{"disease":{"id":"primary-prevention","name":"primary prevention"},"drugs":{"marketed":[{"drug_id":"atorvastatin","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lipitor","generic_name":"atorvastatin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"HMG-CoA reductase","drug_class":"HMG-CoA reductase inhibitor (statin)","quality_score":77,"revenue":"1000.0","mechanism":"Selective competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis."},{"drug_id":"gemfibrozil","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lopid","generic_name":"GEMFIBROZIL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Transthyretin","drug_class":"Peroxisome Proliferator Receptor alpha Agonist [EPC]","quality_score":65,"revenue":null,"mechanism":""},{"drug_id":"rosuvastatin","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Crestor","generic_name":"rosuvastatin","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"HMG-CoA reductase","drug_class":"HMG-CoA reductase inhibitor (statin)","quality_score":74,"revenue":null,"mechanism":"Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate, a cholesterol precursor."},{"drug_id":"lipitor","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lipitor","generic_name":"Atorvastatin Calcium","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","drug_class":"atorvastatin","quality_score":10,"revenue":null,"mechanism":"Lipitor is a selective, competitive inhibitor of HMG-CoA reductase, a key enzyme in cholesterol synthesis."},{"drug_id":"amlodipine","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norvasc","generic_name":"amlodipine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Voltage-dependent calcium channel gamma-1 subunit, 5-hydroxytryptamine receptor 6","drug_class":"Calcium channel blocker (dihydropyridine)","quality_score":55,"revenue":null,"mechanism":"Long-acting dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, reducing blood pressure and myocardial oxygen demand."},{"drug_id":"lovastatin","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Mevacor","generic_name":"LOVASTATIN","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"3-hydroxy-3-methylglutaryl-coenzyme A reductase","drug_class":"HMG-CoA Reductase Inhibitor","quality_score":null,"revenue":null,"mechanism":"Mevacor works by inhibiting the enzyme HMG-CoA reductase, which plays a key role in cholesterol production in the liver."},{"drug_id":"amlodipin","indication_name":"Primary Prevention of Coronary Heart Disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Amlodipin","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Voltage-dependent calcium channel gamma-1 subunit, 5-hydroxytryptamine receptor 6","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07141914","title":"A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World","phase":"","overall_status":"COMPLETED","enrollment_count":285327,"lead_sponsor_name":"Novo Nordisk A/S","has_results":false},{"nct_id":"NCT05431309","title":"Role of Screening With Coronary Computed Tomography Angiography in Primary Prevention of Coronary Heart Disease","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Jinling Hospital, China","has_results":false},{"nct_id":"NCT05739383","title":"A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":14012,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT04450888","title":"Effects of Message Framing and Time Discounting on Health Communication for Optimum Cardiovascular Disease and Stroke Prevention","phase":"NA","overall_status":"COMPLETED","enrollment_count":13114,"lead_sponsor_name":"West China Hospital","has_results":false},{"nct_id":"NCT06503341","title":"A Hospital-Based Registry of Preventive Cardiology Clinics","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"National Institute of Cardiovascular Diseases, Pakistan","has_results":false},{"nct_id":"NCT06722521","title":"GUIDE-CAC: Statin-Ezetimibe Without Aspirin vs. Statin Monotherapy With Aspirin in High Coronary Calcification","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":7435,"lead_sponsor_name":"Asan Medical Center","has_results":false},{"nct_id":"NCT06186037","title":"Clinical Comparison of Low-dose Rosuvastatin Plus Ezetimibe Combination Therapy and High-dose Rosuvastatin Monotherapy in Patients With Minimal to Intermediate Coronary Artery Disease Without Percutaneous Coronary Intervention","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":6356,"lead_sponsor_name":"Saint Vincent's Hospital, Korea","has_results":false},{"nct_id":"NCT03955757","title":"Using Boot Camp Translation to Address Rural Disparities in Adolescent