{"disease":{"id":"neoplasms","name":"neoplasms"},"drugs":{"marketed":[{"drug_id":"sacituzumab-govitecan","indication_name":"Triple negative breast neoplasms","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Trodelvy","generic_name":"sacituzumab-govitecan","company_name":"Immunomedics Inc","drug_phase":"marketed","molecular_target":"Tumor-associated calcium signal transducer 2","drug_class":"","quality_score":68,"revenue":"800","mechanism":"Trodelvy works by binding to the TACI receptor on cancer cells, triggering a cascade of events that ultimately leads to cell death."},{"drug_id":"cobimetinib","indication_name":"Histiocytic Neoplasms","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cotellic","generic_name":"cobimetinib","company_name":"Roche","drug_phase":"marketed","molecular_target":"Dual specificity mitogen-activated protein kinase kinase 1","drug_class":"Kinase Inhibitor","quality_score":66,"revenue":"200","mechanism":"Cotellic works by blocking the activity of two proteins, BRAF and MEK, which are involved in the growth and spread of cancer cells."},{"drug_id":"part-c-met097","indication_name":"Treatment of Myeloproliferative Neoplasms (MPNs)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"(Part C) MET097","generic_name":"part-c-met097","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Unknown","drug_class":"Unknown","quality_score":37,"revenue":null,"mechanism":"The exact mechanism of action is not specified on Wikipedia."},{"drug_id":"pf-07059013","indication_name":"Treatment of certain types of myeloproliferative neoplasms","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pf-07059013","generic_name":"pf-07059013","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Unknown","drug_class":"Unknown","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"fytic-acid","indication_name":"Lymphoscintigraphy in cervical cancer, uterine neoplasms, vulvar cancer, and head and neck canccer","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Phyliance","generic_name":"fytic acid","company_name":"PDRadiopharma Inc","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":20,"revenue":null,"mechanism":""},{"drug_id":"pembrolizuma","indication_name":"Triple negative breast neoplasms","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Pembrolizuma","company_name":"Memorial Sloan Kettering Cancer Center","drug_phase":"marketed","molecular_target":"Programmed cell death protein 1","drug_class":"","quality_score":14,"revenue":null,"mechanism":null}],"pipeline":[{"drug_id":"pf-07260437","indication_name":"Advanced or metastatic solid tumors (including ovarian, endometrial, and breast neoplasms)","indication_type":"pipeline","phase":"Phase 1","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"PF-07260437","generic_name":"pf-07260437","company_name":"Pfizer Inc.","drug_phase":"discontinued","molecular_target":"Unknown","drug_class":"Unknown oncology compound","quality_score":null,"revenue":null,"mechanism":"Mechanism of action unknown; experimental oncology compound discontinued during Phase 1 development."},{"drug_id":"felmetatug-vedotin","indication_name":"Ovarian Neoplasms","indication_type":"pipeline","phase":"discontinued","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Felmetatug Vedotin","generic_name":"felmetatug-vedotin","company_name":"Pfizer Inc.","drug_phase":"discontinued","molecular_target":"","drug_class":"Given into the vein (IV; intravenously)","quality_score":null,"revenue":null,"mechanism":"Given into the vein (IV; intravenously)"},{"drug_id":"palbociclib-plus-fulvestrant","indication_name":"Breast Neoplasms","indication_type":"pipeline","phase":"preclinical","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"palbociclib plus fulvestrant","generic_name":"palbociclib-plus-fulvestrant","company_name":"Pfizer Inc.","drug_phase":"preclinical","molecular_target":"","drug_class":"Patients treated with the combination of palbociclib and fulvestrant","quality_score":null,"revenue":null,"mechanism":"Patients treated with the combination of palbociclib and fulvestrant"},{"drug_id":"palbociclib-endocrine-therapy","indication_name":"Breast Neoplasms","indication_type":"pipeline","phase":"preclinical","line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Palbociclib + endocrine therapy","generic_name":"palbociclib-endocrine-therapy","company_name":"Pfizer Inc.","drug_phase":"preclinical","molecular_target":"","drug_class":"Palbociclib + letrozole, or Palbociclib + anastrozole, or Palbociclib + exemestane, or Palbociclib +","quality_score":null,"revenue":null,"mechanism":"Palbociclib + letrozole, or Palbociclib + anastrozole, or Palbociclib + exemestane, or Palbociclib +"}],"offLabel":[],"totalMarketed":6,"totalPipeline":4},"trials":{"data":[{"nct_id":"NCT03579732","title":"EffectiveNess of Low Dose Aspirin in GastrointEstinal Cancer Prevention - Taiwan","phase":"","overall_status":"COMPLETED","enrollment_count":4710504,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04996732","title":"Long-term Survivorship of Discharged Patients With Malignant Tumor Based on Single-institutional Cancer Registry","phase":"","overall_status":"RECRUITING","enrollment_count":500000,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT05888623","title":"Computer Assisted Detection