{"disease":{"id":"mycobacterium","name":"mycobacterium"},"drugs":{"marketed":[{"drug_id":"azithromycin","indication_name":"Pulmonary Mycobacterium avium complex infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zithromax","generic_name":"azithromycin","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Canalicular multispecific organic anion transporter 1, Taste receptor type 2 member 4, Motilin receptor","drug_class":"Macrolide antibiotic (azalide)","quality_score":67,"revenue":"399","mechanism":"Macrolide antibiotic that binds the 50S ribosomal subunit, inhibiting bacterial protein synthesis with an exceptionally long tissue half-life."},{"drug_id":"tuberculin","indication_name":"infection with Mycobacterium tuberculosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Aplisol","generic_name":"TUBERCULIN","company_name":"ENDO USA, Inc.","drug_phase":"marketed","molecular_target":"","drug_class":"Skin Test Antigen [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"amikacin","indication_name":"Nontuberculous mycobacterial pulmonary disease caused by amikacin-sensitive Mycobacteriumavium complex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Arikayce Kit","generic_name":"AMIKACIN","company_name":"Bristol-Myers Squibb","drug_phase":"marketed","molecular_target":"","drug_class":"Aminoglycoside Antibacterial","quality_score":10,"revenue":null,"mechanism":"Amikacin works by binding to bacterial ribosomes, inhibiting protein synthesis and ultimately killing the bacteria."},{"drug_id":"ethionamide","indication_name":"Pulmonary Mycobacterium avium complex infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Trecator","generic_name":"ETHIONAMIDE","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"","drug_class":"Antimycobacterial","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"clarithromycin","indication_name":"Pulmonary Mycobacterium avium complex infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Biaxin","generic_name":"clarithromycin","company_name":"Generic (originally Abbott/AbbVie)","drug_phase":"marketed","molecular_target":"Potassium voltage-gated channel subfamily H member 2","drug_class":"Macrolide Antimicrobial [EPC]","quality_score":65,"revenue":null,"mechanism":"Clarithromycin is a macrolide antimicrobial drug."},{"drug_id":"mycobutin","indication_name":"Pulmonary Mycobacterium avium complex infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Mycobutin","company_name":"Harriet Shezi Children's Clinic","drug_phase":"marketed","molecular_target":"Bacterial DNA-directed RNA polymerase, DNA-directed RNA polymerase subunit beta","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04351685","title":"Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":6940,"lead_sponsor_name":"Serum Institute of India Pvt. Ltd.","has_results":false},{"nct_id":"NCT05280886","title":"Multi-site Cohort Study for the Development of Personalized Pharmacotherapy in Patients With Tuberculosis (TB)","phase":"","overall_status":"UNKNOWN","enrollment_count":5000,"lead_sponsor_name":"Inje University","has_results":false},{"nct_id":"NCT01547884","title":"Effect of Filarial Infection on Immune Responses in Latent Tuberculosis","phase":"","overall_status":"COMPLETED","enrollment_count":4268,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT02832843","title":"Genome-Wide Association Study in Patients With Nontuberculous Mycobacterial Lung Disease","phase":"","overall_status":"COMPLETED","enrollment_count":2808,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05336851","title":"Emergency PWAS in Respiratory Infectious Disease","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT03120481","title":"Controls for Respiratory Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":1572,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT07377864","title":"Clinical Characteristics and Immune Escape Mechanism of Nontuberculous Mycobacterial Lung Disease in South China","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Eighth Affiliated Hospital, Sun Yat-sen University","has_results":false},{"nct_id":"NCT00018044","title":"Study of Mycobacterial Infections","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT06253715","title":"Shortened Regimen for Drug-susceptible TB in Children","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":860,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT04526613","title":"The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population","phase":"","overall_status":"COMPLETED","enrollment_count":626,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT03672630","title":"Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":474,"lead_sponsor_name":"Kevin Winthrop","has_results":false},{"nct_id":"NCT04677569","title":"Study to Evaluate ALIS (Amikacin Liposome Inhalation Suspension) in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":425,"lead_sponsor_name":"Insmed Incorporated","has_results":false},{"nct_id":"NCT04345939","title":"Rapid and Accurate Detection of Major Mycobacterium Species in Pulmonary Infection Based on GenSeizer Platform","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Shanghai Pulmonary Hospital, Shanghai, China","has_results":false},{"nct_id":"NCT02344004","title":"Study to Evaluate Efficacy of LAI When Added to Multi-drug Regimen Compared to Multi-drug Regimen Alone","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":336,"lead_sponsor_name":"Insmed Incorporated","has_results":true},{"nct_id":"NCT07174076","title":"Prevention of Recurrence With Cordyceps Sinensis in Mycobacterium Avium Complex Pulmonary Disease","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Bin Cao","has_results":false},{"nct_id":"NCT00814827","title":"Mycobacterial and Opportunistic Infections in HIV-Negative Thai and Taiwanese Patients Associated With Autoantibodies to Interferon-gamma","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":224,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT07213765","title":"Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":188,"lead_sponsor_name":"Bin Cao","has_results":false},{"nct_id":"NCT07084402","title":"Short-term Bactericidal Effect of Contezolid in MAC-PD","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":188,"lead_sponsor_name":"Bin Cao","has_results":false},{"nct_id":"NCT01150721","title":"Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection","phase":"","overall_status":"COMPLETED","enrollment_count":177,"lead_sponsor_name":"National