{"disease":{"id":"orthostatic-hypotension","name":"Orthostatic hypotension","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":2,"pipeline_drug_count":0,"trial_count":2},"drugs":{"marketed":[{"drug_id":"droxidopa","indication_name":"Orthostatic hypotension","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Northera","generic_name":"DROXIDOPA","company_name":"Lundbeck Na Ltd","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Catecholamine","quality_score":10,"revenue":null,"mechanism":"Northera works by increasing the levels of certain neurotransmitters in the brain, such as norepinephrine, to help regulate blood pressure and movement."},{"drug_id":"northera","indication_name":"Orthostatic hypotension","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Northera","company_name":"The Cooper Health System","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Adrenergic receptor","drug_class":"","quality_score":13,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT07309666","title":"Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Xuanwu Hospital, Beijing","has_results":false},{"nct_id":"NCT07196397","title":"POLish Registry of CArdioneuroablation and CArdioneuromodulation","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"SABAMED Medical Center Ltd.","has_results":false},{"nct_id":"NCT06647641","title":"The CurePSP Genetics Program","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT04141891","title":"Advancing Understanding of Transportation Options","phase":"NA","overall_status":"COMPLETED","enrollment_count":529,"lead_sponsor_name":"University of Colorado, Denver","has_results":true},{"nct_id":"NCT02586623","title":"Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":453,"lead_sponsor_name":"H. Lundbeck A/S","has_results":true},{"nct_id":"NCT05728255","title":"Assessment of the Mechanism of Non-cardiac Syncope","phase":"","overall_status":"COMPLETED","enrollment_count":330,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT03343574","title":"Cardiovascular Effects of Exercise in Patients With Parkinson's Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Faizan Ahmed","has_results":false},{"nct_id":"NCT03829657","title":"Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":203,"lead_sponsor_name":"Theravance Biopharma","has_results":true},{"nct_id":"NCT05821400","title":"Cognitive Changes in Mild Cognitive Impairment","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Fujian Medical University Union Hospital","has_results":false},{"nct_id":"NCT03750552","title":"Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":195,"lead_sponsor_name":"Theravance Biopharma","has_results":true},{"nct_id":"NCT06439498","title":"Frequency of Orthostatic Hypotension in Patients Who Underwent Colonoscopy","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Ankara University","has_results":false},{"nct_id":"NCT06714565","title":"The Value of Near-infrared Spectroscopy and Blood Pressure Measurements in Estimating Future Fall Risk in Older Adults","phase":"","overall_status":"RECRUITING","enrollment_count":141,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT07139756","title":"Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":130,"lead_sponsor_name":"Centre Hospitalier Universitaire Vaudois","has_results":false},{"nct_id":"NCT05729724","title":"Effect of Pharmacological Interventions on Systolic Blood Pressure Drops (SynABPM 2 Proof-of-concept)","phase":"","overall_status":"COMPLETED","enrollment_count":111,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT04095793","title":"Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":110,"lead_sponsor_name":"Theravance Biopharma","has_results":true},{"nct_id":"NCT07195903","title":"The STAND-UP Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"St. Francis Hospital, New York","has_results":false},{"nct_id":"NCT01515865","title":"Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":98,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT05295810","title":"Hypercapnia in Orthostatic Hypotension","phase":"NA","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT04493372","title":"Deciphering Preserved Autonomic Function After Spinal Cord Injury","phase":"NA","overall_status":"RECRUITING","enrollment_count":69,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT02919917","title":"Treatment of Post-SCI Hypotension","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"James J. Peters Veterans Affairs Medical Center","has_results":true},{"nct_id":"NCT05647473","title":"Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":66,"lead_sponsor_name":"Fujian Medical University Union Hospital","has_results":false},{"nct_id":"NCT05358210","title":"Effects of Blueberries in Older Adults","phase":"NA","overall_status":"COMPLETED","enrollment_count":61,"lead_sponsor_name":"Beth Israel Deaconess Medical Center","has_results":false},{"nct_id":"NCT05400174","title":"Blood Pressure Effects on Cognition and Brain Blood Flow in PD","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT05489575","title":"CPAP