{"disease":{"id":"infections-respiratory","name":"infections respiratory"},"drugs":{"marketed":[{"drug_id":"bicillin-c-r","indication_name":"Moderately severe to severe infections of the upper-respiratory tract","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Bicillin C-R","generic_name":"Penicillin G Benzathine","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Cell-wall peptidoglycan biosynthesis","drug_class":"Beta-lactam antibiotic","quality_score":10,"revenue":null,"mechanism":"Penicillin G inhibits bacterial cell-wall peptidoglycan biosynthesis, rendering the cell wall osmotically unstable."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT03294473","title":"Centralized Reminder Recall - Flu RCT2","phase":"NA","overall_status":"COMPLETED","enrollment_count":70190,"lead_sponsor_name":"University of California, Los Angeles","has_results":false},{"nct_id":"NCT05726084","title":"Immunogenicity, Efficacy and Safety Trial of the Convacell Vaccine in Healthy Volunteers Aged 18 Years and Older","phase":"PHASE2, PHASE3","overall_status":"UNKNOWN","enrollment_count":16304,"lead_sponsor_name":"St. Petersburg Research Institute of Vaccines and Sera","has_results":false},{"nct_id":"NCT04663776","title":"Wide Scale Monitoring for Acute Respiratory Infection Using a Mobile-Based Study Platform","phase":"","overall_status":"COMPLETED","enrollment_count":16000,"lead_sponsor_name":"Boston Children's Hospital","has_results":false},{"nct_id":"NCT03739112","title":"Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":12794,"lead_sponsor_name":"Medicago","has_results":true},{"nct_id":"NCT05620953","title":"Severe Acute Respiratory Infections (SARI) in Belgium (2011-2020)","phase":"","overall_status":"COMPLETED","enrollment_count":12145,"lead_sponsor_name":"Sciensano","has_results":false},{"nct_id":"NCT03301051","title":"Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":10160,"lead_sponsor_name":"Medicago","has_results":true},{"nct_id":"NCT07358910","title":"Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Institut Pasteur du Cambodge","has_results":false},{"nct_id":"NCT05097677","title":"Follow-up of Covid-19 Long Term Sequelae","phase":"","overall_status":"COMPLETED","enrollment_count":7599,"lead_sponsor_name":"Azienda Ospedaliera Universitaria Integrata Verona","has_results":false},{"nct_id":"NCT04367740","title":"ScreenNC, a Study to Determine the Number of Asymptomatic Individuals Who Have Antibodies to the Virus That Causes COVID-19","phase":"","overall_status":"COMPLETED","enrollment_count":6313,"lead_sponsor_name":"University of North Carolina, Chapel Hill","has_results":false},{"nct_id":"NCT04627623","title":"Prevalence and Risk Factors of COVID-19 in the Upper Silesian Agglomeration","phase":"","overall_status":"UNKNOWN","enrollment_count":6000,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT05244356","title":"Health Communication to Influence COVID-19 Vaccination Intent and Message Propagation","phase":"NA","overall_status":"COMPLETED","enrollment_count":5784,"lead_sponsor_name":"Clinical Research Centre, Malaysia","has_results":false},{"nct_id":"NCT06178822","title":"Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room","phase":"","overall_status":"RECRUITING","enrollment_count":3300,"lead_sponsor_name":"Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)","has_results":false},{"nct_id":"NCT06579170","title":"Burden of Recreational Water Illness Due to Exposure to Cyanobacteria and Their Toxins in Freshwater Beaches in Canada","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2500,"lead_sponsor_name":"Toronto Metropolitan University","has_results":false},{"nct_id":"NCT06739499","title":"Bern, Get Ready (BEready) Cohort Study for Pandemic Preparedness","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":2157,"lead_sponsor_name":"University of Bern","has_results":false},{"nct_id":"NCT07348380","title":"Volatile Organic Compounds Analysis by PTR-TOF-MS for Screening Respiratory Infections Using Exhaled Breath.","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":1665,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT03392363","title":"Diagnosing Respiratory Disease in Children Using Cough Sounds 2","phase":"","overall_status":"COMPLETED","enrollment_count":1470,"lead_sponsor_name":"ResApp Health Limited","has_results":false},{"nct_id":"NCT00246480","title":"RSV Disease in the Elderly","phase":"","overall_status":"COMPLETED","enrollment_count":1401,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT03321968","title":"Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1202,"lead_sponsor_name":"Medicago","has_results":true},{"nct_id":"NCT04782427","title":"COVID-19 Infections and Mortality in Long-term Care Facilities During the First Wave","phase":"","overall_status":"COMPLETED","enrollment_count":1197,"lead_sponsor_name":"Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal","has_results":false},{"nct_id":"NCT07279298","title":"Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1097,"lead_sponsor_name":"Bogotá District Health Secretariat","has_results":false},{"nct_id":"NCT07249996","title":"Respiratory Infections in Young Children","phase":"","overall_status":"RECRUITING","enrollment_count":1088,"lead_sponsor_name":"Eduardo Lopez -Medina","has_results":false},{"nct_id":"NCT05661032","title":"Novel Technologies for Respiratory Virus Identification","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Portsmouth Hospitals NHS Trust","has_results":false},{"nct_id":"NCT07229677","title":"Cohort Study of Arbovirus and Other Emerging Virus Infections in Fiji: AEVI-Fiji Cohort.","phase":"","overall_status":"RECRUITING","enrollment_count":910,"lead_sponsor_name":"Fiji National University","has_results":false},{"nct_id":"NCT02768805","title":"Immunogenicity of a Quadrivalent Virus-Like Particles (VLP) Influenza Vaccine in Healthy Adults","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":900,"lead_sponsor_name":"Medicago","has_results":false},{"nct_id":"NCT03996967","title":"Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia","phase":"","overall_status":"COMPLETED","enrollment_count":837,"lead_sponsor_name":"Boston