{"disease":{"id":"mania","name":"mania"},"drugs":{"marketed":[{"drug_id":"aripiprazole","indication_name":"Agitation associated with Bipolar Mania","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abilify","generic_name":"aripiprazole","company_name":"Generic (originally Otsuka/BMS)","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6","drug_class":"Third-generation antipsychotic (D2 partial agonist)","quality_score":63,"revenue":"3000","mechanism":"Third-generation antipsychotic that acts as a partial agonist at D2 and 5-HT1A receptors, stabilizing dopamine activity rather than simply blocking it."},{"drug_id":"olanzapine","indication_name":"Agitation associated with Bipolar Mania","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zyprexa","generic_name":"olanzapine","company_name":"Eli Lilly","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A","drug_class":"Atypical Antipsychotic [EPC]","quality_score":10,"revenue":"300","mechanism":null},{"drug_id":"amphotericin-b","indication_name":"Visceral leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abelcet","generic_name":"AMPHOTERICIN B","company_name":"Astellas Pharma","drug_phase":"marketed","molecular_target":"","drug_class":"Lipid-based Polyene Antifungal [EPC]","quality_score":49,"revenue":null,"mechanism":""},{"drug_id":"miltefosine","indication_name":"American mucocutaneous leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Impavido","generic_name":"MILTEFOSINE","company_name":"Knight Theraps","drug_phase":"marketed","molecular_target":"RAC-alpha serine/threonine-protein kinase","drug_class":"Antileishmanial [EPC]","quality_score":65,"revenue":null,"mechanism":"Impavido works by inhibiting the RAC-alpha serine/threonine-protein kinase, which is essential for the survival of Leishmania parasites."},{"drug_id":"miltefosine","indication_name":"Cutaneous leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Impavido","generic_name":"MILTEFOSINE","company_name":"Knight Theraps","drug_phase":"marketed","molecular_target":"RAC-alpha serine/threonine-protein kinase","drug_class":"Antileishmanial [EPC]","quality_score":65,"revenue":null,"mechanism":"Impavido works by inhibiting the RAC-alpha serine/threonine-protein kinase, which is essential for the survival of Leishmania parasites."},{"drug_id":"miltefosine","indication_name":"Visceral leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Impavido","generic_name":"MILTEFOSINE","company_name":"Knight Theraps","drug_phase":"marketed","molecular_target":"RAC-alpha serine/threonine-protein kinase","drug_class":"Antileishmanial [EPC]","quality_score":65,"revenue":null,"mechanism":"Impavido works by inhibiting the RAC-alpha serine/threonine-protein kinase, which is essential for the survival of Leishmania parasites."},{"drug_id":"pentostam","indication_name":"Leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Pentostam","company_name":"Sheba Medical Center","drug_phase":"phase_2","molecular_target":"","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"abilify","indication_name":"Agitation associated with Bipolar Mania","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Abilify","company_name":"Johnson & Johnson Pharmaceutical Research & Development, L.L.C.","drug_phase":"marketed","molecular_target":"5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"zyprexa","indication_name":"Agitation associated with Bipolar Mania","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Zyprexa","company_name":"Washington University School of Medicine","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A","drug_class":"","quality_score":null,"revenue":null,"mechanism":null},{"drug_id":"amphotericin-b","indication_name":"Leishmaniasis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abelcet","generic_name":"AMPHOTERICIN B","company_name":"Astellas Pharma","drug_phase":"marketed","molecular_target":"","drug_class":"Lipid-based Polyene Antifungal [EPC]","quality_score":49,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":10,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06917040","title":"Enhancing Protection Against Vector-borne Diseases in Forcibly Displaced Communities: Evaluating the Efficacy of Spatial Repellents for Cutaneous Leishmaniasis Control in North-East Syria","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":18404,"lead_sponsor_name":"The Mentor Initiative","has_results":false},{"nct_id":"NCT07358910","title":"Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Institut Pasteur du Cambodge","has_results":false},{"nct_id":"NCT00342823","title":"Immunogenetics of Visceral Leishmaniasis","phase":"","overall_status":"COMPLETED","enrollment_count":7000,"lead_sponsor_name":"National Human Genome Research Institute (NHGRI)","has_results":false},{"nct_id":"NCT07506967","title":"Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":2420,"lead_sponsor_name":"Kenya