{"disease":{"id":"hepatic-disease","name":"hepatic disease"},"drugs":{"marketed":[{"drug_id":"torsemide","indication_name":"Edema associated with hepatic disease","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":null,"generic_name":"TORSEMIDE","company_name":"","drug_phase":"marketed","molecular_target":"Na+/K+/2Cl- carrier system","drug_class":"Loop Diuretic [EPC]","quality_score":10,"revenue":null,"mechanism":"Torsemide inhibits the Na+/K+/2Cl- carrier system in the thick ascending limb of the loop of Henle, leading to increased excretion of sodium, chloride, and water."}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05687474","title":"Baby Detect : Genomic Newborn Screening","phase":"","overall_status":"COMPLETED","enrollment_count":6824,"lead_sponsor_name":"Centre Hospitalier Universitaire de Liege","has_results":false},{"nct_id":"NCT02834013","title":"Nivolumab and Ipilimumab in Treating Patients With Rare Tumors","phase":"PHASE2","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":818,"lead_sponsor_name":"National Cancer Institute (NCI)","has_results":false},{"nct_id":"NCT03405909","title":"Standardized CEUS Algorithms for Diagnosis of HCC - Prospective German Multicenter Study","phase":"","overall_status":"COMPLETED","enrollment_count":517,"lead_sponsor_name":"University Hospital Erlangen","has_results":false},{"nct_id":"NCT06449339","title":"Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":474,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT04014413","title":"Safety and Efficacy of Fecal Microbiota Transplantation","phase":"NA","overall_status":"RECRUITING","enrollment_count":450,"lead_sponsor_name":"Chinese University of Hong Kong","has_results":false},{"nct_id":"NCT04271098","title":"The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries","phase":"","overall_status":"COMPLETED","enrollment_count":340,"lead_sponsor_name":"Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital","has_results":false},{"nct_id":"NCT06950710","title":"Mechanisms of Macrophage Polarization in HIRI in Patients With NAFLD","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":300,"lead_sponsor_name":"Zhifeng Gao","has_results":false},{"nct_id":"NCT04073290","title":"Prevention of Post-TIPS Hepatic Encephalopathy by Administration of Rifaximin and Lactulose","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":238,"lead_sponsor_name":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","has_results":false},{"nct_id":"NCT06637943","title":"Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":210,"lead_sponsor_name":"Konkuk University Medical Center","has_results":false},{"nct_id":"NCT03767517","title":"A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders","phase":"NA","overall_status":"COMPLETED","enrollment_count":209,"lead_sponsor_name":"University of Alabama at Birmingham","has_results":true},{"nct_id":"NCT03486912","title":"A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":155,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":true},{"nct_id":"NCT06619808","title":"Hyperbaric Oxygen Therapy for Metabolic Dysfunction-associated Steatotic Liver Diseases","phase":"NA","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Jinling Hospital, China","has_results":false},{"nct_id":"NCT04168788","title":"Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALL","phase":"NA","overall_status":"UNKNOWN","enrollment_count":150,"lead_sponsor_name":"University Hospital, Angers","has_results":false},{"nct_id":"NCT03329950","title":"A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":132,"lead_sponsor_name":"Celldex Therapeutics","has_results":false},{"nct_id":"NCT03191851","title":"Evaluation of 'Melody' Paracentesis Device for Ascites Therapy","phase":"NA","overall_status":"COMPLETED","enrollment_count":101,"lead_sponsor_name":"University of Nottingham","has_results":false},{"nct_id":"NCT06739486","title":"Efficacy of Sodium Glucose Cotransporter 2 Inhibitors on Non-Alcoholic Fatty Liver Disease","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":100,"lead_sponsor_name":"Assiut University","has_results":false},{"nct_id":"NCT06856655","title":"Achieving Portal Access With Scorpion Post-Approval Study 2","phase":"","overall_status":"COMPLETED","enrollment_count":82,"lead_sponsor_name":"Argon Medical Devices","has_results":false},{"nct_id":"NCT04890886","title":"Magnetic Resonance Imaging and Thermal Imaging of Adiposity in Neonates of Women With Metabolic Diseases","phase":"","overall_status":"UNKNOWN","enrollment_count":80,"lead_sponsor_name":"Guy's and St Thomas' NHS Foundation Trust","has_results":false},{"nct_id":"NCT07192159","title":"Quantitative Ultrasound(DeepUSFF) vs MRI-PDFF for Liver Fat Assessment in MASLD","phase":"NA","overall_status":"RECRUITING","enrollment_count":62,"lead_sponsor_name":"Seoul National University Hospital","has_results":false},{"nct_id":"NCT05616442","title":"Ketotifen in Non-Alcoholic Fatty Liver Disease Patients","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":60,"lead_sponsor_name":"Tanta University","has_results":false},{"nct_id":"NCT03805776","title":"Intermittent