{"disease":{"id":"psychosis","name":"psychosis"},"drugs":{"marketed":[{"drug_id":"thiamine","indication_name":"Korsakoff's psychosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Thiamine Hydrochloride","generic_name":"THIAMINE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Heat shock protein HSP 90-alpha","drug_class":"thiamine (vit B1)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"thiamin","indication_name":"Korsakoff's psychosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Thiamin","company_name":"Hospital Sao Domingos","drug_phase":"marketed","molecular_target":"Thiamin pyrophosphokinase 1, Thiamine transporter 1, Thiamine-triphosphatase","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06518330","title":"Psychosis Associated With Methylphenidate in Children and Adolescents","phase":"","overall_status":"COMPLETED","enrollment_count":46233,"lead_sponsor_name":"University Hospital, Caen","has_results":false},{"nct_id":"NCT06774417","title":"Digital Strategies to Advance Help-Seeking - Aim 3","phase":"NA","overall_status":"RECRUITING","enrollment_count":25000,"lead_sponsor_name":"Columbia University","has_results":false},{"nct_id":"NCT06774430","title":"Digital Strategies to Advance Help-Seeking Aim 1 and 2","phase":"","overall_status":"RECRUITING","enrollment_count":25000,"lead_sponsor_name":"Columbia University","has_results":false},{"nct_id":"NCT04256720","title":"The Multi-Ethnic Lifestyle Study","phase":"","overall_status":"UNKNOWN","enrollment_count":9500,"lead_sponsor_name":"University of Leicester","has_results":false},{"nct_id":"NCT05905003","title":"AMP SCZ® Observational Study: PREDICT-DPACC","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2617,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT04021719","title":"OnTrackNY's Learning Healthcare System","phase":"","overall_status":"SUSPENDED","enrollment_count":2100,"lead_sponsor_name":"New York State Psychiatric Institute","has_results":false},{"nct_id":"NCT04913181","title":"Artificial Intelligence for Sepsis Prediction in ICU","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT03768674","title":"Extreme Challenges - Psychopathology & Treatment Experiences Among Severly Selfharming Inpatients in Norway","phase":"","overall_status":"COMPLETED","enrollment_count":1640,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT00001198","title":"Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia","phase":"","overall_status":"TERMINATED","enrollment_count":1556,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT04007510","title":"California Collaborative Network to Promote Data Driven Care and Improve Outcomes in Early Psychosis","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1329,"lead_sponsor_name":"University of California, Davis","has_results":false},{"nct_id":"NCT06947941","title":"A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":1046,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT05509998","title":"Reducing the Duration of Untreated Psychosis in the United States: The Impact of Screening and Systematic Communication","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":912,"lead_sponsor_name":"Icahn School of Medicine at Mount Sinai","has_results":false},{"nct_id":"NCT04365621","title":"The Clinical and Socio-demographic Characteristics of Young People Aged 12 to 25 Consulting on Ambulatory Structures in the Seine Saint-Denis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":900,"lead_sponsor_name":"Januel","has_results":false},{"nct_id":"NCT05980949","title":"Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"Karuna Therapeutics, Inc., a Bristol Myers Squibb company","has_results":false},{"nct_id":"NCT03152292","title":"The INSYTE (Management of Parkinson's Disease Psychosis in Actual Practice) Study","phase":"","overall_status":"TERMINATED","enrollment_count":764,"lead_sponsor_name":"ACADIA Pharmaceuticals Inc.","has_results":false},{"nct_id":"NCT04004364","title":"Early-Phase Schizophrenia: Practice-based Research to Improve Outcomes","phase":"","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"Northwell Health","has_results":false},{"nct_id":"NCT03975400","title":"Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":698,"lead_sponsor_name":"Northwell Health","has_results":true},{"nct_id":"NCT03434457","title":"Maternal Adversity, Vulnerability and Neurodevelopment","phase":"","overall_status":"COMPLETED","enrollment_count":630,"lead_sponsor_name":"Douglas Mental Health University Institute","has_results":true},{"nct_id":"NCT05127837","title":"CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies","phase":"NA","overall_status":"COMPLETED","enrollment_count":601,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT06590298","title":"Evaluating the Effects of Adjunctive Aripiprazole on Weight and Metabolic Outcomes in Females","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":600,"lead_sponsor_name":"Universiti Putra Malaysia","has_results":false},{"nct_id":"NCT07434973","title":"Stratification and Treatment in Early Psychosis Study - PROMOTE","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":586,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT06978452","title":"Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories","phase":"","overall_status":"RECRUITING","enrollment_count":560,"lead_sponsor_name":"Douglas