of Neoplasia During Colonoscopy Evaluation","phase":"","overall_status":"COMPLETED","enrollment_count":334200,"lead_sponsor_name":"VA Puget Sound Health Care System","has_results":false},{"nct_id":"NCT07513259","title":"Pre-Diagnosis GLP-1 Receptor Agonist Use and Post-Cancer Mortality in Adults With Obesity and Type 2 Diabetes","phase":"","overall_status":"COMPLETED","enrollment_count":203424,"lead_sponsor_name":"Chung Shan Medical University","has_results":false},{"nct_id":"NCT05380570","title":"Epidemiological Study of Korean Radiation Workers","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":196379,"lead_sponsor_name":"Korea Institute of Radiological & Medical Sciences","has_results":false},{"nct_id":"NCT00410475","title":"Cancer Risk in X-Ray Technologists: Second Survey","phase":"","overall_status":"COMPLETED","enrollment_count":146022,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT05526599","title":"The Association of Marital Status With Kidney Cancer Surgery Morbidity","phase":"","overall_status":"COMPLETED","enrollment_count":106752,"lead_sponsor_name":"Beijing Tsinghua Chang Gung Hospital","has_results":false},{"nct_id":"NCT05013944","title":"AnovaOS Network Powered Patient Registry","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Anova Enterprises, Inc","has_results":false},{"nct_id":"NCT06528236","title":"Research and Application of Ultrasonic Intelligent Diagnosis System for Ovarian Mass","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100000,"lead_sponsor_name":"Zhejiang Provincial People's Hospital","has_results":false},{"nct_id":"NCT03085888","title":"The STRIVE Study: Development of a Blood Test for Early Detection of Multiple Cancer Types","phase":"","overall_status":"COMPLETED","enrollment_count":99481,"lead_sponsor_name":"GRAIL, Inc.","has_results":false},{"nct_id":"NCT07143110","title":"LUNG-ROLL: Treatment Patterns and Cost of Illness of Lung Cancer in Canada","phase":"","overall_status":"RECRUITING","enrollment_count":60000,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT04292366","title":"Optimising Colorectal Cancer Screening Participation","phase":"NA","overall_status":"COMPLETED","enrollment_count":60000,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT06187350","title":"The Use of AI to Safely Reduce the Workload in Breast Cancer Screening With Mammography in Region Östergötland","phase":"","overall_status":"COMPLETED","enrollment_count":60000,"lead_sponsor_name":"Ostergotland County Council, Sweden","has_results":false},{"nct_id":"NCT01837693","title":"Cervical Cancer Prevention: From DNA to mRNA? - New Technologies for Cervical Cancer Screening 2","phase":"NA","overall_status":"COMPLETED","enrollment_count":41127,"lead_sponsor_name":"Azienda USL Reggio Emilia - IRCCS","has_results":false},{"nct_id":"NCT03581890","title":"Socioeconomic Position in Acute Colorectal Cancer Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":35000,"lead_sponsor_name":"Zealand University Hospital","has_results":false},{"nct_id":"NCT02623712","title":"The Watch the Spot Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":34686,"lead_sponsor_name":"Kaiser Permanente","has_results":false},{"nct_id":"NCT04679675","title":"Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":32771,"lead_sponsor_name":"Kaiser Permanente","has_results":true},{"nct_id":"NCT06338592","title":"The MyLungHealth Study Protocol: Engaging Patients to Enable Interoperable Lung Cancer Decision Support at Scale","phase":"NA","overall_status":"COMPLETED","enrollment_count":31303,"lead_sponsor_name":"University of Utah","has_results":true},{"nct_id":"NCT03669926","title":"The Tomosynthesis Trial in Bergen - Part 2","phase":"NA","overall_status":"COMPLETED","enrollment_count":31082,"lead_sponsor_name":"Norwegian Institute of Public Health","has_results":false},{"nct_id":"NCT05022511","title":"Three Birds With One Stone","phase":"NA","overall_status":"COMPLETED","enrollment_count":27099,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT03424668","title":"The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":25639,"lead_sponsor_name":"University of Cambridge","has_results":false},{"nct_id":"NCT06001073","title":"Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics","phase":"","overall_status":"RECRUITING","enrollment_count":25000,"lead_sponsor_name":"First Affiliated Hospital Xi'an Jiaotong University","has_results":false},{"nct_id":"NCT05275530","title":"The Impact of Choice on Colorectal Cancer Screening","phase":"NA","overall_status":"COMPLETED","enrollment_count":20509,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT05281159","title":"Increasing Engagement With Messages Regarding CRC Screening Among Adults Aged 45-49","phase":"NA","overall_status":"COMPLETED","enrollment_count":20509,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT04061967","title":"Research Project on Reminders and Self-Sampling Can Increase Participation in Gynecology Cell Sampling - Preventive Examination Against Cervical Cancer.","phase":"NA","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT06591039","title":"A Multicenter Prospective Observational Cohort Based on a Breast Cancer Medical Record Database in China","phase":"","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT05141656","title":"Construction