{"disease":{"id":"osteoarthritis-knee","name":"osteoarthritis knee"},"drugs":{"marketed":[{"drug_id":"diclofenac-etalhyaluronate-sodium","indication_name":"Osteoarthritis of knee","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Joycle","generic_name":"diclofenac etalhyaluronate sodium","company_name":"Seikagaku Corporation","drug_phase":"marketed","molecular_target":"Prostaglandin E2 receptor EP2 subtype","drug_class":"","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"intra-articular-corticosteroid-injections","indication_name":"Osteoarthritis of the knee","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Intra-articular corticosteroid injections","generic_name":"intra-articular-corticosteroid-injections","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05455177","title":"Change in Patient Reported Outcomes and Wish for Joint Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":14018,"lead_sponsor_name":"Joint Academy","has_results":false},{"nct_id":"NCT04203732","title":"Evaluation of Anesthetic Techniques in Outpatient Total Joint Replacement Surgery in an Integrated Health Care Delivery System","phase":"","overall_status":"COMPLETED","enrollment_count":12466,"lead_sponsor_name":"Kaiser Permanente","has_results":false},{"nct_id":"NCT05316194","title":"Minimal Clinically Important Changes in Osteoarthritis Treatment","phase":"","overall_status":"COMPLETED","enrollment_count":11708,"lead_sponsor_name":"Joint Academy","has_results":false},{"nct_id":"NCT03711773","title":"Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain","phase":"NA","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"University of Missouri-Columbia","has_results":false},{"nct_id":"NCT07231471","title":"Platelet Rich Plasma for Musculoskeletal Conditions","phase":"NA","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"University of Utah","has_results":false},{"nct_id":"NCT04135170","title":"Antibiotic Loaded Bone Cement in Prevention of Periprosthetic Joint Infections in Primary Total Knee Arthroplasty","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":9172,"lead_sponsor_name":"The Norwegian Arthroplasty Register","has_results":false},{"nct_id":"NCT00261066","title":"Outcome Following Orthopaedic Surgery","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":8439,"lead_sponsor_name":"Ottawa Hospital Research Institute","has_results":false},{"nct_id":"NCT05543941","title":"Evaluating XPERIENCE™ Advanced Surgical Irrigation","phase":"NA","overall_status":"RECRUITING","enrollment_count":7600,"lead_sponsor_name":"Ottawa Hospital Research Institute","has_results":false},{"nct_id":"NCT04836988","title":"Face to Face or Digitally Delivered First-line Osteoarthritis Treatment?","phase":"","overall_status":"COMPLETED","enrollment_count":6946,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT03737149","title":"A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform","phase":"NA","overall_status":"COMPLETED","enrollment_count":6559,"lead_sponsor_name":"Zimmer Biomet","has_results":true},{"nct_id":"NCT04960098","title":"Patient-reported Outcome Measures in Patient Underwent Total Hip and Knee Arthroplasty","phase":"","overall_status":"RECRUITING","enrollment_count":5816,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT02683239","title":"Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":5331,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT03161093","title":"A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":3307,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT04490798","title":"Effectiveness of Acupuncture Clinical Pathway","phase":"","overall_status":"COMPLETED","enrollment_count":3245,"lead_sponsor_name":"Hospital Son Llatzer","has_results":false},{"nct_id":"NCT02528188","title":"Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":3021,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT06249958","title":"Transforming Rehabilitation: Personalised Care for a Better Quality of Life","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT04369261","title":"Observational Study of Synovian® Inj. in Patients With Osteoarthritis in the Knee","phase":"","overall_status":"COMPLETED","enrollment_count":1949,"lead_sponsor_name":"LG Chem","has_results":false},{"nct_id":"NCT03785561","title":"Effect of Research Participation Versus Usual Clinical Treatment on Pain in Patients With Musculoskeletal Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":1850,"lead_sponsor_name":"Frederiksberg University Hospital","has_results":false},{"nct_id":"NCT03670706","title":"Knee Pain Nurse Led Package of CareTrial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1806,"lead_sponsor_name":"University of Nottingham","has_results":false},{"nct_id":"NCT04049318","title":"Effects of a Structured Digital Osteoarthritis Self-management Program After 6 Months of Adherence","phase":"","overall_status":"COMPLETED","enrollment_count":1709,"lead_sponsor_name":"Lund University","has_results":false},{"nct_id":"NCT03304379","title":"Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1650,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT04670549","title":"Improve Osteoarthritis Care","phase":"NA","overall_status":"COMPLETED","enrollment_count":1541,"lead_sponsor_name":"Diakonhjemmet Hospital","has_results":false},{"nct_id":"NCT06578182","title":"The Effect of ColcHicine on the Incidence of Knee or Hip Replacements","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":1410,"lead_sponsor_name":"Sint Maartenskliniek","has_results":false},{"nct_id":"NCT07212699","title":"Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App","phase":"NA","overall_status":"RECRUITING","enrollment_count":1250,"lead_sponsor_name":"Technical