{"disease":{"id":"prosthetic-infection","name":"prosthetic infection"},"drugs":{"marketed":[{"drug_id":"cefonicid","indication_name":"Prosthetic Arthroplasty Infection Prevention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Monocid","generic_name":"CEFONICID","company_name":"","drug_phase":"marketed","molecular_target":"Matrix metalloproteinase-9","drug_class":"cefonicid","quality_score":30,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05530551","title":"Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Soren Overgaard","has_results":false},{"nct_id":"NCT05164081","title":"Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":7000,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT06771050","title":"Randomised Arthroplasty Infection Worldwide Multidomain Adaptive Platform (ROADMAP) Trial","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":2500,"lead_sponsor_name":"University of Newcastle, Australia","has_results":false},{"nct_id":"NCT05530174","title":"Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Soren Overgaard","has_results":false},{"nct_id":"NCT05117671","title":"Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?","phase":"","overall_status":"COMPLETED","enrollment_count":1554,"lead_sponsor_name":"University Hospital, Basel, Switzerland","has_results":false},{"nct_id":"NCT05399186","title":"Arthroplasty and Modifiable Risk Factors","phase":"NA","overall_status":"COMPLETED","enrollment_count":1484,"lead_sponsor_name":"Landspitali University Hospital","has_results":false},{"nct_id":"NCT01957228","title":"Causative Diagnosis on Prosthetic Joint Infections: Establishment of a Comprehensive Diagnostic Strategy","phase":"NA","overall_status":"COMPLETED","enrollment_count":980,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT04346875","title":"Changing of Dressing for Periprosthetic Joint Infection in Total Knee Arthroplasty","phase":"NA","overall_status":"UNKNOWN","enrollment_count":842,"lead_sponsor_name":"Bezmialem Vakif University","has_results":false},{"nct_id":"NCT03826108","title":"ARTHR-IS (Arthroplasties' Infections Due to Staphylococcus Aureus)","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","has_results":false},{"nct_id":"NCT03806166","title":"Short or Long Antibiotic Regimes in Orthopaedics","phase":"NA","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Oxford University Hospitals NHS Trust","has_results":false},{"nct_id":"NCT05060952","title":"Calprotectin in Chronic Prosthetic Joint Infection","phase":"","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"Technical University of Munich","has_results":false},{"nct_id":"NCT05660733","title":"Study of the Aortic and Large Arterial Vessel Infections","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT05284318","title":"Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"First Affiliated Hospital of Fujian Medical University","has_results":false},{"nct_id":"NCT05084378","title":"Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":495,"lead_sponsor_name":"Hamilton Health Sciences Corporation","has_results":false},{"nct_id":"NCT07313215","title":"Rifampin-combined Antibiotic Therapy for Staphylococcal PJI","phase":"NA","overall_status":"RECRUITING","enrollment_count":428,"lead_sponsor_name":"First Affiliated Hospital of Fujian Medical University","has_results":false},{"nct_id":"NCT06267287","title":"Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period","phase":"","overall_status":"COMPLETED","enrollment_count":342,"lead_sponsor_name":"Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty","has_results":false},{"nct_id":"NCT04858217","title":"Periprosthetic Joint Infections: Diagnostic Accuracy and Cost-effectiveness Analysis of Serum and Synovial Markers","phase":"","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT06268795","title":"A Diagnostic Test Accuracy Study Comparing Biopsy to Aspiration in Shoulder and Elbow Arthroplasty Revision Surgery (BASE Study)","phase":"","overall_status":"RECRUITING","enrollment_count":244,"lead_sponsor_name":"Wrightington, Wigan and Leigh NHS Foundation Trust","has_results":false},{"nct_id":"NCT04390607","title":"Leukocyte Esterase Sensor Test","phase":"","overall_status":"UNKNOWN","enrollment_count":230,"lead_sponsor_name":"Rothman Institute Orthopaedics","has_results":false},{"nct_id":"NCT05211011","title":"Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":226,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT03260010","title":"Efficacy and Safety of Intravenous Fosfomycin in Prosthetic Joint Infection","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":224,"lead_sponsor_name":"Pro-Implant Foundation","has_results":false},{"nct_id":"NCT05361941","title":"Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities","phase":"NA","overall_status":"RECRUITING","enrollment_count":204,"lead_sponsor_name":"Elute, Inc.","has_results":false},{"nct_id":"NCT06467734","title":"Prospective Cohort Study of