{"disease":{"id":"pelvic-prolapse","name":"pelvic prolapse"},"drugs":{"marketed":[],"pipeline":[{"drug_id":"vaginal-estrogen","indication_name":"Pelvic Organ Prolapse","indication_type":"pipeline","phase":"discontinued","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vaginal estrogen","generic_name":"vaginal-estrogen","company_name":"Pfizer Inc.","drug_phase":"discontinued","molecular_target":"","drug_class":"1 gram vaginally for 7 days, followed by 1 gram vaginally twice weekly thereafter","quality_score":null,"revenue":null,"mechanism":"1 gram vaginally for 7 days, followed by 1 gram vaginally twice weekly thereafter"}],"offLabel":[],"totalMarketed":0,"totalPipeline":1},"trials":{"data":[{"nct_id":"NCT07006129","title":"Effectiveness of Perineorrhaphy in Pelvic Organ Prolapse Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":40646,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT03052985","title":"Materiovigilance After Urinary Incontinence or Prolapse Surgery","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":19000,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT03421067","title":"Apical Support During Hysterectomy for Pelvic Organ Prolapse-NSQIP Analysis.","phase":"","overall_status":"COMPLETED","enrollment_count":3458,"lead_sponsor_name":"TriHealth Inc.","has_results":false},{"nct_id":"NCT07137299","title":"POPQ Associated With Total Laparoscopic Hysterectomy","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT04010162","title":"Mesh Debate Awareness Among Non-urogynecologists. A Practical Survey Study.","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Uludag University","has_results":false},{"nct_id":"NCT06461234","title":"Pelvic Floor Rehabilitation of Female Pelvic Floor Dysfunction","phase":"","overall_status":"RECRUITING","enrollment_count":1360,"lead_sponsor_name":"Mingfu Wu","has_results":false},{"nct_id":"NCT04039009","title":"Apical Pelvic Support in Infertility Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":1100,"lead_sponsor_name":"Uludag University","has_results":false},{"nct_id":"NCT04829175","title":"Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Ethicon, Inc.","has_results":false},{"nct_id":"NCT07104292","title":"Pelvic Floor Muscle Training During Pregnancy","phase":"NA","overall_status":"RECRUITING","enrollment_count":734,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT05312047","title":"Continence After Vaginal Prolapse Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":609,"lead_sponsor_name":"Hospital Universitari Vall d'Hebron Research Institute","has_results":false},{"nct_id":"NCT05567900","title":"Health Care Seeking Behavior and Knowledge Assessment of Hungarian Women About Pelvic Floor Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":596,"lead_sponsor_name":"University of Pecs","has_results":false},{"nct_id":"NCT05602246","title":"Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS","phase":"NA","overall_status":"RECRUITING","enrollment_count":592,"lead_sponsor_name":"Charles University, Czech Republic","has_results":false},{"nct_id":"NCT05707533","title":"Vaginal Adventitia Reserved and Anatomical Implant Technique of Transvaginal Mesh Procedure for Pelvic Organ Prolapse","phase":"","overall_status":"COMPLETED","enrollment_count":589,"lead_sponsor_name":"West China Hospital","has_results":false},{"nct_id":"NCT01436708","title":"The Association of Pelvic Organ Prolapse Severity and Urinary Symptoms/Sexual Function","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Far Eastern Memorial Hospital","has_results":false},{"nct_id":"NCT04139083","title":"The Clinical Outcome of TVM or LSC Mesh Suspension for POP","phase":"","overall_status":"COMPLETED","enrollment_count":466,"lead_sponsor_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","has_results":false},{"nct_id":"NCT04429360","title":"What is the Effect of Prolapse Surgery on Voiding?","phase":"","overall_status":"UNKNOWN","enrollment_count":453,"lead_sponsor_name":"Universiteit Antwerpen","has_results":false},{"nct_id":"NCT03973281","title":"EASE: The Materna Prep Pivotal Study","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":420,"lead_sponsor_name":"Materna Medical","has_results":false},{"nct_id":"NCT04393194","title":"The Effect of Intra-vaginal Conjugated Estrogen Cream on Ring Pessary Use for Pelvic Organ Prolapse","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":420,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT07430865","title":"The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation","phase":"NA","overall_status":"RECRUITING","enrollment_count":380,"lead_sponsor_name":"Vastra Gotaland Region","has_results":false},{"nct_id":"NCT01945580","title":"Xenform Postmarket Surveillance Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":374,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT04246996","title":"Gentamicin Intravesical Efficacy for Infection of Urinary Tract","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":370,"lead_sponsor_name":"Kaiser Permanente","has_results":true},{"nct_id":"NCT01320215","title":"Complications Associated With Promontofixation for Pelvic Organ Prolapse: Comparing Robot Assisted Laparoscopic and Non-robot Assisted Laparoscopic Surgical Procedures","phase":"NA","overall_status":"COMPLETED","enrollment_count":365,"lead_sponsor_name":"Centre Hospitalier Universitaire de Nīmes","has_results":false},{"nct_id":"NCT05938881","title":"Long-term Success Rate of Transvaginal Mesh for the Treatment of Pelvic Organ Prolapse: The Extended RCT Study","phase":"","overall_status":"RECRUITING","enrollment_count":336,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT03187054","title":"POPQ Versus Simulated Apical Support as a Guideline for Anterior or Posterior Repair During Vaginal Reconstruction","phase":"NA","overall_status":"UNKNOWN","enrollment_count":335,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT07414849","title":"The AMPER Study: Evaluation of the Efficacy of Human Amniotic Membrane Grafting in