{"disease":{"id":"herpes-labialis","name":"Herpes labialis","therapeutic_area":"","data":{},"enrichment_level":0,"last_enriched_at":null,"visit_count":0,"created_at":"2026-04-19T18:31:21.150Z","updated_at":"2026-04-19T18:39:44.960Z","meddra_pt":null,"meddra_code":null,"icd10_codes":null,"synonyms":[],"prevalence_global":null,"prevalence_us":null,"marketed_drug_count":7,"pipeline_drug_count":0,"trial_count":0},"drugs":{"marketed":[{"drug_id":"abreva","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Abreva","company_name":"University of Utah","drug_phase":"marketed","molecular_target":"Envelope glycoprotein","drug_class":"","quality_score":13,"revenue":null,"mechanism":null},{"drug_id":"cortisone-acetate","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortone","generic_name":"CORTISONE ACETATE","company_name":"","drug_phase":"marketed","molecular_target":"Corticosteroid-binding globulin","drug_class":"alpha-Adrenergic Agonist [EPC]","quality_score":29,"revenue":null,"mechanism":""},{"drug_id":"docosanol","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Abreva","generic_name":"DOCOSANOL","company_name":"","drug_phase":"marketed","molecular_target":"","drug_class":"docosanol","quality_score":24,"revenue":null,"mechanism":""},{"drug_id":"famciclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Famvir","generic_name":"FAMCICLOVIR","company_name":"Novartis","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":59,"revenue":null,"mechanism":"Famvir works by inhibiting the replication of herpes simplex virus DNA through its action as a nucleoside analog DNA polymerase inhibitor."},{"drug_id":"aciclovir","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"aciclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Aciclovir","company_name":"Assistance Publique Hopitaux De Marseille","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":19,"revenue":null,"mechanism":null},{"drug_id":"hydrocortisone","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Cortef","generic_name":"hydrocortisone","company_name":"Generic (originally Merck/Upjohn)","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"Corticosteroid [EPC]","quality_score":10,"revenue":null,"mechanism":""},{"drug_id":"acyclovir","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"acyclovir","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Zovirax","generic_name":"ACYCLOVIR","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":80,"revenue":null,"mechanism":"Acyclovir works by mimicking a building block of DNA to prevent the herpes virus from replicating."},{"drug_id":"valacyclovir","indication_name":"Cold Sores (Herpes Labialis)","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"VALACYCLOVIR","company_name":"","drug_phase":"marketed","molecular_target":"Viral DNA polymerase","drug_class":"Nucleoside analogue","quality_score":80,"revenue":null,"mechanism":"Valacyclovir is an antiviral drug that inhibits viral DNA polymerase to treat herpes simplex and varicella-zoster viruses."},{"drug_id":"penciclovir","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Denavir","generic_name":"PENCICLOVIR","company_name":"Mylan","drug_phase":"marketed","molecular_target":"","drug_class":"Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor [EPC]","quality_score":60,"revenue":null,"mechanism":"Denavir works by inhibiting the DNA polymerase enzyme of the herpes virus, preventing it from replicating and causing infection."},{"drug_id":"valaciclovir","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Valtrex","generic_name":"valaciclovir","company_name":"GSK","drug_phase":"marketed","molecular_target":"","drug_class":"Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor","quality_score":60,"revenue":null,"mechanism":"Valtrex works by inhibiting the replication of herpes simplex virus DNA through interference with viral DNA polymerase."},{"drug_id":"acyc","indication_name":"Herpes labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"acyc","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"ACYC","company_name":"Ligand Pharms","drug_phase":"marketed","molecular_target":"Purine nucleoside phosphorylase, DNA polymerase catalytic subunit, Purine nucleoside phosphorylase","drug_class":"","quality_score":null,"revenue":null,"mechanism":"Acyc works by binding to a specific target in the body, although its exact mechanism is unknown."},{"drug_id":"cortisol","indication_name":"Recurrent herpes simplex labialis","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"Cortisol","company_name":"University of Zurich","drug_phase":"marketed","molecular_target":"Annexin A1, Corticosteroid-binding globulin, Nitric oxide synthase, inducible","drug_class":"","quality_score":null,"revenue":null,"mechanism":null}],"pipeline":[],"offLabel":[],"totalMarketed":15,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT02265913","title":"Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":4076,"lead_sponsor_name":"Padagis LLC","has_results":true},{"nct_id":"NCT05098938","title":"A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works Normally","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":2020,"lead_sponsor_name":"Bayer","has_results":true},{"nct_id":"NCT01306084","title":"Viral Infections in Healthy and Immunocompromised Hosts","phase":"","overall_status":"RECRUITING","enrollment_count":1000,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT04539483","title":"Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":761,"lead_sponsor_name":"Heidelberg ImmunoTherapeutics GmbH","has_results":false},{"nct_id":"NCT03192306","title":"Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":451,"lead_sponsor_name":"Topical Remedy","has_results":true},{"nct_id":"NCT02871492","title":"Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":362,"lead_sponsor_name":"AiCuris Anti-infective Cures AG","has_results":true},{"nct_id":"NCT03469232","title":"Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome","phase":"PHASE1, PHASE2","overall_status":"UNKNOWN","enrollment_count":240,"lead_sponsor_name":"China Academy of Chinese Medical Sciences","has_results":false},{"nct_id":"NCT03310294","title":"Immune Evidence to the Consumption of Lactobacillus GG and FOS Consumption in Patients With Herpes Labialis","phase":"NA","overall_status":"COMPLETED","enrollment_count":157,"lead_sponsor_name":"Sprim Advanced Life Sciences","has_results":false},{"nct_id":"NCT03307772","title":"Immune Response to the Consumption of Lactobacillus GG and FOS in Patients With Recurrent Herpes Labialis","phase":"NA","overall_status":"COMPLETED","enrollment_count":78,"lead_sponsor_name":"Sprim Advanced Life Sciences","has_results":false},{"nct_id":"NCT00306293","title":"VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":70,"lead_sponsor_name":"GlaxoSmithKline","has_results":true},{"nct_id":"NCT00878072","title":"Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis","phase":"PHASE2, PHASE3","overall_status":"COMPLETED","enrollment_count":53,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT03521479","title":"A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis","phase":"PHASE2","overall_status":"TERMINATED","enrollment_count":40,"lead_sponsor_name":"Squarex, LLC","has_results":true},{"nct_id":"NCT03661541","title":"Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":36,"lead_sponsor_name":"Squarex, LLC","has_results":true},{"nct_id":"NCT00711776","title":"Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy Volunteers","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":27,"lead_sponsor_name":"GlaxoSmithKline","has_results":false},{"nct_id":"NCT06135844","title":"Hand Sanitizer Use for Herpes Simplex Virus-1","phase":"EARLY_PHASE1","overall_status":"UNKNOWN","enrollment_count":20,"lead_sponsor_name":"Leciel Bono","has_results":false}],"total":15},"guidelines":[],"source":"Drug Landscape verified database"}