Mental Health University Institute","has_results":false},{"nct_id":"NCT05796401","title":"Efficiency of a Composite Personalised Care on Functional Outcome in Early Psychosis","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Centre Hospitalier St Anne","has_results":false},{"nct_id":"NCT04215094","title":"Early Diagnosis of Intracranial Infection After Craniotomy","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Pan Jun","has_results":false},{"nct_id":"NCT06126224","title":"A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Karuna Therapeutics, Inc., a Bristol Myers Squibb company","has_results":false},{"nct_id":"NCT06856161","title":"A Novel Blood Test as a Biomarker in Mental Health","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Fraser Health","has_results":false},{"nct_id":"NCT07470437","title":"The Mouth Matters in Mental Health Trial -2","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":480,"lead_sponsor_name":"Lancashire and South Cumbria NHS Foundation Trust","has_results":false},{"nct_id":"NCT05511363","title":"A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":410,"lead_sponsor_name":"Karuna Therapeutics, Inc., a Bristol Myers Squibb company","has_results":false},{"nct_id":"NCT05112432","title":"EPI-MINN: Targeting Cognition and Motivation","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":400,"lead_sponsor_name":"University of Minnesota","has_results":false},{"nct_id":"NCT03325556","title":"Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":392,"lead_sponsor_name":"ACADIA Pharmaceuticals Inc.","has_results":true},{"nct_id":"NCT05814913","title":"Culturally Adapted Psychosocial Interventions for Early Psychosis in a Low-resource Setting","phase":"NA","overall_status":"RECRUITING","enrollment_count":390,"lead_sponsor_name":"Pakistan Institute of Living and Learning","has_results":false},{"nct_id":"NCT07387705","title":"On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":365,"lead_sponsor_name":"University of Illinois at Chicago","has_results":false},{"nct_id":"NCT05731414","title":"Outcomes From Remediation and Behavioural Intervention Techniques","phase":"NA","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"University of Toronto","has_results":false},{"nct_id":"NCT05703711","title":"Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in West Africa","phase":"NA","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT04373317","title":"Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":358,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT05074732","title":"Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.","phase":"","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"Health Service Executive, Ireland","has_results":false},{"nct_id":"NCT03465371","title":"CSC OnDemand: An Innovative Online Learning Platform for Implementing Coordinated Specialty Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":349,"lead_sponsor_name":"Center for Social Innovation, Massachusetts","has_results":false},{"nct_id":"NCT03114917","title":"Cognitive AppRoaches to coMbatting Suicidality","phase":"NA","overall_status":"COMPLETED","enrollment_count":329,"lead_sponsor_name":"University of Manchester","has_results":false},{"nct_id":"NCT06740383","title":"Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services","phase":"","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT07092826","title":"Obsessive-Compulsive Disorder: Insight, Trauma, and Links to Schizophrenia Spectrum Disorders","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Matteo Tonna","has_results":false},{"nct_id":"NCT03932136","title":"Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03615794","title":"A Study of Pregnant and Postpartum Women With and Without Mood Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT06453174","title":"CLinical Utility of Early Intervention Including the 5-Step Precision Medicine (5SPM) Method in First-episode Psychosis: The CLUMP Project","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Instituto de Investigación Biomédica de Salamanca","has_results":false},{"nct_id":"NCT04005378","title":"Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Northwell Health","has_results":false},{"nct_id":"NCT04247711","title":"On Track Chile For First Episode Psychosis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"University of Chile","has_results":false},{"nct_id":"NCT03231761","title":"Impact of Video Presentations on Medical Students' Attitudes Toward Mental Illness","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"George Washington University","has_results":false},{"nct_id":"NCT04853485","title":"Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT06542640","title":"Mechanisms of Response to Therapeutic Intervention in Clinical High Risk (CHR) for Psychosis","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT06958341","title":"Neuroimmunology Registry and Biobank","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT02069925","title":"STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.","phase":"NA","overall_status":"COMPLETED","enrollment_count":285,"lead_sponsor_name":"Yale University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}