{"disease":{"id":"menorrhagia","name":"Menorrhagia","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":11,"pipeline_drug_count":0,"trial_count":1},"drugs":{"marketed":[{"drug_id":"relugolix","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Orgovyx","generic_name":"relugolix","company_name":"MYOVANT SCIENCES","drug_phase":"marketed","molecular_target":"Gonadotropin-releasing hormone receptor","drug_class":"Gonadotropin Releasing Hormone Receptor Antagonist [EPC]","quality_score":72,"revenue":"421","mechanism":"Relugolix is a nonpeptide GnRH receptor antagonist that competitively binds to pituitary GnRH receptors."},{"drug_id":"norethynodrel","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Noretynodrel","generic_name":"NORETHYNODREL","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"norethynodrel","quality_score":26,"revenue":null,"mechanism":""},{"drug_id":"chlormadinone","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Menstridyl","generic_name":"chlormadinone","company_name":"","drug_phase":"unknown","molecular_target":"Glucocorticoid receptor","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Menstridyl works by blocking the action of cortisol, a hormone involved in the menstrual cycle."},{"drug_id":"levonorgestrel","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Jadelle","generic_name":"LEVONORGESTREL","company_name":"Fdn Consumer","drug_phase":"marketed","molecular_target":"Progesterone receptor","drug_class":"Progestin","quality_score":10,"revenue":null,"mechanism":"Jadelle works by binding to the progesterone receptor, which helps to prevent ovulation and thicken cervical mucus to prevent sperm from reaching the egg."},{"drug_id":"tranexamic-acid","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cyklokapron","generic_name":"TRANEXAMIC ACID","company_name":"Exela Pharma","drug_phase":"marketed","molecular_target":"Plasminogen","drug_class":"Antifibrinolytic Agent [EPC]","quality_score":10,"revenue":null,"mechanism":"Tranexamic acid works by binding to plasminogen and preventing its conversion to plasmin, thereby inhibiting fibrinolysis."},{"drug_id":"meclofenamic-acid","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Meclofenamate","generic_name":"MECLOFENAMIC ACID","company_name":"","drug_phase":"marketed","molecular_target":"Prostaglandin G/H synthase 2","drug_class":"meclofenamic acid","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"mestranol","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Norinyl 1+50 28-Day","generic_name":"MESTRANOL","company_name":"","drug_phase":"marketed","molecular_target":"Estrogen receptor","drug_class":"Estrogen","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"amchafibrin","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Amchafibrin","company_name":"Fundación Pública Andaluza Progreso y Salud","drug_phase":"phase_3","molecular_target":"Plasminogen","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"transamin","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"transamin","company_name":"Erzincan Military Hospital","drug_phase":"phase_3","molecular_target":"Plasminogen","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"norethisterone","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Micronor","generic_name":"norethisterone","company_name":"Johnson & Johnson","drug_phase":"marketed","molecular_target":"GnRH receptors","drug_class":"Progestin","quality_score":63,"revenue":null,"mechanism":"ORIAHNN combines elagolix, which suppresses LH and FSH to reduce ovarian sex hormones, with estradiol and norethindrone acetate to mitigate side effects."},{"drug_id":"meclofenamate","indication_name":"Menorrhagia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Meclofenamate","company_name":"Memorial Sloan Kettering Cancer Center","drug_phase":"marketed","molecular_target":"Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":11,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT02475356","title":"Prospective, Non-interventional, Multi-center Safety Study of Mirena for Heavy Menstrual Bleeding and Dysmenorrhea","phase":"","overall_status":"COMPLETED","enrollment_count":601,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT03751800","title":"A Study Run at Multiple Study Sites to Test Whether the SAMANTA Questionnaire That is Used to Diagnose Heavy Menstrual Bleeding (HMB), Can Also be Used to Assess Changes of Severity of HMB in Women With HMB Who Are Treated During 12 Months With a Chronic Hormonal Treatment","phase":"","overall_status":"COMPLETED","enrollment_count":422,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT05442827","title":"A Phase II/III Study of Efficacy and Safety of SHR7280 Tablets in Subjects With Menorrhagia With Uterine