{"disease":{"id":"motor-neuron-disease","name":"motor neuron disease"},"drugs":{"marketed":[],"pipeline":[],"offLabel":[],"totalMarketed":0,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05966038","title":"ALS/MND Natural History Study Data Repository","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT00004568","title":"Study of Inherited Neurological Disorders","phase":"","overall_status":"RECRUITING","enrollment_count":3500,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT06201650","title":"Neurofilament Light Chain in Amyotrophic Lateral Sclerosis","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Charite University, Berlin, Germany","has_results":false},{"nct_id":"NCT04961450","title":"Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2500,"lead_sponsor_name":"Peking University Third Hospital","has_results":false},{"nct_id":"NCT05852405","title":"Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS","phase":"","overall_status":"COMPLETED","enrollment_count":2000,"lead_sponsor_name":"Ambulanzpartner Soziotechnologie APST GmbH","has_results":false},{"nct_id":"NCT06885918","title":"ALS Research Collaborative","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"ALS Therapy Development Institute","has_results":false},{"nct_id":"NCT05137665","title":"Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Target ALS Foundation, Inc.","has_results":false},{"nct_id":"NCT06376279","title":"Genetic Diagnosis in Inborn Errors of Metabolism","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1000,"lead_sponsor_name":"Region Stockholm","has_results":false},{"nct_id":"NCT07132879","title":"Telehealth in MND-Research (TIM-R): A Research Database for MND","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Sheffield","has_results":false},{"nct_id":"NCT07233148","title":"Healing ALS Registry Observational Study (HAROS)","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Healing Advocates Registry and Ministry","has_results":false},{"nct_id":"NCT06072287","title":"The Living With a Long-Term Condition Study","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT04706234","title":"Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"Kliniken Beelitz GmbH","has_results":false},{"nct_id":"NCT04430686","title":"Respiratory Complications in ALS","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Liverpool University Hospitals NHS Foundation Trust","has_results":false},{"nct_id":"NCT01900132","title":"Electrical Impedance Myography: Natural History Studies inNeuromuscular Disorders and Healthy Volunteers","phase":"NA","overall_status":"RECRUITING","enrollment_count":275,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT04579666","title":"MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":249,"lead_sponsor_name":"Apellis Pharmaceuticals, Inc.","has_results":true},{"nct_id":"NCT05136222","title":"Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":244,"lead_sponsor_name":"University of Melbourne","has_results":false},{"nct_id":"NCT06320444","title":"Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease","phase":"","overall_status":"UNKNOWN","enrollment_count":240,"lead_sponsor_name":"University of Dublin, Trinity College","has_results":false},{"nct_id":"NCT05744310","title":"Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Haukeland University Hospital","has_results":false},{"nct_id":"NCT03764384","title":"Validation Of Tidal/End -Tidal CO2 in ALS","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Papworth Hospital NHS Foundation Trust","has_results":false},{"nct_id":"NCT06318598","title":"Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT06318585","title":"Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT05354622","title":"Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT06566651","title":"Emotion Processing Among Patients With ALS","phase":"","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT04939818","title":"Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":172,"lead_sponsor_name":"Novoic Limited","has_results":false},{"nct_id":"NCT04695210","title":"Virtual Peer-to-peer Support Programme for Carers of MND","phase":"NA","overall_status":"RECRUITING","enrollment_count":154,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT03127514","title":"AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":137,"lead_sponsor_name":"Amylyx Pharmaceuticals Inc.","has_results":true},{"nct_id":"NCT04825119","title":"Hyperkinetic Movements in Patients With Disease of Motor Neurons and Their Response to Treatment With Nusinersen","phase":"","overall_status":"UNKNOWN","enrollment_count":110,"lead_sponsor_name":"University Medical Centre Ljubljana","has_results":false},{"nct_id":"NCT06765499","title":"The Study Evaluating the Improvement of Nutritional Status and Frailty With Silkworm Pupa Powder Among Patients With Motor Neuron Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"First People's Hospital of Hangzhou","has_results":false},{"nct_id":"NCT05077696","title":"Neurofilament Assay for the Diagnosis of ALS","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05183152","title":"Non-invasive BCI-controlled Assistive Devices","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"University of Texas at Austin","has_results":false},{"nct_id":"NCT02124057","title":"Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy","phase":"","overall_status":"COMPLETED","enrollment_count":71,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT04944940","title":"Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)","phase":"","overall_status":"RECRUITING","enrollment_count":70,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT03356288","title":"The General Breathing Record Study","phase":"","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"TidalSense","has_results":false},{"nct_id":"NCT01369901","title":"Effect of Functional Exercise in Patients With Spinal Bulbar Muscular Atrophy","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":61,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT06820008","title":"Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"University of Dublin, Trinity College","has_results":false},{"nct_id":"NCT03196375","title":"A Study to Assess FLX-787 in Subjects With Motor Neuron Disease Experiencing Muscle Cramps.","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":54,"lead_sponsor_name":"Flex Pharma, Inc.","has_results":false},{"nct_id":"NCT02870634","title":"Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Collaborative Medicinal Development Pty Limited","has_results":false},{"nct_id":"NCT04240925","title":"Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":44,"lead_sponsor_name":"Ospedale San Raffaele","has_results":false},{"nct_id":"NCT02819765","title":"Deep Phenotyping in Patients With ALS","phase":"","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Barrow Neurological Institute","has_results":false},{"nct_id":"NCT04293484","title":"Cortico-Spinal tDCS as Rehabilitative Intervention in Amyotrophic Lateral Sclerosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","has_results":false},{"nct_id":"NCT07204977","title":"Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)","phase":"PHASE1","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":30,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT05314348","title":"Surface EMG and Ultrasound in MND","phase":"NA","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"King's College Hospital NHS Trust","has_results":false},{"nct_id":"NCT03809845","title":"Serial Fasciculation Measurements in Motor Neurone Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"King's College Hospital NHS Trust","has_results":false},{"nct_id":"NCT03706391","title":"Study of ALS Reversals 4: LifeTime Exposures","phase":"","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT00362362","title":"Collection of Blood Samples for DNA in Motor Neuron Disease","phase":"","overall_status":"COMPLETED","enrollment_count":23,"lead_sponsor_name":"National Institute of Neurological Disorders and Stroke (NINDS)","has_results":false},{"nct_id":"NCT03520517","title":"Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"Biohaven Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT04788745","title":"Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":21,"lead_sponsor_name":"The University of Queensland","has_results":false},{"nct_id":"NCT03154450","title":"EncoreAnywhere Use in Motor Neurone Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":19,"lead_sponsor_name":"Sheffield Teaching Hospitals NHS Foundation Trust","has_results":false},{"nct_id":"NCT03690791","title":"Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":17,"lead_sponsor_name":"Gold Coast Hospital and Health Service","has_results":false},{"nct_id":"NCT05292690","title":"An Assistive Powered Wheelchair: Stage 2 Trial","phase":"","overall_status":"COMPLETED","enrollment_count":17,"lead_sponsor_name":"East Kent Hospitals University NHS Foundation Trust","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}