{"disease":{"id":"ototoxicity","name":"ototoxicity"},"drugs":{"marketed":[{"drug_id":"sodium-thiosulfate","indication_name":"Reduce the risk of ototoxicity associated with cisplatin","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sodium Thiosulfate","generic_name":"SODIUM THIOSULFATE","company_name":"Us Army","drug_phase":"marketed","molecular_target":"cytochrome a3, rhodanese","drug_class":"sodium thiosulfate","quality_score":65,"revenue":null,"mechanism":"Sodium nitrite forms methemoglobin to bind cyanide, while sodium thiosulfate donates sulfur for cyanide conversion to thiocyanate."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06490029","title":"Diagnostic of Various Ototoxicity Induced by Cancer Treatment","phase":"","overall_status":"RECRUITING","enrollment_count":540,"lead_sponsor_name":"Direction Centrale du Service de Santé des Armées","has_results":false},{"nct_id":"NCT05641441","title":"Radiosurgery Induced Ototoxicity in Patients Treated for a Vestibular Schwannoma","phase":"","overall_status":"RECRUITING","enrollment_count":258,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT00716976","title":"Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":131,"lead_sponsor_name":"Children's Oncology Group","has_results":true},{"nct_id":"NCT00652132","title":"Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":116,"lead_sponsor_name":"University of Birmingham","has_results":false},{"nct_id":"NCT05730283","title":"Prevention of Ototoxicity in NTM Patients Treated With IV Amikacin","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":105,"lead_sponsor_name":"Kevin Winthrop","has_results":false},{"nct_id":"NCT07254442","title":"Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Zonguldak Bulent Ecevit University","has_results":false},{"nct_id":"NCT01451853","title":"SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Sound Pharmaceuticals, Incorporated","has_results":false},{"nct_id":"NCT06297369","title":"Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT06553157","title":"Statins Effect on Incidence of Side Effects of Platinum Based Chemotherapy","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":56,"lead_sponsor_name":"Minia University","has_results":false},{"nct_id":"NCT06723340","title":"Dermatological Assessment of Primary Dermal Irritability Accumulated, Sensitization, Photoallergy and Photosensitization of a Scar Gel","phase":"NA","overall_status":"COMPLETED","enrollment_count":55,"lead_sponsor_name":"Herbarium Laboratorio Botanico Ltda","has_results":false},{"nct_id":"NCT05936034","title":"Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted.","phase":"NA","overall_status":"RECRUITING","enrollment_count":52,"lead_sponsor_name":"Institut de Cancérologie de Lorraine","has_results":false},{"nct_id":"NCT02099786","title":"Randomized Trial Comparison of Ototoxicity Monitoring Programs","phase":"NA","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT02819856","title":"SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Sound Pharmaceuticals, Incorporated","has_results":false},{"nct_id":"NCT07364747","title":"Protective Effect of Acetylcysteine Against Cisplatinum-Induced Ototoxicity: A Randomized Controlled Trial","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"Siriraj Hospital","has_results":false},{"nct_id":"NCT03892564","title":"Evaluation of Potential Phototoxicity Skin Reaction After Use of MC2-01 Cream","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"MC2 Therapeutics","has_results":true},{"nct_id":"NCT04262336","title":"Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"Decibel Therapeutics","has_results":false},{"nct_id":"NCT04226456","title":"Intratympanic Administration of N-acetylcysteine for Protection of Cisplatin-induced Ototoxicity","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":19,"lead_sponsor_name":"Centre Hospitalier Universitaire Saint Pierre","has_results":false},{"nct_id":"NCT05676944","title":"Vestibular Implantation in Older Adults","phase":"NA","overall_status":"RECRUITING","enrollment_count":15,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT06710600","title":"Phototoxicity of Frequently Prescribed Medicines","phase":"NA","overall_status":"COMPLETED","enrollment_count":12,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT05674786","title":"Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction","phase":"NA","overall_status":"RECRUITING","enrollment_count":8,"lead_sponsor_name":"Johns Hopkins University","has_results":false}],"total":20},"guidelines":[],"source":"Drug Landscape verified database"}