{"disease":{"id":"panic-disorder","name":"Panic disorder","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":12,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"fluoxetine","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Prozac","generic_name":"fluoxetine","company_name":"Eli Lilly and Company","drug_phase":"marketed","molecular_target":"Serotonin reuptake transporter","drug_class":"Selective Serotonin Reuptake Inhibitor (SSRI)","quality_score":81,"revenue":"1000.0","mechanism":"Fluoxetine inhibits CNS neuronal uptake of serotonin, though exact mechanism unknown."},{"drug_id":"sertraline","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zoloft","generic_name":"sertraline","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A","drug_class":"SSRI (Selective serotonin reuptake inhibitor)","quality_score":71,"revenue":"350","mechanism":"Selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter, increasing synaptic serotonin to improve mood and reduce anxiety."},{"drug_id":"paroxetine","indication_name":"Panic Disorder (PD)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Paroxetine","generic_name":"paroxetine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Serotonin (5-HT) reuptake transporter","drug_class":"Selective Serotonin Reuptake Inhibitor (SSRI)","quality_score":73,"revenue":null,"mechanism":"Inhibits neuronal reuptake of serotonin in the central nervous system, presumed mechanism for treating psychiatric disorders."},{"drug_id":"lorazepam","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ativan","generic_name":"lorazepam","company_name":"Generic (originally Wyeth/Pfizer)","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-3/gamma-2, Fatty acid-binding protein, liver","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"clonazepam","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Klonopin","generic_name":"clonazepam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2, GABA-A receptor; anion channel, GABA-A receptor; anion channel","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"venlafaxine","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Effexor","generic_name":"venlafaxine","company_name":"Generic (originally Wyeth/Pfizer)","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C","drug_class":"SNRI (Serotonin-norepinephrine reuptake inhibitor)","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"sertralin","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Sertralin","company_name":"Poznan University of Medical Sciences","drug_phase":"marketed","molecular_target":"Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"prozac","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Prozac","company_name":"RenJi Hospital","drug_phase":"marketed","molecular_target":"Equilibrative nucleoside transporter 4, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A","drug_class":"","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"effexor-xr","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Effexor","generic_name":"Venlafaxine Hydrochloride","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Serotonin and norepinephrine reuptake transporters","drug_class":"Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)","quality_score":70,"revenue":null,"mechanism":"Potentiates serotonin and norepinephrine in CNS through reuptake inhibition."},{"drug_id":"effexor","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Effexor","company_name":"Wyeth is now a wholly owned subsidiary of Pfizer","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2C","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"xanax","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Xanax","company_name":"National Taiwan University Hospital","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"klonopin","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Klonopin","company_name":"Par Pharmaceutical, Inc.","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2, GABA-A receptor; anion channel, GABA-A receptor; anion channel","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"clonazepam","indication_name":"Panic Disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Klonopin","generic_name":"clonazepam","company_name":"Generic (originally Roche)","drug_phase":"marketed","molecular_target":"GABA-A receptor alpha-1/beta-2/gamma-2, GABA-A receptor; anion channel, GABA-A receptor; anion channel","drug_class":"Benzodiazepine [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"alprazolam","indication_name":"Panic disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Xanax","generic_name":"alprazolam","company_name":"Generic (originally Upjohn/Pfizer)","drug_phase":"marketed","molecular_target":"Bromodomain-containing protein 4, Platelet-activating factor receptor, Cytochrome P450 3A4","drug_class":"Benzodiazepine (triazolobenzodiazepine)","quality_score":0,"revenue":null,"mechanism":"Short-acting, high-potency benzodiazepine that enhances GABA-A receptor activity, providing rapid anxiolytic relief."