Medical Research Institute","has_results":false},{"nct_id":"NCT00344084","title":"Surveillance for Leishmaniasis Skin Lesions in Mali","phase":"","overall_status":"COMPLETED","enrollment_count":1593,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT03784248","title":"Mediterranean Visceral Leishmaniasis With Leishmania Infantum","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1400,"lead_sponsor_name":"Centre Hospitalier Universitaire de Nice","has_results":false},{"nct_id":"NCT03573297","title":"A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":901,"lead_sponsor_name":"AbbVie","has_results":true},{"nct_id":"NCT07463040","title":"Study Comparing Several Drugs to Understand Which Work Against Cutaneous Leishmaniasis (CL)","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":900,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT04268524","title":"Randomised Clinical Trial for New Treatment Modalities for Cutaneous Leishmaniasis Caused by Leishmania Tropica, in Pakistan","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":832,"lead_sponsor_name":"Medecins Sans Frontieres, Netherlands","has_results":false},{"nct_id":"NCT05602610","title":"Clinical Prognostic Score to Predict Relapse in VL","phase":"","overall_status":"RECRUITING","enrollment_count":741,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT03646981","title":"Evaluation of Antibody Detection Tests for Visceral Leishmaniasis Diagnosis in Eastern Africa","phase":"","overall_status":"COMPLETED","enrollment_count":704,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT05386875","title":"Evaluation to Assess the Usability of rK28 for the Diagnosis of Visceral Leishmaniasis in Kenya","phase":"","overall_status":"UNKNOWN","enrollment_count":625,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT03013673","title":"Predicting Visceral Leishmaniasis in HIV Infected Patients","phase":"","overall_status":"TERMINATED","enrollment_count":566,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT04003532","title":"LAMP Assay for the Diagnosis of Visceral Leishmaniasis","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Prof. Dawit Wolday","has_results":false},{"nct_id":"NCT06856161","title":"A Novel Blood Test as a Biomarker in Mental Health","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Fraser Health","has_results":false},{"nct_id":"NCT06929273","title":"A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT03129646","title":"Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":439,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT07140913","title":"A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":424,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT00004550","title":"Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions","phase":"","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"National Institute of Mental Health (NIMH)","has_results":false},{"nct_id":"NCT03287869","title":"A Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Participants With Bipolar I Disorder.","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":381,"lead_sponsor_name":"Otsuka Pharmaceutical Development & Commercialization, Inc.","has_results":true},{"nct_id":"NCT05703711","title":"Combining mHealth and Nurse-delivered Care to Improve the Outcomes of People With Serious Mental Illness in West Africa","phase":"NA","overall_status":"RECRUITING","enrollment_count":360,"lead_sponsor_name":"University of Washington","has_results":false},{"nct_id":"NCT03837431","title":"Cutaneous Leishmaniasis Diagnostic Study","phase":"","overall_status":"COMPLETED","enrollment_count":351,"lead_sponsor_name":"Institute of Tropical Medicine, Belgium","has_results":false},{"nct_id":"NCT03023111","title":"Miltefosine and GM-CSF in Cutaneous Leishmaniasis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Hospital Universitário Professor Edgard Santos","has_results":false},{"nct_id":"NCT06793111","title":"Visceral Leishmaniasis in Emilia-Romagna (Leishmania-2019)","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT00344188","title":"Diagnosis and Treatment of Leishmania Infections","phase":"","overall_status":"RECRUITING","enrollment_count":289,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT03311607","title":"Safety and Effectiveness of Short-course AmBisome in the Treatment of PKDL in Bangladesh","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":280,"lead_sponsor_name":"Medecins Sans Frontieres, Netherlands","has_results":false},{"nct_id":"NCT06951711","title":"A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":274,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT03435419","title":"Evaluation of Point-of-care Tests for the Diagnosis of Cutaneous Leishmaniasis in Afghanistan","phase":"","overall_status":"COMPLETED","enrollment_count":274,"lead_sponsor_name":"Foundation for Innovative New