{"disease":{"id":"iron-overload","name":"Iron overload","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"exjade","indication_name":"Chronic Iron Overload","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Exjade","company_name":"DisperSol Technologies, LLC","drug_phase":"marketed","molecular_target":"Flavin reductase (NADPH), Lysine-specific demethylase 5A","drug_class":"","quality_score":16,"revenue":null,"mechanism":null},{"drug_id":"deferoxamine","indication_name":"Chronic Iron Overload","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Desferal","generic_name":"DEFEROXAMINE","company_name":"Mitem Pharma","drug_phase":"marketed","molecular_target":"Deoxyhypusine hydroxylase","drug_class":"Iron Chelator","quality_score":47,"revenue":null,"mechanism":""},{"drug_id":"deferasirox","indication_name":"Chronic Iron Overload","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Exjade","generic_name":"DEFERASIROX","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Flavin reductase (NADPH)","drug_class":"Iron Chelator [EPC]","quality_score":10,"revenue":null,"mechanism":"Exjade works by binding to iron in the body and removing it through the urine."},{"drug_id":"deferiprone","indication_name":"Iron overload","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ferriprox","generic_name":"DEFERIPRONE","company_name":"Chiesi","drug_phase":"marketed","molecular_target":"Deoxyhypusine hydroxylase","drug_class":"Iron Chelator [EPC]","quality_score":75,"revenue":null,"mechanism":"Ferriprox works by binding to iron in the body and removing it, thereby reducing iron overload."},{"drug_id":"desferrioxamine","indication_name":"Chronic Iron Overload","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"desferrioxamine","company_name":"Brigham and Women's Hospital","drug_phase":"phase_3","molecular_target":"Deoxyhypusine hydroxylase, Hypoxia-inducible factor 1-alpha","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":5,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT01865461","title":"Evaluation of MRI Sequences in Hepatic Overload","phase":"","overall_status":"COMPLETED","enrollment_count":706,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT06596746","title":"Neurodegenerative Diseases Progression Markers (MARKERS-NDD)","phase":"","overall_status":"RECRUITING","enrollment_count":600,"lead_sponsor_name":"Casa di Cura San Raffaele Cassino","has_results":false},{"nct_id":"NCT04198545","title":"Ethnic Differences in Iron Absorption (FeGenes)","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":515,"lead_sponsor_name":"Cornell University","has_results":false},{"nct_id":"NCT07028112","title":"Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":500,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT05440487","title":"Study to Assess Iron Chelation Therapy in Patients With Chronic Iron Overload","phase":"","overall_status":"COMPLETED","enrollment_count":489,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT01825512","title":"Efficacy/Safety Study of Deferiprone Compared to Deferasirox in Paediatric Patients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":435,"lead_sponsor_name":"Consorzio per Valutazioni Biologiche e Farmacologiche","has_results":true},{"nct_id":"NCT04515680","title":"Endocrine Function During Deferasirox Therapy","phase":"","overall_status":"COMPLETED","enrollment_count":426,"lead_sponsor_name":"University of Campania Luigi Vanvitelli","has_results":false},{"nct_id":"NCT06215287","title":"Survey to Assess Physicians' Knowledge of Exjade Posology and Biological Monitoring Recommendations as Described in the Educational Materials","phase":"","overall_status":"COMPLETED","enrollment_count":400,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT04292314","title":"Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":350,"lead_sponsor_name":"Beni-Suef University","has_results":false},{"nct_id":"NCT00102245","title":"Clinical and Laboratory Investigation of Humans With Informative Iron or Erythroid Phenotypes","phase":"","overall_status":"TERMINATED","enrollment_count":334,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT02041299","title":"Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":230,"lead_sponsor_name":"ApoPharma","has_results":true},{"nct_id":"NCT00110266","title":"Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":176,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT02125877","title":"Phase II Study to Investigate the Benefits of an Improved Deferasirox Formulation (Film-coated Tablet)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":173,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT04835285","title":"MRI T2* Mapping of Myocardium, Liver, Pancreas and Pituitary Gland","phase":"NA","overall_status":"UNKNOWN","enrollment_count":152,"lead_sponsor_name":"Federal Research Institute of Pediatric Hematology, Oncology and Immunology","has_results":false},{"nct_id":"NCT07352878","title":"Evaluation of the Quality of Life in Patients With Chronic Iron Overload Due to Hemoglobinopathies in Greece.","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Elpen Pharmaceutical Co. Inc.","has_results":false},{"nct_id":"NCT01572922","title":"Massive Iron Deposit Assessment","phase":"NA","overall_status":"COMPLETED","enrollment_count":142,"lead_sponsor_name":"St. Jude Children's Research Hospital","has_results":true},{"nct_id":"NCT06468423","title":"Comparison of Deferasirox and Desferoxamine in Patients of β-Thalassemia Major With Iron Overload","phase":"NA","overall_status":"COMPLETED","enrollment_count":142,"lead_sponsor_name":"RESnTEC, Institute of