{"disease":{"id":"lung-metastases","name":"lung metastases"},"drugs":{"marketed":[{"drug_id":"lorlatinib-with-chemotherapy-2","indication_name":"Anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) with brain metastases","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Lorlatinib with chemotherapy 2","generic_name":"lorlatinib-with-chemotherapy-2","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"ALK","drug_class":"ALK inhibitor","quality_score":40,"revenue":"798","mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04075305","title":"The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study","phase":"","overall_status":"RECRUITING","enrollment_count":8000,"lead_sponsor_name":"UMC Utrecht","has_results":false},{"nct_id":"NCT05816902","title":"AI Prediction Model and Risk Stratification for Lung Metastasis in Colorectal Cancer","phase":"","overall_status":"COMPLETED","enrollment_count":2779,"lead_sponsor_name":"Peking Union Medical College","has_results":false},{"nct_id":"NCT00242723","title":"Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining","phase":"","overall_status":"RECRUITING","enrollment_count":1310,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT05375591","title":"AI & Radiomics for Stratification of Lung Nodules After Radically Treated Cancer","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Royal Marsden NHS Foundation Trust","has_results":false},{"nct_id":"NCT06602674","title":"PET/CT-Based Image Analysis and Machine Learning of Hypermetabolic Pulmonary Lesions","phase":"","overall_status":"COMPLETED","enrollment_count":647,"lead_sponsor_name":"Ruijin Hospital","has_results":false},{"nct_id":"NCT03653546","title":"First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":492,"lead_sponsor_name":"Alpha Biopharma (Jiangsu) Co., Ltd.","has_results":false},{"nct_id":"NCT05808790","title":"Colorectal Pulmonary Metastases: Pulmonary Metastasectomy Versus Stereotactic Ablative Radiotherapy","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":394,"lead_sponsor_name":"Amsterdam UMC, location VUmc","has_results":false},{"nct_id":"NCT07373951","title":"Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":380,"lead_sponsor_name":"Ming Yang","has_results":false},{"nct_id":"NCT06457906","title":"SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":340,"lead_sponsor_name":"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","has_results":false},{"nct_id":"NCT07491211","title":"Osimertinib Combined With Intracranial SRT for EGFR-Mutant NSCLC With Symptomatic Brain Metastases","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Fudan University","has_results":false},{"nct_id":"NCT04058704","title":"A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":296,"lead_sponsor_name":"Betta Pharmaceuticals Co., Ltd.","has_results":false},{"nct_id":"NCT06321640","title":"Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies.","phase":"","overall_status":"UNKNOWN","enrollment_count":265,"lead_sponsor_name":"European Institute of Oncology","has_results":false},{"nct_id":"NCT07481786","title":"Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":220,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT05730972","title":"TEAS for the Treatment of Pain in Bone Metastases of Lung Cancer","phase":"NA","overall_status":"UNKNOWN","enrollment_count":188,"lead_sponsor_name":"The Third Affiliated hospital of Zhejiang Chinese Medical University","has_results":false},{"nct_id":"NCT03143322","title":"Standard Treatment +/- SBRT in Solid Tumors Patients With Between 1 and 5 Bone-only Metastases","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":168,"lead_sponsor_name":"UNICANCER","has_results":false},{"nct_id":"NCT05033691","title":"A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases","phase":"NA","overall_status":"RECRUITING","enrollment_count":162,"lead_sponsor_name":"Hadassah Medical Organization","has_results":false},{"nct_id":"NCT03754530","title":"Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":162,"lead_sponsor_name":"Betta Pharmaceuticals Co., Ltd.","has_results":false},{"nct_id":"NCT02308020","title":"A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"Eli Lilly and Company","has_results":true},{"nct_id":"NCT04568291","title":"CTC in Lung Caner Patients With Bone Metastases","phase":"NA","overall_status":"UNKNOWN","enrollment_count":160,"lead_sponsor_name":"Shanghai 6th People's Hospital","has_results":false},{"nct_id":"NCT03932071","title":"Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT03870464","title":"LIFE - Lung Cancer, Immunotherapy, Frailty, Effect","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":150,"lead_sponsor_name":"University of Southern Denmark","has_results":false},{"nct_id":"NCT07537556","title":"Comprehensive Prospective Comparison Of Two Robotic Platforms In Anatomical Lung Resections: Clinical Outcomes And Cost-utility Analysis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal","has_results":false},{"nct_id":"NCT05354596","title":"A Multicenter Phase II Study of Stereotactic Radiotherapy for Centrally Located Lung Tumors (STRICT-LUNG STUDY) and Ultra-centrally Located Lung Tumors (STAR-LUNG STUDY).","phase":"NA","overall_status":"RECRUITING","enrollment_count":138,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT06542159","title":"Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":130,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT07112989","title":"Development of Innovative Preclinical Ex Vivo Models for the Study of Sarcomas and Metastases From Solid