{"disease":{"id":"hip-replacement","name":"hip replacement"},"drugs":{"marketed":[{"drug_id":"chembl-chembl48361","indication_name":"Prophylaxis of DVT and PE after hip replacement surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dabigatran Etexilate","generic_name":"DABIGATRAN","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":65,"revenue":"1200","mechanism":"Dabigatran works by directly inhibiting the activity of thrombin, a key enzyme in the blood clotting process."},{"drug_id":"chembl-chembl48361","indication_name":"Hip replacement surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dabigatran Etexilate","generic_name":"DABIGATRAN","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":65,"revenue":"1200","mechanism":"Dabigatran works by directly inhibiting the activity of thrombin, a key enzyme in the blood clotting process."},{"drug_id":"chembl-chembl48361","indication_name":"Hip replacement surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dabigatran Etexilate","generic_name":"DABIGATRAN","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":65,"revenue":"1200","mechanism":"Dabigatran works by directly inhibiting the activity of thrombin, a key enzyme in the blood clotting process."},{"drug_id":"fragmin","indication_name":"Prophylaxis of DVT in Hip Replacement Surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fragmin","generic_name":"Dalteparin Sodium","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Factor Xa and thrombin","drug_class":"Low molecular weight heparin (LMWH)","quality_score":68,"revenue":null,"mechanism":"Dalteparin enhances inhibition of Factor Xa and thrombin by antithrombin."},{"drug_id":"dabigatran-etexilate","indication_name":"Prophylaxis of DVT and PE after hip replacement surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Pradaxa","generic_name":"dabigatran-etexilate","company_name":"Boehringer Ingelheim","drug_phase":"marketed","molecular_target":"Thrombin (serine protease)","drug_class":"Direct thrombin inhibitor","quality_score":71,"revenue":null,"mechanism":"Competitive direct thrombin inhibitor preventing fibrin formation and thrombus development."},{"drug_id":"fragmin","indication_name":"Prophylaxis of deep vein thrombosis in patients undergoing hip replacement surgery","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Fragmin","generic_name":"Dalteparin Sodium","company_name":"Pfizer Inc.","drug_phase":"marketed","molecular_target":"Factor Xa and thrombin","drug_class":"Low molecular weight heparin (LMWH)","quality_score":68,"revenue":null,"mechanism":"Dalteparin enhances inhibition of Factor Xa and thrombin by antithrombin."}],"pipeline":[],"offLabel":[],"totalMarketed":6,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT06307145","title":"Korea Hip Replacement Surgery Registry","phase":"","overall_status":"COMPLETED","enrollment_count":124556,"lead_sponsor_name":"Samsung Medical Center","has_results":false},{"nct_id":"NCT06689059","title":"Research on Multimodal Multi-objective Integrated Machine Algorithm for Hip Replacement Surgery","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":6271,"lead_sponsor_name":"Jingkun Liu","has_results":false},{"nct_id":"NCT05044767","title":"Study to Evaluate the Performance and Safety of ATF Implants and Lapé Médical Devices Implanted During Hip Arthroplasty","phase":"","overall_status":"RECRUITING","enrollment_count":4500,"lead_sponsor_name":"ATF Implants","has_results":false},{"nct_id":"NCT03790267","title":"Functional Outcomes and Quality of Life in Hip, Knee and Shoulder Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":4260,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT03570944","title":"Postoperative Outcomes Within an Enhanced Recovery After Surgery Protocol (POWER2)","phase":"","overall_status":"UNKNOWN","enrollment_count":3012,"lead_sponsor_name":"Grupo Español de Rehabilitación Multimodal","has_results":false},{"nct_id":"NCT03120312","title":"Short Term and Long Term Outcome for Elderly Patients Treated With Total Hip Replacement","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Second Hospital of Shanxi Medical University","has_results":false},{"nct_id":"NCT03424382","title":"CREATION Health Readmission Risk Assessment Tool","phase":"","overall_status":"COMPLETED","enrollment_count":1218,"lead_sponsor_name":"AdventHealth","has_results":false},{"nct_id":"NCT01422304","title":"Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":1198,"lead_sponsor_name":"Merck Sharp & Dohme LLC","has_results":true},{"nct_id":"NCT05627544","title":"Blood Transfusion Applications in Hip Replacements","phase":"","overall_status":"COMPLETED","enrollment_count":560,"lead_sponsor_name":"Baskent University","has_results":false},{"nct_id":"NCT02906033","title":"The Effect of A New Perioperative Practice Model on Patient, Nursing And Organisational