{"disease":{"id":"onychomycosis-of-toenail","name":"onychomycosis of toenail"},"drugs":{"marketed":[{"drug_id":"itraconazole","indication_name":"Onychomycosis of toenails","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Sporanox","generic_name":"itraconazole","company_name":"Sebela Ireland Ltd","drug_phase":"marketed","molecular_target":"C-X-C chemokine receptor type 1","drug_class":"Azole Antifungal [EPC]","quality_score":57,"revenue":null,"mechanism":""},{"drug_id":"efinaconazole","indication_name":"Onychomycosis of toenails","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Jublia","generic_name":"EFINACONAZOLE","company_name":"Bausch Health","drug_phase":"marketed","molecular_target":"","drug_class":"Azole Antifungal [EPC]","quality_score":44,"revenue":null,"mechanism":"Jublia works by inhibiting the fungal enzyme lanosterol 14α-demethylase, which is essential for the production of ergosterol, a critical component of fungal cell membranes."}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT01270971","title":"Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":594,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT03382717","title":"Efficacy and Safety of a Medical Device for the Treatment of Toenail Onychomycosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":102,"lead_sponsor_name":"Oystershell NV","has_results":false},{"nct_id":"NCT05139888","title":"Light Therapy for Onychomycosis Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"ToeFX Inc.","has_results":false},{"nct_id":"NCT06971341","title":"Study in Patients With Onychomycosis Treated With Mycoclear® and Ciclopirox","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"University of Bologna","has_results":false},{"nct_id":"NCT04961684","title":"Clinical Evaluation of Efficacy and Safety of a Medical Device for the Treatment of Toenail Onychomycosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":76,"lead_sponsor_name":"Oystershell NV","has_results":false},{"nct_id":"NCT03141840","title":"Clinical Trial of Topical ABL01 Treatment of Onychomycosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":69,"lead_sponsor_name":"Abbell AB","has_results":false},{"nct_id":"NCT02546258","title":"Evaluation of the Performance of a Fungal Nail Treatment on the Visual Signs of Onychomycosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Reckitt Benckiser Healthcare (UK) Limited","has_results":false},{"nct_id":"NCT06417983","title":"Topical Application of Essential Oils to Treat Onchomycosis","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":50,"lead_sponsor_name":"Medical Life Care Planners, LLC","has_results":false},{"nct_id":"NCT07012343","title":"Exploring Different Dose-frequency Home Photodynamic Therapy Protocols Using a Novel Home-targeted LED Device for Onychomycosis","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":50,"lead_sponsor_name":"Chulalongkorn University","has_results":false},{"nct_id":"NCT03098342","title":"Comparison of Efficacy and Safety Between Methylene Blue-mediated Photodynamic Therapy and 5% Amorolfine Nail Lacquer for Toenail Onychomycosis Treatment","phase":"NA","overall_status":"UNKNOWN","enrollment_count":42,"lead_sponsor_name":"Chulalongkorn University","has_results":false},{"nct_id":"NCT05674747","title":"Pilot Study of Swift Microwave Device for Onychomycosis","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"Mediprobe Research Inc.","has_results":false},{"nct_id":"NCT05135910","title":"To Evaluate Hallux Terbinafine Subungual Gel (HSG) in the Treatment of Onychomycosis","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":35,"lead_sponsor_name":"Hallux, Inc.","has_results":false},{"nct_id":"NCT06006455","title":"Effect of the Erchonia® LunulaLaser™ for the Treatment of Toenail Onychomycosis","phase":"NA","overall_status":"TERMINATED","enrollment_count":28,"lead_sponsor_name":"Erchonia Corporation","has_results":true},{"nct_id":"NCT04042857","title":"Safety and Efficacy of Next Science Gel on Toenail Fungus","phase":"NA","overall_status":"RECRUITING","enrollment_count":20,"lead_sponsor_name":"Next Science TM","has_results":false},{"nct_id":"NCT05260450","title":"Laser Treatment of Toenail Onychomycosis With a 1064 nm Nd:YAG-laser","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Aalborg University Hospital","has_results":false},{"nct_id":"NCT05110638","title":"Safety and Tolerability Study of SKX-16 in Subjects With Moderate to Severe Distal Subungual Onychomycosis","phase":"PHASE1","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"SATO Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT06485050","title":"Photodynamic Therapy and Topical Antifungal for Onychomycosis in Patients With Diabetes.","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":10,"lead_sponsor_name":"Universidad Complutense de Madrid","has_results":false},{"nct_id":"NCT03216200","title":"Early Feasibility Study to Evaluate the Efficacy of the RenewalNail™ Plasma Treatment System in Patients With Onychomycosis (Fungal Nail)","phase":"NA","overall_status":"COMPLETED","enrollment_count":5,"lead_sponsor_name":"DeviceFarm, Inc.","has_results":true},{"nct_id":"NCT03066336","title":"A Study to See if Low Level Laser Light Can Help to Treat Toenail Fungus","phase":"NA","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Erchonia Corporation","has_results":false}],"total":19},"guidelines":[],"source":"Drug Landscape verified database"}