{"disease":{"id":"mechanical-ventilation","name":"mechanical ventilation"},"drugs":{"marketed":[{"drug_id":"cisatracurium-besylate","indication_name":"Mechanical ventilation in the ICU in adults","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nimbex","generic_name":"Cisatracurium Besylate","company_name":"AbbVie","drug_phase":"marketed","molecular_target":"Acetylcholine receptor","drug_class":"Nondepolarizing Neuromuscular Blocker","quality_score":10,"revenue":null,"mechanism":"Nimbex works by blocking the action of acetylcholine at the neuromuscular junction, preventing muscle contraction."},{"drug_id":"rocuronium-bromide","indication_name":"Skeletal muscle relaxation during surgery or mechanical ventilation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rocuronium","generic_name":"Rocuronium Bromide","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Cholinergic receptors at the motor end-plate","drug_class":"Nondepolarizing neuromuscular blocking agent","quality_score":10,"revenue":null,"mechanism":"Rocuronium bromide competes for cholinergic receptors at the motor end-plate, antagonized by acetylcholinesterase inhibitors."},{"drug_id":"chembl-chembl1200641","indication_name":"Mechanical Ventilation in ICU","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CISATRACURIUM BESYLATE","company_name":"","drug_phase":"marketed","molecular_target":"cholinergic receptors","drug_class":"","quality_score":60,"revenue":null,"mechanism":"Cisatracurium besylate blocks neuromuscular transmission by competitively binding to cholinergic receptors and antagonizing acetylcholine."},{"drug_id":"chembl-chembl1200641","indication_name":"Skeletal Muscle Relaxation During Mechanical Ventilation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"CISATRACURIUM BESYLATE","company_name":"","drug_phase":"marketed","molecular_target":"cholinergic receptors","drug_class":"","quality_score":60,"revenue":null,"mechanism":"Cisatracurium besylate blocks neuromuscular transmission by competitively binding to cholinergic receptors and antagonizing acetylcholine."},{"drug_id":"chembl-chembl1200648","indication_name":"Skeletal muscle relaxation during surgery or mechanical ventilation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ROCURONIUM BROMIDE","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":30,"revenue":null,"mechanism":null},{"drug_id":"dexmedetomidine-hydrochloride","indication_name":"Sedation of non-intubated patients in the intensive care unit (ICU) or in a hospital setting receiving mechanical ventilation.","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dexmedetomidine Hydrochloride","generic_name":"dexmedetomidine-hydrochloride","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Alpha-1A adrenergic receptor","drug_class":"dexmedetomidine","quality_score":80,"revenue":null,"mechanism":"Dexmedetomidine Hydrochloride is a relatively selective centrally acting alpha 2 -adrenergic agonist with sedative properties."}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05668637","title":"Evaluation and Further Development of an Artificial Intelligence-based Algorithm for Clinical Decision Support","phase":"","overall_status":"RECRUITING","enrollment_count":318542,"lead_sponsor_name":"Technische Universität Dresden","has_results":false},{"nct_id":"NCT03790150","title":"National Approach to Standardize and Improve Mechanical Ventilation","phase":"","overall_status":"COMPLETED","enrollment_count":27966,"lead_sponsor_name":"King Abdullah International Medical Research Center","has_results":false},{"nct_id":"NCT05392010","title":"Global BurdEn of MechanIcal VeNtilatIon (GEMINI). VeNtilatIon (GEMINI Study) 2022 for VENTILAGROUP.","phase":"","overall_status":"UNKNOWN","enrollment_count":10900,"lead_sponsor_name":"Hospital Universitario Getafe","has_results":false},{"nct_id":"NCT06166706","title":"Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT05650957","title":"PRactice of VENTilation in Patients With ARDS Due to COVID-19 vs Pneumonia","phase":"","overall_status":"COMPLETED","enrollment_count":7145,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT05440851","title":"Platform of Randomized Adaptive Clinical Trials in Critical Illness","phase":"NA","overall_status":"RECRUITING","enrollment_count":6250,"lead_sponsor_name":"University Health Network, Toronto","has_results":false},{"nct_id":"NCT04112459","title":"LongVentKids Study","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"St. Justine's Hospital","has_results":false},{"nct_id":"NCT05151094","title":"Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"University Hospital