{"disease":{"id":"interstitial-fibrosis","name":"Interstitial fibrosis","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":3,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"nintedanib","indication_name":"Interstitial fibrosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ofev","generic_name":"NINTEDANIB","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"Receptor-type tyrosine-protein kinase FLT3","drug_class":"Kinase Inhibitor","quality_score":70,"revenue":"2000","mechanism":"Ofev works by blocking enzymes that promote fibrosis and tumor growth."},{"drug_id":"ofev","indication_name":"Interstitial fibrosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"OFEV®","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"Calcium/calmodulin-dependent protein kinase type IV, Cyclin-dependent kinase 18, Cyclin-dependent kinase-like 2","drug_class":"Kinase Inhibitor","quality_score":37,"revenue":null,"mechanism":""},{"drug_id":"vargatef","indication_name":"Interstitial fibrosis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"vargatef","company_name":"ARCAGY/ GINECO GROUP","drug_phase":"discontinued","molecular_target":"Calcium/calmodulin-dependent protein kinase type IV, Cyclin-dependent kinase 18, Cyclin-dependent kinase-like 2","drug_class":"","quality_score":null,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05382572","title":"Pulmonary Fibrosis Foundation Community Registry","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Pulmonary Fibrosis Foundation","has_results":false},{"nct_id":"NCT04896138","title":"University of Virginia Natural History Study","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2500,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT02758808","title":"Pulmonary Fibrosis Foundation Patient Registry","phase":"","overall_status":"COMPLETED","enrollment_count":2004,"lead_sponsor_name":"Pulmonary Fibrosis Foundation","has_results":false},{"nct_id":"NCT04930289","title":"Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2000,"lead_sponsor_name":"Paragonix Technologies","has_results":false},{"nct_id":"NCT05337163","title":"A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China","phase":"","overall_status":"COMPLETED","enrollment_count":1564,"lead_sponsor_name":"Creative Biosciences (Guangzhou) Co., Ltd.","has_results":false},{"nct_id":"NCT06685874","title":"Interstitial Lung Disease Exacerbations Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1500,"lead_sponsor_name":"Royal Devon and Exeter NHS Foundation Trust","has_results":false},{"nct_id":"NCT03995654","title":"Research of Burden of Interstititial Lung Diseases in Turkey","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Karadeniz Technical University","has_results":false},{"nct_id":"NCT05998512","title":"Integrating Molecular, Genomic, Morphology and Environmental Features to Improve Precision Diagnosis and Treatment in Interstitial Lung Diseases (PRECISION-ILD)","phase":"","overall_status":"UNKNOWN","enrollment_count":1000,"lead_sponsor_name":"Institut d'Investigació Biomèdica de Bellvitge","has_results":false},{"nct_id":"NCT05392881","title":"Interstitial Lung Disease Research Unit Biobank","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Kansas Medical Center","has_results":false},{"nct_id":"NCT03747627","title":"BPF Genetics of ILD Study","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":475,"lead_sponsor_name":"University of Dundee","has_results":false},{"nct_id":"NCT06644144","title":"P4O2 ILD Extension","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Amsterdam UMC, location VUmc","has_results":false},{"nct_id":"NCT06383819","title":"Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes in the Lungs After COVID-19","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":392,"lead_sponsor_name":"NPO Petrovax","has_results":false},{"nct_id":"NCT02630316","title":"Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":326,"lead_sponsor_name":"United Therapeutics","has_results":true},{"nct_id":"NCT06702228","title":"Precision Diagnosis and Care for Families With Pulmonary Fibrosis in Ireland","phase":"","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Royal College of Surgeons, Ireland","has_results":false},{"nct_id":"NCT04430491","title":"To Evaluate the Use of Radiomics to Classify Between Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Maastricht University","has_results":false},{"nct_id":"NCT04624490","title":"Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":260,"lead_sponsor_name":"Mario Castro, MD, MPH","has_results":false},{"nct_id":"NCT06922916","title":"Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"Zhejiang University","has_results":false},{"nct_id":"NCT03670576","title":"It's Not JUST Idiopathic Pulmonary Fibrosis Study","phase":"","overall_status":"UNKNOWN","enrollment_count":250,"lead_sponsor_name":"University of Nottingham","has_results":false},{"nct_id":"NCT02633293","title":"An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE","phase":"PHASE2, PHASE3","overall_status":"TERMINATED","enrollment_count":243,"lead_sponsor_name":"United Therapeutics","has_results":true},{"nct_id":"NCT06615492","title":"Routine vs On-demand ECMO for Lung Transplantation","phase":"NA","overall_status":"RECRUITING","enrollment_count":218,"lead_sponsor_name":"Centre hospitalier de l'Université de Montréal (CHUM)","has_results":false},{"nct_id":"NCT03870828","title":"Clinical Characteristics of Interstitial Pneumonia With Autoimmune Features (IPAF) - a Multicenter Prospective Study","phase":"","overall_status":"UNKNOWN","enrollment_count":210,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT02229994","title":"Development of a New Tool for Dyspnea Measurement in Chronic Respiratory Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":199,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT02036970","title":"Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":166,"lead_sponsor_name":"Biogen","has_results":true},{"nct_id":"NCT05318599","title":"Deep Learning Diagnostic and Risk-stratification for IPF and COPD","phase":"","overall_status":"RECRUITING","enrollment_count":160,"lead_sponsor_name":"Pediatric