{"disease":{"id":"heart-transplant","name":"heart transplant"},"drugs":{"marketed":[{"drug_id":"ppsv23","indication_name":"Prevention of invasive disease caused by Streptococcus pneumoniae in adults 2 years of age or older with chronic heart disease, including congestive heart failure, coronary artery disease, or cardiac transplantation","indication_type":"approved","phase":null,"line_of_therapy":null,"is_primary_indication":false,"pivotal_trial_result":null,"pivotal_trial_p_value":null,"patient_population":null,"brand_name":"Ppsv23","generic_name":"ppsv23","company_name":"Pfizer","drug_phase":"marketed","molecular_target":"Streptococcus pneumoniae","drug_class":"Vaccine","quality_score":45,"revenue":null,"mechanism":""}],"pipeline":[],"offLabel":[],"totalMarketed":1,"totalPipeline":0},"trials":{"data":[{"nct_id":"NCT05915299","title":"US National OCS Heart Perfusion (OHP) Registry","phase":"","overall_status":"RECRUITING","enrollment_count":100000,"lead_sponsor_name":"TransMedics","has_results":false},{"nct_id":"NCT07096973","title":"Cardiac REhabilitation COhort at the Medicine Campus DaVos to invEstigate Recovery","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Hochgebirgsklinik Davos","has_results":false},{"nct_id":"NCT05081115","title":"Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging","phase":"","overall_status":"RECRUITING","enrollment_count":10000,"lead_sponsor_name":"Fatebenefratelli Hospital","has_results":false},{"nct_id":"NCT04848844","title":"The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)","phase":"","overall_status":"RECRUITING","enrollment_count":2000,"lead_sponsor_name":"Universitätsklinikum Hamburg-Eppendorf","has_results":false},{"nct_id":"NCT04974372","title":"A Multicenter Clinical Study of Ultrasound Multimodal Imaging in the Evaluation of Heart Transplantation","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Xie Mingxing","has_results":false},{"nct_id":"NCT04976517","title":"Echocardiographic Assessment of the Impact of Diabetes and Prognostic Analysis of Heart Transplantation","phase":"","overall_status":"UNKNOWN","enrollment_count":1500,"lead_sponsor_name":"Xie Mingxing","has_results":false},{"nct_id":"NCT05390411","title":"Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial","phase":"NA","overall_status":"ENROLLING_BY_INVITATION","enrollment_count":1463,"lead_sponsor_name":"Indiana University","has_results":false},{"nct_id":"NCT04966988","title":"Multimodal Imaging Evaluation and Prognostic Analysis of Cardiac Allograft Vasculopathy in Heart Transplantation","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"Xie Mingxing","has_results":false},{"nct_id":"NCT06774768","title":"Use of Machine-learning Algorithms, Biomarkers and Measures of Quality of Life to Personalize Medical Management of Liver and Heart Transplant Recipients","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":1000,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT02182986","title":"Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children","phase":"","overall_status":"COMPLETED","enrollment_count":944,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT02118896","title":"Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":850,"lead_sponsor_name":"Astellas Pharma Europe Ltd.","has_results":true},{"nct_id":"NCT05786482","title":"Evidence Based Mental Wellness Programming Online for Adults Across Chronic Physical Conditions","phase":"NA","overall_status":"COMPLETED","enrollment_count":825,"lead_sponsor_name":"University of Alberta","has_results":false},{"nct_id":"NCT06453148","title":"Brazilian Clinical Registry of Heart Transplantation","phase":"","overall_status":"NOT_YET_RECRUITING","enrollment_count":730,"lead_sponsor_name":"Hospital Israelita Albert Einstein","has_results":false},{"nct_id":"NCT06813443","title":"Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation","phase":"","overall_status":"RECRUITING","enrollment_count":700,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT03393793","title":"HEart trAnsplantation Registry of piTie-Salpetriere University Hospital","phase":"","overall_status":"COMPLETED","enrollment_count":566,"lead_sponsor_name":"Lee S Nguyen","has_results":false},{"nct_id":"NCT02109575","title":"Quantitative Detection of Circulating Donor-Specific DNA in Organ Transplant