Outcomes","phase":"NA","overall_status":"COMPLETED","enrollment_count":517,"lead_sponsor_name":"Hospital District of Helsinki and Uusimaa","has_results":true},{"nct_id":"NCT04199377","title":"Retrospective Evaluation of Clinical and Functional Results and Survivorship of Total Knee Replacement and Total Hip Replacement, Both Isolated or Combined.","phase":"NA","overall_status":"UNKNOWN","enrollment_count":500,"lead_sponsor_name":"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","has_results":false},{"nct_id":"NCT03499028","title":"Improvement of Patient Satisfaction and Clinical Outcomes Using JointCOACH","phase":"NA","overall_status":"COMPLETED","enrollment_count":446,"lead_sponsor_name":"The Cleveland Clinic","has_results":true},{"nct_id":"NCT02685735","title":"Predicting, Understanding and Speeding Recovery After TKA","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":350,"lead_sponsor_name":"Wake Forest University Health Sciences","has_results":true},{"nct_id":"NCT07464665","title":"Comparing Dual-mobility Cups Versus Unipolar Cups for Unselected Primary Total Hip Arthroplasty by Direct Anterior Approach","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Elsan","has_results":false},{"nct_id":"NCT04425603","title":"Anthology Hip Replacement System - Orthopaedic Data Evolution Panel (ODEP) Surveillance Study","phase":"","overall_status":"COMPLETED","enrollment_count":270,"lead_sponsor_name":"Smith & Nephew Orthopaedics AG","has_results":false},{"nct_id":"NCT06628336","title":"Post-Market Observational Study of the HARMONY® Evolution Implants and Instruments","phase":"","overall_status":"RECRUITING","enrollment_count":264,"lead_sponsor_name":"Symbios Orthopedie SA","has_results":false},{"nct_id":"NCT04886570","title":"Clinical Follow-up of Hip Arthroplasty: A Cross-section and Longitudinal Study","phase":"","overall_status":"UNKNOWN","enrollment_count":260,"lead_sponsor_name":"Taipei Veterans General Hospital, Taiwan","has_results":false},{"nct_id":"NCT04277416","title":"Survivorship and Effectiveness of the Ortho Development® Entrada™ Hip System for Total Hip Arthroplasty","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":250,"lead_sponsor_name":"Ortho Development Corporation","has_results":false},{"nct_id":"NCT06178185","title":"A Novel Study Evaluating Patients Awaiting Total Hip Arthroplasty (PRIORITEES)","phase":"","overall_status":"UNKNOWN","enrollment_count":240,"lead_sponsor_name":"Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust","has_results":false},{"nct_id":"NCT02403596","title":"Blood-sparing During Hip Prosthesis Surgery With Exacyl® in Patients Treated With Rivaroxaban","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":231,"lead_sponsor_name":"University Hospital, Brest","has_results":false},{"nct_id":"NCT05291598","title":"Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":223,"lead_sponsor_name":"University of Miami","has_results":true},{"nct_id":"NCT03610789","title":"A Multicenter, Post-Market Clinical Follow-up Study of Subjects With the REDAPT™ System Monolithic Sleeveless/Sleeved Stem and/or Fully Porous Acetabular Shell With XLPE Liner and/or Modular Shell Components Previously Implanted","phase":"","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":220,"lead_sponsor_name":"Smith & Nephew, Inc.","has_results":false},{"nct_id":"NCT07124819","title":"Dimolegin® (60 mg) Given Once Daily in Patients Undergoing Total Hip or Knee Replacement Compared to Enoxaparin","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":215,"lead_sponsor_name":"Avexima Diol LLC","has_results":false},{"nct_id":"NCT03806114","title":"Dislocation Precautions","phase":"NA","overall_status":"UNKNOWN","enrollment_count":212,"lead_sponsor_name":"Ottawa Hospital Research Institute","has_results":false},{"nct_id":"NCT07226700","title":"Suzetrigine in Total Hip Arthroplasty","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":210,"lead_sponsor_name":"Hospital for Special Surgery, New York","has_results":false},{"nct_id":"NCT02042586","title":"Evaluation of Locomotor Activity Before and After Total Hip Replacement in Patients With Hip Osteoarthritis.","phase":"","overall_status":"COMPLETED","enrollment_count":202,"lead_sponsor_name":"Centre Hospitalier Universitaire Dijon","has_results":false},{"nct_id":"NCT07120191","title":"An Open Label Data Collection Study of My Connect Post-Op, a Post-Operative Communication Tool","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Concentra AI, inc","has_results":false},{"nct_id":"NCT02808169","title":"Radlink GPS Provide a Valid Intra-operative Assessment of Acetabular Inclination and Anteversion","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Barrett, William, M.D.","has_results":false},{"nct_id":"NCT06172569","title":"Spartan Stem, World Cup and World Liner Post Market Clinical Follow-up Study","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"Signature