{"disease":{"id":"high-blood-pressure","name":"High blood pressure","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":1,"pipeline_drug_count":0,"trial_count":1},"drugs":{"marketed":[{"drug_id":"aprocitentan","indication_name":"High blood pressure","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Tryvio","generic_name":"APROCITENTAN","company_name":"Idorsia","drug_phase":"marketed","molecular_target":"","drug_class":"Endothelin Receptor Antagonist [EPC]","quality_score":60,"revenue":null,"mechanism":"Tryvio works by blocking the action of endothelin, a protein that constricts blood vessels and increases blood pressure."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05814068","title":"Active Screening of Arterial Hypertension by Community Outreach Workers in the Cayenne Metropolitan Area to Reduce the Incidence of Cardiovascular Disease","phase":"NA","overall_status":"UNKNOWN","enrollment_count":50000,"lead_sponsor_name":"Centre Hospitalier de Cayenne","has_results":false},{"nct_id":"NCT03840928","title":"PatientSpot Formerly Known as ArthritisPower","phase":"","overall_status":"UNKNOWN","enrollment_count":40000,"lead_sponsor_name":"Global Healthy Living Foundation","has_results":false},{"nct_id":"NCT04040634","title":"Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES)","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":9476,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT05488795","title":"Team-Based Home Blood Pressure Monitoring","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":5760,"lead_sponsor_name":"University of Rochester","has_results":false},{"nct_id":"NCT07386535","title":"Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke Prevention","phase":"NA","overall_status":"RECRUITING","enrollment_count":1412,"lead_sponsor_name":"Washington University School of Medicine","has_results":false},{"nct_id":"NCT04451109","title":"Dilapan-S®: A Multicenter US E-registry","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":1200,"lead_sponsor_name":"Medicem Technology s.r.o.","has_results":false},{"nct_id":"NCT06593496","title":"Addressing Cardiometabolic Health In Populations Through Early Prevention in the Great Lakes Region Project 1 - Epidemiology (ACHIEVE P1-EPI)","phase":"NA","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Wayne State University","has_results":false},{"nct_id":"NCT03554382","title":"Efficient Self-management of Chronic Disease Using Health Information Technology - a Study on Hypertension","phase":"NA","overall_status":"COMPLETED","enrollment_count":971,"lead_sponsor_name":"Region Skane","has_results":false},{"nct_id":"NCT01802372","title":"Task Shifting and Blood Pressure Control in Ghana","phase":"NA","overall_status":"COMPLETED","enrollment_count":757,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT05552547","title":"Home BP Monitoring","phase":"NA","overall_status":"RECRUITING","enrollment_count":750,"lead_sponsor_name":"University Hospitals Cleveland Medical Center","has_results":false},{"nct_id":"NCT03490695","title":"Uptake of Task-Strengthening for Blood Pressure Control","phase":"NA","overall_status":"UNKNOWN","enrollment_count":700,"lead_sponsor_name":"Kintampo Health Research Centre, Ghana","has_results":false},{"nct_id":"NCT06072287","title":"The Living With a Long-Term Condition Study","phase":"","overall_status":"UNKNOWN","enrollment_count":600,"lead_sponsor_name":"King's College London","has_results":false},{"nct_id":"NCT04317690","title":"Online Trial Examining Validity and Reliability of the Shared Decision Making Process Survey","phase":"","overall_status":"COMPLETED","enrollment_count":539,"lead_sponsor_name":"Massachusetts General Hospital","has_results":true},{"nct_id":"NCT05180045","title":"Home Blood Pressure Telemonitoring LINKED With Community Health Workers to Improve Blood Pressure","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":472,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT03812614","title":"Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support","phase":"NA","overall_status":"COMPLETED","enrollment_count":444,"lead_sponsor_name":"University of Pittsburgh","has_results":true},{"nct_id":"NCT05321368","title":"A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities","phase":"NA","overall_status":"RECRUITING","enrollment_count":425,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT05528068","title":"Effect of Lifestyle Intervention Among Patients With Hypertension or High-normal Blood Pressure","phase":"NA","overall_status":"UNKNOWN","enrollment_count":424,"lead_sponsor_name":"China National Center for Cardiovascular Diseases","has_results":false},{"nct_id":"NCT04114669","title":"Behavioral Economics Trial To Enhance Regulation of Blood Pressure (BETTER-BP)","phase":"NA","overall_status":"COMPLETED","enrollment_count":401,"lead_sponsor_name":"NYU Langone Health","has_results":false},{"nct_id":"NCT00140907","title":"ALLOGRAFT, A Study to Evaluate the Renal Protective Effects of Losartan (0954-222)(COMPLETED)","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":367,"lead_sponsor_name":"Organon and Co","has_results":false},{"nct_id":"NCT04821505","title":"Stress Reduction and Hypertension Prevention in African Americans","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":304,"lead_sponsor_name":"Maharishi International University","has_results":false},{"nct_id":"NCT04505150","title":"Lowering Blood Pressure by Changing Lifestyle","phase":"NA","overall_status":"UNKNOWN","enrollment_count":300,"lead_sponsor_name":"Organisation for Rural Community Development, Bangladesh","has_results":false},{"nct_id":"NCT05625321","title":"Stepping Into Lifestyle Changes","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":273,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":false},{"nct_id":"NCT06143566","title":"Polypill for Prevention of Cardiomyopathy","phase":"PHASE1, PHASE2","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"University of Texas Southwestern Medical Center","has_results":false},{"nct_id":"NCT03700710","title":"Remote Dietary