{"disease":{"id":"midline","name":"midline"},"drugs":{"marketed":[{"drug_id":"dordaviprone","indication_name":"diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Modeyso","generic_name":"DORDAVIPRONE","company_name":"Chimerix","drug_phase":"marketed","molecular_target":"Dopamine","drug_class":"Protease Activator [EPC]","quality_score":57,"revenue":null,"mechanism":"Modeyso works by binding to dopamine receptors in the brain, which helps to slow the growth of cancer cells."},{"drug_id":"dordaviprone","indication_name":"diffuse midline glioma harboring an H3 K27M mutation with progressive disease following prior therapy","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Modeyso","generic_name":"DORDAVIPRONE","company_name":"Chimerix","drug_phase":"marketed","molecular_target":"Dopamine","drug_class":"Protease Activator [EPC]","quality_score":57,"revenue":null,"mechanism":"Modeyso works by binding to dopamine receptors in the brain, which helps to slow the growth of cancer cells."}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05259605","title":"Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification","phase":"","overall_status":"RECRUITING","enrollment_count":1650,"lead_sponsor_name":"European Organisation for Research and Treatment of Cancer - EORTC","has_results":false},{"nct_id":"NCT07394296","title":"Study of the Prevalence of Midline Replacements and the Reasons for These Replacements","phase":"","overall_status":"RECRUITING","enrollment_count":984,"lead_sponsor_name":"Centre Hospitalier de Valenciennes","has_results":false},{"nct_id":"NCT06207630","title":"Prevention of the Risk of Complete Sternotomy Scar Dehiscence in Cardiac Surgery: A Clinical Investigation Comparing Negative Pressure Wound Therapy (NPWT) vs. Standard Dressing","phase":"NA","overall_status":"COMPLETED","enrollment_count":660,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT05835531","title":"Evaluation of the Efficacy and Safety of Midline Venous Catheters","phase":"","overall_status":"UNKNOWN","enrollment_count":400,"lead_sponsor_name":"Hospital El Cruce","has_results":false},{"nct_id":"NCT05009992","title":"Combination Therapy for the Treatment of Diffuse Midline Gliomas","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT05839379","title":"Targeted Pediatric High-Grade Glioma Therapy","phase":"","overall_status":"RECRUITING","enrollment_count":350,"lead_sponsor_name":"Nationwide Children's Hospital","has_results":false},{"nct_id":"NCT06904651","title":"VADIOR: Advantages of Pre-operative Positioning of Peripherally Inserted Vascular Accesses in DIVA Patients Undergoing Orthopedic Surgery","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT06668766","title":"Single Lumen Midline Catheter vs Long Peripheral Intravenous Cather for Difficult Intravenous Access in the ED","phase":"NA","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"Albany Medical College","has_results":false},{"nct_id":"NCT07254130","title":"COMPARISON OF MEAN DURATION OF POST OPERATIVE ANALGESIA FOLLOWING ADDITION OF DEXMEDETOMIDINE TO ROPIVACAINE VERSUS PLAIN ROPIVACAINE ON ULTRASOUND GUIDED RECTUS SHEATH BLOCK","phase":"NA","overall_status":"COMPLETED","enrollment_count":209,"lead_sponsor_name":"Quaid-e-Azam Medical College","has_results":false},{"nct_id":"NCT04732065","title":"ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":208,"lead_sponsor_name":"Sabine Mueller, MD, PhD","has_results":false},{"nct_id":"NCT04911842","title":"Midline Failures: A Comparison Between a Hydrophilic Biomaterial and Thermoplastic Polyurethane","phase":"","overall_status":"COMPLETED","enrollment_count":205,"lead_sponsor_name":"Access Vascular Inc","has_results":false},{"nct_id":"NCT04358159","title":"RCT Ventralex vs Onlay Mesh in Incisional Hernias","phase":"NA","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Karolinska Institutet","has_results":false},{"nct_id":"NCT01587703","title":"A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":196,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT03243461","title":"International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":167,"lead_sponsor_name":"University of Göttingen","has_results":false},{"nct_id":"NCT04471311","title":"Safety and Efficacy of Prophylactic Re-sorbable Biosynthetic Mesh Following Midline Laparotomy in Clean/Contaminated Field.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":151,"lead_sponsor_name":"Azienda Sanitaria Locale Napoli 2 Nord","has_results":false},{"nct_id":"NCT07218679","title":"Clinical Trial on the Use of Stratafix Symmetric vs. Resorbable Monofilament for Closure of Large Median Laparotomy in Oncological Patients","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":140,"lead_sponsor_name":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","has_results":false},{"nct_id":"NCT05351970","title":"Barbed Suture for Emergency Midline Laparotomy Closure","phase":"","overall_status":"COMPLETED","enrollment_count":128,"lead_sponsor_name":"Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana","has_results":false},{"nct_id":"NCT05843253","title":"Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Nationwide Children's Hospital","has_results":false},{"nct_id":"NCT04808063","title":"Algorithm for Prophylactic Mesh Use in Emergency Laparotomy.