{"disease":{"id":"herpes-simplex","name":"Herpes simplex","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":4,"pipeline_drug_count":0,"trial_count":2},"drugs":{"marketed":[{"drug_id":"acyclovir-sodium","indication_name":"Herpes Simplex in Immunocompromised Patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYCLOVIR SODIUM","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":35,"revenue":null,"mechanism":null},{"drug_id":"acyclovir-sodium","indication_name":"Herpes Simplex Encephalitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYCLOVIR SODIUM","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":35,"revenue":null,"mechanism":null},{"drug_id":"vidarabine","indication_name":"Herpes simplex dendritic keratitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vidarabin","generic_name":"VIDARABINE","company_name":"","drug_phase":"marketed","molecular_target":"Dipeptidyl peptidase 4","drug_class":"vidarabine","quality_score":28,"revenue":null,"mechanism":""},{"drug_id":"vidarabine","indication_name":"Herpes simplex keratitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Vidarabin","generic_name":"VIDARABINE","company_name":"","drug_phase":"marketed","molecular_target":"Dipeptidyl peptidase 4","drug_class":"vidarabine","quality_score":28,"revenue":null,"mechanism":""},{"drug_id":"cortisone-acetate","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortone","generic_name":"CORTISONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":29,"revenue":null,"mechanism":""},{"drug_id":"famciclovir","indication_name":"Herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"famciclovir","indication_name":"Recurrent Mucocutaneous Herpes Simplex in Human Immunodeficiency Virus Infected Patients","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"famciclovir","indication_name":"Recurrent genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"famciclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"famciclovir","indication_name":"Suppression of Recurrent Herpes Simplex Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"aciclovir","indication_name":"Herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Herpes simplex infection of skin","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Recurrent Mucocutaneous Herpes Simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Recurrent genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Suppression of Recurrent Herpes Simplex Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"amenamevir","indication_name":"Recurrent herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Amenalief","generic_name":"AMENAMEVIR","company_name":"Maruho","drug_phase":"marketed","molecular_target":"","drug_class":"","quality_score":13,"revenue":null,"mechanism":""},{"drug_id":"hydrocortisone","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortef","generic_name":"hydrocortisone","company_name":"Generic (originally Merck/Upjohn)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"Corticosteroid [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"acyclovir","indication_name":"Genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Herpes simplex infection of skin","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Recurrent Mucocutaneous Herpes Simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Recurrent genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Suppression of Recurrent Herpes Simplex Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"ganciclovir","indication_name":"Herpes simplex dendritic keratitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cytovene","generic_name":"GANCICLOVIR","company_name":"Roche Palo","drug_phase":"marketed","molecular_target":"Metabotropic glutamate receptor 1","drug_class":"Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":80,"revenue":null,"mechanism":"GANCICLOVIR works by inhibiting the DNA polymerase enzyme of cytomegalovirus, preventing viral replication."},{"drug_id":"idoxuridine","indication_name":"Herpes simplex keratitis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Dendrid","generic_name":"IDOXURIDINE","company_name":"Novartis","drug_phase":"marketed","molecular_target":"Thymidine kinase, cytosolic","drug_class":"Nucleoside Analog Antiviral","quality_score":30,"revenue":null,"mechanism":""},{"drug_id":"valaciclovir","indication_name":"Genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valtrex","generic_name":"valaciclovir","company_name":"GSK","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":60,"revenue":null,"mechanism":"Valtrex works by inhibiting the replication of herpes simplex virus DNA through interference with viral DNA polymerase."},{"drug_id":"valaciclovir","indication_name":"Recurrent genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valtrex","generic_name":"valaciclovir","company_name":"GSK","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":60,"revenue":null,"mechanism":"Valtrex works by inhibiting the replication of herpes simplex virus DNA through interference with viral DNA polymerase."