Vaccination","phase":"NA","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT03439267","title":"Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5765,"lead_sponsor_name":"Intermountain Health Care, Inc.","has_results":false},{"nct_id":"NCT03387384","title":"Appropriateness of Aspirin Use in Medical Outpatients","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"Muğla Sıtkı Koçman University","has_results":false},{"nct_id":"NCT05645640","title":"Strategy for Cardiovascular Disease Prevention Through Tailored Health Management in Individuals With Elevated Risk","phase":"NA","overall_status":"COMPLETED","enrollment_count":4533,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT03927196","title":"Primary Prevention Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":2912,"lead_sponsor_name":"National Research Center for Preventive Medicine","has_results":false},{"nct_id":"NCT06180772","title":"FIT FIRST FOR ALL - The Dose-Response Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2400,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT04279964","title":"Engaging Practices and Communities in the Development of Interventions to Promote HPV Vaccine Uptake","phase":"NA","overall_status":"COMPLETED","enrollment_count":2400,"lead_sponsor_name":"University of Colorado, Denver","has_results":false},{"nct_id":"NCT05178420","title":"STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1881,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT01596595","title":"Longitudinal Surveillance Study of the 4-SITE Lead/Header System","phase":"","overall_status":"COMPLETED","enrollment_count":1820,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT01736618","title":"S-ICD® System Post Approval Study","phase":"","overall_status":"COMPLETED","enrollment_count":1766,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT04291157","title":"Proactive Cardiovascular Prevention Strategy in Subjects With High Genetic Risk","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Alar Irs","has_results":false},{"nct_id":"NCT06615791","title":"FIT FIRST Teen - School Intervention Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":912,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT03958539","title":"Prevention of Primary Foot Ulcers in High-risk Diabetes Patients","phase":"NA","overall_status":"TERMINATED","enrollment_count":900,"lead_sponsor_name":"Countess of Chester NHS Foundation Trust","has_results":false},{"nct_id":"NCT05373940","title":"Cardioverter DefIbriIlator PlacEMent for priMary Prevention of Sudden cArdiac Death in Patients Older Than 70 Years","phase":"NA","overall_status":"RECRUITING","enrollment_count":730,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05463887","title":"Personalized Disease Prevention","phase":"NA","overall_status":"COMPLETED","enrollment_count":721,"lead_sponsor_name":"Glen Taksler","has_results":false},{"nct_id":"NCT03129165","title":"ProSALUTE: Community Program for Cardiovascular Health","phase":"NA","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Centro Cardiologico Monzino","has_results":false},{"nct_id":"NCT05267171","title":"Project Breast47: Effect of an Educational Intervention","phase":"NA","overall_status":"COMPLETED","enrollment_count":451,"lead_sponsor_name":"University of Oviedo","has_results":true},{"nct_id":"NCT03254979","title":"Optimizing the Primary Prevention of Type-2 Diabetes in Primary Health Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":432,"lead_sponsor_name":"Basque Health Service","has_results":false},{"nct_id":"NCT04162626","title":"New Families- Innovation and Development of the Child Health Services in Oslo","phase":"NA","overall_status":"COMPLETED","enrollment_count":428,"lead_sponsor_name":"VID Specialized University","has_results":false},{"nct_id":"NCT03540277","title":"Prevention Program- Promoting Self Resilience, Positive Self-Image and Body Image Among Adolescents and Their Parents","phase":"NA","overall_status":"COMPLETED","enrollment_count":420,"lead_sponsor_name":"Tel Hai College","has_results":false},{"nct_id":"NCT05993754","title":"Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams","phase":"NA","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Pontificia Universidad Catolica de Chile","has_results":false},{"nct_id":"NCT04156061","title":"Effect of the SCOT-HEART 2 Trial on Lifestyle.