{"disease":{"id":"periapical-periodontitis","name":"periapical periodontitis"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07018284","title":"Postoperative Pain Evaluation After Obturation With Different Sealers","phase":"NA","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"University of Siena","has_results":false},{"nct_id":"NCT07019298","title":"Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements","phase":"NA","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"University of Siena","has_results":false},{"nct_id":"NCT05256667","title":"Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair","phase":"PHASE2, PHASE3","overall_status":"UNKNOWN","enrollment_count":210,"lead_sponsor_name":"New York University","has_results":false},{"nct_id":"NCT04812171","title":"Healing of Apical periodontitis-the Effect of Diabetes Mellitus and Tobacco Smoking","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Romana Peršić Bukmir","has_results":false},{"nct_id":"NCT06023901","title":"The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":185,"lead_sponsor_name":"Istanbul Medipol University Hospital","has_results":false},{"nct_id":"NCT05297747","title":"Adrenomedullin Upregulation in Apical Periodontitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":174,"lead_sponsor_name":"Istanbul Medipol University Hospital","has_results":false},{"nct_id":"NCT03990584","title":"Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment","phase":"NA","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"Istanbul Medipol University Hospital","has_results":false},{"nct_id":"NCT06339905","title":"The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success","phase":"NA","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Istanbul Medipol University Hospital","has_results":false},{"nct_id":"NCT05763420","title":"Clinical Efficacy of AH Plus Bioceramic Sealer","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":136,"lead_sponsor_name":"Ministry of Health, Kuwait","has_results":false},{"nct_id":"NCT06991803","title":"Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions","phase":"NA","overall_status":"COMPLETED","enrollment_count":132,"lead_sponsor_name":"Recep Tayyip Erdogan University","has_results":true},{"nct_id":"NCT07197658","title":"Healing After Endodontic Microsurgery Using a Rotary Bur Versus Piezoelectric Unit for Osteotomy and Root Resection","phase":"NA","overall_status":"RECRUITING","enrollment_count":130,"lead_sponsor_name":"National and Kapodistrian University of Athens","has_results":false},{"nct_id":"NCT04495270","title":"2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale","phase":"","overall_status":"COMPLETED","enrollment_count":128,"lead_sponsor_name":"Lithuanian University of Health Sciences","has_results":false},{"nct_id":"NCT05555043","title":"Comparison of Clinical Outcomes Between GentleWave® and Biolase®","phase":"NA","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":false},{"nct_id":"NCT07026435","title":"Comparison of LSTR and Pulpectomy in Primary Molars of Pediatric Patients (LSTR-PULP)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":108,"lead_sponsor_name":"taymour abuawwad","has_results":false},{"nct_id":"NCT05778227","title":"Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"Dow University of Health Sciences","has_results":false},{"nct_id":"NCT06545773","title":"Postoperative Pain After Conservative Root Canal Preparation","phase":"NA","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Istanbul University","has_results":false},{"nct_id":"NCT03918733","title":"Comparision of Non Surgical Retreatment and Endodontic Surgery of Failed Root Canal Treated Teeth","phase":"NA","overall_status":"UNKNOWN","enrollment_count":86,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT06357481","title":"Evaluation of Postoperative Pain After Single Visit Retreatment of Symptomatic and Asymptomatic Teeth","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Saglik Bilimleri Universitesi","has_results":false},{"nct_id":"NCT07437612","title":"Cryotherapy and Intracanal Medicaments for Postoperative Pain in Apical Periodontitis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Celalettin Topbaş","has_results":false},{"nct_id":"NCT07252258","title":"Comparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled Trial","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Aqsa Afzal","has_results":false},{"nct_id":"NCT07418840","title":"Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":75,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT03033147","title":"Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain","phase":"NA","overall_status":"COMPLETED","enrollment_count":72,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT04358861","title":"Healing Outcome of Root Canal Therapy in Maxillary Molars With