Dubrava","has_results":false},{"nct_id":"NCT07233837","title":"Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units","phase":"NA","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT07129733","title":"Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":4800,"lead_sponsor_name":"Hospital do Coracao","has_results":false},{"nct_id":"NCT05456217","title":"Epidemiological Characteristics and Outcomes of Patients Admitted to Kenyan Critical Care Units (EPOK).","phase":"","overall_status":"UNKNOWN","enrollment_count":4000,"lead_sponsor_name":"Nat Intensive Care Surveillance - MORU","has_results":false},{"nct_id":"NCT03937375","title":"Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery (REPEAT)","phase":"","overall_status":"COMPLETED","enrollment_count":3837,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT05886387","title":"a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation","phase":"","overall_status":"COMPLETED","enrollment_count":3836,"lead_sponsor_name":"Instituto de Investigacion Sanitaria La Fe","has_results":false},{"nct_id":"NCT05534243","title":"The ED-AWARENESS-2 Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":3090,"lead_sponsor_name":"Washington University School of Medicine","has_results":false},{"nct_id":"NCT03573739","title":"Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock","phase":"NA","overall_status":"COMPLETED","enrollment_count":3044,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT02731898","title":"Fourth International Study of Mechanical Ventilation From VENTILA GROUP","phase":"","overall_status":"UNKNOWN","enrollment_count":3000,"lead_sponsor_name":"Hospital Universitario Getafe","has_results":false},{"nct_id":"NCT05550181","title":"Intraoperative Hypocapnia in PROVHILO and PROBESE","phase":"","overall_status":"COMPLETED","enrollment_count":2793,"lead_sponsor_name":"NMC Specialty Hospital","has_results":false},{"nct_id":"NCT03111303","title":"Mechanical Ventilation Parameters in HAP Patients","phase":"","overall_status":"COMPLETED","enrollment_count":2654,"lead_sponsor_name":"University Hospital Olomouc","has_results":false},{"nct_id":"NCT05069441","title":"Prediction of Extubation Failure: A Multicenter Prospective Observational Study","phase":"","overall_status":"RECRUITING","enrollment_count":2604,"lead_sponsor_name":"Chongqing Medical University","has_results":false},{"nct_id":"NCT07093125","title":"Rehabilitation Practices in Critically Ill Patients Receiving Invasive Mechanical Ventilation in the Intensive Care Unit.","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":2400,"lead_sponsor_name":"Universita degli Studi di Genova","has_results":false},{"nct_id":"NCT04459884","title":"Multicenter Observational Study on Practice of Ventilation in Brain Injured Patients","phase":"","overall_status":"COMPLETED","enrollment_count":2299,"lead_sponsor_name":"University of Milano Bicocca","has_results":false},{"nct_id":"NCT06421012","title":"Preoxygenation for Tracheal Aspirations in Intensive Care","phase":"NA","overall_status":"RECRUITING","enrollment_count":2260,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07001696","title":"Combining Chest X-Ray and Arterial Blood Gas Findings to Predict Need for Mechanical Ventilation in Critically Ill Patients","phase":"","overall_status":"RECRUITING","enrollment_count":2160,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT06012955","title":"Study on the Effect of Target-controlled Infusion for General Anesthesia in Cardiac Surgery","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT03936231","title":"Cross-sectional, Observational, Prospective and Analytical Study:MECHANICAL POWER DAY (MPDay)","phase":"","overall_status":"UNKNOWN","enrollment_count":2000,"lead_sponsor_name":"Hospital Universitario Marqués de Valdecilla","has_results":false},{"nct_id":"NCT03955874","title":"Mechanical Ventilation Discontinuation Practices","phase":"","overall_status":"COMPLETED","enrollment_count":1868,"lead_sponsor_name":"Unity Health Toronto","has_results":false},{"nct_id":"NCT06890936","title":"Clinical Characteristics and Outcomes of Patients Requiring Mechanical Ventilation in an ICU- a Registry Based Study","phase":"","overall_status":"COMPLETED","enrollment_count":1800,"lead_sponsor_name":"Tribhuvan University Teaching Hospital, Institute Of Medicine.","has_results":false},{"nct_id":"NCT04410783","title":"The Emergency Department Sedation Pilot Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1771,"lead_sponsor_name":"Washington University School of Medicine","has_results":true},{"nct_id":"NCT04741555","title":"The Effect of Preoperative Values on Mortality in Patients