Synovial Biomarkers in the Diagnosis and Prediction of Periprosthetic Joint Infection","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"First Affiliated Hospital of Xinjiang Medical University","has_results":false},{"nct_id":"NCT05320354","title":"Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT07232771","title":"Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"First Affiliated Hospital of Fujian Medical University","has_results":false},{"nct_id":"NCT06468163","title":"Efficacy of Local Antibiotic Injection Via a Catheter for Treating Acute Periprosthetic Infections After Knee DAIR Surgery","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"First Affiliated Hospital of Xinjiang Medical University","has_results":false},{"nct_id":"NCT06189885","title":"Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":184,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT05265598","title":"Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic)","phase":"","overall_status":"COMPLETED","enrollment_count":176,"lead_sponsor_name":"University Hospital, Basel, Switzerland","has_results":false},{"nct_id":"NCT07494630","title":"Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":174,"lead_sponsor_name":"University Hospital, Ghent","has_results":false},{"nct_id":"NCT06782295","title":"The Use of CCK vs PS in Revision TKAs","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":170,"lead_sponsor_name":"Rush University Medical Center","has_results":false},{"nct_id":"NCT03694925","title":"Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":156,"lead_sponsor_name":"The Cleveland Clinic","has_results":true},{"nct_id":"NCT06919913","title":"The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee","phase":"NA","overall_status":"RECRUITING","enrollment_count":152,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT04056780","title":"Integrated Microfluidic Systems for Diagnosis of Periprosthetic Joint Infection","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT06627842","title":"OsteoArticular Sepsis in Intensive Care unitS","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07107685","title":"Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07434258","title":"Dose-Response Association Between Cerclage Wire Number and Infection Risk","phase":"","overall_status":"COMPLETED","enrollment_count":148,"lead_sponsor_name":"Istanbul University","has_results":false},{"nct_id":"NCT07322289","title":"Antibiotic-coated Braided Suture Study","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":142,"lead_sponsor_name":"University of Miami","has_results":false},{"nct_id":"NCT04620395","title":"Percutaneous Punch Biopsy for Diagnosis of Septic and Aseptic Prosthetic Joint Failure","phase":"NA","overall_status":"UNKNOWN","enrollment_count":132,"lead_sponsor_name":"Vivantes Netzwerk für Gesundheit GmbH","has_results":false},{"nct_id":"NCT03769337","title":"New Markers for Diagnosis of Prosthetic Infections","phase":"","overall_status":"UNKNOWN","enrollment_count":130,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT04946500","title":"Clindamycin in Prosthetic Joint Infections Caused by Staphylococcus (CISTA)","phase":"","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT03612076","title":"Cost Of Failure Following Reimplantation After a 2-Stage Exchange Strategy For Hip Or Knee Prosthetic Joint Infection","phase":"","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT04661345","title":"Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint Infections","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT04650607","title":"Phage Safety Cohort Study","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT05642013","title":"SHort Interval Full Two-stage Implant Exchange","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT06804265","title":"Molecular Biology in the Identification of Pathogens at Reimplantation in the Two-Stage Treatment of Periprosthetic Infections","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT04746001","title":"Artificial Intelligence in the Diagnosis of Orthopaedic Conditions, Particularly Bone Tumours and Infection","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust","has_results":false},{"nct_id":"NCT04636125","title":"Prospective Evaluation of Oral Antibiotics for Treatment of Shoulder PJI","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Rothman Institute Orthopaedics","has_results":false},{"nct_id":"NCT03784807","title":"New Strategies for Biofilm Related Infections","phase":"","overall_status":"UNKNOWN","enrollment_count":99,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT03435679","title":"One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":97,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT03714165","title":"Alpha Defensin and 16S rRNA Gene in Diagnosis of PJI","phase":"","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Assiut University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}