},{"drug_id":"chembl-chembl809","indication_name":"Panic Disorder","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"SERTRALINE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":30,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":15,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04433832","title":"Physical and Psychological Health Trajectories in the Context of Coronary Heart Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":3610,"lead_sponsor_name":"Laval University","has_results":false},{"nct_id":"NCT07129408","title":"Epidemiological Study on the Prevalence of Mental Disorders in Slovakia","phase":"","overall_status":"COMPLETED","enrollment_count":3100,"lead_sponsor_name":"Comenius University","has_results":false},{"nct_id":"NCT07212075","title":"Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track Subgroups","phase":"","overall_status":"RECRUITING","enrollment_count":1809,"lead_sponsor_name":"Forschungsinstitut der Diabetes Akademie Mergentheim","has_results":false},{"nct_id":"NCT04900064","title":"Evaluation of Primary Care Behavioral Health (PCBH) With the Addition of Self-help CBT - A Randomized Multicenter Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":1242,"lead_sponsor_name":"Linnaeus University","has_results":false},{"nct_id":"NCT05868135","title":"Effects and Cost-effectiveness of e-Meistring - a Guided Internet-delivered Psychological Treatment","phase":"","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"St. Olavs Hospital","has_results":false},{"nct_id":"NCT02605668","title":"Providing Tools for Effective Care and Treatment of Anxiety Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":726,"lead_sponsor_name":"Technische Universität Dresden","has_results":false},{"nct_id":"NCT05467683","title":"CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy","phase":"NA","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"University of Texas at Austin","has_results":false},{"nct_id":"NCT06942429","title":"Stepped Versus Stratified Care for Anxiety Disorders in Youth","phase":"NA","overall_status":"RECRUITING","enrollment_count":556,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06934525","title":"Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings","phase":"NA","overall_status":"RECRUITING","enrollment_count":501,"lead_sponsor_name":"Bradley Hospital","has_results":false},{"nct_id":"NCT05663489","title":"Neurobiological Markers of Treatment Response for Anxiety and OCD","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Haukeland University Hospital","has_results":false},{"nct_id":"NCT06856161","title":"A Novel Blood Test as a Biomarker in Mental Health","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Fraser Health","has_results":false},{"nct_id":"NCT07268729","title":"Investigation of Pathogenic Gut Microbiota Patterns in Anxiety, Depression and Panic Disorders","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"University of Toronto","has_results":false},{"nct_id":"NCT05124639","title":"Clinical Trial of a Group Self-management Support Program for Anxiety Disorders","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":414,"lead_sponsor_name":"Université de Sherbrooke","has_results":false},{"nct_id":"NCT03188575","title":"Effectiveness & Cost-effectiveness of Internet-delivered Interventions for Depression and Anxiety Disorders in IAPT","phase":"NA","overall_status":"UNKNOWN","enrollment_count":384,"lead_sponsor_name":"Silver Cloud Health","has_results":false},{"nct_id":"NCT03528109","title":"Improving Access to Child Anxiety Treatment","phase":"NA","overall_status":"UNKNOWN","enrollment_count":379,"lead_sponsor_name":"Bradley Hospital","has_results":false},{"nct_id":"NCT04911933","title":"Development of Mental Health Outcomes Following the 2020 Petrinja Earthquake","phase":"NA","overall_status":"UNKNOWN","enrollment_count":350,"lead_sponsor_name":"Neuropsychiatric Hospital dr Ivan Barbot","has_results":false},{"nct_id":"NCT06370559","title":"Relationship Between Repetitive Negative Thinking and CBT Outcomes","phase":"","overall_status":"COMPLETED","enrollment_count":320,"lead_sponsor_name":"South London and Maudsley NHS Foundation Trust","has_results":false},{"nct_id":"NCT04293341","title":"Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":304,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT03113175","title":"Collabri Flex - Effect of Collaborative Care for People With Anxiety Disorders in General Practice","phase":"NA","overall_status":"COMPLETED","enrollment_count":302,"lead_sponsor_name":"Amager Hospital","has_results":false},{"nct_id":"NCT06071819","title":"Clinical Markers of Panic and Generalized Anxiety Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":290,"lead_sponsor_name":"University of Milano Bicocca","has_results":false},{"nct_id":"NCT03118752","title":"Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety","phase":"NA","overall_status":"COMPLETED","enrollment_count":290,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT03522844","title":"Treatments for Anxiety: Meditation and Escitalopram","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":276,"lead_sponsor_name":"Georgetown University","has_results":false},{"nct_id":"NCT03917550","title":"RECOVERY: A Transdiagnostic Intervention for Anxiety and Depression","phase":"NA","overall_status":"UNKNOWN","enrollment_count":260,"lead_sponsor_name":"West University of Timisoara","has_results":false},{"nct_id":"NCT05117255","title":"Validating an Autonomous Interactive Internet-Based Delivery of an Empirically Supported Cognitive Behavioral Therapy for Comorbidity","phase":"NA","overall_status":"RECRUITING","enrollment_count":256,"lead_sponsor_name":"University of Minnesota","has_results":false},{"nct_id":"NCT02811458","title":"Clinical Trial of Transdiagnostic Cognitive-Behavior Therapy for Anxiety Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":231,"lead_sponsor_name":"Université de