{"disease":{"id":"neuritis","name":"neuritis"},"drugs":{"marketed":[{"drug_id":"prednisone","indication_name":"Optic neuritis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Deltasone","generic_name":"prednisone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Sodium/nucleoside cotransporter 1, Glucocorticoid receptor","drug_class":"Corticosteroid [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"dexamethasone-phosphate","indication_name":"Optic neuritis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dexamethasone Sodium Phosphate","generic_name":"dexamethasone phosphate","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Androgen receptor, Glucocorticoid receptor, Mineralocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05095844","title":"National Vaccine Adverse Event Reporting Survey and Etiology","phase":"","overall_status":"UNKNOWN","enrollment_count":100000,"lead_sponsor_name":"Neuroganics LLC","has_results":false},{"nct_id":"NCT03753893","title":"Ocular Manifestations in Rheumatic Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":5000,"lead_sponsor_name":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","has_results":false},{"nct_id":"NCT04846010","title":"Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"All Natural Medicine Clinic, LLC","has_results":false},{"nct_id":"NCT04792866","title":"3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)","phase":"","overall_status":"COMPLETED","enrollment_count":1200,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT04793087","title":"Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)","phase":"","overall_status":"COMPLETED","enrollment_count":1200,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT04257734","title":"Epidemiologic and Clinical Characteristics of Optic Neuritis in China","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT06390579","title":"Building Research With Artificial Intelligence in Neuro-Ophthalmology","phase":"","overall_status":"COMPLETED","enrollment_count":693,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT05017142","title":"Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"University of Bern","has_results":false},{"nct_id":"NCT07100990","title":"Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":382,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT05605951","title":"Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic Nerve","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecul","has_results":false},{"nct_id":"NCT04926363","title":"Prevalence of Cardiovascular Risk Factors in Upper Vestibular Neuritis","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"University Hospital, Strasbourg, France","has_results":false},{"nct_id":"NCT03586557","title":"Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":142,"lead_sponsor_name":"Chinese PLA General Hospital","has_results":false},{"nct_id":"NCT04131764","title":"Diagnosis of ON With or Without MS or NMOSD","phase":"","overall_status":"TERMINATED","enrollment_count":112,"lead_sponsor_name":"Jagannadha R Avasarala","has_results":false},{"nct_id":"NCT01962571","title":"Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":108,"lead_sponsor_name":"University Eye Hospital, Freiburg","has_results":false},{"nct_id":"NCT03451955","title":"The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CIS","phase":"NA","overall_status":"COMPLETED","enrollment_count":103,"lead_sponsor_name":"University of Copenhagen","has_results":false},{"nct_id":"NCT03345537","title":"Initial Clinical Presentation of Inflammatory Optic Neuritis Associated or Not With Autoantibodies Anti-Myelin-oligodendrocyte-glycoprotein","phase":"","overall_status":"COMPLETED","enrollment_count":103,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT05487989","title":"VIsual Pathways Model in Neuro-inflammatory Disorders","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University Hospital, Lille","has_results":false},{"nct_id":"NCT04935970","title":"Metabolic Disorders and Vertigo","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"I.M. Sechenov First Moscow State Medical University","has_results":false},{"nct_id":"NCT03493321","title":"Role of PRF With MTA and Theracal After Pulpotomy in Relieving Pain","phase":"NA","overall_status":"UNKNOWN","enrollment_count":98,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT03533426","title":"Ultrasound-guided Serratus Block and the Emergence of Post-thoracotomy Pain Syndrome","phase":"NA","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"National Cancer Institute, Egypt","has_results":false},{"nct_id":"NCT03536559","title":"Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":73,"lead_sponsor_name":"Clene Nanomedicine","has_results":false},{"nct_id":"NCT02939937","title":"Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":71,"lead_sponsor_name":"Tehran