{"disease":{"id":"neuropathic-pain","name":"neuropathic pain"},"drugs":{"marketed":[{"drug_id":"mirogabalin","indication_name":"Peripheral neuropathic pain","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tarlige","generic_name":"MIROGABALIN","company_name":"Daiichi Sankyo","drug_phase":"marketed","molecular_target":"Voltage-dependent calcium channel subunit alpha-2/delta-1","drug_class":"","quality_score":35,"revenue":"300","mechanism":""},{"drug_id":"lyrica","indication_name":"Neuropathic pain associated with spinal cord injury","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lyrica","generic_name":"Pregabalin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"alpha-2-delta subunit (auxiliary subunit of voltage-gated calcium channels)","drug_class":"Anticonvulsant, analgesic","quality_score":69,"revenue":null,"mechanism":"Pregabalin binds alpha-2-delta subunit of voltage-gated calcium channels in CNS."},{"drug_id":"lyrica","indication_name":"Neuropathic pain associated with diabetic peripheral neuropathy","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lyrica","generic_name":"Pregabalin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"alpha-2-delta subunit (auxiliary subunit of voltage-gated calcium channels)","drug_class":"Anticonvulsant, analgesic","quality_score":69,"revenue":null,"mechanism":"Pregabalin binds alpha-2-delta subunit of voltage-gated calcium channels in CNS."},{"drug_id":"lyrica","indication_name":"Neuropathic pain associated with diabetic peripheral neuropathy","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lyrica","generic_name":"Pregabalin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"alpha-2-delta subunit (auxiliary subunit of voltage-gated calcium channels)","drug_class":"Anticonvulsant, analgesic","quality_score":69,"revenue":null,"mechanism":"Pregabalin binds alpha-2-delta subunit of voltage-gated calcium channels in CNS."},{"drug_id":"bat","indication_name":"Treatment of neuropathic pain associated with diabetic peripheral neuropathy in adults","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bat","generic_name":"bat","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Unknown","drug_class":"Unknown","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"neurontin","indication_name":"Neuropathic pain associated with spinal cord injury","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Neurontin","generic_name":"Gabapentin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"α2δ subunit of voltage-activated calcium channels","drug_class":"Antiepileptic/Analgesic","quality_score":79,"revenue":null,"mechanism":"Gabapentin binds with high-affinity to α2δ subunit of voltage-activated calcium channels; precise mechanism unknown."},{"drug_id":"lyrica","indication_name":"Neuropathic pain associated with spinal cord injury","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lyrica","generic_name":"Pregabalin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"alpha-2-delta subunit (auxiliary subunit of voltage-gated calcium channels)","drug_class":"Anticonvulsant, analgesic","quality_score":69,"revenue":null,"mechanism":"Pregabalin binds alpha-2-delta subunit of voltage-gated calcium channels in CNS."}],"pipeline":[],"offLabel":[],"totalMarketed":7,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03862365","title":"Exploring the Genetics of Neuropathic Pain","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT05900791","title":"Persistent Pain After Knee Replacement","phase":"","overall_status":"COMPLETED","enrollment_count":3710,"lead_sponsor_name":"University Hospital Bispebjerg and Frederiksberg","has_results":false},{"nct_id":"NCT05845177","title":"Persistent Pain After Hip Replacement","phase":"","overall_status":"COMPLETED","enrollment_count":2777,"lead_sponsor_name":"University Hospital Bispebjerg and Frederiksberg","has_results":false},{"nct_id":"NCT06353100","title":"Chronic Pain in the General Population of Chile","phase":"","overall_status":"COMPLETED","enrollment_count":2365,"lead_sponsor_name":"Pontificia Universidad Catolica de Chile","has_results":false},{"nct_id":"NCT05837923","title":"Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health Outcomes","phase":"NA","overall_status":"COMPLETED","enrollment_count":2016,"lead_sponsor_name":"Radicle Science","has_results":false},{"nct_id":"NCT06546202","title":"Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China","phase":"","overall_status":"COMPLETED","enrollment_count":1271,"lead_sponsor_name":"Daiichi Sankyo","has_results":false},{"nct_id":"NCT06628908","title":"Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":1100,"lead_sponsor_name":"Vertex