Tumors","phase":"","overall_status":"RECRUITING","enrollment_count":125,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT06683703","title":"Utidelone Injection Combined with Bevacizumab Injection for Non-small Cell Lung Cancer Patients with Brain Metastases","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":118,"lead_sponsor_name":"Beijing Biostar Pharmaceuticals Co., Ltd.","has_results":false},{"nct_id":"NCT05241873","title":"(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":103,"lead_sponsor_name":"Blueprint Medicines Corporation","has_results":false},{"nct_id":"NCT07511933","title":"Novel Ga68-PSMA PET/CT-tracer to Differentiate Between Radiation Necrosis and Tumor Progression in Brain Metastases","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"The Netherlands Cancer Institute","has_results":false},{"nct_id":"NCT04193007","title":"The Role of Brain Radiotherapy in Patients With Asymptomatic Brain Metastasis in the Era of Targeted Therapy for NSCLC","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Second Affiliated Hospital of Nanchang University","has_results":false},{"nct_id":"NCT06971406","title":"High-Dose Firmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed in the Treatment of EGFR-Mutated Non-Small Cell Lung Cancer With Leptomeningeal Metastasis","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Qiming Wang","has_results":false},{"nct_id":"NCT03108677","title":"Circulating Exosome RNA in Lung Metastases of Primary High-Grade Osteosarcoma","phase":"","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Ruijin Hospital","has_results":false},{"nct_id":"NCT06145048","title":"Phase 2B Safety and Efficacy Study of VGT-309 in Subjects With Cancer in the Lung.","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":89,"lead_sponsor_name":"Vergent Bioscience, Inc.","has_results":false},{"nct_id":"NCT03669523","title":"Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":82,"lead_sponsor_name":"Centre Hospitalier Annecy Genevois","has_results":false},{"nct_id":"NCT07505173","title":"Hippocampus-Protective Radiotherapy Combined With Osimertinib for Symptomatic Brain Metastases in EGFR-Mutated Lung Cancer","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":74,"lead_sponsor_name":"Tianjin Medical University Cancer Institute and Hospital","has_results":false},{"nct_id":"NCT06238882","title":"Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.","phase":"NA","overall_status":"RECRUITING","enrollment_count":74,"lead_sponsor_name":"Instituto Nacional de Cancerologia de Mexico","has_results":false},{"nct_id":"NCT05012254","title":"Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":71,"lead_sponsor_name":"Fundación GECP","has_results":false},{"nct_id":"NCT06728865","title":"Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":70,"lead_sponsor_name":"Li-kun Chen","has_results":false},{"nct_id":"NCT07272356","title":"Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":68,"lead_sponsor_name":"Aurimas Macionis","has_results":false},{"nct_id":"NCT05419076","title":"A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":62,"lead_sponsor_name":"Memorial Sloan Kettering Cancer Center","has_results":false},{"nct_id":"NCT04684186","title":"Comparison Between Endovascular and Bronchoscopic Tumor Marker Insertion for Real-time Stereotactic-guided Radiotherapy in Lung Cancer","phase":"","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Centre Hospitalier Universitaire Vaudois","has_results":false},{"nct_id":"NCT04233021","title":"Study of Osimertinib in Patients with a Lung Cancer with Brain or Leptomeningeal Metastases with EGFR Mutation","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":57,"lead_sponsor_name":"Intergroupe Francophone de Cancerologie Thoracique","has_results":false},{"nct_id":"NCT05987644","title":"Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":56,"lead_sponsor_name":"Joshua Palmer","has_results":false},{"nct_id":"NCT04978753","title":"the Efficacy and Safety of Anlotinib Combined With Almonertinib in the First-line Treatment of Patients With Brain Metastases From EGFR Mutation-positive Non-small Cell Lung Cancer","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":54,"lead_sponsor_name":"Li-kun Chen","has_results":false},{"nct_id":"NCT03257735","title":"A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT05737589","title":"Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Xiaorong Dong","has_results":false},{"nct_id":"NCT04339829","title":"An Open Label, Multicenter, Phase II Study of Dacomitinib for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Guangdong Association of Clinical Trials","has_results":false},{"nct_id":"NCT04643847","title":"A Phase II Trial of Upfront Radiotherapy Plus Almonertinib for Epidermal Growth Factor Receptor(EGFR)-Mutant Non-small-cell Lung Cancer(NSCLC) Patients With Brain Metastases","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":47,"lead_sponsor_name":"First People's Hospital of Hangzhou","has_results":false},{"nct_id":"NCT06822543","title":"A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":46,"lead_sponsor_name":"Latin American Cooperative Oncology Group","has_results":false},{"nct_id":"NCT06476093","title":"SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer","phase":"NA","overall_status":"RECRUITING","enrollment_count":46,"lead_sponsor_name":"The First People's Hospital of Lianyungang","has_results":false},{"nct_id":"NCT04211090","title":"Camrelizumab With AC in Patients With Brain Metastases of Driven Gene-negative,NSCLC","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":45,"lead_sponsor_name":"Sun Yat-sen University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}