and Evaluation of China's Advanced Pancreatic Tumor Big Data Center","phase":"","overall_status":"UNKNOWN","enrollment_count":20000,"lead_sponsor_name":"RenJi Hospital","has_results":false},{"nct_id":"NCT06167356","title":"Study on the Occurrence of Possible Relapses and on the Quality of Life in Patients Who Underwent TURBK.","phase":"","overall_status":"RECRUITING","enrollment_count":20000,"lead_sponsor_name":"IRCCS San Raffaele","has_results":false},{"nct_id":"NCT06917612","title":"Preserving or Resecting the Normal Appendix in Patients Undergoing Laparoscopy Surgery for Suspected Appendicitis","phase":"","overall_status":"COMPLETED","enrollment_count":20000,"lead_sponsor_name":"Herlev Hospital","has_results":false},{"nct_id":"NCT05184751","title":"Incidence and Risk Factors of Early Onset Colorectal Cancer","phase":"","overall_status":"COMPLETED","enrollment_count":18257,"lead_sponsor_name":"Hospital Frydek-Mistek","has_results":false},{"nct_id":"NCT06548464","title":"Interpretable Machine Learning Models for Prognosis in Gastric Cancer Patients","phase":"","overall_status":"COMPLETED","enrollment_count":18000,"lead_sponsor_name":"Chang-Ming Huang, Prof.","has_results":false},{"nct_id":"NCT02900287","title":"Cancer Survival in Reunion Island , 1998-2008 (SUCRE)","phase":"","overall_status":"COMPLETED","enrollment_count":18000,"lead_sponsor_name":"Centre Hospitalier Universitaire de la Réunion","has_results":false},{"nct_id":"NCT07415291","title":"CNN-Based AI Versus Physicians for Solitary Skin Lesion Diagnosis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":17625,"lead_sponsor_name":"Istanbul Training and Research Hospital","has_results":false},{"nct_id":"NCT03510923","title":"Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy","phase":"","overall_status":"COMPLETED","enrollment_count":17380,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT03471494","title":"GlobalSurg 3: Quality and Outcomes in Global Cancer Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":15958,"lead_sponsor_name":"University of Edinburgh","has_results":false},{"nct_id":"NCT02963675","title":"Incidence of Second Primary Malignancies in Prostate Cancer Patients With Bone Metastases - an Observational Retrospective Cohort Study in Sweden","phase":"","overall_status":"COMPLETED","enrollment_count":15953,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT04395352","title":"Effectiveness of Endocuff Vision in Improving ADR","phase":"","overall_status":"COMPLETED","enrollment_count":15816,"lead_sponsor_name":"University of Calgary","has_results":false},{"nct_id":"NCT05012527","title":"Retrospective Review of Gastrointestinal System Endoscopy Procedures","phase":"","overall_status":"COMPLETED","enrollment_count":15448,"lead_sponsor_name":"Istanbul Sultanbeyli State Hospital","has_results":false},{"nct_id":"NCT05636085","title":"Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":15000,"lead_sponsor_name":"Mainz Biomed","has_results":false},{"nct_id":"NCT04712292","title":"Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer","phase":"","overall_status":"UNKNOWN","enrollment_count":15000,"lead_sponsor_name":"University of Bologna","has_results":false},{"nct_id":"NCT04991805","title":"Descriptive Study of the Incidence of Malignancy in Severe Asthma Patients Receiving Benralizumab and Other Biologic Therapy, a Post Authorization Safety Study","phase":"","overall_status":"COMPLETED","enrollment_count":14000,"lead_sponsor_name":"AstraZeneca","has_results":false},{"nct_id":"NCT02613260","title":"Mailed FIT Outreach to Improve Colon Cancer Screening in the Safety-net System","phase":"NA","overall_status":"COMPLETED","enrollment_count":13470,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT06335290","title":"Radiotherapy Treatments for the Treatment of Thoracic District Tumors","phase":"","overall_status":"UNKNOWN","enrollment_count":13200,"lead_sponsor_name":"European Institute of Oncology","has_results":false},{"nct_id":"NCT03598946","title":"Urinary Human Papilloma Virus Test in the General Population in Brittany","phase":"NA","overall_status":"UNKNOWN","enrollment_count":12500,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04404777","title":"Local Recurrence Due to Rectal Cancer in Sweden","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":12000,"lead_sponsor_name":"Sahlgrenska University Hospital","has_results":false},{"nct_id":"NCT04129177","title":"Reduction of Surgical Site Infections in Elective Colorectal Surgery After the Implementation of a Bundle of Care.","phase":"","overall_status":"COMPLETED","enrollment_count":12000,"lead_sponsor_name":"Hospital de Granollers","has_results":false},{"nct_id":"NCT05675085","title":"Risk-Based Breast Screening in Young Women","phase":"NA","overall_status":"UNKNOWN","enrollment_count":10269,"lead_sponsor_name":"Istituto Oncologico Veneto IRCCS","has_results":false},{"nct_id":"NCT03739827","title":"Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT06815939","title":"Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"DL Analytics","has_results":false},{"nct_id":"NCT04654975","title":"Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Universitaire Ziekenhuizen KU Leuven","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}