{"disease":{"id":"pituitary-disease","name":"pituitary disease"},"drugs":{"marketed":[{"drug_id":"osilodrostat","indication_name":"Pituitary-dependent Cushing's disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Isturisa","generic_name":"OSILODROSTAT","company_name":"Recordati","drug_phase":"marketed","molecular_target":"Cytochrome P450 11B2, mitochondrial","drug_class":"Cortisol Synthesis Inhibitor","quality_score":70,"revenue":"200","mechanism":"Isturisa blocks the production of cortisol in the adrenal glands by inhibiting the cytochrome P450 11B2 enzyme."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03655223","title":"Early Check: Expanded Screening in Newborns","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":30000,"lead_sponsor_name":"RTI International","has_results":false},{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT04951557","title":"Setting Benchmarks for Transsphenoidal Resection of Pituitary Adenomas","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT04713293","title":"China Pituitary Disease Registry (CAPASITY)","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Shanghai Jiao Tong University School of Medicine","has_results":false},{"nct_id":"NCT03474601","title":"Seoul National University Pituitary Disease Cohort Study","phase":"","overall_status":"UNKNOWN","enrollment_count":1600,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT06973824","title":"A Twenty-years' Experience in Pituitary Disease.","phase":"","overall_status":"RECRUITING","enrollment_count":1600,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT03665064","title":"Long Term Outcome Study in Patients With Pituitary Disorders","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT00001452","title":"Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex","phase":"","overall_status":"COMPLETED","enrollment_count":1387,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT06523582","title":"Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients","phase":"","overall_status":"RECRUITING","enrollment_count":750,"lead_sponsor_name":"Universidad Nacional Autonoma de Mexico","has_results":false},{"nct_id":"NCT03344458","title":"A Long-Term Trial Investigating Safety and Efficacy of TransCon hGH in Children With Growth Hormone Deficiency Who Have Completed a Prior TransCon hGH Clinical Trial","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":298,"lead_sponsor_name":"Ascendis Pharma A/S","has_results":true},{"nct_id":"NCT01504399","title":"Rhinological Outcomes in Endonasal Pituitary Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":235,"lead_sponsor_name":"St. Joseph's Hospital and Medical Center, Phoenix","has_results":false},{"nct_id":"NCT02781727","title":"A Phase 3 Trial of the Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"Ascendis Pharma Endocrinology Division A/S","has_results":true},{"nct_id":"NCT04252001","title":"Growing up With the Young Endocrine Support System (YESS!)","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":160,"lead_sponsor_name":"dr. Laura C. G. de Graaff-Herder","has_results":false},{"nct_id":"NCT03305016","title":"A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":146,"lead_sponsor_name":"Ascendis Pharma Endocrinology Division A/S","has_results":true},{"nct_id":"NCT00054756","title":"Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":96,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":true},{"nct_id":"NCT04902235","title":"Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","has_results":false},{"nct_id":"NCT04897802","title":"Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","has_results":false},{"nct_id":"NCT03882034","title":"Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":12,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT02782208","title":"Lipolytic Effects of GH in Hypopituitary Patients in Vivo","phase":"NA","overall_status":"COMPLETED","enrollment_count":9,"lead_sponsor_name":"University of Aarhus","has_results":false}],"total":19},"guidelines":[],"source":"Drug Landscape verified database"}