Undergoing Open Heart Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1600,"lead_sponsor_name":"Karadeniz Technical University","has_results":false},{"nct_id":"NCT06215001","title":"Individualized Selection of PEEP in Patients Affected by Expiratory Flow Limitation","phase":"NA","overall_status":"UNKNOWN","enrollment_count":1536,"lead_sponsor_name":"Università degli Studi di Ferrara","has_results":false},{"nct_id":"NCT03188770","title":"Practice of Ventilation in Middle-Income Countries","phase":"","overall_status":"COMPLETED","enrollment_count":1315,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT04110613","title":"RCT: Early Feeding After PEG Placement","phase":"NA","overall_status":"RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Carilion Clinic","has_results":false},{"nct_id":"NCT04346342","title":"PRactice of VENTilation in COVID-19 Patients (PRoVENT-COVID)","phase":"","overall_status":"COMPLETED","enrollment_count":1122,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT06683781","title":"Ventilatory Settings and Monitoring Variables Associated With Weaning Failure in Critically Ill Patients","phase":"","overall_status":"RECRUITING","enrollment_count":1077,"lead_sponsor_name":"Hospital Italiano de Buenos Aires","has_results":false},{"nct_id":"NCT05556174","title":"Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers","phase":"NA","overall_status":"COMPLETED","enrollment_count":1060,"lead_sponsor_name":"Sixth Affiliated Hospital, Sun Yat-sen University","has_results":false},{"nct_id":"NCT02989415","title":"Assessment of Ventilatory Management During General Anesthesia for Robotic Surgery","phase":"","overall_status":"COMPLETED","enrollment_count":1015,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT04227639","title":"T-piece Versus Pressure-support for the Spontaneous Breathing Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":1000,"lead_sponsor_name":"Poitiers University Hospital","has_results":false},{"nct_id":"NCT05991258","title":"Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"University of Padova","has_results":false},{"nct_id":"NCT05188092","title":"Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT06655805","title":"Registry for Automated Mechanical VEntilation in Adults","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Hamilton Medical AG","has_results":false},{"nct_id":"NCT04611269","title":"Clinical Characteristics and Outcomes of Patients With COVID-19 on Mechanical Ventilation in Argentina","phase":"","overall_status":"COMPLETED","enrollment_count":950,"lead_sponsor_name":"Argentinian Intensive Care Society","has_results":false},{"nct_id":"NCT06581939","title":"Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU","phase":"NA","overall_status":"RECRUITING","enrollment_count":830,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT03288311","title":"Protocolized Post-Extubation Respiratory Support Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":751,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":true},{"nct_id":"NCT05719194","title":"Effect of a Personalized Weaning Strategy on Weaning Success","phase":"NA","overall_status":"RECRUITING","enrollment_count":750,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04068038","title":"Pediatric Acute Respiratory Distress Syndrome Asia Study","phase":"","overall_status":"COMPLETED","enrollment_count":738,"lead_sponsor_name":"KK Women's and Children's Hospital","has_results":false},{"nct_id":"NCT05555667","title":"Long-term Sedation With Remimazolam Besylate in Critically Ill Patients","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":728,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT03918811","title":"Comparison of Two Extubation Techniques in Critically Ill Adult Patients","phase":"NA","overall_status":"TERMINATED","enrollment_count":725,"lead_sponsor_name":"Hospital Donación Francisco Santojanni","has_results":true},{"nct_id":"NCT03987789","title":"Intraoperative Protective Mechanical Ventilation in Patients Requiring Emergency Abdominal Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":707,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04849039","title":"Lung Microbiota and VAP Development (PULMIVAP)","phase":"","overall_status":"UNKNOWN","enrollment_count":700,"lead_sponsor_name":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","has_results":false},{"nct_id":"NCT05411315","title":"Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment","phase":"NA","overall_status":"COMPLETED","enrollment_count":700,"lead_sponsor_name":"Dartmouth-Hitchcock Medical Center","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}