{"disease":{"id":"renal-cell-carcinoma","name":"Renal Cell Carcinoma","therapeutic_area":"Oncology","data":{"aiSummary":"The treatment landscape for renal cell carcinoma (RCC) has evolved significantly with the advent of targeted therapies and immunotherapy. Clear cell RCC is the most common subtype, with first-line treatment often involving combinations of immunotherapy (e.g., nivolumab/ipilimumab) or targeted therapies (e.g., axitinib/pembrolizumab). Second-line options include targeted therapies like cabozantinib and tivozanib. Non-clear cell RCC treatment is more variable and often relies on targeted therapies. Ongoing research focuses on improving outcomes and identifying biomarkers to guide treatment decisions.","drug_count":7,"description":"Renal cell carcinoma (RCC) is the most common type of kidney cancer, originating in the lining of the renal tubules. The most common subtype is clear cell RCC. RCC is often asymptomatic in its early stages, but can present with hematuria, flank pain, and a palpable mass. Treatment options vary based on stage and include surgery, targeted therapies, and immunotherapy.","subtype_count":7},"enrichment_level":2,"last_enriched_at":null,"visit_count":0,"created_at":"2026-03-25T12:16:34.962Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":22,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"nivolumab","indication_name":"Metastatic renal cell carcinoma","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Opdivo","generic_name":"nivolumab","company_name":"Bristol-Myers Squibb","drug_phase":"marketed","molecular_target":"Programmed cell death protein 1","drug_class":"Programmed Death Receptor-1 Blocking Antibody [EPC]","quality_score":79,"revenue":"9200","mechanism":"Opdivo 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