{"disease":{"id":"pneumonitis","name":"pneumonitis"},"drugs":{"marketed":[{"drug_id":"prednisone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Deltasone","generic_name":"prednisone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Sodium/nucleoside cotransporter 1, Glucocorticoid receptor","drug_class":"Corticosteroid [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"dexamethasone-phosphate","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dexamethasone Sodium Phosphate","generic_name":"dexamethasone phosphate","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Androgen receptor, Glucocorticoid receptor, Mineralocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"hydrocortisone-succinate","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Solu-Cortef","generic_name":"hydrocortisone succinate","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"hydrocortisone-acetate","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortifoam","generic_name":"HYDROCORTISONE ACETATE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"cortisone-acetate","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortone","generic_name":"CORTISONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":29,"revenue":null,"mechanism":""},{"drug_id":"betamethasone-acetate","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Celestone Soluspan","generic_name":"BETAMETHASONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":42,"revenue":null,"mechanism":""},{"drug_id":"methylprednisolone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Medrol","generic_name":"methylprednisolone","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"Glucocorticoid (corticosteroid)","quality_score":62,"revenue":null,"mechanism":"Potent synthetic glucocorticoid with 5x hydrocortisone potency and minimal mineralocorticoid activity, used for severe inflammatory conditions."},{"drug_id":"hydrocortisone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortef","generic_name":"hydrocortisone","company_name":"Generic (originally Merck/Upjohn)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"Corticosteroid [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"triamcinolone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rodinolone","generic_name":"TRIAMCINOLONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"betamethasone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Betametasone","generic_name":"BETAMETHASONE","company_name":"","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":65,"revenue":null,"mechanism":"Betamethasone works by binding to the glucocorticoid receptor, which then triggers a series of downstream effects that reduce inflammation and suppress the immune system."},{"drug_id":"cortisol","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cortisol","company_name":"University of Zurich","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"prednisolone","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prelone","generic_name":"prednisolone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"Glucocorticoid (corticosteroid)","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"prednisolon","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"prednisolon","company_name":"Hannover Medical School","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, G-protein coupled bile acid receptor 1","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"methylprednisolon","indication_name":"Aspiration pneumonitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Methylprednisolon","company_name":"Leiden University Medical Center","drug_phase":"marketed","molecular_target":"Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":14,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04896138","title":"University of Virginia Natural History Study","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2500,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT04721444","title":"Optimising Cancer Therapy And Identifying Causes of Pneumonitis USing Artificial Intelligence (COVID-19)","phase":"","overall_status":"COMPLETED","enrollment_count":1211,"lead_sponsor_name":"Royal Marsden NHS Foundation Trust","has_results":false},{"nct_id":"NCT05392881","title":"Interstitial Lung Disease Research Unit Biobank","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Kansas Medical Center","has_results":false},{"nct_id":"NCT04302688","title":"Accurate Classification System for Patients With COVID-19 Pneumonitis","phase":"","overall_status":"COMPLETED","enrollment_count":669,"lead_sponsor_name":"Renmin Hospital of Wuhan University","has_results":false},{"nct_id":"NCT04843345","title":"Sjogren's Lung Study","phase":"","overall_status":"SUSPENDED","enrollment_count":500,"lead_sponsor_name":"Stanford University","has_results":false},{"nct_id":"NCT06644144","title":"P4O2 ILD Extension","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Amsterdam UMC, location VUmc","has_results":false},{"nct_id":"NCT03462524","title":"Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology","phase":"","overall_status":"COMPLETED","enrollment_count":384,"lead_sponsor_name":"St. James's Hospital, Ireland","has_results":false},{"nct_id":"NCT05189496","title":"Hyperbaric Oxygen in the Prevention of Radiation Pneumonitis","phase":"NA","overall_status":"RECRUITING","enrollment_count":380,"lead_sponsor_name":"Guangdong Provincial People's Hospital","has_results":false},{"nct_id":"NCT05448703","title":"A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT07312682","title":"Application of 4DCT-Based Pulmonary Ventilation Imaging in Lung Cancer Radiotherapy","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":202,"lead_sponsor_name":"The Second Affiliated Hospital of Chongqing Medical University","has_results":false},{"nct_id":"NCT07186933","title":"Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"University General Hospital of Patras","has_results":false},{"nct_id":"NCT06069115","title":"Radiotherapy Exposed Lung Injury: Effect on Functioning - Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Meshalkin Research Institute of Pathology of Circulation","has_results":false},{"nct_id":"NCT04425863","title":"Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19","phase":"","overall_status":"COMPLETED","enrollment_count":167,"lead_sponsor_name":"Eurnekian Public Hospital","has_results":true},{"nct_id":"NCT02036970","title":"Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":166,"lead_sponsor_name":"Biogen","has_results":true},{"nct_id":"NCT03828500","title":"Preoperative Fasting for Ambulatory Cataract Surgery: The PRACTICE Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"University of Toronto","has_results":false},{"nct_id":"NCT04961944","title":"HypErsensitiVity PneumonITis: DiseAse Progression Characterization","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Hospital do