{"disease":{"id":"percutaneous","name":"percutaneous"},"drugs":{"marketed":[{"drug_id":"ticagrelor","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brilinta","generic_name":"ticagrelor","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"Equilibrative nucleoside transporter 1, P2Y purinoceptor 12, P2Y purinoceptor 12","drug_class":"P2Y12 Platelet Inhibitor [EPC]","quality_score":10,"revenue":"1100","mechanism":null},{"drug_id":"prasugrel","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Effient","generic_name":"PRASUGREL","company_name":"Cosette","drug_phase":"marketed","molecular_target":"P2Y purinoceptor 12","drug_class":"P2Y12 Platelet Inhibitor","quality_score":80,"revenue":"400","mechanism":"Effient works by blocking the P2Y12 receptor on platelets, preventing them from aggregating and forming blood clots."},{"drug_id":"cangrelor","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Kengreal","generic_name":"CANGRELOR","company_name":"Chiesi","drug_phase":"marketed","molecular_target":"P2Y purinoceptor 12","drug_class":"P2Y12 Platelet Inhibitor [EPC]","quality_score":66,"revenue":"200","mechanism":"Kengreal blocks the action of ADP on platelets, preventing platelet activation and aggregation."},{"drug_id":"tirofiban","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aggrastat","generic_name":"TIROFIBAN","company_name":"Medicure","drug_phase":"marketed","molecular_target":"Integrin alpha-IIb/beta-3","drug_class":"Platelet Aggregation Inhibitor","quality_score":75,"revenue":null,"mechanism":"Aggrastat works by blocking the integrin alpha-IIb/beta-3 receptor on platelets, preventing them from aggregating and forming blood clots."},{"drug_id":"brilinta","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Brilinta","company_name":"AstraZeneca","drug_phase":"marketed","molecular_target":"Equilibrative nucleoside transporter 1, P2Y purinoceptor 12, P2Y purinoceptor 12","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"eptifibatide","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Integrilin","generic_name":"EPTIFIBATIDE","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Integrin alpha-IIb/beta-3","drug_class":"Platelet Aggregation Inhibitor [EPC]","quality_score":75,"revenue":null,"mechanism":"Integrilin blocks the binding of fibrinogen to platelets, preventing them from clumping together and forming clots."},{"drug_id":"abciximab","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Reopro","generic_name":"ABCIXIMAB","company_name":"Johnson & Johnson","drug_phase":"marketed","molecular_target":"Integrin alpha-IIb/beta-3","drug_class":"","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"integrilin","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"integrilin","company_name":"University of Cincinnati","drug_phase":"phase_1","molecular_target":"Integrin alpha-IIb/beta-3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"argatroban","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Argatroban","generic_name":"ARGATROBAN","company_name":"Hikma Pharm Co Ltd","drug_phase":"marketed","molecular_target":"Prothrombin","drug_class":"Anti-coagulant [EPC]","quality_score":63,"revenue":null,"mechanism":"Argatroban works by directly inhibiting the activity of thrombin, a key enzyme in the blood clotting process."},{"drug_id":"ticlopidine","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ticlid","generic_name":"TICLOPIDINE","company_name":"","drug_phase":"marketed","molecular_target":"P2Y12","drug_class":"ADP receptor antagonist","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"bivalirudin","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Angiomax","generic_name":"BIVALIRUDIN","company_name":"Novartis","drug_phase":"marketed","molecular_target":"thrombin","drug_class":"Anti-coagulant [EPC]","quality_score":10,"revenue":null,"mechanism":"Bivalirudin directly inhibits thrombin by binding to its catalytic site and anion-binding exosite, preventing thrombus formation."},{"drug_id":"apraclonidine","indication_name":"Percutaneous coronary intervention","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Iopidine","generic_name":"APRACLONIDINE","company_name":"Harrow Health","drug_phase":"marketed","molecular_target":"Alpha-2A adrenergic receptor","drug_class":"alpha-Adrenergic Agonist","quality_score":42,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":12,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07442500","title":"Drug Coated Balloon vs. Drug-eluting Stent in Patients With Coronary Artery Disease","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":470000,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06521801","title":"Cardio-Renal Registry","phase":"","overall_status":"RECRUITING","enrollment_count":60000,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT03776266","title":"The Long-term Clinical Outcomes and Patterns of Transfusion in PCI Patients: Retrospective Cohort Study","phase":"","overall_status":"COMPLETED","enrollment_count":48786,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT03785509","title":"The Compliance of DAPT and Statins on Clinical Outcomes in Percutaneous Coronary Intervention Patients","phase":"","overall_status":"COMPLETED","enrollment_count":47291,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06736626","title":"The xDAPT External Validation Study","phase":"","overall_status":"COMPLETED","enrollment_count":30000,"lead_sponsor_name":"Icahn School of Medicine at Mount Sinai","has_results":false},{"nct_id":"NCT03788148","title":"Bare Metal Stents and Drug Eluting Stents in Patients Who Underwent Blood Transfusion","phase":"","overall_status":"COMPLETED","enrollment_count":28322,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT03338335","title":"Ethnic Differences and the Ischemia/Bleeding Risk of DAPT Duration","phase":"","overall_status":"UNKNOWN","enrollment_count":16000,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05624905","title":"Prospective Pecutaneous Coronary Intervention Registry","phase":"","overall_status":"RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06821711","title":"Optimal LDL-C Target in High-risk Patients After PCI","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":12000,"lead_sponsor_name":"Xijing Hospital","has_results":false},{"nct_id":"NCT05719545","title":"A Cohort of Patients Undergoing Percutaneous Coronary Intervention","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Su Guohai","has_results":false},{"nct_id":"NCT05728580","title":"PCI in Beijing Friendship Hospital","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Beijing Friendship Hospital","has_results":false},{"nct_id":"NCT07153744","title":"Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":9588,"lead_sponsor_name":"Shanghai Hutchison Pharmaceuticals Limited","has_results":false},{"nct_id":"NCT04288596","title":"Canadian Adult Congenital Heart Disease Intervention Registry","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":9000,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT06472908","title":"Efficacy and Safety of Colchicine After PCI","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":8862,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT07383155","title":"Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary Syndromes","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":5270,"lead_sponsor_name":"Shenyang Northern Hospital","has_results":false},{"nct_id":"NCT03461367","title":"CTO Registry From Insight of IVUS in Fuwai Hospital","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT05248165","title":"Naples PCI Registry","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Federico II University","has_results":false},{"nct_id":"NCT07231939","title":"Use of Flozins (Empagliflozin/Dapagliflozin) for Prevention of AKI","phase":"","overall_status":"RECRUITING","enrollment_count":4000,"lead_sponsor_name":"Collegium Medicum w Bydgoszczy","has_results":false},{"nct_id":"NCT03656848","title":"The FAVOR III China Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":3847,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT06648720","title":"Efficacy and Safety of Shortening Dual Antiplatelet Therapy Duration with IVUS Guidance in PCI Patients","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":3566,"lead_sponsor_name":"University Medical Center Ho Chi Minh City (UMC)","has_results":false},{"nct_id":"NCT04416581","title":"Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":3320,"lead_sponsor_name":"Duk-Woo Park, MD","has_results":false},{"nct_id":"NCT07182799","title":"Starring Optical Coherence Tomography During Percutaneous Coronary Intervention Guidance","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3200,"lead_sponsor_name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","has_results":false},{"nct_id":"NCT04332250","title":"Influence Of Incomplete Revascularization on Long-Term Outcomes After Primary Percutaneous Coronary Intervention (PPCI)","phase":"","overall_status":"COMPLETED","enrollment_count":3200,"lead_sponsor_name":"Amany Edward Ramzy","has_results":false},{"nct_id":"NCT06692140","title":"Comparison of an Ultra-low Strut Thickness Everolimus-eluting Biodegradable Polymer Stent Versus Durable Polymer Everolimus-eluting Stents in Patients Treated with Percutaneous Coronary Intervention","phase":"NA","overall_status":"RECRUITING","enrollment_count":3150,"lead_sponsor_name":"Odense University Hospital","has_results":false},{"nct_id":"NCT05955365","title":"Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":3010,"lead_sponsor_name":"Insel Gruppe AG, University Hospital Bern","has_results":false},{"nct_id":"NCT03462498","title":"ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-2 Study for the Patients With ACS","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":3008,"lead_sponsor_name":"Kyoto University, Graduate School of Medicine","has_results":false},{"nct_id":"NCT04185285","title":"Percutaneous Coronary Intervention Registry FRIBOURG","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"University of Freiburg","has_results":false},{"nct_id":"NCT06763744","title":"Genotype-Guided Abbreviated DAPT Versus Un-Guided De-escalation Therapy in Patients With ACS and HBR","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT07231835","title":"Registry