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The competitive landscape is intense, with next-generation EGFR/MET bispecifics (amivantamab+lazertinib) and KRAS combination strategies seeking to address the inevitable acquired resistance.","drug_count":14,"description":"Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all lung cancer diagnoses. It encompasses three major histological subtypes — adenocarcinoma (~40%), squamous cell carcinoma (~25%), and large cell carcinoma (~10%) — each with distinct molecular profiles. The last decade has seen a paradigm shift from empirical chemotherapy to biomarker-directed precision oncology: comprehensive genomic profiling at diagnosis now identifies actionable driver mutations (EGFR, ALK, ROS1, KRAS G12C, BRAF V600E, MET, RET, NTRK) in ~30–40% of patients, while PD-L1 testing identifies patients who benefit from immune checkpoint inhibition in the remainder.","subtype_count":18},"enrichment_level":2,"last_enriched_at":null,"visit_count":0,"created_at":"2026-03-25T12:16:34.950Z","updated_at":"2026-03-25T12:16:34.950Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":0,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"pembrolizumab","indication_name":"NSCLC 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