Sherbrooke","has_results":false},{"nct_id":"NCT00025974","title":"Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":230,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT05510804","title":"Efficacy of an App-based CBT Featuring Virtual Reality for Anxiety Disorders","phase":"NA","overall_status":"UNKNOWN","enrollment_count":222,"lead_sponsor_name":"Bartosz of Zurowski","has_results":false},{"nct_id":"NCT05530642","title":"An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel","phase":"NA","overall_status":"UNKNOWN","enrollment_count":192,"lead_sponsor_name":"University of Regina","has_results":false},{"nct_id":"NCT06773585","title":"Investigations of Factors Associated With Treatment Response and Prognosis in Anxiety Disorders","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":185,"lead_sponsor_name":"Kangbuk Samsung Hospital","has_results":false},{"nct_id":"NCT07024758","title":"Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD","phase":"NA","overall_status":"RECRUITING","enrollment_count":174,"lead_sponsor_name":"Baylor College of Medicine","has_results":false},{"nct_id":"NCT02150265","title":"Effectiveness of Six Sessions CBT for Adolescents With Emotional Problems in Community Clinics","phase":"NA","overall_status":"COMPLETED","enrollment_count":163,"lead_sponsor_name":"University of Tromso","has_results":false},{"nct_id":"NCT05832905","title":"Mobile-assisted Case Management for Panic Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":159,"lead_sponsor_name":"En Chu Kong Hospital","has_results":false},{"nct_id":"NCT06788119","title":"Analyzing the Benefits of Using SYMPTOMS-JIT for in Vivo Exposure in Anxiety Disorders","phase":"NA","overall_status":"RECRUITING","enrollment_count":158,"lead_sponsor_name":"Universitat Jaume I","has_results":false},{"nct_id":"NCT00803400","title":"Efficacy of Aerobic Exercise Added to Alprazolam in Panic Disorder Treatment","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":150,"lead_sponsor_name":"University of Buenos Aires","has_results":true},{"nct_id":"NCT04659577","title":"Attitudes of Professionals and the General Public in Israel Regarding ICBT","phase":"NA","overall_status":"COMPLETED","enrollment_count":130,"lead_sponsor_name":"Hebrew University of Jerusalem","has_results":false},{"nct_id":"NCT06577051","title":"Evaluation of Eustachian Tube Function With 226 and 1000 Hz Probes in Children Undergoing Tonsillectomy ± Adenoidectomy","phase":"","overall_status":"COMPLETED","enrollment_count":128,"lead_sponsor_name":"Sumeyra DOLUOGLU","has_results":false},{"nct_id":"NCT06823492","title":"Investigating the Impacts of Early Life Experience on the Brain & Behaviour","phase":"","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Manchester","has_results":false},{"nct_id":"NCT00083265","title":"Genetic Causes of Panic Disorder","phase":"","overall_status":"COMPLETED","enrollment_count":117,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT04179526","title":"Transdiagnostic Internet-delivered REBT Intervention for Adolescents' Internalizing Problems","phase":"NA","overall_status":"COMPLETED","enrollment_count":106,"lead_sponsor_name":"Babes-Bolyai University","has_results":false},{"nct_id":"NCT07228143","title":"Stepped Care Treatment for Anxiety Resilience","phase":"NA","overall_status":"RECRUITING","enrollment_count":106,"lead_sponsor_name":"Andrew Wiese","has_results":false},{"nct_id":"NCT01947647","title":"Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":105,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT05967468","title":"Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Baylor College of Medicine","has_results":false},{"nct_id":"NCT03507114","title":"Rumination Focus Cognitive Behavior Therapy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"West University of Timisoara","has_results":false},{"nct_id":"NCT04048824","title":"Optimizing Exposure Therapy for Anxiety Disorders","phase":"NA","overall_status":"COMPLETED","enrollment_count":89,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT03233542","title":"The Association Between Physical Sensations and Thinking Styles","phase":"NA","overall_status":"COMPLETED","enrollment_count":87,"lead_sponsor_name":"Ruhr University of Bochum","has_results":false},{"nct_id":"NCT05071430","title":"Safety and Efficacy of HB-1 for Panic Disorder","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"Honeybrains Biotech LLC","has_results":true},{"nct_id":"NCT07000201","title":"Preoperative Pregabalin vs Gabapentin in Elderly Undergoing Surgry,Controlled Trial","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":84,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT00088738","title":"Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":84,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT05261594","title":"Effects of Caffeine on Anxiety, Emotional Processing, Approach-avoidance Behavior, and Interoception in Panic Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":83,"lead_sponsor_name":"Uppsala University","has_results":false},{"nct_id":"NCT05737511","title":"Efficacy of Hydroxyzine for Patients With Panic Disorder","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Sultan Qaboos University","has_results":false}],"total":50},"guidelines":[{"drug_id":"fluoxetine","guideline_body":"FDA label","recommendation":"Fluoxetine is indicated for the acute treatment of Panic Disorder, with or without agoraphobia.","line_of_therapy":"1L","evidence_grade":"A","guideline_year":null}],"source":"Drug Landscape verified database"}