University of Medical Sciences","has_results":true},{"nct_id":"NCT06776224","title":"Visual (Path)Ways in Multiple Sclerosis - Part II","phase":"NA","overall_status":"RECRUITING","enrollment_count":64,"lead_sponsor_name":"University Hospital, Lille","has_results":false},{"nct_id":"NCT03247413","title":"Post-lesion Administration of Dexamethasone to Prevent the Development of Neuritis After Radiofrequency Ablation","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":63,"lead_sponsor_name":"Johns Hopkins University","has_results":true},{"nct_id":"NCT02657915","title":"Long-Term Assessment of Remyelinating Therapy","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Biogen","has_results":true},{"nct_id":"NCT04678167","title":"Boarding Ring Glasses Versus Placebo Glasses or Not Glasses in the Treatment of Vestibular Neuritis","phase":"NA","overall_status":"RECRUITING","enrollment_count":51,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04942002","title":"Retrobulbar Methylprednisolone as Adjunctive Treatment in Optic Neuritis Trial","phase":"PHASE2, PHASE3","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Asociación para Evitar la Ceguera en México","has_results":false},{"nct_id":"NCT03821155","title":"Does Vestibular Rehabilitation Significantly Improve the Level of Vestibular Function Following Vestibular Neuritis?","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Aalborg University Hospital","has_results":false},{"nct_id":"NCT06389968","title":"Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple Sclerosis","phase":"NA","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"Technical University of Munich","has_results":false},{"nct_id":"NCT05540262","title":"Edaravone in the Treatment of Optic Neuritis","phase":"NA","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"First Affiliated Hospital of Guangxi Medical University","has_results":false},{"nct_id":"NCT04289909","title":"Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Institut National de la Santé Et de la Recherche Médicale, France","has_results":false},{"nct_id":"NCT03630497","title":"BN201 SAD MAD Study in Healthy Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":48,"lead_sponsor_name":"Accure Therapeutics","has_results":false},{"nct_id":"NCT05881811","title":"The Drug-drug Interaction of HSK16149 Capsule With Probenecid Tablets or Cimetidine Tablets in Healthy Subjects","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Haisco Pharmaceutical Group Co., Ltd.","has_results":false},{"nct_id":"NCT03441347","title":"Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction","phase":"NA","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT03570385","title":"Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT03963310","title":"Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis","phase":"","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"Fondation Ophtalmologique Adolphe de Rothschild","has_results":false},{"nct_id":"NCT04762017","title":"OCS-05 in Patients With Optic Neuritis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"Oculis","has_results":false},{"nct_id":"NCT03452410","title":"MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla","phase":"","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"University Hospital, Strasbourg, France","has_results":false},{"nct_id":"NCT05444413","title":"Platelet-rich Plasma in the Treatment of Intractable Postherpetic Neuralgia","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Affiliated Hospital of Nantong University","has_results":false},{"nct_id":"NCT05157399","title":"Quantification of the Effect of the OtoBand on Objective Measures of Vertigo and Dizziness","phase":"NA","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"Otolith Labs","has_results":false},{"nct_id":"NCT05537636","title":"Physical Therapy on Non-structural Medial Elbow Pain","phase":"NA","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"Timothy Uhl","has_results":false},{"nct_id":"NCT05353413","title":"Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"Medical University of Bialystok","has_results":false},{"nct_id":"NCT03302585","title":"High-Dose Vitamin D Induction in Optic Neuritis","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":12,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT02976766","title":"Gypenosides Treatment for Optic Neuritis","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":10,"lead_sponsor_name":"First Affiliated Hospital of Guangxi Medical University","has_results":false},{"nct_id":"NCT03862313","title":"Repetitive Transorbital Alternating Current Stimulation in Acute Autoimmune Optic Neuritis","phase":"NA","overall_status":"TERMINATED","enrollment_count":2,"lead_sponsor_name":"University of Zurich","has_results":false}],"total":45},"guidelines":[],"source":"Drug Landscape verified database"}