{"disease":{"id":"hypersensitivity","name":"hypersensitivity"},"drugs":{"marketed":[{"drug_id":"prednisone","indication_name":"Drug hypersensitivity reactions","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Deltasone","generic_name":"prednisone","company_name":"Generic (originally Schering)","drug_phase":"marketed","molecular_target":"Annexin A1, Sodium/nucleoside cotransporter 1, Glucocorticoid receptor","drug_class":"Corticosteroid [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"dexamethasone-phosphate","indication_name":"Drug hypersensitivity reactions","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dexamethasone Sodium Phosphate","generic_name":"dexamethasone phosphate","company_name":"Merck & Co.","drug_phase":"marketed","molecular_target":"Androgen receptor, Glucocorticoid receptor, Mineralocorticoid receptor","drug_class":"Corticosteroid","quality_score":10,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":2,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT04605471","title":"A Study to Learn More About the Safety of Ultravist in Children and in the Elderly","phase":"","overall_status":"COMPLETED","enrollment_count":132850,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT03974555","title":"Epidemiological Investigation and Cohort Study on Food Allergy in Children Aged 3 to 6 Years in Wenzhou and Taizhou Urban Areas","phase":"","overall_status":"UNKNOWN","enrollment_count":8000,"lead_sponsor_name":"Second Affiliated Hospital of Wenzhou Medical University","has_results":false},{"nct_id":"NCT04654923","title":"GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions","phase":"","overall_status":"RECRUITING","enrollment_count":3000,"lead_sponsor_name":"University Hospital, Strasbourg, France","has_results":false},{"nct_id":"NCT04896138","title":"University of Virginia Natural History Study","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2500,"lead_sponsor_name":"University of Virginia","has_results":false},{"nct_id":"NCT04839666","title":"Hypersensitivity Reactions to Propofol in Children","phase":"","overall_status":"COMPLETED","enrollment_count":2299,"lead_sponsor_name":"Universitair Ziekenhuis Brussel","has_results":false},{"nct_id":"NCT05039229","title":"Measures for Bioaerosol Reduction in the Salmon Industry","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":2000,"lead_sponsor_name":"University Hospital of North Norway","has_results":false},{"nct_id":"NCT02839551","title":"Optimal Doses for Drug Provocation Tests to Beta-lactams","phase":"NA","overall_status":"COMPLETED","enrollment_count":1252,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT03627767","title":"Study to Investigate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years and Over With Moderate to Severe Atopic Dermatitis With the Option of Rescue Treatment in Flaring Subjects","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1235,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT05076227","title":"Effect of Different SARS-CoV-2 Vaccine Schedules and Vaccination Intervals on Reactogenicity and Humoral Immunogenicity","phase":"","overall_status":"COMPLETED","enrollment_count":1206,"lead_sponsor_name":"Serge Thal","has_results":false},{"nct_id":"NCT05177744","title":"Toxicity of Micro and Nano Plastics Combined With Environmental Contaminants on the Risk of Allergic Disease","phase":"","overall_status":"COMPLETED","enrollment_count":1156,"lead_sponsor_name":"Children's Hospital Srebrnjak","has_results":false},{"nct_id":"NCT04005417","title":"Meta-analysis of Stannous Fluoride Dentifrice and the Effects on Dentine Hypersensitivity","phase":"","overall_status":"COMPLETED","enrollment_count":1036,"lead_sponsor_name":"Procter and Gamble","has_results":false},{"nct_id":"NCT05392881","title":"Interstitial Lung Disease Research Unit Biobank","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"University of Kansas Medical Center","has_results":false},{"nct_id":"NCT04827602","title":"Drug Allergy Labels After Drug Allergy Investigation","phase":"","overall_status":"COMPLETED","enrollment_count":849,"lead_sponsor_name":"University Hospital, Gentofte, Copenhagen","has_results":false},{"nct_id":"NCT03720470","title":"Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapy","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":838,"lead_sponsor_name":"Pfizer","has_results":true},{"nct_id":"NCT00001406","title":"Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia","phase":"","overall_status":"RECRUITING","enrollment_count":800,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT07316465","title":"Birth Cohort: Development of IgE Autoantibodies in Newborns With (High Risk of) Atopic Dermatitis","phase":"NA","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Universitair Ziekenhuis Brussel","has_results":false},{"nct_id":"NCT04421638","title":"Cephalosporin Hypersensitivity","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT03771118","title":"Drug Provocation Test (DPT) to Paracetamol","phase":"","overall_status":"COMPLETED","enrollment_count":498,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT03369509","title":"Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)","phase":"","overall_status":"TERMINATED","enrollment_count":456,"lead_sponsor_name":"University Hospital, Grenoble","has_results":false},{"nct_id":"NCT06644144","title":"P4O2 ILD Extension","phase":"","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Amsterdam UMC, location VUmc","has_results":false},{"nct_id":"NCT00988065","title":"Sugammadex Hypersensitivity Study (Study P06042)","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":448,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT04454229","title":"The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge","phase":"NA","overall_status":"COMPLETED","enrollment_count":382,"lead_sponsor_name":"Austin Health","has_results":false},{"nct_id":"NCT02028065","title":"A Study to Evaluate the Incidence of Hypersensitivity After Administration of Sugammadex in Healthy Participants (MK-8616-101)","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":382,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT03743220","title":"Drug Provocation Test (DPT) to Non Steroidal Anti-inflammatory Drugs (NSAID)","phase":"","overall_status":"COMPLETED","enrollment_count":311,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT06406114","title":"Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":300,"lead_sponsor_name":"Massachusetts General Hospital","has_results":false},{"nct_id":"NCT06428162","title":"An Evaluation of Healthcare Providers' Adherence to Pharmacovigilance Practices in an African Community","phase":"","overall_status":"COMPLETED","enrollment_count":300,"lead_sponsor_name":"Deraya University","has_results":false},{"nct_id":"NCT05661812","title":"Norwegian Birch Rust Allergy Study","phase":"","overall_status":"COMPLETED","enrollment_count":287,"lead_sponsor_name":"University Hospital of North Norway","has_results":false},{"nct_id":"NCT05003804","title":"Allergic Disease Onset Prevention Study","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":283,"lead_sponsor_name":"Siolta Therapeutics, Inc.","has_results":false},{"nct_id":"NCT00102570","title":"Clinical and Immunological Evaluation of Children With Allergies","phase":"","overall_status":"COMPLETED","enrollment_count":270,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT02349763","title":"Dexamethasone Regimens for Prophylaxis of Paclitaxel-associated Hypersensitivity Reaction","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":260,"lead_sponsor_name":"Department of Medical Services Ministry of Public Health of Thailand","has_results":false},{"nct_id":"NCT07297732","title":"A Study to Investigate the Tooth Whitening and Dentin Hypersensitivity Effectiveness of Two Experimental Toothpastes","phase":"NA","overall_status":"COMPLETED","enrollment_count":254,"lead_sponsor_name":"HALEON","has_results":false},{"nct_id":"NCT03054428","title":"Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe Atopic Dermatitis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":251,"lead_sponsor_name":"Regeneron Pharmaceuticals","has_results":true},{"nct_id":"NCT07524712","title":"Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":248,"lead_sponsor_name":"Tongji Hospital","has_results":false},{"nct_id":"NCT04531540","title":"Study to Determine Skin Irritation and/or Sensitization Potential of an Antifungal Cream Containing Trolamine (Repeated Insult Patch Test)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":225,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT06466200","title":"Validation of a French Version of the DHEQ","phase":"NA","overall_status":"COMPLETED","enrollment_count":216,"lead_sponsor_name":"University Hospital, Clermont-Ferrand","has_results":false},{"nct_id":"NCT02031120","title":"Management of Drug Hypersensitivity in Children","phase":"","overall_status":"TERMINATED","enrollment_count":207,"lead_sponsor_name":"University Hospital, Geneva","has_results":false},{"nct_id":"NCT06624696","title":"Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":204,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT03553251","title":"Protocol of Reintroduction of Beta-lactams in Children at Low Risk of Anaphylaxis.","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Nantes University Hospital","has_results":false},{"nct_id":"NCT07390370","title":"Establishment of a Registry for Immediate Drug Allergy","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Yonsei University","has_results":false},{"nct_id":"NCT03224494","title":"Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag","phase":"NA","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Queen's University","has_results":false},{"nct_id":"NCT05675241","title":"Characterizing the Inflammation Around Dental Implants","phase":"","overall_status":"UNKNOWN","enrollment_count":177,"lead_sponsor_name":"McGill University","has_results":false},{"nct_id":"NCT00887939","title":"Pathogenesis of Physical Induced Urticarial Syndromes","phase":"","overall_status":"COMPLETED","enrollment_count":173,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT06759454","title":"Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":172,"lead_sponsor_name":"Kemia Gul","has_results":false},{"nct_id":"NCT05119751","title":"Vestibular Versus Sublingual Route of AIT Tablets","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":172,"lead_sponsor_name":"Clinique Spécialisée en Allergies de la Capitale","has_results":false},{"nct_id":"NCT06264453","title":"A Study to Evaluate the Efficacy and Safety of KH001 in Patients with Dentin Hypersensitivity","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":171,"lead_sponsor_name":"HysensBio Co., Ltd","has_results":false},{"nct_id":"NCT03158831","title":"Drug Challenges Without Prior Skin Testing","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":166,"lead_sponsor_name":"Montefiore Medical Center","has_results":false},{"nct_id":"NCT05392868","title":"Managing Dentine Hypersensitivity With Silver Diamine Fluoride on Older Adults","phase":"PHASE2","overall_status":"UNKNOWN","enrollment_count":166,"lead_sponsor_name":"The University of Hong Kong","has_results":false},{"nct_id":"NCT03790033","title":"Efficacy and Safety of Ucha-Shinki-Hwan on Korean Patients With Cold Hypersensitivity in the Hands and Feet-Double Blinded, Randomized, Multicenter, Placebo Controlled Clinical Trial","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":164,"lead_sponsor_name":"Gachon University Gil Oriental Medical Hospital","has_results":false},{"nct_id":"NCT04961944","title":"HypErsensitiVity PneumonITis: DiseAse Progression Characterization","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Hospital do Coracao","has_results":false},{"nct_id":"NCT01867671","title":"Peanut Oral Immunotherapy in Children","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":146,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":true}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}