{"disease":{"id":"icu-patients","name":"icu patients"},"drugs":{"marketed":[{"drug_id":"upadacitinib","indication_name":"Active polyarticular juvenile idiopathic arthritis in patients 2 years of age and older with inadequate response or intolerance to TNF blockers","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rinvoq","generic_name":"upadacitinib","company_name":"AbbVie Inc.","drug_phase":"marketed","molecular_target":"Janus kinase (JAK) enzymes, particularly JAK1 and JAK2","drug_class":"JAK inhibitor","quality_score":86,"revenue":"5300","mechanism":"JAK inhibitor that prevents STAT phosphorylation and activation in cytokine signaling pathways."},{"drug_id":"verapamil-hydrochloride","indication_name":"Control of ventricular rate at rest in patients with chronic atrial flutter and/or atrial fibrillation (in association with digitalis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Verapamil Hydrochloride","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"L-type calcium channels (slow channels)","drug_class":"Calcium channel blocker","quality_score":56,"revenue":null,"mechanism":"Calcium ion influx inhibitor that modulates ionic calcium across cell membranes of arterial smooth muscle and myocardial cells."},{"drug_id":"verapamil-hydrochloride","indication_name":"Control of ventricular rate during stress in patients with chronic atrial flutter and/or atrial fibrillation (in association with digitalis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Verapamil Hydrochloride","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"L-type calcium channels (slow channels)","drug_class":"Calcium channel blocker","quality_score":56,"revenue":null,"mechanism":"Calcium ion influx inhibitor that modulates ionic calcium across cell membranes of arterial smooth muscle and myocardial cells."}],"pipeline":[],"offLabel":[],"totalMarketed":3,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04041323","title":"Incidence and Outcomes of Acute Kidney Injury in Postoperative ICU Patients - a Retrospective Data Analysis","phase":"","overall_status":"COMPLETED","enrollment_count":5000,"lead_sponsor_name":"Medical University of Vienna","has_results":false},{"nct_id":"NCT06421012","title":"Preoxygenation for Tracheal Aspirations in Intensive Care","phase":"NA","overall_status":"RECRUITING","enrollment_count":2260,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT03846323","title":"Liberalization of Visiting Policies in ICU for Reducing High Risk of Post-traumatic Stress Disorder","phase":"NA","overall_status":"COMPLETED","enrollment_count":1289,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07373561","title":"Post-Intensive Care Syndrome and Associated Symptom Burden Among Danish ICU Survivors","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":800,"lead_sponsor_name":"Zealand University Hospital","has_results":false},{"nct_id":"NCT03977883","title":"Management of Paroxystic Atrial Fibrillation in French Intensive Care Units","phase":"","overall_status":"COMPLETED","enrollment_count":742,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT01311232","title":"Factors Influencing Hepatitis B Virus Reactivation in Lymphoma Patients Treated With Rituximab","phase":"","overall_status":"COMPLETED","enrollment_count":600,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT04954755","title":"Development and Validation of a Prediction Model for Refeeding Syndrome in ICU Patients Undergoing Enteral Nutrition Patients","phase":"","overall_status":"COMPLETED","enrollment_count":553,"lead_sponsor_name":"Second Affiliated Hospital, School of Medicine, Zhejiang University","has_results":false},{"nct_id":"NCT03651635","title":"MR-proADM and CT-proET-1 During ICU Treatment","phase":"","overall_status":"COMPLETED","enrollment_count":533,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT06908408","title":"Correlation Between Base Excess in Patients Upon Admission to the ICU and Platelet Count Trend in the Following Days","phase":"","overall_status":"COMPLETED","enrollment_count":484,"lead_sponsor_name":"University Medical Centre Ljubljana","has_results":false},{"nct_id":"NCT04096768","title":"The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":394,"lead_sponsor_name":"Lebanese American University Medical Center","has_results":false},{"nct_id":"NCT01582776","title":"Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":317,"lead_sponsor_name":"The Lymphoma Academic Research Organisation","has_results":false},{"nct_id":"NCT07149246","title":"The