Clinical Research Platform","has_results":false},{"nct_id":"NCT06416163","title":"FIBRotic Interstitial Lung Disease With Nocturnal hypOXaemia and EXercise Induced desaTuRAtion","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":160,"lead_sponsor_name":"Guy's and St Thomas' NHS Foundation Trust","has_results":false},{"nct_id":"NCT07486206","title":"Optimizing the Follow-Up Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-2 Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":152,"lead_sponsor_name":"Hospital de Granollers","has_results":false},{"nct_id":"NCT00677560","title":"The Natural History of Small Airways Physiology in Diseased and Healthy States","phase":"","overall_status":"COMPLETED","enrollment_count":126,"lead_sponsor_name":"Imperial College London","has_results":true},{"nct_id":"NCT03641742","title":"Families-At-risk for Interstitial Lung Disease Study","phase":"","overall_status":"COMPLETED","enrollment_count":125,"lead_sponsor_name":"Columbia University","has_results":true},{"nct_id":"NCT07091838","title":"Lung Diffusing Capacities Normality Thresholds in Pulmonary Fibrosis and Emphysema","phase":"","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","has_results":false},{"nct_id":"NCT04136223","title":"Rheumatoid Arthritis-Associated Interstitial Lung Disease: Characterization of Lung Disease Progression","phase":"","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Hospital do Coracao","has_results":false},{"nct_id":"NCT07466420","title":"Study on the Efficacy of Quercetin Intake in Patients With Fibrotic Interstitial Lung Diseases.","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Katerina M. Antoniou","has_results":false},{"nct_id":"NCT03321942","title":"Treatment of Chronic Renal Failure With Adipose Tissue-derived Mesenchymal Stem Cells","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"The Affiliated Hospital of Xuzhou Medical University","has_results":false},{"nct_id":"NCT07482917","title":"Optimizing the Diagnostic Journey in Interstitial Lung Disease: The OPTIMIZE-ILD-1 Trial","phase":"NA","overall_status":"RECRUITING","enrollment_count":92,"lead_sponsor_name":"Hospital de Granollers","has_results":false},{"nct_id":"NCT03901196","title":"Multi-elemental Imaging of Lung Tissues With LIBS (Laser-induced Breakdown Spectroscopy)","phase":"","overall_status":"COMPLETED","enrollment_count":86,"lead_sponsor_name":"University Hospital, Grenoble","has_results":false},{"nct_id":"NCT03918161","title":"Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)","phase":"NA","overall_status":"COMPLETED","enrollment_count":73,"lead_sponsor_name":"University Hospital, Bordeaux","has_results":false},{"nct_id":"NCT06482190","title":"A Study to Evaluate Safety, Tolerability and Pharmacokinetics of RSN0402 in Healthy Volunteers","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":72,"lead_sponsor_name":"Shenzhen Resproly Biopharmaceutical Co., Ltd","has_results":false},{"nct_id":"NCT04529993","title":"An Atlas of Airways at a Single Cell Level in Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Controls","phase":"NA","overall_status":"COMPLETED","enrollment_count":71,"lead_sponsor_name":"Centre Hospitalier Universitaire de Nice","has_results":false},{"nct_id":"NCT04803617","title":"Investigation of Pectoralis Muscle Strength in Elderly With Interstitial Lung Disease","phase":"","overall_status":"COMPLETED","enrollment_count":68,"lead_sponsor_name":"Habibedurdu","has_results":false},{"nct_id":"NCT03836417","title":"Molecular Diagnosis of Idiopathic Interstitial Pneumonias: a Prospective Study","phase":"","overall_status":"COMPLETED","enrollment_count":55,"lead_sponsor_name":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","has_results":false},{"nct_id":"NCT04574050","title":"SELF-BREATHE RCT for Chronic Breathlessness","phase":"NA","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"King's College Hospital NHS Trust","has_results":false},{"nct_id":"NCT03752892","title":"Partitioned Training of Patients With Idiopathic Pulmonary Fibrosis","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":50,"lead_sponsor_name":"West Park Healthcare Centre","has_results":false},{"nct_id":"NCT02019641","title":"The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients With Interstitial Lung Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":46,"lead_sponsor_name":"National Institutes of Health Clinical Center (CC)","has_results":true},{"nct_id":"NCT05095363","title":"Palliative Care Planner (PCplanner)","phase":"NA","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Duke University","has_results":false},{"nct_id":"NCT03800017","title":"Skeletal Muscle Function in Interstitial Lung Disease","phase":"NA","overall_status":"RECRUITING","enrollment_count":40,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT04138173","title":"Enhancing Physical Activity in Patients With Interstitial Lung Disease","phase":"NA","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"KU Leuven","has_results":false},{"nct_id":"NCT01570764","title":"Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06325696","title":"H01 in Adults With Interstitial Lung Disease (The SOLIS Study)","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":37,"lead_sponsor_name":"National Institute of Environmental Health Sciences (NIEHS)","has_results":false},{"nct_id":"NCT05227443","title":"Effects of Exercise Training on Respiratory Performance in Patients With Fibrosing Interstitial Lung Diseases","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Alexandria University","has_results":false},{"nct_id":"NCT07061873","title":"Physical Exercise Program for Adults With Diffuse Interstitial Lung Disease in a Pulmonary Rehabilitation Context","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":29,"lead_sponsor_name":"Universidad de La Frontera","has_results":false},{"nct_id":"NCT04119115","title":"Integrated Radiographic and Metabolomics Risk Assessment in Patients With Interstitial Lung Diseases","phase":"","overall_status":"TERMINATED","enrollment_count":28,"lead_sponsor_name":"Corewell Health East","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}