Coracao","has_results":false},{"nct_id":"NCT05626387","title":"An RCT of Mycophenolate Mofetil (MMF) in Fibrotic Hypersensitivity Pneumonitis","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":144,"lead_sponsor_name":"Post Graduate Institute of Medical Education and Research, Chandigarh","has_results":false},{"nct_id":"NCT07169253","title":"Prognostic Score Comparison in IPF and HP","phase":"","overall_status":"COMPLETED","enrollment_count":143,"lead_sponsor_name":"Saglik Bilimleri Universitesi","has_results":false},{"nct_id":"NCT04844359","title":"A Prognostic Transcriptomic Signature for Chronic Hypersensitivity Pneumonitis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":137,"lead_sponsor_name":"National Jewish Health","has_results":false},{"nct_id":"NCT04590547","title":"GLS-1027 for the Prevention of Severe Pneumonitis Caused by SARS-CoV-2 Infection (COVID-19)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":132,"lead_sponsor_name":"GeneOne Life Science, Inc.","has_results":true},{"nct_id":"NCT03796364","title":"Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":126,"lead_sponsor_name":"Xinqiao Hospital of Chongqing","has_results":false},{"nct_id":"NCT07210008","title":"\"Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity Pneumonitis\"","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":120,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04402177","title":"This Study Aim is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis as it Was Found That Not All Patients Get Satisfying Therapeutic Effect After Taking Corticosteroids.","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":110,"lead_sponsor_name":"Al-Azhar University","has_results":false},{"nct_id":"NCT07339644","title":"Functional Lung Avoidance Radiotherapy Guided by 4DCT Pulmonary Ventilation Function Imaging: A Prospective Single-arm Clinical Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"The Second Affiliated Hospital of Chongqing Medical University","has_results":false},{"nct_id":"NCT05988437","title":"Contribution of the Indoor Environment Medical Advisor in the Management of Fibrosing Hypersensitivity Pneumonitis","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT06860542","title":"Inhaled Budesonide for REcurrence Prevention and Adjuvant THerapy in Checkpoint Inhibitor Pneumonitis","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":94,"lead_sponsor_name":"AHS Cancer Control Alberta","has_results":false},{"nct_id":"NCT04676828","title":"Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":90,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT03730428","title":"Everolimus Related Pneumonitis in MBC","phase":"","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT04326725","title":"Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia","phase":"","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Istinye University","has_results":false},{"nct_id":"NCT03803787","title":"Prophylactic Inhaled Steroids to Reduce Radiation Pneumonitis Frequency and Severity in Lung Cancer Patients","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":72,"lead_sponsor_name":"Instituto Nacional de Cancerologia de Mexico","has_results":false},{"nct_id":"NCT05957562","title":"Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair","phase":"NA","overall_status":"COMPLETED","enrollment_count":64,"lead_sponsor_name":"dr. Muhammad Abdelhafez Mahmoud, MD","has_results":false},{"nct_id":"NCT04807127","title":"A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT05899725","title":"The Efficacy and Safety of Corticosteroids in Combination With Ruxolitinib in the Management of Checkpoint Inhibitor Pneumonia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT04273867","title":"Assessing Health Related Quality of Life in Hypersensitivity Pneumonitis","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Weill Medical College of Cornell University","has_results":false},{"nct_id":"NCT02735746","title":"Novel Lung Imaging in Adults Undergoing Radiation Therapy to Assess for Radiation Pneumonitis","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Cedars-Sinai Medical Center","has_results":false},{"nct_id":"NCT05458635","title":"Predictors of Pulmonary Hypertension in Patients With Hypersensitivity Pneumonitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT07340892","title":"Diagnostic Biomarkers for Checkpoint Inhibitor-related Pneumonitis","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Zhou Chengzhi","has_results":false},{"nct_id":"NCT07432503","title":"Diagnostic Yield and Safety of Lung Biopsy Techniques in Interstitial Lung Diseases","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Mansoura University","has_results":false},{"nct_id":"NCT05549635","title":"Database and Biobank of Patients With Hypersensitivity Pneumonitis","phase":"","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"Nils Hoyer","has_results":false},{"nct_id":"NCT01754909","title":"Mitigation of Radiation Pneumonitis and Fibrosis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT05280873","title":"Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":48,"lead_sponsor_name":"Zhou Chengzhi","has_results":false},{"nct_id":"NCT02019641","title":"The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"National Institutes of Health Clinical Center (CC)","has_results":true},{"nct_id":"NCT05723796","title":"Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT05455034","title":"Single-cell Sequencing of BLF to Guide the Treatment of Radiation Pneumonitis or Immune Checkpoint Inhibitor Pneumonitis","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"Xinqiao Hospital of Chongqing","has_results":false},{"nct_id":"NCT04675619","title":"Evaluation of the Efficacy of Pirfenidone in Progressive Chronic Hypersensitivity Pneumonitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT06570317","title":"Nintedanib for the Prevention of Radiation Pneumonia in Unresectable NSCLC","phase":"","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"Second Hospital of Shanxi Medical University","has_results":false},{"nct_id":"NCT03800017","title":"Skeletal Muscle Function in Interstitial Lung Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT06861179","title":"The Formulation of Compound Phellinus Igniarius Decoction on Radiation Pneumonitis","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Zhejiang Cancer Hospital","has_results":false},{"nct_id":"NCT07035561","title":"Rituximab Therapy in Patients With Treatment Refractory Hypersenstivity Pneumonitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Shereen Medhat Mohammed Elsayed Nassar","has_results":false},{"nct_id":"NCT04561479","title":"Pulmonary Rehabilitation in Patients With Chronic Fibrotic Hypersensitivity Pneumonitis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Gazi University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}