{"disease":{"id":"infective-endocarditis","name":"Infective endocarditis","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":3},"drugs":{"marketed":[{"drug_id":"vancomycin","indication_name":"Infective endocarditis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vancocin","generic_name":"vancomycin","company_name":"ANI Pharmaceuticals","drug_phase":"marketed","molecular_target":"Alpha-2A adrenergic receptor, D-alanyl-D-alanine dipeptidase, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase","drug_class":"","quality_score":40,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06418048","title":"INfectious DIsease REgistry BIObank","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"IRCCS San Raffaele","has_results":false},{"nct_id":"NCT03272724","title":"French National Observatory on Infective Endocarditis","phase":"","overall_status":"RECRUITING","enrollment_count":5000,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT03768180","title":"Infective Endocarditis After TAVR","phase":"","overall_status":"COMPLETED","enrollment_count":4600,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT02816307","title":"Etiology of Endocarditis in Negative Blood Cultures","phase":"NA","overall_status":"COMPLETED","enrollment_count":3033,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT07108803","title":"European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2500,"lead_sponsor_name":"Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)","has_results":false},{"nct_id":"NCT07156292","title":"The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2247,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT05965362","title":"Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR）","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"First Affiliated Hospital Xi'an Jiaotong University","has_results":false},{"nct_id":"NCT07511673","title":"The Study is a Randomised Clinical Trial (RCT) to Test if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1300,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT06434012","title":"Barts Endocarditis Research Registry","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT05253469","title":"Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":760,"lead_sponsor_name":"Centre Cardiologique du Nord","has_results":false},{"nct_id":"NCT05264181","title":"Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Centre Chirurgical Marie Lannelongue","has_results":false},{"nct_id":"NCT03295045","title":"Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008)","phase":"","overall_status":"COMPLETED","enrollment_count":484,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT05862025","title":"Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia (ET-AUREUS Study).","phase":"NA","overall_status":"UNKNOWN","enrollment_count":470,"lead_sponsor_name":"Puerta de Hierro University Hospital","has_results":false},{"nct_id":"NCT03979261","title":"Predisposition to Infectious Endocarditis","phase":"","overall_status":"UNKNOWN","enrollment_count":450,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT03612245","title":"Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":403,"lead_sponsor_name":"Centre Hospitalier Universitaire de Besancon","has_results":false},{"nct_id":"NCT02701595","title":"Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcus","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":324,"lead_sponsor_name":"University Hospital, Tours","has_results":false},{"nct_id":"NCT06745440","title":"Belgian Infective Endocarditis Registry","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Universitair Ziekenhuis Brussel","has_results":false},{"nct_id":"NCT06186258","title":"Infective Endocarditis in Percutaneous Pulmonary Revalvulation: Comparison Between Melody and Sapien Valves","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Centre Chirurgical Marie Lannelongue","has_results":false},{"nct_id":"NCT03266302","title":"Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective Endocarditis","phase":"NA","overall_status":"COMPLETED","enrollment_count":288,"lead_sponsor_name":"Jena University Hospital","has_results":false},{"nct_id":"NCT03153384","title":"Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":269,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT03365193","title":"PRetest prObability of Infectious ENDOCARDITIS for Appropriate Criteria Regarding Transesophageal ECHOcardiography in Tertiary Care Facilities (PRO ENDOCARDITIS ECHO-Study)","phase":"","overall_status":"COMPLETED","enrollment_count":263,"lead_sponsor_name":"University Hospital, Essen","has_results":false},{"nct_id":"NCT06309680","title":"Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT02887079","title":"Research Interest Antiphospholipid in Predicting Embolic Risk During Infective Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":186,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT04977518","title":"Characteristics of Infective Endocarditis in East China","phase":"","overall_status":"COMPLETED","enrollment_count":183,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT06269679","title":"CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.","phase":"NA","overall_status":"RECRUITING","enrollment_count":170,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT02701608","title":"Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"University Hospital, Tours","has_results":false},{"nct_id":"NCT04647331","title":"Betalactam Pharmacokinetics in Endocarditis Patients","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Uppsala University","has_results":false},{"nct_id":"NCT07529730","title":"Outcomes of Surgical Treatment in Patients With Infective Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria","has_results":false},{"nct_id":"NCT07029295","title":"Evaluation of the Impact of a Patient Education Protocol on the Quality of 18F-FDG PET Imaging Indicated for Investigation of Cardiac Inflammation","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":138,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04178915","title":"Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":100,"lead_sponsor_name":"The Republican Research and Practical Center for Epidemiology and Microbiology","has_results":false},{"nct_id":"NCT04792281","title":"Impact of FDG-PET/CT on Management of Patients with Native Valve Infective Endocarditis","phase":"","overall_status":"RECRUITING","enrollment_count":97,"lead_sponsor_name":"Montreal Heart Institute","has_results":false},{"nct_id":"NCT07313865","title":"From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":90,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT03961503","title":"Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients","phase":"","overall_status":"COMPLETED","enrollment_count":72,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT06266741","title":"The Predictive Value of Lubricin in Patients With Infective Endocarditis","phase":"","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Aydin Adnan Menderes University","has_results":false},{"nct_id":"NCT04544306","title":"Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject Drugs","phase":"NA","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","has_results":false},{"nct_id":"NCT03487653","title":"Detection of the Most Common Microorganism of Infective Endocarditis in Assiut University Hospital","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Safaa Samir","has_results":false},{"nct_id":"NCT00695903","title":"Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":38,"lead_sponsor_name":"Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)","has_results":true},{"nct_id":"NCT04838938","title":"Personalized Medicine in Patients With Infective Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":32,"lead_sponsor_name":"Fundación para la Investigación Biosanitaria del Principado de Asturias","has_results":false},{"nct_id":"NCT03683355","title":"Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves.","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec","has_results":false},{"nct_id":"NCT05692089","title":"Incidence of Infective Endocarditis in End Stage Renal Disease Patients on Hemodialysis by Transesophageal Echocardiography in Assuit University Hospital","phase":"","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT06777615","title":"Electronic Archive of Patients With Congenital Heart Disease and Diagnosis of Infective Endocarditis","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":30,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT03688659","title":"Vancomycin, Gentamycin in Infective Endocarditis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT03465098","title":"Evaluation of a Metabolic Preparation by a Low-carbohydrate Diet as Atkins-diet to Help in Detecting Infective Endocarditis by 18F-FDG PET","phase":"NA","overall_status":"COMPLETED","enrollment_count":26,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT00638157","title":"Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":24,"lead_sponsor_name":"Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)","has_results":true},{"nct_id":"NCT03945708","title":"Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery?","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Emma Hansson","has_results":false},{"nct_id":"NCT03199287","title":"Clinical Metagenomics of Infective Endocarditis","phase":"","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT06563609","title":"Combined Rehabilitation and Nutritional Support vs. Standard Care in In-Hospital Endocarditis Treatment","phase":"NA","overall_status":"TERMINATED","enrollment_count":15,"lead_sponsor_name":"Johannes Grand","has_results":false},{"nct_id":"NCT05183555","title":"Early Feasibility Study of Somatostatin Receptors PET Imaging for the Diagnosis of Infective Endocarditis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":14,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT04257292","title":"NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis","phase":"","overall_status":"UNKNOWN","enrollment_count":10,"lead_sponsor_name":"Jena University Hospital","has_results":false},{"nct_id":"NCT03590106","title":"Cardiac Surgery Peer Recovery Support Program","phase":"NA","overall_status":"COMPLETED","enrollment_count":8,"lead_sponsor_name":"University of Rochester","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}