Diagnostics, Switzerland","has_results":false},{"nct_id":"NCT06951698","title":"A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":274,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT06692985","title":"Epidemiology of Cutaneous Leishmaniasis in Niger, Mali, Togo : Mapping of Clinical Cases, Species, Reservoirs and Vectors of the Disease","phase":"","overall_status":"COMPLETED","enrollment_count":270,"lead_sponsor_name":"Centre Hospitalier de Cayenne","has_results":false},{"nct_id":"NCT03993093","title":"Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART Centre","phase":"","overall_status":"COMPLETED","enrollment_count":257,"lead_sponsor_name":"Singh, Ranjan Kumar, M.D.","has_results":false},{"nct_id":"NCT06997159","title":"A Clinical Trial to Investigate Efficacy, Safety and Pharmacokinetics (PK) of Two LXE408 Oral Regimens and Oral Miltefosine as Active Control in Participants Aged ≥ 18 Years Old With Localized Cutaneous Leishmaniasis in the Region of the Americas (AMR).","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT03300778","title":"A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes","phase":"NA","overall_status":"COMPLETED","enrollment_count":224,"lead_sponsor_name":"Guangzhou Psychiatric Hospital","has_results":false},{"nct_id":"NCT04342715","title":"A Study to Assess Immune Response Status in Patients Before and After Treatment for Visceral Leishmaniasis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":216,"lead_sponsor_name":"University of York","has_results":false},{"nct_id":"NCT03269006","title":"Improved Case Detection and Vector Control for Visceral Leishmaniasis","phase":"NA","overall_status":"COMPLETED","enrollment_count":202,"lead_sponsor_name":"International Centre for Diarrhoeal Disease Research, Bangladesh","has_results":false},{"nct_id":"NCT07504757","title":"LEISH-PED: Study on Leishmaniasis in Children","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Meyer Children's Hospital IRCCS","has_results":false},{"nct_id":"NCT07269314","title":"Introduction of Polymerase Chain Reaction (PCR) in Microbiology and Parasitology","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Fondazione IRCCS Policlinico San Matteo di Pavia","has_results":false},{"nct_id":"NCT04515186","title":"Combination, Miltefosine Monotherapy for Cutaneous Leishmaniasis in New World","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":184,"lead_sponsor_name":"Drugs for Neglected Diseases","has_results":false},{"nct_id":"NCT06859619","title":"Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":183,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT05766007","title":"Long-acting Injectable Antipsychotics for Mental Ill-Health in Pregnancy and Postpartum","phase":"","overall_status":"COMPLETED","enrollment_count":168,"lead_sponsor_name":"University of Liverpool","has_results":false},{"nct_id":"NCT06746350","title":"Feasibility of Integrating Thermotherapy for Treatment of Cutaneous Leishmaniasis in Primary Health Care Setup","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":165,"lead_sponsor_name":"Armauer Hansen Research Institute, Ethiopia","has_results":false},{"nct_id":"NCT02747771","title":"Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder)","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT06548841","title":"Development and Validation of (Bio)Sensors for the Identification of Pathogens","phase":"","overall_status":"COMPLETED","enrollment_count":149,"lead_sponsor_name":"University of Bologna","has_results":false},{"nct_id":"NCT03636659","title":"Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Aurobindo Pharma Ltd","has_results":false},{"nct_id":"NCT05708625","title":"Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasis","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":136,"lead_sponsor_name":"Zagazig University","has_results":false},{"nct_id":"NCT04500873","title":"Performance of RPA-LF for Cutaneous Leishmaniasis","phase":"","overall_status":"COMPLETED","enrollment_count":128,"lead_sponsor_name":"Centro Internacional de Entrenamiento e Investigaciones Médicas","has_results":false},{"nct_id":"NCT03797521","title":"A Study in Patients With Trichotillomania","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":128,"lead_sponsor_name":"Promentis Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT03004651","title":"BMI and Ultrasound/Clinical Assessments of RA Disease Activity","phase":"","overall_status":"COMPLETED","enrollment_count":121,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT04799236","title":"Treatment of Mucosal Bolivian Leishmaniasis","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":120,"lead_sponsor_name":"Fundacion Nacional de Dermatologia","has_results":false},{"nct_id":"NCT03829917","title":"Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Fundacion Nacional de Dermatologia","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}