{"disease":{"id":"ovarian-failure","name":"ovarian failure"},"drugs":{"marketed":[{"drug_id":"estradiol-valerate","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Delestrogen","generic_name":"ESTRADIOL VALERATE","company_name":"Ph Health","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":65,"revenue":null,"mechanism":"Delestrogen works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen."},{"drug_id":"norethisterone","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Micronor","generic_name":"norethisterone","company_name":"Johnson & Johnson","drug_phase":"marketed","molecular_target":"GnRH receptors","drug_class":"Progestin","quality_score":63,"revenue":null,"mechanism":"ORIAHNN combines elagolix, which suppresses LH and FSH to reduce ovarian sex hormones, with estradiol and norethindrone acetate to mitigate side effects."},{"drug_id":"estradiol","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estrace","generic_name":"ESTRADIOL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":"Estrace works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen."},{"drug_id":"menest","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Menest","generic_name":"Estrogens, Esterified","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":"Esterified estrogens, sold under the brand names Estratab and Menest, are used for hormone therapy and cancer treatment."},{"drug_id":"estring","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Estring","generic_name":"Estradiol","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Ovulation","drug_class":"Combined Oral Contraceptive (COC)","quality_score":71,"revenue":null,"mechanism":"Prevents pregnancy primarily by suppressing ovulation."},{"drug_id":"estradiol-cypionate","indication_name":"Primary ovarian failure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Depoestradiol","generic_name":"ESTRADIOL CYPIONATE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Estrogen receptor beta","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06583395","title":"Quest to Analyze One Thousand Humans Meditating","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":3000,"lead_sponsor_name":"Tobias Moeller-Bertram","has_results":false},{"nct_id":"NCT00001275","title":"Ovarian Follicle Function in Patients With Primary Ovarian Failure","phase":"","overall_status":"COMPLETED","enrollment_count":1134,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT05838157","title":"The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT04237909","title":"Effects of Intraovarian Platelet Rich Plasma in Women With Poor Ovarian Response and Premature Ovarian Insufficiency","phase":"NA","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Acibadem University","has_results":false},{"nct_id":"NCT06394466","title":"Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":453,"lead_sponsor_name":"Rio de Janeiro State University","has_results":false},{"nct_id":"NCT06645379","title":"Application of Platelet-rich Plasma (PRP) in Reproductive Medicine","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"The Fourth Affiliated Hospital of Zhejiang University School of Medicine","has_results":false},{"nct_id":"NCT03474120","title":"Prospective Genetic Study in Patients With Ovarian Insufficiency","phase":"","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"The First Affiliated Hospital of Anhui Medical University","has_results":false},{"nct_id":"NCT03674164","title":"Fertility Preservation With Ovarian Tissue Freezing","phase":"NA","overall_status":"UNKNOWN","enrollment_count":250,"lead_sponsor_name":"St. Justine's Hospital","has_results":false},{"nct_id":"NCT01197456","title":"Predictors of Ovarian Insufficiency in Young Breast Cancer Patients","phase":"","overall_status":"COMPLETED","enrollment_count":232,"lead_sponsor_name":"University of California, San Diego","has_results":true},{"nct_id":"NCT04071574","title":"Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Lebanese University","has_results":false},{"nct_id":"NCT03178695","title":"Inovium Ovarian Rejuvenation Trials","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Ascendance Biomedical","has_results":false},{"nct_id":"NCT05667428","title":"A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"First Affiliated Hospital Xi'an Jiaotong University","has_results":false},{"nct_id":"NCT04776902","title":"Effects of Ovarian Reserve on Sexual Satisfaction","phase":"NA","overall_status":"COMPLETED","enrollment_count":180,"lead_sponsor_name":"Uludag University","has_results":false},{"nct_id":"NCT04881695","title":"Evaluation of Child Desire in Young Women With Premature Ovarian Failure","phase":"","overall_status":"UNKNOWN","enrollment_count":160,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04800705","title":"Levels of Selected Macroelements in Premature Ovarian Insufficiency","phase":"","overall_status":"UNKNOWN","enrollment_count":140,"lead_sponsor_name":"Cengiz Gokcek Women's and Children's Hospital","has_results":false},{"nct_id":"NCT05443282","title":"Ovarian Reserve and Matrix Metalloproteinases","phase":"","overall_status":"COMPLETED","enrollment_count":133,"lead_sponsor_name":"Ankara City Hospital Bilkent","has_results":false},{"nct_id":"NCT03381300","title":"Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":106,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT03907618","title":"Evaluation of HbA1c Levels and Ovarian Reserve and Type 1 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":104,"lead_sponsor_name":"Kanuni Sultan Suleyman Training and Research Hospital","has_results":false},{"nct_id":"NCT04031456","title":"Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Genesis Athens Clinic","has_results":false},{"nct_id":"NCT05740579","title":"The Danish TURNER Cryopreservation Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT05181748","title":"Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Genesis Athens Clinic","has_results":false},{"nct_id":"NCT06121388","title":"Brain MRI