{"disease":{"id":"obstructive-lung-disease","name":"obstructive lung disease"},"drugs":{"marketed":[{"drug_id":"vilanterol","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Breo Ellipta","generic_name":"VILANTEROL","company_name":"Glaxo Grp Ltd","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"beta2-Adrenergic Agonist","quality_score":60,"revenue":"3100","mechanism":"Breo Ellipta works by stimulating the beta-2 adrenergic receptor to relax airway muscles and improve breathing."},{"drug_id":"umeclidinium","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Incruse Ellipta","generic_name":"UMECLIDINIUM","company_name":"Glaxo Grp England","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M4","drug_class":"Anticholinergic","quality_score":70,"revenue":"3100","mechanism":"Umeclidinium works by blocking the M4 muscarinic acetylcholine receptor to relax airway smooth muscle and improve breathing."},{"drug_id":"fluticasone-furoate","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Arnuity Ellipta","generic_name":"FLUTICASONE FUROATE","company_name":"Haleon Us Holdings","drug_phase":"marketed","molecular_target":"Glucocorticoid receptor","drug_class":"Corticosteroid","quality_score":62,"revenue":"3100","mechanism":""},{"drug_id":"arformoterol","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Brovana","generic_name":"ARFORMOTEROL","company_name":"Lupin","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"beta2-Adrenergic Agonist","quality_score":58,"revenue":null,"mechanism":"Brovana works by activating the beta-2 adrenergic receptor to relax airway muscles and improve breathing."},{"drug_id":"glycopyrrolate","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Glycopyrrolate","company_name":"Yonsei University","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"almitrine","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Duxil","generic_name":"ALMITRINE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"almitrine","quality_score":22,"revenue":null,"mechanism":""},{"drug_id":"aclidinium-bromide","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tudorza Pressair","generic_name":"ACLIDINIUM BROMIDE","company_name":"Covis","drug_phase":"marketed","molecular_target":"M3 receptors, beta 2 -adrenergic receptors","drug_class":"Anticholinergic","quality_score":10,"revenue":null,"mechanism":"DUAKLIR PRESSAIR combines aclidinium, an anticholinergic, and formoterol, a beta 2 -adrenergic agonist, to provide bronchodilation in COPD."},{"drug_id":"ipratropium","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Atrovent","generic_name":"IPRATROPIUM","company_name":"","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Anticholinergic","quality_score":50,"revenue":null,"mechanism":""},{"drug_id":"oxitropium","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Oxytropium Bromide","generic_name":"OXITROPIUM","company_name":"","drug_phase":"phase_3","molecular_target":"","drug_class":"oxitropium","quality_score":null,"revenue":null,"mechanism":"Oxytropium works by blocking the action of acetylcholine, a neurotransmitter that causes airway muscles to contract."},{"drug_id":"umec","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"UMEC","company_name":"Glaxo Grp England","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":"UmeC is a small molecule drug that works by interacting with a specific target in the body."},{"drug_id":"incruse","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Incruse","company_name":"Fundacio Privada Mon Clinic Barcelona","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"brovana","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Brovana","company_name":"Wake Forest University Health Sciences","drug_phase":"marketed","molecular_target":"Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Beta-3 adrenergic receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"olodaterol","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Striverdi Respimat","generic_name":"OLODATEROL","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"Beta-2 adrenergic receptor","drug_class":"beta2-Adrenergic Agonist","quality_score":55,"revenue":null,"mechanism":"Striverdi Respimat works by stimulating the beta-2 receptors in the lungs to relax airway muscles and improve breathing."},{"drug_id":"sialanar","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Sialanar","company_name":"Proveca Pharma Limited","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"revefenacin","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Yupelri","generic_name":"REVEFENACIN","company_name":"Mylan Ireland Ltd","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M3","drug_class":"Anticholinergic [EPC]","quality_score":10,"revenue":null,"mechanism":"Yupelri works by blocking the action of a chemical called acetylcholine, which stimulates the muscles in the airways, leading to bronchodilation."},{"drug_id":"glycopyrronium-bromide","indication_name":"Chronic obstructive lung disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cuvposa","generic_name":"GLYCOPYRRONIUM BROMIDE","company_name":"Shionogi","drug_phase":"marketed","molecular_target":"Muscarinic acetylcholine receptor M1","drug_class":"Anticholinergic","quality_score":62,"revenue":null,"mechanism":"Cuvposa works by blocking the action of a chemical called acetylcholine, which stimulates the muscarinic receptors in the body."