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Hospital del Mar","has_results":false},{"nct_id":"NCT07389278","title":"Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)","phase":"PHASE1, PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":97,"lead_sponsor_name":"Sabine Mueller, MD, PhD","has_results":false},{"nct_id":"NCT04131348","title":"Botulinum Toxin to Avoid Component Separation in Midline Large Hernias","phase":"NA","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Hospital Universitario La Fe","has_results":false},{"nct_id":"NCT05768880","title":"Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors","phase":"PHASE1","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":72,"lead_sponsor_name":"Seattle Children's Hospital","has_results":false},{"nct_id":"NCT06639607","title":"PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma","phase":"PHASE1, PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":68,"lead_sponsor_name":"Washington University School of Medicine","has_results":false},{"nct_id":"NCT03434262","title":"SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":68,"lead_sponsor_name":"St. Jude Children's Research Hospital","has_results":false},{"nct_id":"NCT04870944","title":"CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":63,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT03750357","title":"Percutaneous Electrical Nerve Stimulation (PENS) of the Auricle for Post Operative Pain Solution(POPS) - Cardiac Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"DyAnsys, Inc.","has_results":false},{"nct_id":"NCT06894979","title":"Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":54,"lead_sponsor_name":"Children's Oncology Group","has_results":false},{"nct_id":"NCT02960230","title":"H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Sabine Mueller, MD, PhD","has_results":true},{"nct_id":"NCT07416422","title":"Onlay Mesh in Abdominal Aortic Aneurysm Repair.","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Hospital Universitario Ramon y Cajal","has_results":false},{"nct_id":"NCT05199974","title":"Comparison Between Conventional and Modified Smead Jones Method for Mass Closure in Emergency Midline Laparotomy","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT06902909","title":"Laparoscopic Pectopexy and Laparoscopic Colporrhaphies in Pelvic Organ Prolapse Treatment","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":50,"lead_sponsor_name":"Tampere University Hospital","has_results":false},{"nct_id":"NCT05449054","title":"Continuous Stitches Versus Simple Interrupted Stitches for Anterior Colporrhaphy","phase":"NA","overall_status":"UNKNOWN","enrollment_count":48,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT06979167","title":"Complications of Midline Catheter in Surgical Children","phase":"","overall_status":"COMPLETED","enrollment_count":48,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT02259114","title":"A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Oncoethix GmbH, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)","has_results":true},{"nct_id":"NCT01922076","title":"Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":true},{"nct_id":"NCT07455045","title":"A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":40,"lead_sponsor_name":"Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.","has_results":false},{"nct_id":"NCT07020052","title":"Phase II Exploratory Study of Sequential Triple Therapy (Temozolomide/Anlotinib/Bemarituzumab) in Combination With Concurrent Radiotherapy With Temozolomide and Anlotinib for the Maintenance Treatment of Diffuse Midline Gliomas in Children","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":33,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT06860594","title":"Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma","phase":"PHASE1","overall_status":"SUSPENDED","enrollment_count":30,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT07248683","title":"Application of Intermittent Training in Radial Artery Puncture and Catheterization Skills Under Ultrasound-Guided Line Guidance","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":30,"lead_sponsor_name":"General Hospital of Ningxia Medical University","has_results":false},{"nct_id":"NCT07501156","title":"H3K27M-specific Immune Effector Cells Targeting DMG/DIPG","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Shenzhen Geno-Immune Medical Institute","has_results":false},{"nct_id":"NCT05077735","title":"Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":29,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT06305910","title":"CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":24,"lead_sponsor_name":"OX2 Therapeutics","has_results":false},{"nct_id":"NCT04166201","title":"Double Mesh Modification of Incisional Hernia Can be Effective Without Severe Local Complications","phase":"NA","overall_status":"COMPLETED","enrollment_count":22,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT05123534","title":"A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients with DIPG","phase":"PHASE2","overall_status":"SUSPENDED","enrollment_count":15,"lead_sponsor_name":"SonALAsense, Inc.","has_results":false},{"nct_id":"NCT00470496","title":"Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Roswell Park Cancer Institute","has_results":false},{"nct_id":"NCT07331064","title":"Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor","phase":"PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":15,"lead_sponsor_name":"Sarah Rumler","has_results":false},{"nct_id":"NCT06333899","title":"Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion","phase":"EARLY_PHASE1","overall_status":"RECRUITING","enrollment_count":15,"lead_sponsor_name":"Nationwide Children's Hospital","has_results":false},{"nct_id":"NCT05500508","title":"Oral AMXT 1501 Dicaprate in Combination With IV DFMO","phase":"PHASE1, PHASE2","overall_status":"TERMINATED","enrollment_count":15,"lead_sponsor_name":"Aminex Therapeutics, Inc.","has_results":false},{"nct_id":"NCT02698176","title":"A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Advanced Solid Tumors (MK-8628-006)","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":13,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT05478837","title":"Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma","phase":"PHASE1","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":12,"lead_sponsor_name":"University of California, San Francisco","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}