DOM","phase":"NA","overall_status":"COMPLETED","enrollment_count":67,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT03660163","title":"Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.","phase":"","overall_status":"UNKNOWN","enrollment_count":65,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT07239739","title":"Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":62,"lead_sponsor_name":"Faiz ur rahman","has_results":false},{"nct_id":"NCT07237620","title":"The Effect of Different Intracanal Medicaments on Periapical Lesion Healing","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Mustafa Kemal University","has_results":false},{"nct_id":"NCT05857436","title":"Relationship Apical Periodontitis and the Main Bacterial Species in the Oral Microbiota","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Seyda Ersahan, DDS, PhD","has_results":false},{"nct_id":"NCT03708081","title":"Comparative Evaluation of Different File Systems in Postoperative Pain","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Bulent Ecevit University","has_results":false},{"nct_id":"NCT07354373","title":"Single-Visit and Two-Visit Endodontic Treatments","phase":"NA","overall_status":"COMPLETED","enrollment_count":59,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06643676","title":"Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT06322979","title":"Premixed Bioceramic Putty as an Apical Plug in Immature Anterior Permanent Teeth","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT04324398","title":"Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":48,"lead_sponsor_name":"Suez Canal University","has_results":false},{"nct_id":"NCT07239752","title":"Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":48,"lead_sponsor_name":"College of Physicians and Surgeons Pakistan","has_results":false},{"nct_id":"NCT07501585","title":"Hyaluronic Acid in Endodontic Microsurgery","phase":"NA","overall_status":"RECRUITING","enrollment_count":46,"lead_sponsor_name":"University of Bern","has_results":false},{"nct_id":"NCT03537664","title":"Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections","phase":"NA","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"University of Sao Paulo","has_results":true},{"nct_id":"NCT06587048","title":"Outcome of Bone Window Approach in Endodontic Microsurgery Using Novel Piezoelectric Device","phase":"NA","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT03102879","title":"Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.","phase":"NA","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"Universidad de los Andes, Chile","has_results":true},{"nct_id":"NCT05525013","title":"Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT07265804","title":"PRF and CGF Scaffolds With EDTA in Regeneration","phase":"NA","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Kahramanmaras Sutcu Imam University","has_results":false},{"nct_id":"NCT05585359","title":"Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":28,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT04980768","title":"Association of Apical Periodontitis With Hs-CRP and Hemogram Indices","phase":"NA","overall_status":"UNKNOWN","enrollment_count":25,"lead_sponsor_name":"Postgraduate Institute of Dental Sciences Rohtak","has_results":false},{"nct_id":"NCT05719987","title":"Biodentine as an Apical Plug in Immature Permanent Molars","phase":"NA","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Damascus University","has_results":false},{"nct_id":"NCT07005219","title":"Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria","phase":"NA","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Medipol University","has_results":false},{"nct_id":"NCT06713174","title":"Interleukin 8 and10 Levels Changes in Teeth With Necrotic Pulp and Apical Periodontitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"Faculty of Dental Medicine for Girls","has_results":false},{"nct_id":"NCT05690763","title":"Quantitative Assessment of the Efficacy of Two Irrigation Activation Systems","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Seyda Ersahan, DDS, PhD","has_results":false},{"nct_id":"NCT05718596","title":"Quantitative Assessment of the Efficacy of Sweeps Laser Activation Systems","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Seyda Ersahan, DDS, PhD","has_results":false},{"nct_id":"NCT04978545","title":"The Effect of Ca(OH)2 in Apical Periodontitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Seyda Ersahan, DDS, PhD","has_results":false},{"nct_id":"NCT05599087","title":"Encapsulated Acellular System From Mesenchymal Stem Cells for Dental Pulp Regeneration","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":10,"lead_sponsor_name":"Universidad de los Andes, Chile","has_results":false}],"total":48},"guidelines":[],"source":"Drug Landscape verified database"}