of Coronary Disease Outcomes Revascularizing With Drug-Coated Balloons","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT02164864","title":"Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":2725,"lead_sponsor_name":"Boehringer Ingelheim","has_results":true},{"nct_id":"NCT04937699","title":"Sequential MonotherApy of TicagrElor and Clopidogrel After Coronary Intervention","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":2690,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT04566497","title":"Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.","phase":"NA","overall_status":"RECRUITING","enrollment_count":2664,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT03852082","title":"Predictors and Clinical Outcomes of Patients With Coronary Heart Disease Co-morbid Depression Post Percutaneous Coronary Intervention","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2600,"lead_sponsor_name":"Nanjing First Hospital, Nanjing Medical University","has_results":false},{"nct_id":"NCT05554588","title":"Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI","phase":"NA","overall_status":"RECRUITING","enrollment_count":2500,"lead_sponsor_name":"China-Japan Friendship Hospital","has_results":false},{"nct_id":"NCT04837001","title":"Evaluation in STEMI Patients Using FDY-5301","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":2351,"lead_sponsor_name":"Faraday Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT06101862","title":"Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome","phase":"NA","overall_status":"RECRUITING","enrollment_count":2300,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT04695106","title":"Dual Antithrombotic Therapy With Dabigatran and Ticagrelor in Patients With ACS and Non-valvular AF Undergoing PCI","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":2230,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT01830543","title":"A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":2124,"lead_sponsor_name":"Janssen Scientific Affairs, LLC","has_results":true},{"nct_id":"NCT03197298","title":"Change of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome","phase":"","overall_status":"COMPLETED","enrollment_count":2062,"lead_sponsor_name":"Thorax Centrum Twente","has_results":false},{"nct_id":"NCT04338919","title":"Optimized Antiplatelet Therapy on the Prognosis of ACS Patients With Non-predominant Coronary Artery Disease After PCI","phase":"NA","overall_status":"UNKNOWN","enrollment_count":2020,"lead_sponsor_name":"Fujian Medical University","has_results":false},{"nct_id":"NCT03614559","title":"Contemporary Clinical Treatment and Long-term Outcomes in Patient With Coronary Chronic Total Occlusion","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT07098195","title":"To Evaluate the Performance and Safety of RisoR Crest Everolimus Eluting Coronary Stent System","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Poly Medicure Limited","has_results":false},{"nct_id":"NCT04806633","title":"Dapagliflozin to Prevent the Incidence of Contrast Induced Nephropathy After Heart Catheterization and Percutaneous Coronary Intervention","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":1722,"lead_sponsor_name":"G.Gennimatas General Hospital","has_results":false},{"nct_id":"NCT06143709","title":"Precision PCI Registry","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1643,"lead_sponsor_name":"University of Florida","has_results":false},{"nct_id":"NCT03315650","title":"Rivaroxaban in Patients With Atrial Fibrillation Undergoing PCI","phase":"","overall_status":"COMPLETED","enrollment_count":1632,"lead_sponsor_name":"IHF GmbH - Institut für Herzinfarktforschung","has_results":false},{"nct_id":"NCT04918030","title":"STaged Interventional Strategies for Acute ST-seGment Elevation Myocardial Infarction Patient With Multi-vessel Disease（STAGED）","phase":"NA","overall_status":"COMPLETED","enrollment_count":1586,"lead_sponsor_name":"Xiamen Cardiovascular Hospital, Xiamen University","has_results":false},{"nct_id":"NCT04999293","title":"Ticagrelor in Elderly Patients Undergoing Percutaneous Coronary Intervention","phase":"","overall_status":"COMPLETED","enrollment_count":1505,"lead_sponsor_name":"The First Affiliated Hospital of Dalian Medical University","has_results":false},{"nct_id":"NCT05134129","title":"Correlation Between Targeted HbA1c Values and Prevention of Recurrent Cardiovascular Events in Type 2 Diabetes After PCI","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Shanghai 10th People's Hospital","has_results":false},{"nct_id":"NCT06910436","title":"Artificial Intelligence Based Timing, Infarct Size and Outcomes in Acute Coronary Occlusion Myocardial Infarction","phase":"","overall_status":"RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Azienda Ospedaliera di Bolzano","has_results":false},{"nct_id":"NCT04665648","title":"Clinical Efficacy and sAfety of Intravenous Infusion of Nicorandil During Primary Percutaneous Coronary Intervention","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1500,"lead_sponsor_name":"Fudan University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}