Fibroids","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":357,"lead_sponsor_name":"Jiangsu HengRui Medicine Co., Ltd.","has_results":false},{"nct_id":"NCT05922657","title":"A Registry to Gather Real World Use Data on the Cerene® Cryotherapy Device","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Channel Medsystems","has_results":false},{"nct_id":"NCT07378098","title":"to Evaluate the Efficacy and Safety of KLH-2109 in Patients With Uterine Fibroids and Menorrhagia","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":254,"lead_sponsor_name":"JW Pharmaceutical","has_results":false},{"nct_id":"NCT00904709","title":"The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":249,"lead_sponsor_name":"K. Sue Robinson","has_results":false},{"nct_id":"NCT04267562","title":"Minitouch Endometrial Ablation System Treatment for Menorrhagia: An Evaluation of Safety & Effectiveness","phase":"NA","overall_status":"COMPLETED","enrollment_count":219,"lead_sponsor_name":"MicroCube, LLC","has_results":true},{"nct_id":"NCT01740687","title":"A Study to Evaluate the Effectiveness of Essure Post-NovaSure Radiofrequency Endometrial Ablation Procedure Following a Successful Essure Confirmation Test","phase":"","overall_status":"COMPLETED","enrollment_count":211,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT07478614","title":"Multicenter Observational Cohort Study on the Epidemiology of Therapeutic Strategies in Patients Affected by Adenomyosis","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"SCHETTINI SERGIO","has_results":false},{"nct_id":"NCT03725306","title":"Librata Endometrial Ablation Device Treatment to Reduce Menstrual Blood Loss","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"LiNA Medical","has_results":false},{"nct_id":"NCT07402369","title":"Phase II Study of CMS-D002 Capsule for Uterine Fibroids With Menorrhagia","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Shenzhen Kangzhe Biotechnology Co., Ltd.","has_results":false},{"nct_id":"NCT03642210","title":"Study of a Levonorgestrel 52 mg Intrauterine System for the Treatment of Heavy Menstrual Bleeding","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":105,"lead_sponsor_name":"Medicines360","has_results":true},{"nct_id":"NCT06660459","title":"Pattern of Menorrhagic Female Attending the Hematology Unit in Assuit University Children Hospital","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":50,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT02824224","title":"Tamoxifen to Reduce Unscheduled Bleeding in New Users of the Levonorgestrel-releasing Intrauterine System (LNG-IUS)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Oregon Health and Science University","has_results":true},{"nct_id":"NCT03704454","title":"The Use of Pycnogenol® to Alleviate Menopausal Symptoms Induced or Increased by Breast and Gynecological Cancer Treatments","phase":"NA","overall_status":"UNKNOWN","enrollment_count":40,"lead_sponsor_name":"Legacy Health System","has_results":false},{"nct_id":"NCT03670680","title":"Efficiency of Lina LibrataTM System","phase":"NA","overall_status":"COMPLETED","enrollment_count":38,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT05384340","title":"NO3-rich Beet Juice and Exercise on Postmenopausal Women Cardiovascular Health","phase":"NA","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"University of Sao Paulo","has_results":false},{"nct_id":"NCT03317795","title":"Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":18,"lead_sponsor_name":"Shannon K. Laughlin-Tommaso","has_results":true},{"nct_id":"NCT07518693","title":"Clinical Observation of Hysteroscopy-Assisted Placement of Handmade Frameless GyneFix-LNG-IUS (Retrospective Cohort)","phase":"","overall_status":"COMPLETED","enrollment_count":15,"lead_sponsor_name":"Yu Wang","has_results":false},{"nct_id":"NCT05820321","title":"Effects of Dietary Nitrate Intake on Physical Performance of Middle-aged Women","phase":"NA","overall_status":"UNKNOWN","enrollment_count":15,"lead_sponsor_name":"University of Sao Paulo","has_results":false},{"nct_id":"NCT05406960","title":"Therapeutic Effect of Herbal Infusion on Menometrorrhagia","phase":"NA","overall_status":"COMPLETED","enrollment_count":13,"lead_sponsor_name":"Faculty of Medicine, Sousse","has_results":false},{"nct_id":"NCT05788172","title":"Measuring Menstrual Iron Loss Using the Iron Isotope Dilution Technique","phase":"","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Isabelle Herter-Aeberli","has_results":false},{"nct_id":"NCT05538689","title":"Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL)","phase":"PHASE4","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"University of Chicago","has_results":false}],"total":23},"guidelines":[],"source":"Drug Landscape verified database"}