Pharmaceuticals Incorporated","has_results":false},{"nct_id":"NCT07354243","title":"International Neuromodulation Registry","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT06224959","title":"Migraine and Neuropathic Pain in Osteoarthritis","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT05754190","title":"Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA","phase":"","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"Brown University","has_results":false},{"nct_id":"NCT07231419","title":"Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":734,"lead_sponsor_name":"Vertex Pharmaceuticals Incorporated","has_results":false},{"nct_id":"NCT06812117","title":"A Study to Evaluate the Safety and Effectiveness of Mirogabalin in Chinese Adult Patients With Diabetic Peripheral Neuropathic Pain (DPNP) in Real-world Clinical Practice Setting (ReMIssion Study)","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":721,"lead_sponsor_name":"Daiichi Sankyo","has_results":false},{"nct_id":"NCT04647773","title":"To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain","phase":"PHASE2, PHASE3","overall_status":"UNKNOWN","enrollment_count":687,"lead_sponsor_name":"Haisco Pharmaceutical Group Co., Ltd.","has_results":false},{"nct_id":"NCT06511674","title":"Vulnerability and Risk of Neuropathic Pain in Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":625,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04171453","title":"Post-marketing Surveillance (PMS) to Observe the Safety and Effectiveness of Lyrica CR Extended Release Tablets","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Viatris Korea","has_results":false},{"nct_id":"NCT06071988","title":"Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":558,"lead_sponsor_name":"Apurano Pharmaceuticals GmbH","has_results":false},{"nct_id":"NCT06071949","title":"Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":558,"lead_sponsor_name":"Apurano Pharmaceuticals GmbH","has_results":false},{"nct_id":"NCT06071936","title":"Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":558,"lead_sponsor_name":"Apurano Pharmaceuticals GmbH","has_results":false},{"nct_id":"NCT06072001","title":"Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":558,"lead_sponsor_name":"Apurano Pharmaceuticals GmbH","has_results":false},{"nct_id":"NCT06813391","title":"Prevalence of Central Neuropathic Pain After a Stroke in Patients Attending Post-stroke Consultations in the Île-de-France Region","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Fondation Hôpital Saint-Joseph","has_results":false},{"nct_id":"NCT06203002","title":"A Dose-ranging Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":496,"lead_sponsor_name":"Lexicon Pharmaceuticals","has_results":false},{"nct_id":"NCT05589935","title":"Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes","phase":"NA","overall_status":"COMPLETED","enrollment_count":457,"lead_sponsor_name":"Radicle Science","has_results":false},{"nct_id":"NCT06696443","title":"Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN)","phase":"PHASE3","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":455,"lead_sponsor_name":"Vertex Pharmaceuticals Incorporated","has_results":false},{"nct_id":"NCT07487610","title":"Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Sultan 1. Murat State Hospital","has_results":false},{"nct_id":"NCT04538170","title":"Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":423,"lead_sponsor_name":"University Hospital Tuebingen","has_results":true},{"nct_id":"NCT04967664","title":"Comparison of Qutenza (8% Capsaicin) With a Low-dose Capsaicin for Treatment of Nerve Pain After Surgery","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":409,"lead_sponsor_name":"Averitas Pharma, Inc.","has_results":false},{"nct_id":"NCT06422117","title":"Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate and Severe Central Neuropathic Pain in China","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":408,"lead_sponsor_name":"Haisco Pharmaceutical Group Co., Ltd.","has_results":false},{"nct_id":"NCT02487524","title":"Biomarkers of Neuropathic Pain in Women Treated for Breast Cancer","phase":"NA","overall_status":"COMPLETED","enrollment_count":402,"lead_sponsor_name":"Helsinki University Central Hospital","has_results":false},{"nct_id":"NCT05817591","title":"Response Profiles to High-concentration Capsaicin Desensitization in Patients with Peripheral Neuropathic Pain with or Without Allodynia: a Regional Multicenter Prospective Cohort","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Centre