Preventing Mesh Exposure in Vaginal Reconstructive Surgery Using Polypropylene Mesh.","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":330,"lead_sponsor_name":"Hospital General de Agudos J. M. Penna","has_results":false},{"nct_id":"NCT06187558","title":"Suspension of the Pelvic and Abdominal Organs During Minimally Invasive Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":330,"lead_sponsor_name":"University of Cagliari","has_results":false},{"nct_id":"NCT03591393","title":"Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual Function","phase":"NA","overall_status":"COMPLETED","enrollment_count":328,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT05530681","title":"Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth","phase":"NA","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false},{"nct_id":"NCT03849157","title":"RCT for Transvaginal Self-cut Mesh vs Mesh-kit for Severe POP","phase":"NA","overall_status":"UNKNOWN","enrollment_count":312,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT03113513","title":"Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse","phase":"NA","overall_status":"UNKNOWN","enrollment_count":312,"lead_sponsor_name":"Medical University of Graz","has_results":false},{"nct_id":"NCT03283124","title":"Comparing Transvaginal Self-tailored Titanium-coated Polypropylene Mesh Procedure With Mesh-kit Procedure.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":312,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT05422209","title":"The Influence of Simultaneous Posterior Colporrhaphy and Perineoplasty on the Efficiency and Safety of Mesh-augmented Sacrospinal Fixation (Apical Sling) in Advanced POP Repair.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":310,"lead_sponsor_name":"Saint Petersburg State University, Russia","has_results":false},{"nct_id":"NCT06268782","title":"The Effectiveness of an Online Exercise Program on Well-being of Postpartum Women","phase":"NA","overall_status":"COMPLETED","enrollment_count":308,"lead_sponsor_name":"University of Turku","has_results":false},{"nct_id":"NCT06372340","title":"Intelligent Diagnosis and Treatment System for Pelvic Floor Dysfunction in Elderly Women","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Beijing Hospital","has_results":false},{"nct_id":"NCT01632839","title":"Psychometric Validation of a French Version of the PISQ-R and a New Questionnaire About Sexuality","phase":"","overall_status":"COMPLETED","enrollment_count":298,"lead_sponsor_name":"Centre Hospitalier Universitaire de Nīmes","has_results":false},{"nct_id":"NCT01917968","title":"Uphold LITE Post-Market Surveillance Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":289,"lead_sponsor_name":"Boston Scientific Corporation","has_results":true},{"nct_id":"NCT05885711","title":"Self-management Pessary Project","phase":"","overall_status":"UNKNOWN","enrollment_count":288,"lead_sponsor_name":"Zuyderland Medisch Centrum","has_results":false},{"nct_id":"NCT07218016","title":"The AccelERate Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":288,"lead_sponsor_name":"NICHD Pelvic Floor Disorders Network","has_results":false},{"nct_id":"NCT04306250","title":"Comparison of Posterior and Anterior Approach to Sacrospinous Ligament Apical Fixation - Randomized Controlled Trial","phase":"NA","overall_status":"UNKNOWN","enrollment_count":280,"lead_sponsor_name":"HaEmek Medical Center, Israel","has_results":false},{"nct_id":"NCT03098641","title":"Smartmesh Technology in Pelvic Floor Repair Procedures","phase":"","overall_status":"COMPLETED","enrollment_count":272,"lead_sponsor_name":"Groupe Hospitalier de la Rochelle Ré Aunis","has_results":true},{"nct_id":"NCT04915664","title":"Pelvic Ultrasound Pessary Study: Changes in Pelvic Anatomy After Placing a Pessary","phase":"","overall_status":"UNKNOWN","enrollment_count":269,"lead_sponsor_name":"Universiteit Antwerpen","has_results":false},{"nct_id":"NCT03070873","title":"Anatomical and Functional Outcomes of Perigee and Apogee Mesh in Total Pelvic Floor Reconstruction Versus Gynecare Prolift","phase":"NA","overall_status":"COMPLETED","enrollment_count":258,"lead_sponsor_name":"Nanjing Medical University","has_results":false},{"nct_id":"NCT02943525","title":"Vaginal Packing After Laparoscopic Sacrocolpopexy","phase":"NA","overall_status":"COMPLETED","enrollment_count":253,"lead_sponsor_name":"Charles University, Czech Republic","has_results":false},{"nct_id":"NCT03349736","title":"Pelvic Floor Muscle Training Programme in Pregnant Nepalese Women- a Feasibility Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":253,"lead_sponsor_name":"Kathmandu University School of Medical Sciences","has_results":false},{"nct_id":"NCT03379246","title":"Apical Support During Hysterectomy for Pelvic Organ Prolapse","phase":"","overall_status":"COMPLETED","enrollment_count":236,"lead_sponsor_name":"TriHealth Inc.","has_results":true},{"nct_id":"NCT03715803","title":"Calistar A vs. Calistar S - Comparative Cohort Retrospective Analysis of Single Incision POP Systems","phase":"","overall_status":"COMPLETED","enrollment_count":217,"lead_sponsor_name":"Agustin Sampietro","has_results":true},{"nct_id":"NCT06126328","title":"Materna Prep Study Phase II","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":214,"lead_sponsor_name":"Materna Medical","has_results":false},{"nct_id":"NCT04977141","title":"Race, Ethnicity, Socioeconomic Status and Prolapse-rElated Decisional ConflicT","phase":"","overall_status":"COMPLETED","enrollment_count":210,"lead_sponsor_name":"Women and Infants Hospital of Rhode Island","has_results":false},{"nct_id":"NCT02277925","title":"Permanent Versus Absorbable Colpopexy Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":204,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":true},{"nct_id":"NCT04274491","title":"Predictors of Recovery Expectancy","phase":"","overall_status":"COMPLETED","enrollment_count":202,"lead_sponsor_name":"Indiana University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}