Recipients (DTRT-Multi-Center Study)","phase":"","overall_status":"COMPLETED","enrollment_count":540,"lead_sponsor_name":"Medical College of Wisconsin","has_results":false},{"nct_id":"NCT06280898","title":"Perioperative Factors and Early Postoperative Kidney Graft Function Recovery","phase":"","overall_status":"COMPLETED","enrollment_count":539,"lead_sponsor_name":"Seoul St. Mary's Hospital","has_results":false},{"nct_id":"NCT03081052","title":"Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation Outcomes","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":519,"lead_sponsor_name":"Duke University","has_results":true},{"nct_id":"NCT05933083","title":"MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation","phase":"NA","overall_status":"RECRUITING","enrollment_count":516,"lead_sponsor_name":"University of California, San Francisco","has_results":false},{"nct_id":"NCT07132554","title":"Mixing 1:1 HIIT and MICT in Early to Very Early Phase HTx Recipients : a Retrospective Study From a 510 Patients/12 Years Database","phase":"","overall_status":"COMPLETED","enrollment_count":510,"lead_sponsor_name":"Hôpital Léon Bérard","has_results":false},{"nct_id":"NCT03026634","title":"Prevalence and Dynamic of Sleep-disordered Breathing in Patients Pre and Post Heart Transplantation","phase":"","overall_status":"COMPLETED","enrollment_count":500,"lead_sponsor_name":"Heart and Diabetes Center North-Rhine Westfalia","has_results":false},{"nct_id":"NCT04393181","title":"IMPact of Donor Heart Function on Recipient Outcomes - a prospectiVE Study to Increase the Utilization of Donor HEARTs","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Vastra Gotaland Region","has_results":false},{"nct_id":"NCT01733082","title":"The Mycophenolate Pregnancy Registry","phase":"","overall_status":"RECRUITING","enrollment_count":500,"lead_sponsor_name":"Genentech, Inc.","has_results":false},{"nct_id":"NCT06436027","title":"Molecular Diagnosis of Heart Allograft Rejection Using Intra-Graft Targeted Gene Expression Profiling.","phase":"","overall_status":"COMPLETED","enrollment_count":496,"lead_sponsor_name":"Paris Translational Research Center for Organ Transplantation","has_results":false},{"nct_id":"NCT05321706","title":"DAPAgliflozin for Renal Protection in Heart Transplant Recipients","phase":"PHASE3","overall_status":"RECRUITING","enrollment_count":430,"lead_sponsor_name":"Oslo University Hospital","has_results":false},{"nct_id":"NCT05205551","title":"Prospera Test Evaluation in Cardiac Transplant (ProTECT)","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":411,"lead_sponsor_name":"Natera, Inc.","has_results":false},{"nct_id":"NCT02752789","title":"Impact of Allo- and Autoantibodies on Chronic Cardiac Allograft Function","phase":"","overall_status":"COMPLETED","enrollment_count":407,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT07008729","title":"Heart Failure Patient Management and Interventions Using Continuous Patient Monitoring Outside Hospitals and Real-world Data","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":390,"lead_sponsor_name":"Puerta de Hierro University Hospital","has_results":false},{"nct_id":"NCT03644667","title":"Tocilizumab in Cardiac Transplantation","phase":"PHASE2","overall_status":"COMPLETED","enrollment_count":385,"lead_sponsor_name":"National Institute of Allergy and Infectious Diseases (NIAID)","has_results":false},{"nct_id":"NCT05212649","title":"Optimized Peak VO2 in Predicting Advanced HF","phase":"","overall_status":"COMPLETED","enrollment_count":377,"lead_sponsor_name":"Chang Gung Memorial Hospital","has_results":false},{"nct_id":"NCT03102125","title":"Allograft Dysfunction in Heart Transplant","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":376,"lead_sponsor_name":"Paul Kim","has_results":false},{"nct_id":"NCT03152422","title":"Urinary Proteomics in Predicting Heart Transplantation Outcomes","phase":"","overall_status":"UNKNOWN","enrollment_count":352,"lead_sponsor_name":"KU Leuven","has_results":false},{"nct_id":"NCT06740578","title":"Evaluation of the Added Clinical Value of Donor-derived Cell-free DNA for the Monitoring of Cardiac Allograft Rejection.","phase":"","overall_status":"COMPLETED","enrollment_count":320,"lead_sponsor_name":"Paris Translational Research Center for Organ Transplantation","has_results":false},{"nct_id":"NCT07372820","title":"METABolic Deterioration in HTX Determines Outcomes","phase":"","overall_status":"RECRUITING","enrollment_count":270,"lead_sponsor_name":"Heinrich-Heine University, Duesseldorf","has_results":false},{"nct_id":"NCT03991923","title":"Non-ischemic Preservation of the Donor Heart in Heart Transplantation","phase":"NA","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":230,"lead_sponsor_name":"XVIVO Perfusion","has_results":false},{"nct_id":"NCT07359690","title":"Multimodal Analysis of Endomyocardial Biopsies","phase":"","overall_status":"RECRUITING","enrollment_count":216,"lead_sponsor_name":"University Hospital, Essen","has_results":false},{"nct_id":"NCT04508907","title":"A Study to Evaluate Preemptive Therapy in Hepatitis C (HCV) Organ Transplant Recipients","phase":"PHASE4","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":200,"lead_sponsor_name":"Mayo Clinic","has_results":false},{"nct_id":"NCT07301788","title":"Donor Circadian Rhythm and Its Correlation With Prognosis After Heart Transplantation","phase":"","overall_status":"COMPLETED","enrollment_count":200,"lead_sponsor_name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","has_results":false},{"nct_id":"NCT06774794","title":"Precision Medicine in the Management of Heart Transplant Recipients","phase":"","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna","has_results":false},{"nct_id":"NCT06625073","title":"Randomized Trial of SGLT2i in Heart Transplant Recipients","phase":"PHASE4","overall_status":"RECRUITING","enrollment_count":200,"lead_sponsor_name":"VA Office of Research and Development","has_results":false},{"nct_id":"NCT00098007","title":"A Study of Safety, Tolerability & Efficacy of Certican in de Novo Heart Transplant (Tx) Patients","phase":"PHASE3","overall_status":"COMPLETED","enrollment_count":199,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":false},{"nct_id":"NCT03575910","title":"HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection","phase":"","overall_status":"ACTIVE_NOT_RECRUITING","enrollment_count":196,"lead_sponsor_name":"University of British Columbia","has_results":false},{"nct_id":"NCT05268679","title":"Covid-19 Vaccine Response in Heart Transplant Recipients","phase":"","overall_status":"COMPLETED","enrollment_count":190,"lead_sponsor_name":"Assistance Publique - Hôpitaux de Paris","has_results":false},{"nct_id":"NCT00042614","title":"Study of Heart Transplant Rejection","phase":"","overall_status":"COMPLETED","enrollment_count":188,"lead_sponsor_name":"National Institutes of Health Clinical Center (CC)","has_results":false},{"nct_id":"NCT04278547","title":"Multicenter Clinical Trial to Evaluate the Efficacy of a Preventive Strategy Against CMV Infection in Heart Transplant Patients, Based on the Specific T Cells Response","phase":"PHASE4","overall_status":"UNKNOWN","enrollment_count":188,"lead_sponsor_name":"Hospital Universitari de Bellvitge","has_results":false},{"nct_id":"NCT03831048","title":"Donors After Circulatory Death Heart Trial","phase":"NA","overall_status":"COMPLETED","enrollment_count":180,"lead_sponsor_name":"TransMedics","has_results":true},{"nct_id":"NCT00862979","title":"A Study Investigating the Renal Tolerability, Efficacy, and Safety of a CNI-free Versus a Standard Regimen in de Novo Heart Transplant (HTx) Recipients","phase":"PHASE4","overall_status":"COMPLETED","enrollment_count":162,"lead_sponsor_name":"Novartis Pharmaceuticals","has_results":true},{"nct_id":"NCT03924219","title":"CMV T Cell Immunity in Pediatric Solid Organ Transplant Recipients","phase":"","overall_status":"COMPLETED","enrollment_count":161,"lead_sponsor_name":"Vanderbilt University Medical Center","has_results":false},{"nct_id":"NCT06556485","title":"Preventive Catheter Ablation for Ventricular arrhythmiaS in Patients With End-sTage Heart faiLure","phase":"NA","overall_status":"RECRUITING","enrollment_count":160,"lead_sponsor_name":"Heart and Diabetes Center North-Rhine Westfalia","has_results":false},{"nct_id":"NCT07079735","title":"Valganciclovir vs. Letermovir for CMV Prophylaxis in Heart Transplant","phase":"PHASE2, PHASE3","overall_status":"RECRUITING","enrollment_count":150,"lead_sponsor_name":"Columbia University","has_results":false}],"total":50},"guidelines":[],"source":"Drug Landscape verified database"}