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The pipeline is intensely competitive, with next-generation agents including the amylin/GLP-1 combination CagriSema, triple agonist retatrutide, and oral orforglipron all targeting >20% weight loss, while setmelanotide (Imcivree) addresses the rare but important niche of MC4R pathway genetic obesity.","drug_count":17,"description":"Obesity is a chronic, relapsing, multifactorial neurobehavioural disease defined by excess adiposity that impairs health. It is characterised by dysregulation of energy homeostasis driven by genetic, environmental, hormonal, and behavioural factors. Clinically staged by BMI, obesity significantly increases the risk of type 2 diabetes, cardiovascular disease, obstructive sleep apnoea, non-alcoholic fatty liver disease, osteoarthritis, and multiple malignancies. The emergence of highly effective GLP-1 receptor agonists and dual GLP-1/GIP agonists has transformed treatment, enabling 15–25% sustained weight loss and meaningful reduction in cardiometabolic risk in large Phase 3 trials.","subtype_count":20},"enrichment_level":2,"last_enriched_at":null,"visit_count":0,"created_at":"2026-03-25T12:16:34.952Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":24,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"semaglutide","indication_name":"Obesity","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ozempic","generic_name":"semaglutide","company_name":"Novo Nordisk","drug_phase":"marketed","molecular_target":"GLP-1 receptor","drug_class":"GLP-1 Receptor Agonist 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