Fasting in Dyslipidemia","phase":"NA","overall_status":"UNKNOWN","enrollment_count":60,"lead_sponsor_name":"Aga Khan University","has_results":false},{"nct_id":"NCT06373523","title":"MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin","phase":"EARLY_PHASE1","overall_status":"NOT_YET_RECRUITING","enrollment_count":60,"lead_sponsor_name":"Post Graduate Institute of Medical Education and Research, Chandigarh","has_results":false},{"nct_id":"NCT04946929","title":"Ticagrelor in Post-transplant Patients With Pediatric Hepatic Artery Thrombosis (HAT)","phase":"PHASE3","overall_status":"UNKNOWN","enrollment_count":50,"lead_sponsor_name":"RenJi Hospital","has_results":false},{"nct_id":"NCT06153394","title":"Prolonged Hypercoagulability Following Major Liver Resection for Malignancy","phase":"PHASE3","overall_status":"NOT_YET_RECRUITING","enrollment_count":50,"lead_sponsor_name":"Western University, Canada","has_results":false},{"nct_id":"NCT03652636","title":"Evaluation of the Efficacy of Contrast Enhanced Ultrasound Compared to MRI for Differentiation of Hepatic Lesions","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":47,"lead_sponsor_name":"Indiana University","has_results":true},{"nct_id":"NCT03493204","title":"Tackling 30-day Readmissions in Patients With Cirrhosis: The SALTYFOOD Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":44,"lead_sponsor_name":"University of Michigan","has_results":false},{"nct_id":"NCT04787276","title":"Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy","phase":"NA","overall_status":"COMPLETED","enrollment_count":42,"lead_sponsor_name":"Bogomolets National Medical University","has_results":false},{"nct_id":"NCT05822635","title":"SpyGlass Surgical Study","phase":"","overall_status":"COMPLETED","enrollment_count":34,"lead_sponsor_name":"Boston Scientific Corporation","has_results":false},{"nct_id":"NCT05593211","title":"Assess Safety and Performance of the Kronos Electrocautery Device for Electrocautery Procedures Following Coaxial Biopsy Procedures","phase":"NA","overall_status":"COMPLETED","enrollment_count":31,"lead_sponsor_name":"Single Pass Inc","has_results":true},{"nct_id":"NCT03765671","title":"Elafibranor Pharmacokinetic Parameters in Hepatic Impaired Patients","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Genfit","has_results":false},{"nct_id":"NCT05045482","title":"Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease","phase":"PHASE1","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Zydus Therapeutics Inc.","has_results":false},{"nct_id":"NCT06601829","title":"Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease in Children at Sohag University Hospital","phase":"","overall_status":"RECRUITING","enrollment_count":30,"lead_sponsor_name":"Sohag University","has_results":false},{"nct_id":"NCT03445208","title":"A Study of Experimental Medication BMS-986036 Given to Healthy Participants","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":30,"lead_sponsor_name":"Bristol-Myers Squibb","has_results":false},{"nct_id":"NCT04729751","title":"A Study to Evaluate the Safety and Tolerability of Maralixibat in Infant Participants With Cholestatic Liver Diseases Including Progressive Familial Intrahepatic Cholestasis (PFIC) and Alagille Syndrome (ALGS).","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":27,"lead_sponsor_name":"Mirum Pharmaceuticals, Inc.","has_results":false},{"nct_id":"NCT05116826","title":"Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":25,"lead_sponsor_name":"Genfit","has_results":false},{"nct_id":"NCT04055870","title":"Efficacy, Safety, and Adequacy of EUS-guided Liver Biopsy","phase":"","overall_status":"COMPLETED","enrollment_count":24,"lead_sponsor_name":"Methodist Health System","has_results":false},{"nct_id":"NCT05499585","title":"Treating Pediatric NAFLD with Nutrition","phase":"NA","overall_status":"COMPLETED","enrollment_count":20,"lead_sponsor_name":"University of California, San Diego","has_results":false},{"nct_id":"NCT07514455","title":"Regorafenib After Treatment Failure of First Line Immune Checkpoint Inhibitor Treatment in Advanced Hepatocellular Carcinoma Patients","phase":"PHASE2","overall_status":"NOT_YET_RECRUITING","enrollment_count":20,"lead_sponsor_name":"Ju Hyun Shim","has_results":false},{"nct_id":"NCT07102095","title":"A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose","phase":"PHASE1","overall_status":"COMPLETED","enrollment_count":18,"lead_sponsor_name":"Bayer","has_results":false},{"nct_id":"NCT06435611","title":"Adiposity, Cardiometabolic and Neurocognitive Health Among Ethnic Groups: a Feasibility and Pilot Study","phase":"","overall_status":"RECRUITING","enrollment_count":10,"lead_sponsor_name":"King's College Hospital NHS Trust","has_results":false},{"nct_id":"NCT05765253","title":"Achieving Portal Access With Scorpion Post-Approval Study (APASS)","phase":"NA","overall_status":"TERMINATED","enrollment_count":3,"lead_sponsor_name":"Argon Medical Devices","has_results":true}],"total":41},"guidelines":[],"source":"Drug Landscape verified database"}