498156","title":"Survey of Patient and Physician Awareness and Values to the Diagnosis and Treatment of Reduced Kidney Function (Chronic Kidney Disease) in Patients With High Blood Sugar Level (Type 2 Diabetes) (AWARE-CKD in T2D)","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04367714","title":"Antibody Response Against SARS-CoV-2 in Dialysis Patients During COVID-19","phase":"","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Region MidtJylland Denmark","has_results":false},{"nct_id":"NCT04451018","title":"Evaluation of Macro and Microcirculatory Arterial Condition of the Upper Limb in Insufficiently Renal Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"University Hospital, Grenoble","has_results":false},{"nct_id":"NCT05085275","title":"Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":289,"lead_sponsor_name":"USRC Kidney Research","has_results":true},{"nct_id":"NCT04876963","title":"HOLT-ED: Holter-monitoring in End-stage Renal Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":268,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}