Research","has_results":false},{"nct_id":"NCT02443545","title":"Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":134,"lead_sponsor_name":"ApoPharma","has_results":true},{"nct_id":"NCT06146608","title":"Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption","phase":"","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Cornell University","has_results":false},{"nct_id":"NCT00000588","title":"Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Case Western Reserve University","has_results":false},{"nct_id":"NCT03200457","title":"Comparison of the Variability of Hepatic Load Quantification in Iron and Fat Estimated by MRI at 1.5 and 3 Tesla","phase":"NA","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT03942432","title":"A Prospective, Mono-center, Interventional Study Evaluating the Effect of One Year Initial Care by Hygieno-dietary Advices With or Without Phlebotomy on Glycemia After at Least 5 Years in Patients With Dysmetabolic Iron Overload Syndrome","phase":"NA","overall_status":"COMPLETED","enrollment_count":75,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT02099214","title":"Estimation of Myocardial Iron Overload by 3 Tesla MRI in HFE Hereditary Haemochromatosis","phase":"NA","overall_status":"COMPLETED","enrollment_count":66,"lead_sponsor_name":"Rennes University Hospital","has_results":false},{"nct_id":"NCT03591575","title":"Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":64,"lead_sponsor_name":"Chiesi Canada Corp","has_results":true},{"nct_id":"NCT04631718","title":"MRI QSM Imaging for Iron Overload","phase":"","overall_status":"COMPLETED","enrollment_count":63,"lead_sponsor_name":"University of Wisconsin, Madison","has_results":false},{"nct_id":"NCT06137079","title":"\"Iron Overload and Endocrinological Diseases\"","phase":"","overall_status":"UNKNOWN","enrollment_count":62,"lead_sponsor_name":"Azienda Ospedaliero-Universitaria di Modena","has_results":false},{"nct_id":"NCT02720536","title":"Extended Evaluation of Deferasirox Film-coated Tablet (FCT) Formulation","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":53,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT01186419","title":"Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":51,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT04329286","title":"Platelet Changes in Cases of Chronic Iron Over Load","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT04329377","title":"Platelet Changes in Cases of Iron Overload(IO)","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT03372083","title":"Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT03453918","title":"Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.","phase":"NA","overall_status":"COMPLETED","enrollment_count":41,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT04423237","title":"Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT","phase":"","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"University of Pisa","has_results":false},{"nct_id":"NCT01604941","title":"Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":32,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT01363908","title":"Safety, Efficacy and Pharmacokinetics of an Oral Iron Chelator Given for a Year to Pediatric Patients With Iron Overload","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":30,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT01671111","title":"Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184)","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":30,"lead_sponsor_name":"Shire","has_results":true},{"nct_id":"NCT03802916","title":"Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"ApoPharma","has_results":true},{"nct_id":"NCT05326503","title":"Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults with Thalassemia","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Swiss Federal Institute of Technology","has_results":false},{"nct_id":"NCT04614779","title":"Long-term Clinical Study of CN128 in Thalassemia Patients","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":18,"lead_sponsor_name":"Hangzhou Zede Pharma-Tech Co., Ltd.","has_results":false},{"nct_id":"NCT04018300","title":"Iron Supplementation and Side Effects","phase":"NA","overall_status":"COMPLETED","enrollment_count":17,"lead_sponsor_name":"Iowa State University","has_results":false},{"nct_id":"NCT05355766","title":"Long-term Clinical Study of CN128 in Thalassemia With Sever Liver Iron Overloaded Patients","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Hangzhou Zede Pharma-Tech Co., Ltd.","has_results":false},{"nct_id":"NCT03990181","title":"Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement","phase":"NA","overall_status":"COMPLETED","enrollment_count":14,"lead_sponsor_name":"Swiss Federal Institute of Technology","has_results":false},{"nct_id":"NCT03777904","title":"The Iron Content of Ferritin in Serum and Urine of Children With High Serum Ferritin Levels","phase":"","overall_status":"TERMINATED","enrollment_count":11,"lead_sponsor_name":"University of Utah","has_results":false},{"nct_id":"NCT00712738","title":"Oral Nifedipine to Treat Iron Overload","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":6,"lead_sponsor_name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","has_results":false},{"nct_id":"NCT04741542","title":"Safety of SP-420 in the Treatment of Transfusional Iron Overload","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":2,"lead_sponsor_name":"The University of Texas Health Science Center at San Antonio","has_results":false},{"nct_id":"NCT01927913","title":"Treatment of Iron Overload Requiring Chelation Therapy","phase":"PHASE2","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"Shire","has_results":false}],"total":46},"guidelines":[],"source":"Drug Landscape verified database"}