},{"drug_id":"valaciclovir","indication_name":"Suppression of Recurrent Herpes Simplex Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valtrex","generic_name":"valaciclovir","company_name":"GSK","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":60,"revenue":null,"mechanism":"Valtrex works by inhibiting the replication of herpes simplex virus DNA through interference with viral DNA polymerase."},{"drug_id":"valaciclovir","indication_name":"Suppression of Recurrent Herpes Simplex Infection in HIV","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valtrex","generic_name":"valaciclovir","company_name":"GSK","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":60,"revenue":null,"mechanism":"Valtrex works by inhibiting the replication of herpes simplex virus DNA through interference with viral DNA polymerase."},{"drug_id":"acyc","indication_name":"Genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Herpes simplex infection of skin","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Recurrent Mucocutaneous Herpes Simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Recurrent genital herpes simplex","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Suppression of Recurrent Herpes Simplex Infection","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"cortisol","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cortisol","company_name":"University of Zurich","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":40,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05429346","title":"Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity","phase":"","overall_status":"RECRUITING","enrollment_count":339000,"lead_sponsor_name":"Kaiser Permanente","has_results":false},{"nct_id":"NCT04239521","title":"The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata","phase":"","overall_status":"COMPLETED","enrollment_count":51955,"lead_sponsor_name":"Momentum Data","has_results":false},{"nct_id":"NCT01681420","title":"Improving Blood Safety and HIV Testing in Brazil","phase":"NA","overall_status":"COMPLETED","enrollment_count":11900,"lead_sponsor_name":"Vitalant Research Institute","has_results":false},{"nct_id":"NCT00057330","title":"HerpeVac Trial for Young Women","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":8323,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT00224484","title":"Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":5960,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT05298254","title":"A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes","phase":"PHASE1, PHASE2","overall_status":"COMPLETED","enrollment_count":505,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT03469232","title":"Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":240,"lead_sponsor_name":"China Academy of Chinese Medical Sciences","has_results":false},{"nct_id":"NCT05198570","title":"Pharmacokinetics of Intravenous Acyclovir in Oncologic Paediatric Patients","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"University of Pisa","has_results":false},{"nct_id":"NCT05226949","title":"Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus Infection","phase":"","overall_status":"COMPLETED","enrollment_count":159,"lead_sponsor_name":"Rigshospitalet, Denmark","has_results":false},{"nct_id":"NCT03090802","title":"MAMAS: Mentoring Adolescent Mothers at School","phase":"NA","overall_status":"COMPLETED","enrollment_count":152,"lead_sponsor_name":"Drexel University","has_results":false},{"nct_id":"NCT03178747","title":"Tzanck Smear With Methylene Blue Stain for Herpes","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"Chulalongkorn University","has_results":false},{"nct_id":"NCT05452928","title":"Aciclovir Versus Placebo for HSV-2 Meningitis","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":150,"lead_sponsor_name":"Jacob Bodilsen","has_results":false},{"nct_id":"NCT02910284","title":"Long-term Follow-up of GEN-003-002 Subjects for Efficacy and Immunogenicity","phase":"","overall_status":"COMPLETED","enrollment_count":140,"lead_sponsor_name":"Genocea Biosciences, Inc.","has_results":false},{"nct_id":"NCT04065971","title":"Randomized, Placebo-controlled, Double-blind Study of 2LHERP® in Orofacial Herpes Infections.","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":140,"lead_sponsor_name":"Labo'Life","has_results":false},{"nct_id":"NCT03282916","title":"Anti-viral Therapy in Alzheimer's Disease","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":120,"lead_sponsor_name":"Columbia University","has_results":true},{"nct_id":"NCT06385327","title":"A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":115,"lead_sponsor_name":"Assembly Biosciences","has_results":false},{"nct_id":"NCT06698575","title":"A Study to Assess the Safety, Pharmacokinetics, and Tolerability of ABI-1179 in Healthy Subjects and in Subjects Seropositive for HSV-2 With Recurrent Genital Herpes","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":103,"lead_sponsor_name":"Assembly Biosciences","has_results":false},{"nct_id":"NCT03217474","title":"Femtosecond Laser-assisted Corneal Debridement for Herpes Simplex Keratitis","phase":"NA","overall_status":"UNKNOWN","enrollment_count":100,"lead_sponsor_name":"Chunxiao Wang","has_results":false},{"nct_id":"NCT07341386","title":"Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases","phase":"PHASE4","overall_status":"NOT_YET_RECRUITING","enrollment_count":62,"lead_sponsor_name":"University