{"disease":{"id":"hypophosphatemia","name":"Hypophosphatemia","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":6,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"sodium-phosphate-monobasic-monohydrate","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Osmoprep","generic_name":"sodium phosphate, monobasic, monohydrate","company_name":"Salix Pharms","drug_phase":"marketed","molecular_target":"","drug_class":"Calculi Dissolution Agent [EPC]","quality_score":20,"revenue":null,"mechanism":""},{"drug_id":"sodium-glycerophosphate","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Perikabiven In Plastic Container","generic_name":"SODIUM GLYCEROPHOSPHATE","company_name":"Fresenius Kabi","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":25,"revenue":null,"mechanism":""},{"drug_id":"dihydrotachysterol","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dichystrolum","generic_name":"DIHYDROTACHYSTEROL","company_name":"","drug_phase":"phase_2","molecular_target":"Vitamin D3 receptor","drug_class":"dihydrotachysterol","quality_score":0,"revenue":null,"mechanism":"Dichystrolum works by activating the Vitamin D3 receptor to increase calcium levels in the body."},{"drug_id":"calcitriol","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Calcijex","generic_name":"CALCITRIOL","company_name":"Esjay Pharma","drug_phase":"marketed","molecular_target":"Vitamin D3 receptor","drug_class":"Vitamin D3 Analog [EPC]","quality_score":60,"revenue":null,"mechanism":""},{"drug_id":"calcifediol","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Rayaldee","generic_name":"CALCIFEDIOL","company_name":"","drug_phase":"marketed","molecular_target":"Sterol regulatory element-binding protein 1","drug_class":"calcifediol","quality_score":10,"revenue":null,"mechanism":"Rayaldee works by increasing the levels of active vitamin D in the body."},{"drug_id":"rocaltrol","indication_name":"Hypophosphatemia","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Rocaltrol","company_name":"Shandong University","drug_phase":"marketed","molecular_target":"Vitamin D 25-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, Vitamin D-binding protein","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT05909722","title":"Validation of the GIDS and Description of Phosphate Disorders","phase":"","overall_status":"COMPLETED","enrollment_count":2681,"lead_sponsor_name":"University of Tartu","has_results":false},{"nct_id":"NCT03193476","title":"Registry for Patients With X-Linked Hypophosphatemia","phase":"","overall_status":"RECRUITING","enrollment_count":1343,"lead_sponsor_name":"Kyowa Kirin Pharmaceutical Development Ltd","has_results":false},{"nct_id":"NCT04455113","title":"Hypophosphatemia Deleteriously Affects Outcome of Septic Shock Patients Admitted to ICU","phase":"","overall_status":"COMPLETED","enrollment_count":317,"lead_sponsor_name":"Ayman Anis Metry","has_results":false},{"nct_id":"NCT03740802","title":"Hypophosphatemia as a Predictor in Surgical Resuscitation Sepsis","phase":"","overall_status":"COMPLETED","enrollment_count":264,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT04846647","title":"Study of the Inappropriate Secretion of FGF23 in Patients Followed in Hospital in a Context of Hypophosphatemia","phase":"","overall_status":"COMPLETED","enrollment_count":260,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT06112236","title":"Effects of Treatments for Anemia and Iron Deficiency on the Electrolyte Balance in Lung Transplant Recipients: A Special Focus on Hypophosphatemia","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":250,"lead_sponsor_name":"University of Zurich","has_results":false},{"nct_id":"NCT03745521","title":"Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":226,"lead_sponsor_name":"Kyowa Kirin Co., Ltd.","has_results":false},{"nct_id":"NCT06344546","title":"Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome","phase":"","overall_status":"COMPLETED","enrollment_count":218,"lead_sponsor_name":"Karolinska University Hospital","has_results":false},{"nct_id":"NCT03529058","title":"Hypophosphatemia as a Predictive Marker of Mortality During Sepsis in ICU","phase":"","overall_status":"COMPLETED","enrollment_count":193,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT02526160","title":"Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":134,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT07183579","title":"Effective Dosing of Burosumab in XLH","phase":"","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"University of Nottingham","has_results":false},{"nct_id":"NCT00975000","title":"Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":114,"lead_sponsor_name":"Amgen","has_results":true},{"nct_id":"NCT03820518","title":"Using Different Doses of Active Vitamin D Combined With Neutral Phosphate in Children With X-linked Hypophosphatemia","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Peking Union Medical College Hospital","has_results":false},{"nct_id":"NCT04519762","title":"Levels of 'Hypophosphatemia Affect Outcome of Septic Patients in ICU","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT04273490","title":"Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls","phase":"","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"University of Aarhus","has_results":false},{"nct_id":"NCT05098249","title":"Ferric Carboxymaltose With or Without Phosphate Substitution for the Treatment of Iron Deficiency or Iron Deficiency Anemia","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"Donat R. Spahn","has_results":false},{"nct_id":"NCT06754670","title":"Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning","phase":"","overall_status":"RECRUITING","enrollment_count":70,"lead_sponsor_name":"Peking Union Medical