University of Munich","has_results":false},{"nct_id":"NCT05946044","title":"The Osteoarthritis Prevention Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":1230,"lead_sponsor_name":"Wake Forest University","has_results":false},{"nct_id":"NCT03172780","title":"A Bioequivalence Study Using Clinical Endpoint for Diclofenac Sodium Gel 1% in Osteoarthritis Knee\"","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1220,"lead_sponsor_name":"Mylan Pharmaceuticals Private Limited","has_results":true},{"nct_id":"NCT03358641","title":"The Relationship Between Physical Activity and Radiographic Osteoarthritis Worsening","phase":"","overall_status":"UNKNOWN","enrollment_count":1200,"lead_sponsor_name":"Peking University People's Hospital","has_results":false},{"nct_id":"NCT04837053","title":"Implementation of Indication Criteria for Total Knee Replacement in Osteoarthritis (Value-based TKR)","phase":"NA","overall_status":"COMPLETED","enrollment_count":1092,"lead_sponsor_name":"Technische Universität Dresden","has_results":false},{"nct_id":"NCT03988023","title":"Study of Ampion for the Treatment of Pain and Function in Patients With Severe Osteoarthritis of the Knee.","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":1043,"lead_sponsor_name":"Ampio Pharmaceuticals. Inc.","has_results":true},{"nct_id":"NCT06477965","title":"Embo Registry; National Registry for Artery Embolization","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Vascular Solutions of North Carolina","has_results":false},{"nct_id":"NCT04691466","title":"Study Evaluating the Efficacy of Joint Replacement","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Nicolaus Copernicus University","has_results":false},{"nct_id":"NCT04958551","title":"Basic Research Projects Related to Sports Injuries","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT03183583","title":"Tissue Adhesive in Hip and Knee Arthroplasty, A Cost -Effectiveness Analysis","phase":"","overall_status":"UNKNOWN","enrollment_count":980,"lead_sponsor_name":"Amphia Hospital","has_results":false},{"nct_id":"NCT03152357","title":"A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS","phase":"","overall_status":"COMPLETED","enrollment_count":950,"lead_sponsor_name":"Restor3D","has_results":false},{"nct_id":"NCT00289133","title":"Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":938,"lead_sponsor_name":"DePuy Orthopaedics","has_results":true},{"nct_id":"NCT04247672","title":"The ATtune Knee Outcome Study","phase":"","overall_status":"RECRUITING","enrollment_count":900,"lead_sponsor_name":"Spaarne Gasthuis","has_results":false},{"nct_id":"NCT03059004","title":"Comparing Different Types of Physical Therapy for Treating People With a Meniscal Tear and Osteoarthritis","phase":"NA","overall_status":"COMPLETED","enrollment_count":879,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":false},{"nct_id":"NCT02709486","title":"Study of the Analgesic Efficacy and Safety of Subcutaneous Tanezumab in Subjects With Osteoarthritis of the Hip or Knee.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":849,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT03446404","title":"Standing Computed Tomography (SCT) Imaging of the Knee Joint","phase":"","overall_status":"COMPLETED","enrollment_count":826,"lead_sponsor_name":"Neil A Segal","has_results":false},{"nct_id":"NCT04057651","title":"Hip and Knee Scores","phase":"","overall_status":"COMPLETED","enrollment_count":800,"lead_sponsor_name":"University Hospital, Lille","has_results":false},{"nct_id":"NCT04333160","title":"Phase III Study on the Safety and Efficacy of a Single Intra-articular Administration of JTA-004 in Symptomatic Knee Osteoarthritis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":746,"lead_sponsor_name":"Bone Therapeutics S.A","has_results":false},{"nct_id":"NCT04698655","title":"Influence of Osteoarthritis Information on Treatment Beliefs","phase":"NA","overall_status":"COMPLETED","enrollment_count":735,"lead_sponsor_name":"University of Melbourne","has_results":false},{"nct_id":"NCT06358521","title":"Determining the Impact of a Physiotherapist-led Primary Care Model for Hip and Knee Pain - A Cluster Trial","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":728,"lead_sponsor_name":"Queen's University","has_results":false},{"nct_id":"NCT06124170","title":"Improved Pain Management in Knee Osteoarthritis-related Surgeries","phase":"","overall_status":"COMPLETED","enrollment_count":714,"lead_sponsor_name":"Peng Liu","has_results":false},{"nct_id":"NCT02697773","title":"Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":698,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT05362851","title":"Clinical Trial of YYC301 P3 for Treatment of Osteoarthritis of the Knee","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":692,"lead_sponsor_name":"Yooyoung Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT00994890","title":"A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":679,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT02830919","title":"Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":627,"lead_sponsor_name":"Eurofarma Laboratorios S.A.","has_results":false},{"nct_id":"NCT03245008","title":"Efficacy and Safety of MT-5547 in Patients With Osteoarthritis Accompanied by Moderate to Severe Pain","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":626,"lead_sponsor_name":"Tanabe Pharma Corporation","has_results":true},{"nct_id":"NCT05972525","title":"What Matters to Patients With Severe Hip or Knee Osteoarthritis?","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":615,"lead_sponsor_name":"Vejle Hospital","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}