Effect of a 6-month Dietitian-tailored Nutrition Intervention to Patients With Critical Illness (DETAIL)","phase":"NA","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"University Hospital of North Norway","has_results":false},{"nct_id":"NCT06387667","title":"Characterizing Diversity and Antifungal Resistance in Immunocompromised ICU Patients With Respiratory Tract Infections","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":250,"lead_sponsor_name":"New Valley University","has_results":false},{"nct_id":"NCT05522400","title":"Development and Application of Virtual Reality (VR) and Human Computer Interaction System in the ICU Patients","phase":"NA","overall_status":"UNKNOWN","enrollment_count":244,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT07390162","title":"The Effect of Changes in the Frequency of Endotracheal Tube Repositioning in Intensive Care Units on the Prevention of Oral Mucosal Pressure Injuries","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":230,"lead_sponsor_name":"Hacettepe University","has_results":false},{"nct_id":"NCT07129174","title":"Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":220,"lead_sponsor_name":"Jian-Xin Zhou","has_results":false},{"nct_id":"NCT04067271","title":"LUEbeck Registry of Intensive Care Patients - Characterization of the Patients Intestinal MICROBIOME","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"University of Luebeck","has_results":false},{"nct_id":"NCT07337798","title":"Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Xuanwu Hospital, Beijing","has_results":false},{"nct_id":"NCT05161104","title":"A Multicenter Cross-sectional Study of Cardiac Ultrasound Phenotypes in Patients With Sepsis","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Fujian Provincial Hospital","has_results":false},{"nct_id":"NCT03156192","title":"Music Use and Perceived Psycho-social Benefits of Music of Caregivers of Patients in an Intensive Care Unit","phase":"NA","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT07482436","title":"Comparison of Airway Ultrasonography and Laryngoscopy Methods in Obese Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":180,"lead_sponsor_name":"Trabzon Kanuni Education and Research Hospital","has_results":false},{"nct_id":"NCT03045692","title":"Assessment of Kidney Function for Drug Dosage Adjustments in Critically Ill Patients","phase":"NA","overall_status":"UNKNOWN","enrollment_count":172,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT07469397","title":"Preliminary Exploration of Factors Affecting Complete Hemostasis and Supine Time After Removal of Femoral Arterial Sheath in ICU Patients","phase":"","overall_status":"RECRUITING","enrollment_count":157,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT07107685","title":"Prosthetic Joint Infection : Lessons From Deceased Patients in Critical Care.","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06627842","title":"OsteoArticular Sepsis in Intensive Care unitS","phase":"","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT06993987","title":"Study of Interactions Between Oncologists and Resuscitators to Optimize Decision Making for Admission of Patients With Metastatic Solid Cancer to the ICU (InterOncoRea)","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":139,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT07291908","title":"Inflammation Severity and miRNA-126 in Trauma","phase":"","overall_status":"RECRUITING","enrollment_count":130,"lead_sponsor_name":"Melike Cengiz","has_results":false},{"nct_id":"NCT02908659","title":"Relevance and Nuisances of Respiratory Rate Alarm Generated by Multi-parametric Monitors in Non Ventilated ICU Patients","phase":"","overall_status":"COMPLETED","enrollment_count":122,"lead_sponsor_name":"Centre Hospitalier Departemental Vendee","has_results":false},{"nct_id":"NCT03641911","title":"Incidence of Inadequate Pain Treatment in Ventilated Critically Ill Surgical Patients","phase":"","overall_status":"COMPLETED","enrollment_count":118,"lead_sponsor_name":"Mahidol University","has_results":false},{"nct_id":"NCT07089004","title":"Hypomagnesemia and Its Clinical Outcome","phase":"","overall_status":"COMPLETED","enrollment_count":112,"lead_sponsor_name":"Bangladesh Bioscience Research Group","has_results":false},{"nct_id":"NCT01539746","title":"Transcatheter Aortic Valve Implantation Without Predilation","phase":"NA","overall_status":"COMPLETED","enrollment_count":110,"lead_sponsor_name":"University