{"disease":{"id":"nyha-class-ii-iv-heart-failure","name":"nyha class ii iv heart failure"},"drugs":{"marketed":[{"drug_id":"aldactone","indication_name":"NYHA Class III-IV heart failure with reduced ejection fraction","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aldactone","generic_name":"Spironolactone","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Aldosterone receptors at aldosterone-dependent sodium-potassium exchange site in distal convoluted renal tubule","drug_class":"Potassium-sparing diuretic, aldosterone antagonist","quality_score":66,"revenue":null,"mechanism":"Aldosterone antagonist causing increased sodium and water excretion while retaining potassium."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03387813","title":"Hemodynamic-GUIDEd Management of Heart Failure","phase":"NA","overall_status":"COMPLETED","enrollment_count":2358,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT07064525","title":"Evaluate the Efficacy and Safety of SPC1001 Low in Patients With Essential Hypertension","phase":"PHASE2","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":252,"lead_sponsor_name":"Shin Poong Pharmaceutical Co. Ltd.","has_results":false},{"nct_id":"NCT03388918","title":"Future Patient - Telerehabilitation of Heart Failure Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Aalborg University","has_results":false},{"nct_id":"NCT04862273","title":"CMR T1 Mapping for Diagnosis of Cardiac Amyloidosis","phase":"","overall_status":"COMPLETED","enrollment_count":112,"lead_sponsor_name":"University of Leipzig","has_results":false},{"nct_id":"NCT06270875","title":"Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":10,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT06299176","title":"Whole Heart Radiotherapy for End-stage Heart Failure","phase":"PHASE1","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":6,"lead_sponsor_name":"McGill University Health Centre/Research Institute of the McGill University Health Centre","has_results":false}],"total":6},"guidelines":[],"source":"Drug Landscape verified database"}