{"disease":{"id":"hypercortisolism","name":"Hypercortisolism","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":5,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"osilodrostat","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Isturisa","generic_name":"OSILODROSTAT","company_name":"Recordati","drug_phase":"marketed","molecular_target":"Cytochrome P450 11B2, mitochondrial","drug_class":"Cortisol Synthesis Inhibitor","quality_score":70,"revenue":"200","mechanism":"Isturisa blocks the production of cortisol in the adrenal glands by inhibiting the cytochrome P450 11B2 enzyme."},{"drug_id":"trilostane","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Desopan","generic_name":"TRILOSTANE","company_name":"Bioenvision","drug_phase":"marketed","molecular_target":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2","drug_class":"trilostane","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"pasireotide","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Signifor","generic_name":"PASIREOTIDE","company_name":"Recordati","drug_phase":"marketed","molecular_target":"Somatostatin receptor type 5","drug_class":"Somatostatin Analog [EPC]","quality_score":50,"revenue":null,"mechanism":"Signifor works by binding to somatostatin receptors on the surface of cells, mimicking the natural hormone somatostatin to reduce cortisol production."},{"drug_id":"corticorelin","indication_name":"Diagnosis of Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Corticotropin-Releasing Factor (Human)","generic_name":"CORTICORELIN","company_name":"","drug_phase":"marketed","molecular_target":"Corticotropin-releasing factor receptor 1","drug_class":"","quality_score":17,"revenue":null,"mechanism":""},{"drug_id":"ketoconazole","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Nizoral","generic_name":"ketoconazole","company_name":"Johnson & Johnson (Janssen)","drug_phase":"marketed","molecular_target":"Aldehyde oxidase, Cytochrome P450 21, Sodium/nucleoside cotransporter 1","drug_class":"Azole Antifungal [EPC]","quality_score":40,"revenue":null,"mechanism":""},{"drug_id":"signifor","indication_name":"Hypercortisolism","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Signifor","company_name":"University Hospital Heidelberg","drug_phase":"marketed","molecular_target":"Somatostatin receptor type 1, Somatostatin receptor type 2, Somatostatin receptor type 3","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06829537","title":"Study of the Prevalence of Endogenous Hypercortisolism in Patients With Resistant Hypertension (MOMENTUM)","phase":"","overall_status":"COMPLETED","enrollment_count":1143,"lead_sponsor_name":"Corcept Therapeutics","has_results":false},{"nct_id":"NCT05772169","title":"Study to Determine the Prevalence of Hypercortisolism in Patients With Type 2 Diabetes and Treatment With Korlym® (Mifepristone) (CATALYST)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":1113,"lead_sponsor_name":"Corcept Therapeutics","has_results":false},{"nct_id":"NCT07156370","title":"Salivary Cortisol and Hypercortisolism in Type 2 Diabetes","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Shanghai 6th People's Hospital","has_results":false},{"nct_id":"NCT05766085","title":"Cortisol Secretion, Sensitivity and Activity and Hypertension","phase":"","overall_status":"UNKNOWN","enrollment_count":290,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT07350031","title":"Serum and Salivary Cortisol Assessment in Patients With Adrenal Incidentalomas and Healthy Controls","phase":"","overall_status":"COMPLETED","enrollment_count":209,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT04833192","title":"Evaluation of New Diagnostic Indicator of Subclinical Hypercortisolism","phase":"","overall_status":"UNKNOWN","enrollment_count":202,"lead_sponsor_name":"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","has_results":false},{"nct_id":"NCT04433819","title":"Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients","phase":"","overall_status":"UNKNOWN","enrollment_count":200,"lead_sponsor_name":"Marmara University","has_results":false},{"nct_id":"NCT04308590","title":"A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":137,"lead_sponsor_name":"Corcept Therapeutics","has_results":true},{"nct_id":"NCT07412782","title":"REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Meyer Children's Hospital IRCCS","has_results":false},{"nct_id":"NCT06246357","title":"Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and Hypercortisolism","phase":"PHASE2","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT04127552","title":"Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations","phase":"","overall_status":"RECRUITING","enrollment_count":68,"lead_sponsor_name":"University of Roma La Sapienza","has_results":false},{"nct_id":"NCT04860180","title":"Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas","phase":"NA","overall_status":"UNKNOWN","enrollment_count":61,"lead_sponsor_name":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","has_results":false},{"nct_id":"NCT05368090","title":"Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism","phase":"NA","overall_status":"RECRUITING","enrollment_count":60,"lead_sponsor_name":"Haukeland University Hospital","has_results":false},{"nct_id":"NCT02335996","title":"Hypercortisolism and Epicardial Adipose Tissue","phase":"NA","overall_status":"COMPLETED","enrollment_count":43,"lead_sponsor_name":"Assistance Publique Hopitaux De Marseille","has_results":false},{"nct_id":"NCT04045015","title":"Liquorice and Salivary Cortisol","phase":"NA","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Umeå University","has_results":false},{"nct_id":"NCT05255900","title":"Effects of Metyrapone in Patients With Hypercortisolism","phase":"","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT06701838","title":"Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":15,"lead_sponsor_name":"Imperial College London","has_results":false},{"nct_id":"NCT02001051","title":"Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":4,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":true},{"nct_id":"NCT03379363","title":"Retrospective Chart Review Study of Pediatric Patients Treated With Korlym for Cushing Syndrome","phase":"","overall_status":"TERMINATED","enrollment_count":2,"lead_sponsor_name":"Corcept Therapeutics","has_results":false}],"total":19},"guidelines":[],"source":"Drug Landscape verified database"}