Hospital, Bonn","has_results":false},{"nct_id":"NCT06796218","title":"Validity and Reliability of the Arabic Version of De Morton Mobility Index After Abdominal Surgeries","phase":"","overall_status":"RECRUITING","enrollment_count":103,"lead_sponsor_name":"Cairo University","has_results":false},{"nct_id":"NCT03856489","title":"Patients' Sleep at the Intensive Care Unit","phase":"","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"University Hospital Ostrava","has_results":false},{"nct_id":"NCT07268274","title":"Metabolic Trajectories and Protein Intake in Long-Stay Ventilated Intensive Care Unit (ICU) Patients","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Universidade do Algarve","has_results":false},{"nct_id":"NCT04857216","title":"Comparison of the Block Characteristics of USG Guided Costoclavicular and Infraclavicular Block With the Perfusion Index","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Izmir Ataturk Training and Research Hospital","has_results":false},{"nct_id":"NCT07318571","title":"AI-Assisted Skin Assessment for Pressure Injury Prevention in Critical Care Nurses","phase":"NA","overall_status":"RECRUITING","enrollment_count":90,"lead_sponsor_name":"King Faisal Specialist Hospital & Research Center","has_results":false},{"nct_id":"NCT06967623","title":"Comparison of Weaning Parameters and Diaphragm Thickness Changes","phase":"","overall_status":"COMPLETED","enrollment_count":90,"lead_sponsor_name":"Tarık Durna","has_results":false},{"nct_id":"NCT06677099","title":"Electrical Impedance Tomography in Guiding Early and Precise Rehabilitation of Patients with Difficult Ventilator Weaning","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Capital Medical University","has_results":false},{"nct_id":"NCT06461754","title":"Prediction of Successful Liberation From Invasive Mechanical Ventilation Via Lung and Diaphragmatic Ultrasound in Intensive Care Unit Patients, Prospective, Observational Study","phase":"","overall_status":"COMPLETED","enrollment_count":80,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT05221879","title":"Anti-factor Xa Based Venous Thromboembolism Prophylaxis","phase":"NA","overall_status":"COMPLETED","enrollment_count":75,"lead_sponsor_name":"Meir Medical Center","has_results":false},{"nct_id":"NCT06640374","title":"Role of Clinical Pulmonary Infection Score and Sonopulmonary Infection Score in Diagnosis and Predicting Outcome of VAP in RUCU","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":70,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT02998294","title":"Respiratory Volume Measure Using ExSpiron 1Xi","phase":"NA","overall_status":"COMPLETED","enrollment_count":63,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT07153380","title":"Evolution of Physical and Emotional Distress in ICU","phase":"","overall_status":"COMPLETED","enrollment_count":62,"lead_sponsor_name":"Corporacion Parc Tauli","has_results":false},{"nct_id":"NCT01409044","title":"Effect of Music on Pain and Anxiety After Surgery","phase":"PHASE3","overall_status":"TERMINATED","enrollment_count":62,"lead_sponsor_name":"National Institutes of Health Clinical Center (CC)","has_results":false},{"nct_id":"NCT07332403","title":"The Relationship Between Diaphragm Function Assessed by Ultrasound and Weaning Success in Mechanically Ventilated Patients in the ICU","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Fatih Sultan Mehmet Training and Research Hospital","has_results":false},{"nct_id":"NCT07205419","title":"Eye-Tracking Interaction System for Non-verbal ICU Patients","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Shanghai Zhongshan Hospital","has_results":false},{"nct_id":"NCT04017299","title":"Electronic Distraction for ICU Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT07475650","title":"Virtual Reality in ICU Patients With COPD","phase":"NA","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"TC Erciyes University","has_results":false},{"nct_id":"NCT04811638","title":"The Validity and Reliability Study of the Chelsea Critical Care Physical Assesment Tool","phase":"","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"Saglik Bilimleri Universitesi","has_results":false},{"nct_id":"NCT07179705","title":"Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients","phase":"NA","overall_status":"RECRUITING","enrollment_count":46,"lead_sponsor_name":"Chulalongkorn University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}