Imaging Changes and Associated Factors on Cognition Function in Patients With Premature Ovarian Failure","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"International Peace Maternity and Child Health Hospital","has_results":false},{"nct_id":"NCT05522634","title":"A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian Insufficiency","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT04444245","title":"Ovarian Rejuvenation Using Platelet Rich Plasma (PRP) & Autologous Tissue Stromal Vascular Fraction (tSVF) and Cell Enriched tSVF","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Black Tie Medical, Inc.","has_results":false},{"nct_id":"NCT05440617","title":"Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT04767451","title":"Levels of Selected Microelements in Premature Ovarian Insufficiency","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Cengiz Gokcek Women's and Children's Hospital","has_results":false},{"nct_id":"NCT01366144","title":"Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction","phase":"PHASE1","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":94,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT04163640","title":"Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response","phase":"NA","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Reproductive Medicine Associates of New Jersey","has_results":false},{"nct_id":"NCT06426771","title":"Effect of Antimullerian Hormone Levels on the Inflammatory Index, Phytochemical Index and NRF Nutrient Density","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital","has_results":false},{"nct_id":"NCT04675970","title":"Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"Ukraine Association of Biobank","has_results":false},{"nct_id":"NCT04536467","title":"Prevention of Chemotherapy-Induced Ovarian Failure With Goserelin in Premenopausal Lymphoma Patients","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Beni-Suef University","has_results":false},{"nct_id":"NCT04275700","title":"Study of PRP in Women With Evidence of Diminished Ovarian Reserve","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Center for Human Reproduction","has_results":false},{"nct_id":"NCT03924648","title":"Endocan Levels in Women With Premature Ovarian Insufficiency","phase":"","overall_status":"COMPLETED","enrollment_count":77,"lead_sponsor_name":"Cengiz Gokcek Women's and Children's Hospital","has_results":false},{"nct_id":"NCT00471731","title":"Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure","phase":"","overall_status":"COMPLETED","enrollment_count":72,"lead_sponsor_name":"National Eye Institute (NEI)","has_results":false},{"nct_id":"NCT04390308","title":"Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?","phase":"","overall_status":"RECRUITING","enrollment_count":70,"lead_sponsor_name":"ART Fertility Clinics LLC","has_results":false},{"nct_id":"NCT04922398","title":"Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Ahmed Saad","has_results":false},{"nct_id":"NCT07308327","title":"The Influence of Gut Microbiota on Ovarian Function: A Single-center, Randomized,Double Blind, Parallel-controlled, Exploratory Clinical Trial","phase":"EARLY_PHASE1","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Songling Zhang","has_results":false},{"nct_id":"NCT03398603","title":"Is the Concentration of Anti-Muellerian Hormon (AMH) Depending on the Menstrual Cycle?","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"University Hospital, Basel, Switzerland","has_results":false},{"nct_id":"NCT06261658","title":"Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma","phase":"NA","overall_status":"RECRUITING","enrollment_count":45,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT04024449","title":"Can Celiac Disease Affect Ovarian Function in Adolescent?","phase":"","overall_status":"COMPLETED","enrollment_count":37,"lead_sponsor_name":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","has_results":false},{"nct_id":"NCT02912104","title":"A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"International Peace Maternity and Child Health Hospital","has_results":false},{"nct_id":"NCT04381299","title":"Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":35,"lead_sponsor_name":"ART Fertility Clinics LLC","has_results":false},{"nct_id":"NCT00001306","title":"Steroid Therapy in Autoimmune Premature Ovarian Failure","phase":"","overall_status":"COMPLETED","enrollment_count":33,"lead_sponsor_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","has_results":false},{"nct_id":"NCT04306185","title":"Ovarian Fragmentation Study (Crespo Medical Team)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Equipo Juana Crespo","has_results":false},{"nct_id":"NCT04189406","title":"Turner Syndrome Minipuberty Study","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT07117682","title":"Safety and Efficacy of Autologous Adipose-Derived Regenerative Cells (ADRCs) Injection for Improving Diminished Ovarian Reserve","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":25,"lead_sponsor_name":"Cytori Therapeutics","has_results":false},{"nct_id":"NCT05462379","title":"Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.","phase":"PHASE1, PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":22,"lead_sponsor_name":"MARILIA ALBANEZI BERTOLAZZI","has_results":false},{"nct_id":"NCT03207412","title":"Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency","phase":"NA","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"The Second Affiliated Hospital of Chongqing Medical University","has_results":false},{"nct_id":"NCT05138367","title":"Effects of UCA-PSCs in Women With POF","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Li-jun Ding","has_results":false},{"nct_id":"NCT04149028","title":"Platelet Rich Plasma Injection Into Ovary of Patients With Premature Ovarian Insufficiency","phase":"NA","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Tanta University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}