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":400,"lead_sponsor_name":"University of Edinburgh","has_results":false},{"nct_id":"NCT07045623","title":"Comparison of Intensive Versus Standard Care & Education for Dyslipidemia in Hypertension and Diabetes Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":348,"lead_sponsor_name":"Saint Vincent's Hospital, Korea","has_results":false},{"nct_id":"NCT03397849","title":"Lifestyle Intervention Using Mobile Technology in Patients With High Cardiovascular Risk","phase":"NA","overall_status":"COMPLETED","enrollment_count":320,"lead_sponsor_name":"Ministry of Health, Turkey","has_results":false},{"nct_id":"NCT03234322","title":"The Impact of a Diabetes Risk Prediction Model in Primary Care.","phase":"NA","overall_status":"COMPLETED","enrollment_count":315,"lead_sponsor_name":"German Diabetes Center","has_results":false},{"nct_id":"NCT04065191","title":"Workplace HIIT: Feasibility and Preventive Effects of HIIT in the Real-World","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"University of Erlangen-Nürnberg Medical School","has_results":false},{"nct_id":"NCT04114864","title":"A Primary Prevention Intervention for the Promotion of Psycho-social Wellbeing in Adolescent Young Carers:","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":295,"lead_sponsor_name":"Valentina Hlebec","has_results":false},{"nct_id":"NCT03316911","title":"A Pilot Study Testing a Life Skills Application to Address Interpersonal Relationships in College","phase":"NA","overall_status":"COMPLETED","enrollment_count":261,"lead_sponsor_name":"University of Michigan","has_results":true},{"nct_id":"NCT03715426","title":"Testing a Life Skills Application to Address Interpersonal Relationships in College (MKit)","phase":"NA","overall_status":"COMPLETED","enrollment_count":250,"lead_sponsor_name":"University of Michigan","has_results":true},{"nct_id":"NCT04307745","title":"Primary Prevention Habits for the Shoulder: Survey of the Sportsman's Entourage","phase":"","overall_status":"COMPLETED","enrollment_count":213,"lead_sponsor_name":"University of Liege","has_results":false},{"nct_id":"NCT04014946","title":"Assessment of Risk Factors for Appropriate ICD (Implantable Cardioverter-defibrillator) Intervention in Patients With Ischemic Cardiomyopathy","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Biotronik SE & Co. KG","has_results":false},{"nct_id":"NCT03216018","title":"Prevention Program Promoting Self Resilience, Positive Self-Image and Body Image Among Adolescents","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Tel Hai College","has_results":false},{"nct_id":"NCT06793930","title":"A Tailored, Optimised, and Person-centred Programme to Promote Lifestyle Modification in People With Metabolic Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":152,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT04688619","title":"Adolescents as Change Agents in the Incorporation of a Parental Component for a School Based Prevention Program","phase":"NA","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Tel Hai College","has_results":false},{"nct_id":"NCT05103371","title":"A Prevention Program to Encourage Self-care, Self-esteem and Body-esteem Among Young Adolescents","phase":"NA","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Tel Hai College","has_results":false},{"nct_id":"NCT05781295","title":"Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology","phase":"NA","overall_status":"RECRUITING","enrollment_count":148,"lead_sponsor_name":"Institut Curie","has_results":false},{"nct_id":"NCT05360849","title":"Implementing PrEP for Women Who Inject Drugs","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":130,"lead_sponsor_name":"University of Pennsylvania","has_results":false},{"nct_id":"NCT02556112","title":"Effectiveness of a Group Lifestyle Balance Class in a Military Population","phase":"NA","overall_status":"COMPLETED","enrollment_count":122,"lead_sponsor_name":"David Grant U.S. Air Force Medical Center","has_results":true},{"nct_id":"NCT07299201","title":"Proactive Telemedicine to Improve Healthcare Access and Prevention in Rural Primary Care (PTM)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":120,"lead_sponsor_name":"Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina","has_results":false},{"nct_id":"NCT04626037","title":"CLC Parent-Child Emotional Preparation Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":109,"lead_sponsor_name":"Columbia University","has_results":false},{"nct_id":"NCT06865885","title":"LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT05102526","title":"Increasing the Impact of a School Prevention Program Among Young Adolescents by Adding a Teacher Component","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Tel Hai College","has_results":false},{"nct_id":"NCT04359342","title":"Protein Supplementation and HIIT: Impact on Cardiorespiratory Fitness","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"University of Erlangen-Nürnberg Medical School","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}