Hospitalier Annecy Genevois","has_results":false},{"nct_id":"NCT06270940","title":"Pulsed Radiofrequency Therapy on Peripheral Nerves Monitoring Pain, Quality of Life, Patient Satisfaction and Efficacy","phase":"","overall_status":"RECRUITING","enrollment_count":400,"lead_sponsor_name":"Amsterdam UMC, location VUmc","has_results":false},{"nct_id":"NCT04094662","title":"A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled 14-week Study of DS-5565 in Chinese Patients With Diabetic Peripheral Neuropathic Pain","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":393,"lead_sponsor_name":"Daiichi Sankyo Co., Ltd.","has_results":false},{"nct_id":"NCT02985216","title":"Clinical Trial of YHD1119 in Patients With Peripheral Neuropathic Pain","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":371,"lead_sponsor_name":"Yuhan Corporation","has_results":false},{"nct_id":"NCT06967363","title":"Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":360,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT05351801","title":"Proof of Concept Trial of Cannabis Derivatives in Neuropathic Pain","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":320,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT05581836","title":"The Effect of Central Sensitization and Neuropathic Pain After Total Knee Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":312,"lead_sponsor_name":"The Catholic University of Korea","has_results":false},{"nct_id":"NCT02957617","title":"Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":302,"lead_sponsor_name":"Biogen","has_results":false},{"nct_id":"NCT05890053","title":"To Evaluate the Long-term Safety and Efficacy of HSK16149 in Chinese Patients With Peripheral Neuralgia","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":301,"lead_sponsor_name":"Haisco Pharmaceutical Group Co., Ltd.","has_results":false},{"nct_id":"NCT06619860","title":"Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Vertex Pharmaceuticals Incorporated","has_results":false},{"nct_id":"NCT03276689","title":"'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug","phase":"NA","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Rambam Health Care Campus","has_results":false},{"nct_id":"NCT03901352","title":"Study of Mirogabalin for Central Neuropathic Pain","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Daiichi Sankyo Co., Ltd.","has_results":true},{"nct_id":"NCT07195045","title":"Thai PainPREDICT Validation Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":277,"lead_sponsor_name":"Chulalongkorn University","has_results":false},{"nct_id":"NCT04479787","title":"Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)","phase":"NA","overall_status":"COMPLETED","enrollment_count":270,"lead_sponsor_name":"Abbott Medical Devices","has_results":true},{"nct_id":"NCT04015401","title":"Neuropathic Pain in Jamaicans With Sickle Cell Disease","phase":"","overall_status":"COMPLETED","enrollment_count":257,"lead_sponsor_name":"The University of The West Indies","has_results":false},{"nct_id":"NCT06019325","title":"Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy","phase":"NA","overall_status":"COMPLETED","enrollment_count":254,"lead_sponsor_name":"Muğla Sıtkı Koçman University","has_results":false},{"nct_id":"NCT06420141","title":"The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture","phase":"","overall_status":"RECRUITING","enrollment_count":250,"lead_sponsor_name":"Indiana University","has_results":false},{"nct_id":"NCT02804126","title":"Comparison of Two Pain-treatment Techniques After Cesarean Section","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":232,"lead_sponsor_name":"Michał Borys","has_results":false},{"nct_id":"NCT04146896","title":"Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":228,"lead_sponsor_name":"Aptinyx","has_results":true},{"nct_id":"NCT04953221","title":"The Effect of YJ001 on Diabetic Peripheral Neuropathic Pain.","phase":"","overall_status":"UNKNOWN","enrollment_count":225,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT06221241","title":"Evaluate the Efficacy and Safety of JMKX000623 in Participants With Diabetic Peripheral Neuropathic Pain","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":220,"lead_sponsor_name":"Jemincare","has_results":false},{"nct_id":"NCT05895552","title":"A Study of RTA 901 (BIIB143) in Participants With Diabetic Peripheral Neuropathic Pain","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":209,"lead_sponsor_name":"Reata, a wholly owned subsidiary of Biogen","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}