University","has_results":false},{"nct_id":"NCT07382219","title":"Real-World Effectiveness of Nirsevimab Against RSV-Related and All-Cause Respiratory Tract Infections in Chinese Infants","phase":"","overall_status":"COMPLETED","enrollment_count":816,"lead_sponsor_name":"Han Tongyan","has_results":false},{"nct_id":"NCT03636191","title":"The Effect of a Probiotic on Upper Respiratory Tract Infections","phase":"NA","overall_status":"COMPLETED","enrollment_count":619,"lead_sponsor_name":"Chr Hansen","has_results":false},{"nct_id":"NCT05875961","title":"Study to Evaluate Immunogenicity, Safety and Tolerability of Adjuvanted and Non-Adjuvanted H2N3 Influenza Vaccines in Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"Seqirus","has_results":false},{"nct_id":"NCT05721183","title":"Evaluation of the National Tool for Observation of Infection Prevention Measures in the Healthcare (NOST)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"Norwegian Institute of Public Health","has_results":false},{"nct_id":"NCT04616586","title":"SILtuximab in Viral ARds (SILVAR) Study","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":555,"lead_sponsor_name":"RECORDATI GROUP","has_results":false},{"nct_id":"NCT04321369","title":"Impact of Swab Site and Sample Collector on Testing Sensitivity for COVID-19 Virus in Symptomatic Individuals","phase":"","overall_status":"COMPLETED","enrollment_count":530,"lead_sponsor_name":"UnitedHealth Group","has_results":false},{"nct_id":"NCT05677763","title":"OM-85 in Paediatric Recurrent Respiratory Tract Infections With Wheezing Lower Respiratory Illness","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":525,"lead_sponsor_name":"OM Pharma SA","has_results":false},{"nct_id":"NCT04380701","title":"A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-19 in Healthy and Immunocompromised Adults","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":512,"lead_sponsor_name":"BioNTech SE","has_results":true},{"nct_id":"NCT07211529","title":"Intraoperative Paravertebral Block and Postoperative Complications","phase":"NA","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT05874713","title":"Study to Evaluate Safety and Immunogenicity of Different Priming and Booster Regimens With Adjuvanted H5N8 and/or H5N6 Influenza Vaccine in Adults","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":480,"lead_sponsor_name":"Seqirus","has_results":false},{"nct_id":"NCT04476979","title":"Comparison of Tocilizumab Plus Dexamethasone vs. Dexamethasone for Patients With Covid-19","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":453,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT02236052","title":"Immunogenicity, Safety and Tolerability of a Plant-Derived Seasonal VLP Quadrivalent Influenza Vaccine in the Elderly Population","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":450,"lead_sponsor_name":"Medicago","has_results":false},{"nct_id":"NCT03392207","title":"Active Surveillance for Adverse Events Following Immunization With the Butantan Trivalent Influenza Vaccine (2018)","phase":"","overall_status":"COMPLETED","enrollment_count":403,"lead_sponsor_name":"Butantan Institute","has_results":false},{"nct_id":"NCT04925310","title":"Infection With Respiratory Syncytial Virus in Infants","phase":"","overall_status":"UNKNOWN","enrollment_count":350,"lead_sponsor_name":"Hannover Medical School","has_results":false},{"nct_id":"NCT04326309","title":"Audio Data Collection for Identification and Classification of Coughing","phase":"","overall_status":"COMPLETED","enrollment_count":336,"lead_sponsor_name":"HealthMode Inc.","has_results":false},{"nct_id":"NCT05618769","title":"Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants","phase":"NA","overall_status":"UNKNOWN","enrollment_count":330,"lead_sponsor_name":"Franciscus Gasthuis","has_results":false},{"nct_id":"NCT04600752","title":"Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Otitis Media in India","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":310,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT02233816","title":"Immunogenicity, Safety and Tolerability of a Plant-Derived Seasonal Virus-Like-Particle Quadrivalent Influenza Vaccine in Adults","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Medicago","has_results":false},{"nct_id":"NCT05422326","title":"A Study to Evaluate Safety and Immunogenicity of One or Two Booster Vaccinations With H5N6 Influenza Vaccine in Adults Primed With H5N1 Influenza Vaccine or Unprimed","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":260,"lead_sponsor_name":"Seqirus","has_results":false},{"nct_id":"NCT04328129","title":"Household Transmission Investigation Study for COVID-19 in Tropical Regions","phase":"NA","overall_status":"COMPLETED","enrollment_count":245,"lead_sponsor_name":"Institut Pasteur","has_results":false},{"nct_id":"NCT05897801","title":"Distinguishing Bacterial and Viral Infections by MeMed BV® Test to Limit Gut Colonization by MDRO","phase":"","overall_status":"COMPLETED","enrollment_count":230,"lead_sponsor_name":"Hellenic Institute for the Study of Sepsis","has_results":false},{"nct_id":"NCT05064631","title":"Bacterial Lysate In Preventing Asthma","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":173,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT05223114","title":"Airway Microbiome and Th17-mediated Inflammation in COPD Among HIV-infected Individuals in a Rural Ugandan Cohort","phase":"","overall_status":"COMPLETED","enrollment_count":160,"lead_sponsor_name":"Makerere University","has_results":false},{"nct_id":"NCT07381881","title":"GEL-AID: Safe and Effective Hydration for Institutionalized Older Adults","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":156,"lead_sponsor_name":"Universitat de Lleida","has_results":false},{"nct_id":"NCT05156723","title":"Study of the Immunogenicity, Safety and Tolerability of the Convacell Vaccine.","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":155,"lead_sponsor_name":"St. Petersburg Research Institute of Vaccines and Sera","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}