of Sao Paulo General Hospital","has_results":false},{"nct_id":"NCT00001648","title":"Structure of the Herpes Simplex Virus Receptor","phase":"","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT05823779","title":"A 48 Week Observational Study of the Frequency of Symptomatic Herpes Virus I and II in HIV Infected Subjects","phase":"","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"Global Research Institute","has_results":false},{"nct_id":"NCT05989672","title":"A Study on the Reactogenicity, Safety and Immune Response of a Targeted Immunotherapy Against HSV in Healthy Japanese Participants Aged 18-40 Years","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT04710030","title":"Valacyclovir for Mild Cognitive Impairment","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":50,"lead_sponsor_name":"New York State Psychiatric Institute","has_results":true},{"nct_id":"NCT04664127","title":"Study of the Efficacy and Safety of Combined Treatment of Patients With Severe Herpes Simplex (HSV) Infection by Valacyclovir and Interferon Inducer Kagocel","phase":"","overall_status":"COMPLETED","enrollment_count":45,"lead_sponsor_name":"Nearmedic Plus LLC","has_results":false},{"nct_id":"NCT01602562","title":"Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT06558838","title":"Efficacy and Safety of Acyclovir-penciclovir Cream Versus an Abreva in the Suppression of Herpes Simplex Virus Eruptions","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":40,"lead_sponsor_name":"University of Utah","has_results":false},{"nct_id":"NCT00297206","title":"A Safety And Tolerability Study Of Valaciclovir Oral Suspension In Infants And Children","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT06627010","title":"Herpes Simplex Meningo Encephalitis Recurrence","phase":"","overall_status":"UNKNOWN","enrollment_count":30,"lead_sponsor_name":"Central Hospital, Nancy, France","has_results":false},{"nct_id":"NCT04037475","title":"Treatment of Herpes Labialis by Photodynamic Therapy","phase":"NA","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"University of Nove de Julho","has_results":false},{"nct_id":"NCT06135844","title":"Hand Sanitizer Use for Herpes Simplex Virus-1","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"Leciel Bono","has_results":false},{"nct_id":"NCT06435507","title":"Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of IM-250 in Healthy Volunteers","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":18,"lead_sponsor_name":"Innovative Molecules GmbH","has_results":false},{"nct_id":"NCT05468619","title":"Neonatal Phase 1 Valacyclovir Study","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":17,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT04762511","title":"A Study on the Reactogenicity, Safety and Immune Response of a Vaccine Against Herpes Simplex Virus (HSV)-2 in Healthy Participants Aged 18-40 Years","phase":"PHASE1","overall_status":"TERMINATED","enrollment_count":17,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT00698893","title":"Evaluation of Safety of Candidate gD Vaccine, With or Without MPL in Healthy Herpes Simplex Virus-positive Adults","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":16,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT04893577","title":"EDTA Eye Drops Compared to Abreva for Herpes Simplex Virus Eruptions","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":10,"lead_sponsor_name":"University of Utah","has_results":true},{"nct_id":"NCT04081480","title":"Pharmacokinetics of Valacyclovir Oral Solution in Children","phase":"NA","overall_status":"TERMINATED","enrollment_count":7,"lead_sponsor_name":"Radboud University Medical Center","has_results":false},{"nct_id":"NCT04448392","title":"Valacyclovir in Neonatal Herpes Simplex Virus Disease","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":7,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":true},{"nct_id":"NCT04235322","title":"Study of 2LHERP® in Genital Herpes Infections","phase":"PHASE4","overall_status":"TERMINATED","enrollment_count":6,"lead_sponsor_name":"Labo'Life","has_results":false},{"nct_id":"NCT04560790","title":"Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral Keratitis","phase":"NA","overall_status":"COMPLETED","enrollment_count":3,"lead_sponsor_name":"Shanghai BDgene Co., Ltd.","has_results":false},{"nct_id":"NCT04713423","title":"Oral and Perioral Herpes Simplex Virus Infection Type I in a Five-month-old Infant: A Case Report","phase":"","overall_status":"COMPLETED","enrollment_count":1,"lead_sponsor_name":"Princess Nourah Bint Abdulrahman University","has_results":false},{"nct_id":"NCT04294030","title":"NOWDx Test for the Diagnosis of Herpes Simplex Virus Type 2","phase":"","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"NOWDiagnostics, Inc.","has_results":false},{"nct_id":"NCT03626376","title":"Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis","phase":"PHASE4","overall_status":"WITHDRAWN","enrollment_count":0,"lead_sponsor_name":"NYU Langone Health","has_results":false}],"total":42},"guidelines":[],"source":"Drug Landscape verified database"}