Counseling to Promote Healthy Diet and Blood Pressure","phase":"NA","overall_status":"COMPLETED","enrollment_count":187,"lead_sponsor_name":"Geisinger Clinic","has_results":false},{"nct_id":"NCT07218198","title":"Clinical Decision Support Tool for the Treatment of Uncontrolled Hypertension","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":168,"lead_sponsor_name":"The Cleveland Clinic","has_results":false},{"nct_id":"NCT07506707","title":"Digital Education for Hypertension Management: Effects on Self-Care and Health Literacy","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":166,"lead_sponsor_name":"Bartın Unıversity","has_results":false},{"nct_id":"NCT05776394","title":"Study on Hypertension and Frailty in the Older People","phase":"","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Istituto Auxologico Italiano","has_results":false},{"nct_id":"NCT04064177","title":"Non-invasive Continuous Cardiac Output Monitoring in Preterm Infants Study","phase":"","overall_status":"RECRUITING","enrollment_count":148,"lead_sponsor_name":"Imperial College Healthcare NHS Trust","has_results":false},{"nct_id":"NCT03193177","title":"A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases","phase":"","overall_status":"COMPLETED","enrollment_count":144,"lead_sponsor_name":"Tsinghua University","has_results":false},{"nct_id":"NCT07259733","title":"Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)","phase":"NA","overall_status":"RECRUITING","enrollment_count":142,"lead_sponsor_name":"Instituto Dante Pazzanese de Cardiologia","has_results":false},{"nct_id":"NCT03151096","title":"Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype","phase":"NA","overall_status":"TERMINATED","enrollment_count":133,"lead_sponsor_name":"London School of Hygiene and Tropical Medicine","has_results":false},{"nct_id":"NCT04403789","title":"Effects of a Workplace Exercise Intervention on Cardio-Metabolic Health","phase":"NA","overall_status":"COMPLETED","enrollment_count":130,"lead_sponsor_name":"United Arab Emirates University","has_results":false},{"nct_id":"NCT06150560","title":"A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":120,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT03686657","title":"Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients","phase":"PHASE1, PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":115,"lead_sponsor_name":"ARKAY Therapeutics","has_results":false},{"nct_id":"NCT04286555","title":"Dietary Approaches to Stop Hypertension for Diabetes","phase":"NA","overall_status":"COMPLETED","enrollment_count":105,"lead_sponsor_name":"Johns Hopkins University","has_results":false},{"nct_id":"NCT05765786","title":"Diagnosing Variable Primary Aldosteronism.","phase":"","overall_status":"RECRUITING","enrollment_count":100,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT03555344","title":"Effect of Mantra on Hypertensive Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":96,"lead_sponsor_name":"NMP Medical Research Institute","has_results":false},{"nct_id":"NCT04082819","title":"MediBeat - HeartBeat Observation Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":94,"lead_sponsor_name":"SE Health","has_results":true},{"nct_id":"NCT04255745","title":"The Impact of a Resistance Training Intervention on Blood Pressure Control in Older Adults With Sarcopenia","phase":"NA","overall_status":"COMPLETED","enrollment_count":91,"lead_sponsor_name":"University of Illinois at Chicago","has_results":false},{"nct_id":"NCT04064281","title":"The Healthy Cantonese Diet on Cardiometabolic Syndrome","phase":"NA","overall_status":"UNKNOWN","enrollment_count":90,"lead_sponsor_name":"Sun Yat-sen University","has_results":false},{"nct_id":"NCT04105192","title":"Effectiveness of a Natural Ingredient on Obesity","phase":"NA","overall_status":"COMPLETED","enrollment_count":84,"lead_sponsor_name":"Universidad Católica San Antonio de Murcia","has_results":false},{"nct_id":"NCT01885390","title":"Registry to Evaluate the ROX COUPLER in Patients With Resistant or Uncontrolled Hypertension","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":83,"lead_sponsor_name":"ROX Medical, Inc.","has_results":false},{"nct_id":"NCT06508619","title":"Blood Pressure Treatment by the Corsano CardioWatch 287-2 Evaluation Study","phase":"NA","overall_status":"RECRUITING","enrollment_count":80,"lead_sponsor_name":"Corsano Health B.V.","has_results":false},{"nct_id":"NCT07310992","title":"Effect of Meditation as an Adjunct to Cardiac Rehabilitation","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":80,"lead_sponsor_name":"Instituto Dante Pazzanese de Cardiologia","has_results":false},{"nct_id":"NCT07491510","title":"Improving Prenatal Care to Reduce Early Onset Preeclampsia in Low-Income","phase":"NA","overall_status":"NOT_YET_RECRUITING","enrollment_count":72,"lead_sponsor_name":"University of Kansas Medical Center","has_results":false},{"nct_id":"NCT05179343","title":"SCRATCH-HTN Study: Evaluating Autonomic Neuromodulation Using Trans-cutaneous Vagal Stimulation in Hypertensive Patients","phase":"NA","overall_status":"COMPLETED","enrollment_count":63,"lead_sponsor_name":"Queen Mary University of London","has_results":false},{"nct_id":"NCT03650166","title":"High BP and Home Monitoring Experience (HoME) Study","phase":"NA","overall_status":"COMPLETED","enrollment_count":62,"lead_sponsor_name":"University of Pittsburgh","has_results":false},{"nct_id":"NCT06227819","title":"BVA-200 vs BVA-100 Validation Study","phase":"","overall_status":"COMPLETED","enrollment_count":62,"lead_sponsor_name":"Daxor Corporation","has_results":false},{"nct_id":"NCT06295874","title":"The Effect of Aromatherapy Massage on Pain, Anxiety and Comfort","phase":"NA","overall_status":"UNKNOWN","enrollment_count":61,"lead_sponsor_name":"Nilgün Erdoğan","has_results":false},{"nct_id":"NCT04681560","title":"Impact of Platinum-based Cancer Treatment on Endothelial Function","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"I.M. Sechenov First Moscow State Medical University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}