}],"pipeline":[],"offLabel":[],"totalMarketed":16,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03840928","title":"PatientSpot Formerly Known as ArthritisPower","phase":"","overall_status":"UNKNOWN","enrollment_count":40000,"lead_sponsor_name":"Global Healthy Living Foundation","has_results":false},{"nct_id":"NCT07363980","title":"Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":4000,"lead_sponsor_name":"Ellen Margrethe Hauge","has_results":false},{"nct_id":"NCT04281784","title":"Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)","phase":"NA","overall_status":"COMPLETED","enrollment_count":2512,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT01443845","title":"Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":2354,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT02073708","title":"A Population-based Investigation of Asthma in the Telemark Region of Norway","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Sykehuset Telemark","has_results":false},{"nct_id":"NCT00136006","title":"The Vancouver-BOLD Study: The Burden of Chronic Obstructive Lung Disease","phase":"","overall_status":"COMPLETED","enrollment_count":1000,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT03721952","title":"Facilitating Communication Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":977,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT03516994","title":"Reducing Disparities in the Quality of Advance Care Planning for Older Adults","phase":"NA","overall_status":"COMPLETED","enrollment_count":790,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT04283994","title":"Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)","phase":"NA","overall_status":"COMPLETED","enrollment_count":756,"lead_sponsor_name":"University of Washington","has_results":true},{"nct_id":"NCT05209607","title":"Social Media-based Bundle Care of AECOPD Patients.","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":648,"lead_sponsor_name":"Beijing Chao Yang Hospital","has_results":false},{"nct_id":"NCT04919200","title":"Optimized Single-breath Helium Lung Volume in Obstructive Lung Disease","phase":"","overall_status":"COMPLETED","enrollment_count":628,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT04387799","title":"Determinants of COVID-19 Pneumonia (MC-19)","phase":"","overall_status":"COMPLETED","enrollment_count":520,"lead_sponsor_name":"Catholic University of the Sacred Heart","has_results":false},{"nct_id":"NCT05830318","title":"Usability and Acceptability Study of the P-STEP Mobile Application","phase":"","overall_status":"UNKNOWN","enrollment_count":380,"lead_sponsor_name":"University of Leicester","has_results":false},{"nct_id":"NCT02713347","title":"Advancing Symptom Alleviation With Palliative Treatment","phase":"NA","overall_status":"COMPLETED","enrollment_count":306,"lead_sponsor_name":"VA Office of Research and Development","has_results":true},{"nct_id":"NCT06251271","title":"Diagnosing Obstructive Lung Disease With Point of Care Ultrasound","phase":"","overall_status":"COMPLETED","enrollment_count":301,"lead_sponsor_name":"Soroka University Medical Center","has_results":false},{"nct_id":"NCT02988388","title":"Lung Tissue Research Consortium","phase":"","overall_status":"COMPLETED","enrollment_count":247,"lead_sponsor_name":"National Heart, Lung, and Blood Institute (NHLBI)","has_results":false},{"nct_id":"NCT06897410","title":"Reforça't: A Community, Social, and Healthcare Program for Patients With Cardiorespiratory Conditions Upon Hospital Discharge","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Corporació de Salut del Maresme i la Selva","has_results":false},{"nct_id":"NCT04324684","title":"Prognostic Factors Keeping Track for COVID-19 Pneumonia","phase":"","overall_status":"COMPLETED","enrollment_count":198,"lead_sponsor_name":"Catholic University of the Sacred Heart","has_results":false},{"nct_id":"NCT05227547","title":"Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":186,"lead_sponsor_name":"Centre Hospitalier Intercommunal Creteil","has_results":false},{"nct_id":"NCT04354220","title":"Capnography Monitoring in Ventilated Children","phase":"","overall_status":"UNKNOWN","enrollment_count":178,"lead_sponsor_name":"Vincenzo Cannizzaro","has_results":false},{"nct_id":"NCT03688074","title":"Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":116,"lead_sponsor_name":"AstraZeneca","has_results":true},{"nct_id":"NCT07451977","title":"Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia","phase":"NA","overall_status":"RECRUITING","enrollment_count":114,"lead_sponsor_name":"Istituti Clinici Scientifici Maugeri SpA","has_results":false},{"nct_id":"NCT03087188","title":"Inhalation Therapy in Ambulant and Hospitalized Patient Using Available Film Sequences From the Internet","phase":"","overall_status":"COMPLETED","enrollment_count":114,"lead_sponsor_name":"RWTH Aachen University","has_results":false},{"nct_id":"NCT02797275","title":"Secondhand Smoke Respiratory Health Study","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":107,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT04668599","title":"Cardio-pulmonary Rehabilitation and Sleep