Orthopaedics","has_results":false},{"nct_id":"NCT07449585","title":"Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":180,"lead_sponsor_name":"Medical University of Gdansk","has_results":false},{"nct_id":"NCT03666260","title":"Analgesia in Total Hip Arthroplasty by Quadratus Lumborum Block","phase":"NA","overall_status":"COMPLETED","enrollment_count":179,"lead_sponsor_name":"CHU de Reims","has_results":false},{"nct_id":"NCT06006572","title":"Hip DAA Closure Techniques","phase":"NA","overall_status":"UNKNOWN","enrollment_count":172,"lead_sponsor_name":"Rothman Institute Orthopaedics","has_results":false},{"nct_id":"NCT04960241","title":"Does Rehabilitation After Total Hip Or Knee Arthroplasty Work (DRAW2)","phase":"NA","overall_status":"COMPLETED","enrollment_count":169,"lead_sponsor_name":"Troels Mark Christensen","has_results":false},{"nct_id":"NCT03863743","title":"Impact of Integrated Care Pathways for Prevention of Post-operative Urinary Retention (POUR)","phase":"NA","overall_status":"UNKNOWN","enrollment_count":164,"lead_sponsor_name":"TriHealth Inc.","has_results":false},{"nct_id":"NCT05452161","title":"Effects of Preoperative Education, and Follow-up Sessions of Patients With Total Hip and Knee Arthroplasty (ESIPPES)","phase":"NA","overall_status":"COMPLETED","enrollment_count":163,"lead_sponsor_name":"Haute Ecole de Santé Vaud","has_results":false},{"nct_id":"NCT03240484","title":"Examining Effects of Spinal Fusion on Outcomes Following Total Hip Replacement","phase":"","overall_status":"UNKNOWN","enrollment_count":160,"lead_sponsor_name":"Ottawa Hospital Research Institute","has_results":false},{"nct_id":"NCT04256291","title":"Total Hip Replacement With Ceramic on Ceramic Bearing- Clinical Follow-up Study","phase":"","overall_status":"UNKNOWN","enrollment_count":160,"lead_sponsor_name":"National Taiwan University Hospital","has_results":false},{"nct_id":"NCT07201116","title":"Health-GIS Platform for Hip Replacement Rehabilitation Coordination","phase":"NA","overall_status":"COMPLETED","enrollment_count":142,"lead_sponsor_name":"Tulip Medicine","has_results":false},{"nct_id":"NCT06878014","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Medical University of Silesia","has_results":false},{"nct_id":"NCT04166539","title":"Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty","phase":"","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT05710107","title":"QL vs PENG for Analgesia After Hip Arthroplasty","phase":"NA","overall_status":"COMPLETED","enrollment_count":106,"lead_sponsor_name":"Medical University of South Carolina","has_results":true},{"nct_id":"NCT03393819","title":"Efficacy of Surgical Skin Preparation Solutions in Hip Arthroplasty Surgery","phase":"NA","overall_status":"COMPLETED","enrollment_count":105,"lead_sponsor_name":"Lakehead University","has_results":false},{"nct_id":"NCT06238960","title":"Effectiveness of Telerehabilitation in Continuity With Outpatient Physiotherapy After Total Hip Replacement.","phase":"NA","overall_status":"RECRUITING","enrollment_count":104,"lead_sponsor_name":"Istituto Ortopedico Rizzoli","has_results":false},{"nct_id":"NCT07239817","title":"PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach","phase":"NA","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"ASST Gaetano Pini-CTO","has_results":false},{"nct_id":"NCT03189290","title":"Study of the QUadratus Lumborum Bloc in Total Hip ARthroplasty: Efficacy and Safety","phase":"NA","overall_status":"COMPLETED","enrollment_count":100,"lead_sponsor_name":"University Hospital, Montpellier","has_results":false},{"nct_id":"NCT07471243","title":"Dressing-related Experiences and Surgical Site Self-care in Hip and Knee Replacement: an Observational Cohort Study","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Bournemouth University","has_results":false},{"nct_id":"NCT07110324","title":"Characteristics of Persistent Pain Composition Following Total Hip or Knee Arthroplasty: a Descriptive Study","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT07207005","title":"Comparison of Wear Between Two Dual-mobility Acetabular Cups in Patients Undergoing Total Hip Arthroplasty","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":96,"lead_sponsor_name":"GCS Ramsay Santé pour l'Enseignement et la Recherche","has_results":false},{"nct_id":"NCT03833258","title":"Unrestricted Rehabilitation Pathway Following Total Hip Replacement","phase":"NA","overall_status":"TERMINATED","enrollment_count":95,"lead_sponsor_name":"University of Manchester","has_results":false},{"nct_id":"NCT06653699","title":"Effectiveness of Peri-operative Combined Use of 2 Doses of Dexamethasone With Tranexamic Acid in Lower Limb Joint Replacements-A Randomized Controlled Trial.","phase":"NA","overall_status":"COMPLETED","enrollment_count":92,"lead_sponsor_name":"Indus Hospital and Health Network","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}