for the Treatment of Supine Hypertension","phase":"NA","overall_status":"RECRUITING","enrollment_count":59,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT03721393","title":"Data Collection - Of Syncope Tilt Table Testing Study","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Boston Scientific Corporation","has_results":false},{"nct_id":"NCT03743116","title":"Postoperative Orthostatic Intolerance and Hypotension in Unilateral TKA","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Hvidovre University Hospital","has_results":false},{"nct_id":"NCT04440085","title":"RaGuS Trial by Postoperative Patients","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Bürgerspital Solothurn","has_results":false},{"nct_id":"NCT03350659","title":"Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT03354234","title":"Evaluation of the ORTHO-LBNP System","phase":"NA","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"Military Institute of Aviation Medicine","has_results":false},{"nct_id":"NCT03924388","title":"Spinal Cord Stimulation and Autonomic Response in People With SCI.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":46,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT03674541","title":"The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"Brigham and Women's Hospital","has_results":true},{"nct_id":"NCT06694688","title":"Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic Hypotension","phase":"NA","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Gérond'if","has_results":false},{"nct_id":"NCT04195360","title":"Postoperative Incidence of Orthostatic Intolerance and Hypotension in Primary Unicompartmental Knee Arthroplasty (UKA)","phase":"","overall_status":"UNKNOWN","enrollment_count":42,"lead_sponsor_name":"Copenhagen University Hospital, Hvidovre","has_results":false},{"nct_id":"NCT05487300","title":"Effect of Levodopa on Cardiovascular Autonomic Function in Parkinson's Disease","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"University of Utah","has_results":true},{"nct_id":"NCT02632318","title":"Dawn Simulation and Postural Hypotension","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"VA Palo Alto Health Care System","has_results":false},{"nct_id":"NCT02705755","title":"TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":34,"lead_sponsor_name":"Theravance Biopharma","has_results":true},{"nct_id":"NCT04510974","title":"RAAS and Arterial Stiffness in SCI","phase":"","overall_status":"COMPLETED","enrollment_count":33,"lead_sponsor_name":"James J. Peters Veterans Affairs Medical Center","has_results":true},{"nct_id":"NCT04620382","title":"Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients","phase":"EARLY_PHASE1","overall_status":"RECRUITING","enrollment_count":31,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT03482297","title":"Automated Abdominal Binder for Orthostatic Hypotension","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":31,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT05982652","title":"Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Pusan National University Yangsan Hospital","has_results":false},{"nct_id":"NCT04782830","title":"Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms","phase":"NA","overall_status":"RECRUITING","enrollment_count":29,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT06751888","title":"Controlled CO2 Inhalation in NOH","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":28,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT04902222","title":"Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty","phase":"","overall_status":"UNKNOWN","enrollment_count":26,"lead_sponsor_name":"Copenhagen University Hospital, Hvidovre","has_results":false},{"nct_id":"NCT03759574","title":"Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty (THA)","phase":"","overall_status":"UNKNOWN","enrollment_count":26,"lead_sponsor_name":"Hvidovre University Hospital","has_results":false},{"nct_id":"NCT05233865","title":"Hemodynamic Effects During Land vs Water Exercise for Older Adults With Orthostatic Hypotension","phase":"NA","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"University of Texas at Austin","has_results":false},{"nct_id":"NCT01518946","title":"Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT04842058","title":"Pathophysiologic Hemodynamics After Primary Unilateral Total Hip Arthroplasty in Patients Receiving ACEIs and ARBs","phase":"","overall_status":"UNKNOWN","enrollment_count":24,"lead_sponsor_name":"Hvidovre University Hospital","has_results":false},{"nct_id":"NCT03602014","title":"Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"James J. Peters Veterans Affairs Medical Center","has_results":true},{"nct_id":"NCT05304806","title":"Effective Volemia in Older Adults With Orthostatic Hypotension","phase":"","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05960448","title":"Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"James J. Peters Veterans Affairs Medical Center","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}