Quality","phase":"","overall_status":"COMPLETED","enrollment_count":106,"lead_sponsor_name":"MetroHealth Medical Center","has_results":true},{"nct_id":"NCT03506906","title":"The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation","phase":"NA","overall_status":"COMPLETED","enrollment_count":105,"lead_sponsor_name":"Wissenschaftliches Institut Bethanien e.V","has_results":false},{"nct_id":"NCT03718780","title":"Assessment of Continuous Measurement of Transcutaneous CO2 for Evaluation of Alveolar Dead Space During Exercise","phase":"NA","overall_status":"UNKNOWN","enrollment_count":105,"lead_sponsor_name":"Centre Hospitalier Metropole Savoie","has_results":false},{"nct_id":"NCT06272370","title":"Individualizing Treatment for Asthma in Primary Care","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":103,"lead_sponsor_name":"DARTNet Institute","has_results":true},{"nct_id":"NCT05631132","title":"May Noninvasive Mechanical Ventilation (NIV) and/or Continuous Positive Airway Pressure (CPAP) Increase the Bronchoalveolar Lavage (BAL) Salvage in Patients With Pulmonary Diseases?","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT06713512","title":"InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Guy's and St Thomas' NHS Foundation Trust","has_results":false},{"nct_id":"NCT07460999","title":"Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Zealand University Hospital","has_results":false},{"nct_id":"NCT04319705","title":"Anti-viral Effects of Azithromycin in Patients With Asthma and COPD","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Bispebjerg Hospital","has_results":false},{"nct_id":"NCT05299385","title":"The Study for Evaluating the Clinical Effectiveness and Safety of Respiratory Rehabilitation Software 'Redpill Breath'(COPD, Asthma, Lung Cancer, Etc.)","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Lifesemantics Corp.","has_results":false},{"nct_id":"NCT05504993","title":"Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD","phase":"","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"Ankara University","has_results":false},{"nct_id":"NCT06306482","title":"Determination of Posture in Patients With Restrictive and Obstructive Lung Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Hacettepe University","has_results":false},{"nct_id":"NCT04711057","title":"CENTR(AR): Lungs Moving","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Aveiro University","has_results":false},{"nct_id":"NCT05565872","title":"Effects of Supervision During a Community-based Exercise Intervention (Urban Training) in Patients With COPD","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Universidad Complutense de Madrid","has_results":false},{"nct_id":"NCT06022627","title":"EFFECT OF PRANAYAMA YOGA ON COPD","phase":"NA","overall_status":"UNKNOWN","enrollment_count":66,"lead_sponsor_name":"Yeditepe University","has_results":false},{"nct_id":"NCT05029557","title":"The Effect of Education Based on the Chronic Care Model in COPD Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"Hasan Kalyoncu University","has_results":false},{"nct_id":"NCT05630599","title":"Remote Assessment of Lung Disease and Impact on Physical and Mental Health","phase":"","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"University College, London","has_results":false},{"nct_id":"NCT05838911","title":"Does Neuromuscular Electrical Stimulation Benefit the Functional Ability of Elderly Patients With Chronic Obstructive Lung Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Beni-Suef University","has_results":false},{"nct_id":"NCT05940480","title":"TCM Daoyin Therapy in Individuals At-risk for COPD","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Shanghai University of Traditional Chinese Medicine","has_results":false},{"nct_id":"NCT06582082","title":"Digital Health Integration With Pulmonary Rehabilitation on Patients With Chronic Obstructive Lung Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT06149494","title":"RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Altesa Biosciences, Inc.","has_results":false},{"nct_id":"NCT05595733","title":"Can NAVA Mode Reduce Mechanical Ventilation Day in Patients With COPD ?","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Fu Jen Catholic University Hospital","has_results":false},{"nct_id":"NCT04630743","title":"Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":49,"lead_sponsor_name":"University of Cologne","has_results":false},{"nct_id":"NCT04159129","title":"Effects of Pulmonary Rehabilitation on Walking Speed in Patients With COPD or ILD Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":43,"lead_sponsor_name":"Schön Klinik Berchtesgadener Land","has_results":false},{"nct_id":"NCT05646407","title":"Move With Air: Exercise Training Study","phase":"NA","overall_status":"UNKNOWN","enrollment_count":32,"lead_sponsor_name":"McGill University","has_results":false},{"nct_id":"NCT06090149","title":"Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Pauls Stradins Clinical University Hospital","has_results":false},{"nct_id":"NCT05267418","title":"Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance","phase":"NA","overall_status":"TERMINATED","enrollment_count":30,"lead_sponsor_name":"Laval University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}