Institutes of Health Clinical Center (CC)","has_results":false},{"nct_id":"NCT01212003","title":"Training Protocol on the Natural History of Tuberculosis","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT06845618","title":"Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment","phase":"","overall_status":"RECRUITING","enrollment_count":140,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT04493671","title":"Evaluate Safety, Tolerability, PK of TBAJ-876 in Healthy Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":137,"lead_sponsor_name":"Global Alliance for TB Drug Development","has_results":false},{"nct_id":"NCT06418711","title":"ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":132,"lead_sponsor_name":"Mannkind Corporation","has_results":false},{"nct_id":"NCT04630145","title":"A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":129,"lead_sponsor_name":"Janssen Pharmaceutical K.K.","has_results":true},{"nct_id":"NCT00340990","title":"Immune Responses to Mycobacterium Tuberculosis","phase":"","overall_status":"COMPLETED","enrollment_count":111,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT05906316","title":"A Prospective, Multicenter, Single-arm MAC-PD Cohort: a NTM-NET and ESGMYC Collaborative Study","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT06155747","title":"Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"National Jewish Health","has_results":false},{"nct_id":"NCT06531772","title":"Characteristics and Outcomes of TB and HIV Co-infections","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT05610098","title":"Gene Expression Profiles in Spinal Tuberculosis.","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Cape Town","has_results":false},{"nct_id":"NCT04024423","title":"Healthcare-associated Links in Transmission of Nontuberculous Mycobacteria in Cystic Fibrosis","phase":"","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"National Jewish Health","has_results":false},{"nct_id":"NCT04677543","title":"Validation of Patient Reported Outcome Measures in Participants With Nontuberculous Mycobacterial Lung Infection Caused by Mycobacterium Avium Complex","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":99,"lead_sponsor_name":"Insmed Incorporated","has_results":true},{"nct_id":"NCT01315236","title":"Liposomal Amikacin for Inhalation (LAI) for Nontuberculous Mycobacteria","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Insmed Incorporated","has_results":true},{"nct_id":"NCT04922554","title":"Oral Omadacycline vs. Placebo in Adults With NTM Pulmonary Disease Caused by Mycobacterium Abscessus Complex (MABc)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"Paratek Pharmaceuticals Inc","has_results":true},{"nct_id":"NCT07514364","title":"The Effect of Rifabutin in Mycobacterium Abscessus With Inducible Clarithromycin Resistance","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT06819449","title":"Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"South Valley University","has_results":false},{"nct_id":"NCT04921943","title":"Hypertonic Saline for MAC","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":50,"lead_sponsor_name":"Oregon Health and Science University","has_results":false},{"nct_id":"NCT07094711","title":"Safety, Immunogenicity, and Efficacy of Therapeutic Mycobacterium Bovis BCG (BOOST)","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":48,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT04294043","title":"IV Gallium Study for Patients With Cystic Fibrosis Who Have NTM (ABATE Study)","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"Chris Goss","has_results":false},{"nct_id":"NCT04121494","title":"ChAdOx1 85A Aerosol Versus Intramuscular Vaccination in Healthy Adults (TB039)","phase":"EARLY_PHASE1","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"François Spertini","has_results":false},{"nct_id":"NCT05354583","title":"Treatment Outcome Between Mycobacterium Abscessus Infection in Chronic Lung Disease and Acquired Interferon-gamma Autoantibody Syndrome","phase":"","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"King Chulalongkorn Memorial Hospital","has_results":false},{"nct_id":"NCT01381757","title":"Utility of MODS for Diagnosis of MDR-TB and Second-Line Antituberculous Drug Susceptibility Testing in Mali","phase":"","overall_status":"TERMINATED","enrollment_count":34,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT03309358","title":"A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":32,"lead_sponsor_name":"Synspira, Inc.","has_results":false},{"nct_id":"NCT03421743","title":"Pilot Trial of Inhaled Molgramostim in Non-tuberculous Mycobacterial (NTM) Infection","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Savara Inc.","has_results":true},{"nct_id":"NCT03590600","title":"A Single Ascending Dose Study of BTZ043","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Michael Hoelscher","has_results":false},{"nct_id":"NCT05192057","title":"Hypertonic Saline Inhalation for Mycobacterium Avium Complex Pulmonary Disease","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT03027193","title":"A Study to Determine the Safety and Immunogenicity of a Candidate MAP Vaccines ChAdOx2 HAV and MVA in Healthy Adult Volunteers","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"University of Oxford","has_results":false},{"nct_id":"NCT05526911","title":"A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"Global Alliance for TB Drug Development","has_results":true},{"nct_id":"NCT07372781","title":"Clinical Study on the Early Bactericidal Activity of Contezolid Against Mycobacterium Abscessus Disease","phase":"PHASE2","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":24,"lead_sponsor_name":"Beijing Chest Hospital","has_results":false},{"nct_id":"NCT06004037","title":"Study to Evaluate the Efficacy of Delpazolid as Add-on Therapy in Refractory Mycobacterium Abscessus Complex","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":20,"lead_sponsor_name":"LigaChem Biosciences, Inc.","has_results":false},{"nct_id":"NCT04685720","title":"A Pilot Study to Assess the Effect of Intermittent iNO on the Treatment of NTM Lung Infection in CF and Non-CF Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Beyond Air Inc.","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}