College","has_results":false},{"nct_id":"NCT06921720","title":"Phosphorus-31 Spectroscopy in Phosphate Diabetes","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":65,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT02915705","title":"Efficacy and Safety of Burosumab Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With XLH","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":61,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT04872907","title":"Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT07233889","title":"Enteral Supplementation With Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for the Treatment of Hypophosphatemia.","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT04419363","title":"Burosumab in Children and Adolescents With X-linked Hypophosphatemia","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":57,"lead_sponsor_name":"Bicetre Hospital","has_results":false},{"nct_id":"NCT02163577","title":"Study of KRN23 (Burosumab), a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":52,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT06108258","title":"Newborn Phosphocalcic Metabolism After Intravenous Iron Administration During Pregnancy","phase":"","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT06651892","title":"The Efficacy and Safety of Diluted Oral Phosphate Enema Versus Intravenous Sodium Glycerophosphate in The Treatment of Hypophosphatemia in ICU Patients","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Ain Shams University","has_results":false},{"nct_id":"NCT04502784","title":"Investigation of Hypophosphataemia Following Intravenous Iron","phase":"","overall_status":"UNKNOWN","enrollment_count":40,"lead_sponsor_name":"Belfast Health and Social Care Trust","has_results":false},{"nct_id":"NCT03596554","title":"X-linked Hypophosphatemia and FGF21","phase":"","overall_status":"COMPLETED","enrollment_count":39,"lead_sponsor_name":"Hospices Civils de Lyon","has_results":false},{"nct_id":"NCT03879915","title":"Dental Implants in Patients With X-linked Hypophosphatemia","phase":"","overall_status":"UNKNOWN","enrollment_count":36,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT04695860","title":"Anti-FGF23 (Burosumab) in Adult Patients With XLH","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"Wuerzburg University Hospital","has_results":false},{"nct_id":"NCT03920072","title":"Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":35,"lead_sponsor_name":"Kyowa Kirin Pharmaceutical Development Ltd","has_results":false},{"nct_id":"NCT03976440","title":"Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED: a Pilot Study","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"University of Parma","has_results":false},{"nct_id":"NCT04842032","title":"Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"Kyowa Kirin Co., Ltd.","has_results":false},{"nct_id":"NCT06067932","title":"Foot Disorders in X-linked Hypophosphatemia","phase":"","overall_status":"COMPLETED","enrollment_count":28,"lead_sponsor_name":"Orthopedic Hospital Vienna Speising","has_results":false},{"nct_id":"NCT05181839","title":"A Study to Describe the Lived Experience of XLH for Adolescents at End of Skeletal Growth","phase":"","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Kyowa Kirin Pharmaceutical Development Ltd","has_results":false},{"nct_id":"NCT06525636","title":"A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":24,"lead_sponsor_name":"Kyowa Kirin Co., Ltd.","has_results":false},{"nct_id":"NCT02312687","title":"Long-Term Extension Study of KRN23 in Adult Subjects With X-Linked Hypophosphatemia (XLH)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT04842019","title":"Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Adult Chinese Patients With XLH","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":18,"lead_sponsor_name":"Kyowa Kirin Co., Ltd.","has_results":false},{"nct_id":"NCT04188964","title":"Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of Burosumab in Patients Less Than 1 Year of Age","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"Kyowa Kirin Pharmaceutical Development Ltd","has_results":false},{"nct_id":"NCT02537431","title":"Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":14,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT02750618","title":"Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":13,"lead_sponsor_name":"Kyowa Kirin, Inc.","has_results":true},{"nct_id":"NCT04049877","title":"Retrospective and Prospective Disease Progression and Quality of Life in XLH","phase":"","overall_status":"COMPLETED","enrollment_count":11,"lead_sponsor_name":"Medialis Ltd.","has_results":false},{"nct_id":"NCT04146935","title":"Examining the Effect of Burosumab on Muscle Function","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"Yale University","has_results":true},{"nct_id":"NCT03489993","title":"FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP)","phase":"","overall_status":"COMPLETED","enrollment_count":8,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":false},{"nct_id":"NCT03581591","title":"Open Label Trial Assessing Safety and Efficacy of Burosumab (KRN23), in a Patient With ENS and Hypophosphatemic Rickets","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1,"lead_sponsor_name":"Redwood Dermatology Sciences","has_results":false},{"nct_id":"NCT02837523","title":"Biomarker for Cystinosis Disease: BioCystinosis (BioCystinosis)","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"CENTOGENE GmbH Rostock","has_results":false},{"nct_id":"NCT03775187","title":"Expanded Access to Burosumab","phase":"","overall_status":"AVAILABLE","enrollment_count":null,"lead_sponsor_name":"Kyowa Kirin Co., Ltd.","has_results":false}],"total":47},"guidelines":[],"source":"Drug Landscape verified database"}